Entry
Name
intermediate cleaving peptidase 55;
Icp55;
mitochondrial intermediate cleaving peptidase 55 kDa
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC
2.8.1.7 ) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.
Comment
Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC
2.8.1.7 ), where three amino acids are removed.
History
EC 3.4.11.26 created 2011
Orthology
K18573 intermediate cleaving peptidase 55
Genes
CGR : 2889735(GVI51_J03135)
NCS : NCAS_0E03450(NCAS0E03450)
NDI : NDAI_0A03130(NDAI0A03130)
TPF : TPHA_0P00720(TPHA0P00720)
TBL : TBLA_0F01960(TBLA0F01960)
TDL : TDEL_0H01760(TDEL0H01760)
KAF : KAFR_0L01090(KAFR0L01090)
KNG : KNAG_0L01730(KNAG0L01730)
LBG : 92208761(LODBEIA_P35650)
CAL : CAALFM_C303560WA(CaO19.354)
ASAU : 88172683(PUMCH_001618)
YLI : 2906696(YALI2_C00673g)
NTE : NEUTE1DRAFT124894(NEUTE1DRAFT_124894)
SMP : 10806645(SMAC4_07000)
PBEL : QC761_407480(ICP55)
PPSD : QC762_407480(ICP55)
PPSP : QC763_407480(ICP55)
PPSA : QC764_407480(ICP55)
RTHE : 98126801(VTJ83DRAFT_5545)
TATV : 25784762(TrAtP1_001053)
TASP : 36608008(TrAFT101_001403)
PLJ : 28886164(PLICBS_007656)
PTKZ : JDV02_004490(ICP55)
CDET : 87947685(CDEST_11185)
PTRR : 6339498(PtrM4_021090)
ADAC : 96082414(ACET3X_002092)
CDEC : 89987739(IAS62_000964)
CTEG : 91989112(I308_102254)
CBAS : 91982303(I312_102255)
CDEP : 91084978(L203_100764)
KMG : 30165380(I203_101514)
KNE : 92178150(IAR55_000891)
KDJ : 28966771(I303_103052)
KBI : 30205388(I302_102297)
KPIN : 30171127(I206_102411)
KSH : 87954941(IL334_002810)
KER : 91102440(V865_003637)
CCAC : CcaHIS019_0704360(ICP55)
ABP : AGABI1DRAFT64099(AGABI1DRAFT_64099)
ABV : AGABI2DRAFT219147(AGABI2DRAFT_219147)
SCM : SCHCO_02527674(SCHCODRAFT_02527674)
PSTR : Pst134EA_028203 Pst134EA_032300
TVA : 4762505(TVAGG3_0182750)
» show all
Taxonomy
Reference
Authors
Naamati A, Regev-Rudzki N, Galperin S, Lill R, Pines O
Title
Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.
Journal
Sequence
Reference
Authors
Vogtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C
Title
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.11.26