KEGG   ENZYME: 3.4.11.26
Entry
EC 3.4.11.26                Enzyme                                 
Name
intermediate cleaving peptidase 55;
Icp55;
mitochondrial intermediate cleaving peptidase 55 kDa
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
Reaction(IUBMB)
The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.
Comment
Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed.
History
EC 3.4.11.26 created 2011
Orthology
K18573  intermediate cleaving peptidase 55
Genes
BPG: Bathy01g04420
SCE: YER078C(ICP55)
SEUB: DI49_1483
SPAO: SPAR_E01550
AGO: AGOS_ACL028W
ERC: Ecym_8027
KLA: KLLA0_C07645g
KMX: KLMA_40410(ICP55)
LTH: KLTH0A04950g
VPO: Kpol_411p9
ZRO: ZYRO0C08822g
CGR: 2889735(GVI51_J03135)
NCS: NCAS_0E03450(NCAS0E03450)
NDI: NDAI_0A03130(NDAI0A03130)
TPF: TPHA_0P00720(TPHA0P00720)
TBL: TBLA_0F01960(TBLA0F01960)
TGB: HG536_0C05170
TDL: TDEL_0H01760(TDEL0H01760)
KAF: KAFR_0L01090(KAFR0L01090)
KNG: KNAG_0L01730(KNAG0L01730)
ZMK: HG535_0E03330
SLUD: SCDLUD_000319
DHA: DEHA2B13750g
PIC: PICST_67038
PGU: PGUG_01816
SPAA: SPAPADRAFT_141091
LEL: PVL30_003526(ICP55)
LBG: 92208761(LODBEIA_P35650)
CAL: CAALFM_C303560WA(CaO19.354)
CTP: CTRG_02467
COT: CORT_0C03790
CDU: CD36_83570
CTEN: 18245981(ICP55)
CLU: CLUG_01193
CLUS: A9F13_09g02596
CAUR: CJI96_0004241
ASAU: 88172683(PUMCH_001618)
PPA: PAS_chr1-4_0468
PKZ: C5L36_0A11900
BNN: FOA43_000088
BBRX: BRETT_001012
OPA: HPODL_05013
YLI: 2906696(YALI2_C00673g)
SLB: AWJ20_1960(ICP55)
NCR: NCU05971
NTE: NEUTE1DRAFT124894(NEUTE1DRAFT_124894)
SMP: 10806645(SMAC4_07000)
PAN: PODANSg3115
PBEL: QC761_407480(ICP55)
PPSD: QC762_407480(ICP55)
PPSP: QC763_407480(ICP55)
PPSA: QC764_407480(ICP55)
TTT: THITE_2142112
MTM: MYCTH_2127963
CTHR: CTHT_0040650
RTHE: 98126801(VTJ83DRAFT_5545)
MGR: MGG_00596
PPEI: PpBr36_08571
PGRI: PgNI_08742
TMN: UCRPA7_2733
SSCK: SPSK_00770
FGR: FGSG_09309
FPU: FPSE_09708
FPOA: FPOAC1_012382
FVN: FVRRES_13462
FVR: FVEG_03796
FOX: FOXG_05925
NHE: NECHADRAFT_76810
FFC: NCS54_00299100
FKR: NCS57_00294300
FMU: J7337_003804
TRE: TRIREDRAFT_29108
TRR: M419DRAFT_9997
TATV: 25784762(TrAtP1_001053)
TASP: 36608008(TrAFT101_001403)
MAW: 19247048(ICP55)
MAJ: MAA_02070
MBRN: 26239638(ICP55)
PCHM: VFPPC_01620
CMT: CCM_04066
AMUS: LMH87_009204
PLJ: 28886164(PLICBS_007656)
PTKZ: JDV02_004490(ICP55)
VAL: VDBG_08169
CFJ: CFIO01_05130
CLUP: CLUP02_16445
CHIG: CH63R_14111
CDET: 87947685(CDEST_11185)
SAPO: SAPIO_CDS5427
ELA: UCREL1_6641
PFY: PFICI_09832
SSL: SS1G_02276
BFU: BCIN_16g00690
MBE: MBM_06434
PSCO: LY89DRAFT_547068
GLZ: GLAREA_01487
ANI: ANIA_01780
AFM: AFUA_6G09190
ACT: ACLA_083200
NFI: NFIA_054880
AOR: AO090001000597
ANG: An11g06960
AFV: AFLA_012730
ALUC: AKAW2_80621A
ACHE: ACHE_80717S
APUU: APUU_21327S
PCS: N7525_001752
PDP: PDIP_35620
POU: POX_a01223
TMF: EYB26_001473
TRG: TRUGW13939_05872
CIM: CIMG_01195
URE: UREG_01135
