KEGG   ENZYME: 3.4.11.22Help
Entry
EC 3.4.11.22                Enzyme                                 

Name
aminopeptidase I;
aminopeptidase III;
aminopeptidase yscI;
leucine aminopeptidase IV;
yeast aminopeptidase I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
Comment
A 640-kDa, dodecameric enzyme best known as the major vacuolar aminopeptidase of yeast, Saccharomyces cervisiae, in which species it was first given the name aminopeptidase I (one), amongst others. Activity is stimulated by both Zn2+ and Cl- ions. Type example of peptidase family M18
History
EC 3.4.11.22 created 1997
Orthology
K01268  aminopeptidase I
Genes
SCE: YKL103C(APE1)
AGO: AGOS_ABL035C
ERC: Ecym_7393
KLA: KLLA0_F13574g
KMX: KLMA_20156(LAP4)
LTH: KLTH0D05544g
VPO: Kpol_431p10
ZRO: ZYRO0G03344g
CGR: CAGL0K08536g
NCS: NCAS_0A05740(NCAS0A05740)
NDI: NDAI_0K02710(NDAI0K02710)
TPF: TPHA_0G03190(TPHA0G03190)
TBL: TBLA_0I01160(TBLA0I01160)
TDL: TDEL_0A02540(TDEL0A02540)
KAF: KAFR_0D03190(KAFR0D03190)
CAUR: QG37_07195
SLB: AWJ20_2140(APE1) AWJ20_3899(APE1)
NCR: NCU04192
NTE: NEUTE1DRAFT75349(NEUTE1DRAFT_75349)
MGR: MGG_07536
SSCK: SPSK_07290
MAW: MAC_05085
MAJ: MAA_08385
CMT: CCM_03061
BFU: BCIN_02g00170(Bcape1)
MBE: MBM_02737
ANI: AN8252.2
ANG: ANI_1_802084(An09g06250)
ABE: ARB_06983
TVE: TRV_00340
PTE: PTT_10165
 » show all
Taxonomy
Reference
1
  Authors
Johnson, M.J.
  Title
Isolation and properties of a pure yeast polypeptidase.
  Journal
J Biol Chem 137:575-586 (1941)
Reference
2  [PMID:5147]
  Authors
Metz G, Rohm KH.
  Title
Yeast aminopeptidase I. Chemical composition and catalytic properties.
  Journal
Biochim Biophys Acta 429:933-49 (1976)
DOI:10.1016/0005-2744(76)90338-7
Reference
3  [PMID:2651436]
  Authors
Chang YH, Smith JA.
  Title
Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae.
  Journal
J Biol Chem 264:6979-83 (1989)
  Sequence
[sce:YKL103C]
Reference
4  [PMID:8601598]
  Authors
Oda MN, Scott SV, Hefner-Gravink A, Caffarelli AD, Klionsky DJ.
  Title
Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.
  Journal
J Cell Biol 132:999-1010 (1996)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.22
IUBMB Enzyme Nomenclature: 3.4.11.22
ExPASy - ENZYME nomenclature database: 3.4.11.22
BRENDA, the Enzyme Database: 3.4.11.22
CAS: 9031-94-1

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