KEGG   ENZYME: 3.4.11.22
Entry
EC 3.4.11.22                Enzyme                                 
Name
aminopeptidase I;
aminopeptidase III;
aminopeptidase yscI (gene name);
leucine aminopeptidase IV;
yeast aminopeptidase I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
Reaction(IUBMB)
Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
Comment
A 640-kDa, dodecameric enzyme best known as the major vacuolar aminopeptidase of yeast, Saccharomyces cervisiae, in which species it was first given the name aminopeptidase I (one), amongst others. Activity is stimulated by both Zn2+ and Cl- ions. Type example of peptidase family M18
History
EC 3.4.11.22 created 1997
Orthology
K01268  aminopeptidase I
Genes
QSU111984477 111994960
SCEYKL103C(APE1)
SEUBDI49_3273
SPAOSPAR_K01100
AGOAGOS_ABL035C
ERCEcym_7393
KLAKLLA0_F13574g
KMXKLMA_20156(LAP4)
LTHKLTH0D05544g
VPOKpol_431p10
ZROZYRO0G03344g
CGRCAGL0K08536g
NCSNCAS_0A05740(NCAS0A05740)
NDINDAI_0K02710(NDAI0K02710)
TPFTPHA_0G03190(TPHA0G03190)
TBLTBLA_0I01160(TBLA0I01160)
TDLTDEL_0A02540(TDEL0A02540)
TGBHG536_0A04090
KAFKAFR_0D03190(KAFR0D03190)
KNGKNAG_0A06510(KNAG0A06510)
ZMKHG535_0D03390
PPAPAS_chr3_0803
DHADEHA2F19096g DEHA2G02354g
PICPICST_36090 PICST_47494
PGUPGUG_00246 PGUG_00667
SPAASPAPADRAFT_61203 SPAPADRAFT_62038
LELLELG_02749 LELG_03688
CALCAALFM_C302170CA(LAP41) CAALFM_C503590WA(LAP4)
CTPCTRG_02402 CTRG_05533
COTCORT_0E06480 CORT_0F01780
CDUCD36_53340 CD36_82150
CTENCANTEDRAFT_114626 CANTEDRAFT_114712
YLIYALI0C10494g YALI0F20592g
CLUCLUG_02667 CLUG_03302
CLUSA9F13_01g08910 A9F13_07g01903
CAURCJI97_002690
SLBAWJ20_2140(APE1) AWJ20_3899(APE1)
SLUDSCDLUD_003934
NCRNCU04192
NTENEUTE1DRAFT75349(NEUTE1DRAFT_75349)
SMPSMAC_04402
PANPODANSg8736
TTTTHITE_2061958
MTMMYCTH_2301014
CTHRCTHT_0065300
MGRMGG_07536
PPEIPpBr36_02447
TMNUCRPA7_5870
SSCKSPSK_07290
FGRFGSG_06133
FPUFPSE_00893
FVRFVEG_04770
FOXFOXG_07850
NHENECHADRAFT_48635
TRETRIREDRAFT_47127
TRRM419DRAFT_129298
MAWMAC_05085
MAJMAA_08385
CMTCCM_03061
PLJVFPFJ_08117
VDAVDAG_05108
CFJCFIO01_01316
CLUPCLUP02_07390
CHIGCH63R_03792
SAPOSAPIO_CDS4088
ELAUCREL1_825
PFYPFICI_09596
SSLSS1G_01464
BFUBCIN_02g00170(Bcape1)
MBEMBM_02737
PSCOLY89DRAFT_584072
GLZGLAREA_06492
ANIAN8252.2
AFMAFUA_5G03990
ACTACLA_001190
NFINFIA_038130
AORAO090102000599
ANGANI_1_802084(An09g06250)
AFVAFLA_012032
ALUCAKAW2_40626A
ACHEACHE_60794A
APUUAPUU_60596A
PCSPc22g13950
PDPPDIP_53680
TMFPMAA_083510
TRGTRUGW13939_08287
CIMCIMG_06637
CPWCPC735_030920
UREUREG_03805
PBLPAAG_04205
PBNPADG_07460
ABEARB_06983
TVETRV_00340
AJEHCAG_00603
BGHBDBG_01282
PNOSNOG_11059
PTEPTT_10165
BZECOCCADRAFT_92436
BSCCOCSADRAFT_82527
BORCOCMIDRAFT_4161
AALTCC77DRAFT_1067065
ZTRMYCGRDRAFT_75118
PFJMYCFIDRAFT_32616
FFUCLAFUR5_07190
BCOMBAUCODRAFT_74522
NPAUCRNP2_372
SHSSTEHIDRAFT_166950
 » show all
Reference
1
  Authors
Johnson, M.J.
  Title
Isolation and properties of a pure yeast polypeptidase.
  Journal
J Biol Chem 137:575-586 (1941)
Reference
2  [PMID:5147]
  Authors
Metz G, Rohm KH.
  Title
Yeast aminopeptidase I. Chemical composition and catalytic properties.
  Journal
Biochim Biophys Acta 429:933-49 (1976)
DOI:10.1016/0005-2744(76)90338-7
Reference
3  [PMID:2651436]
  Authors
Chang YH, Smith JA
  Title
Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae.
  Journal
J Biol Chem 264:6979-83 (1989)
  Sequence
[sce:YKL103C]
Reference
4  [PMID:8601598]
  Authors
Oda MN, Scott SV, Hefner-Gravink A, Caffarelli AD, Klionsky DJ.
  Title
Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.
  Journal
J Cell Biol 132:999-1010 (1996)
DOI:10.1083/jcb.132.6.999
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.22
IUBMB Enzyme Nomenclature: 3.4.11.22
ExPASy - ENZYME nomenclature database: 3.4.11.22
BRENDA, the Enzyme Database: 3.4.11.22
CAS: 9031-94-1

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