ABE: ARB_05294
TVE: TRV_02331
PBL: PAAG_01230
PBN: PADG_03595
AJE: HCAG_05830
BGH: BDBG_02164
PNO: SNOG_06295
PTE: PTT_13396
PTRR: 6339498(PtrM4_021090)
BZE: COCCADRAFT_30228
BSC: COCSADRAFT_40620
BOR: COCMIDRAFT_1198
AALT: CC77DRAFT_1094573
ADAC: 96082414(ACET3X_002092)
ARAB: EKO05_0006035
ZTR: MYCGRDRAFT_71838
PFJ: MYCFIDRAFT_160714
FFU: CLAFUR5_00699
CBET: CB0940_01761
BCOM: BAUCODRAFT_63038
NPA: UCRNP2_9365
TML: GSTUM_00000329001
SPO: 2542952(icp55)
SOM: SOMG_03759(icp55)
CNE: CNC05670
CNB: CNBC1520
CNG: CNAG_07509
CGI: CGB_C8230W
CDEU: CNBG_3599
CDEC: 89987739(IAS62_000964)
CTEG: 91989112(I308_102254)
CBAS: 91982303(I312_102255)
CDEP: 91084978(L203_100764)
KMG: 30165380(I203_101514)
KNE: 92178150(IAR55_000891)
KDJ: 28966771(I303_103052)
KBI: 30205388(I302_102297)
KPIN: 30171127(I206_102411)
KSH: 87954941(IL334_002810)
KER: 91102440(V865_003637)
TMS: TREMEDRAFT_25984
TASA: A1Q1_05829
CCAC: CcaHIS019_0704360(ICP55)
TVS: TRAVEDRAFT_70397
DSQ: DICSQDRAFT_154298
SHS: STEHIDRAFT_122394
HIR: HETIRDRAFT_439291
PSQ: PUNSTDRAFT_64678
ADL: AURDEDRAFT_80933
FME: FOMMEDRAFT_157919
GTR: GLOTRDRAFT_34532
RSX: RhiXN_03685
LBC: LACBIDRAFT_303704
CCI: CC1G_11395
ABP: AGABI1DRAFT64099(AGABI1DRAFT_64099)
ABV: AGABI2DRAFT219147(AGABI2DRAFT_219147)
PCUB: JR316_0005122
MRR: Moror_8821
MORE: E1B28_003929
SCM: SCHCO_02527674(SCHCODRAFT_02527674)
CPUT: CONPUDRAFT_143630
SLA: SERLADRAFT_434905
WSE: WALSEDRAFT_61425
WIC: J056_002554
UMA: UMAG_04738
PFP: PFL1_04380
SGRA: EX895_000230
MGL: MGL_2324
MRT: MRET_0188
MSYM: MSY001_2032
PGR: PGTG_05721
PTRC: PtA15_15A33
PSTR: Pst134EA_028203 Pst134EA_032300
MLR: MELLADRAFT_85093
RIE: OCT59_011176
MBR: MONBRDRAFT_37508
TVA: 4762505(TVAGG3_0182750)
 » show all
Reference
1  [PMID:19720832]
  Authors
Naamati A, Regev-Rudzki N, Galperin S, Lill R, Pines O
  Title
Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.
  Journal
J Biol Chem 284:30200-8 (2009)
DOI:10.1074/jbc.M109.034694
  Sequence
[sce:YER078C]
Reference
2  [PMID:19837041]
  Authors
Vogtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C
  Title
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.
  Journal
Cell 139:428-39 (2009)
DOI:10.1016/j.cell.2009.07.045
  Sequence
[sce:YER078C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.26
IUBMB Enzyme Nomenclature: 3.4.11.26
ExPASy - ENZYME nomenclature database: 3.4.11.26
BRENDA, the Enzyme Database: 3.4.11.26

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Gene (104)   
   MGENES (43)   
   RefGene (61)   
Protein sequence (76)   
   UniProt (46)   
   SWISS-PROT (2)   
   RefSeq(pep) (24)   
   PDBSTR (4)   
DNA sequence (92)   
   RefSeq(nuc) (48)   
   GenBank (22)   
   EMBL (22)   
3D Structure (3)   
   PDB (3)   
Protein domain (6)   
   InterPro (6)   
All databases (281)   

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