KEGG   ENZYME: 3.4.11.26Help
Entry
EC 3.4.11.26                Enzyme                                 

Name
intermediate cleaving peptidase 55;
Icp55;
mitochondrial intermediate cleaving peptidase 55 kDa
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.
Comment
Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed.
History
EC 3.4.11.26 created 2011
Orthology
K18573  intermediate cleaving peptidase 55
Genes
CRE: CHLREDRAFT_172074
BPG: Bathy01g04420
SCE: YER078C(ICP55)
AGO: AGOS_ACL028W
ERC: Ecym_8027
KLA: KLLA0_C07645g
KMX: KLMA_40410(ICP55)
LTH: KLTH0A04950g
VPO: Kpol_411p9
ZRO: ZYRO0C08822g
CGR: CAGL0J03300g
NCS: NCAS_0E03450(NCAS0E03450)
NDI: NDAI_0A03130(NDAI0A03130)
TPF: TPHA_0P00720(TPHA0P00720)
TBL: TBLA_0F01960(TBLA0F01960)
TDL: TDEL_0H01760(TDEL0H01760)
KAF: KAFR_0L01090(KAFR0L01090)
PPA: PAS_chr1-4_0468
DHA: DEHA2B13750g
PIC: PICST_67038
PGU: PGUG_01816
SPAA: SPAPADRAFT_141091
LEL: LELG_02680
CAL: CAALFM_C303560WA(CaO19.354)
CTP: CTRG_02467
COT: CORT_0C03790
CDU: CD36_83570
CTEN: CANTEDRAFT_107785
YLI: YALI0B20394g
CLU: CLUG_01193
CLUS: A9F13_09g02596
CAUR: QG37_05795
SLB: AWJ20_1960(ICP55)
NCR: NCU05971
NTE: NEUTE1DRAFT124894(NEUTE1DRAFT_124894)
SMP: SMAC_07000
PAN: PODANSg3115
TTT: THITE_2142112
MTM: MYCTH_2127963
CTHR: CTHT_0040650
MGR: MGG_00596
TMN: UCRPA7_2733
SSCK: SPSK_00770
FGR: FGSG_09309
FPU: FPSE_09708
FVR: FVEG_03796
FOX: FOXG_05925
NHE: NECHADRAFT_76810
TRE: TRIREDRAFT_29108
MAW: MAC_02737
MAJ: MAA_02070
CMT: CCM_04066
PLJ: VFPFJ_04033
VAL: VDBG_08169
VDA: VDAG_10061
CFJ: CFIO01_05130
ELA: UCREL1_6641
PFY: PFICI_09832
SSL: SS1G_02276
BFU: BCIN_16g00690
MBE: MBM_06434
PSCO: LY89DRAFT_547068
GLZ: GLAREA_01487
ANI: AN1780.2
AFM: AFUA_6G09190
AOR: AO090001000597
ANG: ANI_1_928094(An11g06960)
AFV: AFLA_129040
ACT: ACLA_083200
NFI: NFIA_054880
PCS: Pc12g08060
PDP: PDIP_35620
CIM: CIMG_01195
CPW: CPC735_051910
PBL: PAAG_01230
PBN: PADG_03595
URE: UREG_01135
ABE: ARB_05294
TVE: TRV_02331
AJE: HCAG_05830
PNO: SNOG_06295
PTE: PTT_13396
BZE: COCCADRAFT_30228
BSC: COCSADRAFT_40620
BOR: COCMIDRAFT_1198
AALT: CC77DRAFT_1094573
ZTR: MYCGRDRAFT_71838
PFJ: MYCFIDRAFT_160714
BCOM: BAUCODRAFT_63038
NPA: UCRNP2_9365
TML: GSTUM_00000329001
SPO: SPAC12B10.05(icp55)
CNE: CNC05670
CNB: CNBC1520
CGI: CGB_C8230W
TMS: TREMEDRAFT_25984
TVS: TRAVEDRAFT_70397
DSQ: DICSQDRAFT_154298
SHS: STEHIDRAFT_122394
HIR: HETIRDRAFT_439291
PSQ: PUNSTDRAFT_116255 PUNSTDRAFT_64678
ADL: AURDEDRAFT_80933
FME: FOMMEDRAFT_157919
GTR: GLOTRDRAFT_34532
LBC: LACBIDRAFT_303704
MRR: Moror_8821
CCI: CC1G_11395
SCM: SCHCODRAFT_46782
ABP: AGABI1DRAFT64099(AGABI1DRAFT_64099)
ABV: AGABI2DRAFT219147(AGABI2DRAFT_219147)
CPUT: CONPUDRAFT_143630
SLA: SERLADRAFT_434905
WSE: WALSEDRAFT_61425
WIC: J056_002554
UMA: UMAG_04738
PFP: PFL1_04380
PGR: PGTG_05721
MLR: MELLADRAFT_85093
 » show all
Taxonomy
Reference
1  [PMID:19720832]
  Authors
Naamati A, Regev-Rudzki N, Galperin S, Lill R, Pines O
  Title
Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.
  Journal
J Biol Chem 284:30200-8 (2009)
DOI:10.1074/jbc.M109.034694
  Sequence
[sce:YER078C]
Reference
2  [PMID:19837041]
  Authors
Vogtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C
  Title
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.
  Journal
Cell 139:428-39 (2009)
DOI:10.1016/j.cell.2009.07.045
  Sequence
[sce:YER078C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.26
IUBMB Enzyme Nomenclature: 3.4.11.26
ExPASy - ENZYME nomenclature database: 3.4.11.26
BRENDA, the Enzyme Database: 3.4.11.26

  All links  
Gene (222)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (119)   
   KEGG MGENES (41)   
   RefGene (61)   
Protein sequence (13)   
   UniProt (5)   
   SWISS-PROT (2)   
   RefSeq(pep) (2)   
   PDBSTR (4)   
DNA sequence (7)   
   RefSeq(nuc) (4)   
   GenBank (1)   
   EMBL (2)   
3D Structure (3)   
   PDB (3)   
All databases (245)   

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