KEGG   ENZYME: 3.4.11.3Help
Entry
EC 3.4.11.3                 Enzyme                                 

Name
cystinyl aminopeptidase;
cystyl-aminopeptidase;
oxytocinase;
cystine aminopeptidase;
L-cystine aminopeptidase;
oxytocin peptidase;
vasopresssinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal amino acid, Cys!Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however [4]
Comment
A zinc-containing sialoglycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family)
History
EC 3.4.11.3 created 1972
Orthology
K01257  cystinyl aminopeptidase
Genes
HSA: 4012(LNPEP)
PTR: 461960(LNPEP)
PPS: 100975663(LNPEP)
GGO: 101139054(LNPEP)
PON: 100439455(LNPEP)
NLE: 100603383(LNPEP)
MCC: 703949(LNPEP)
MCF: 102115644(LNPEP)
CSAB: 103225023(LNPEP)
RRO: 104657441(LNPEP)
RBB: 108519674(LNPEP)
CJC: 100391174(LNPEP)
SBQ: 101040288(LNPEP)
MMU: 240028(Lnpep)
RNO: 108348118 171105(Lnpep)
CGE: 100759698(Lnpep)
NGI: 103732022(Lnpep)
HGL: 101709446(Lnpep)
CCAN: 109695473(Lnpep)
OCU: 100353022(LNPEP)
TUP: 102474416(LNPEP)
CFA: 488896(LNPEP)
AML: 100473699(LNPEP)
UMR: 103672209(LNPEP)
ORO: 101372794(LNPEP)
FCA: 101083321(LNPEP)
PTG: 102969445(LNPEP)
AJU: 106969070(LNPEP)
BTA: 521633(LNPEP)
BOM: 102267303(LNPEP)
BIU: 109562347(LNPEP)
PHD: 102319089(LNPEP)
CHX: 102186394(LNPEP)
OAS: 101102729(LNPEP)
SSC: 100125826(LNPEP)
CFR: 102509485(LNPEP)
CDK: 105100897(LNPEP)
BACU: 103014830(LNPEP)
LVE: 103071064(LNPEP)
OOR: 101286074(LNPEP)
ECB: 100073222(LNPEP)
EPZ: 103560188(LNPEP) 103561283
EAI: 106847763(LNPEP)
MYB: 102260924(LNPEP)
MYD: 102768292(LNPEP)
HAI: 109390161(LNPEP)
RSS: 109445502(LNPEP)
PALE: 102892183(LNPEP)
LAV: 100664517(LNPEP)
TMU: 101354580
MDO: 100015080(LNPEP)
SHR: 100925233(LNPEP)
OAA: 100081694(LNPEP)
GGA: 427279(LNPEP)
MGP: 104915194(LNPEP)
CJO: 107306379(LNPEP)
APLA: 101792280(LNPEP)
ACYG: 106046475(LNPEP)
TGU: 100218959
GFR: 102036062(LNPEP)
FAB: 101815820(LNPEP)
PHI: 102109326(LNPEP)
PMAJ: 107198251(LNPEP)
CCW: 104689772(LNPEP)
FPG: 101921722(LNPEP)
FCH: 102053784(LNPEP)
CLV: 102089254(LNPEP)
EGZ: 104135054(LNPEP)
ASN: 102376681(LNPEP)
AMJ: 106736966(LNPEP)
CMY: 102930761(LNPEP)
CPIC: 101948346(LNPEP)
ACS: 100565555(lnpep)
PVT: 110078770(LNPEP)
PBI: 103049159(LNPEP)
GJA: 107107285(LNPEP)
XLA: 379719(lnpep.S) 495293(lnpep.L)
XTR: 100216271(lnpep)
NPR: 108790051(LNPEP)
DRE: 322814(lnpep)
CCAR: 109082479
IPU: 108255525(lnpep)
AMEX: 103042675(lnpep)
TRU: 101075332(lnpep)
LCO: 104921214(lnpep)
NCC: 104943771
MZE: 101464558
OLA: 101154957
XMA: 102233247
PRET: 103470390
NFU: 107393919(lnpep)
CSEM: 103398275
LCF: 108878318(lnpep)
HCQ: 109514097
BPEC: 110156743(lnpep)
SASA: 106580282(lnpep) 106585016
ELS: 105007007
SFM: 108938375(lnpep)
LCM: 102360095(LNPEP)
CMK: 103178390(lnpep)
 » show all
Taxonomy
Reference
1  [PMID:6041057]
  Authors
Sjoholm I.
  Title
Biochemical studies on oxytocin and oxytocinase.
  Journal
Acta Pharm Suec 4:81-96 (1967)
Reference
2  [PMID:4292447]
  Authors
Sjoholm I, Yman L.
  Title
Degradation of oxytocin, lysine-vasopressin, angiotensin II and angiotensin-II-amide by oxytocinase (cystine aminopeptidase).
  Journal
Acta Pharm Suec 4:65-76 (1967)
Reference
3  [PMID:5421622]
  Authors
Yman L.
  Title
Studies on human serum aminopeptidases. Some properties of oxytocinase, human serum aminopeptidase A and leucine aminopeptidase and their purification from retroplacental serum.
  Journal
Acta Pharm Suec 7:75-86 (1970)
Reference
4
  Authors
Sakura, H., Lin, T.Y., Doi, M., Mizutani, S. and Kawashima, Y.
  Title
Purification and properties of oxytocinase, a metalloenzyme.
  Journal
Biochem Int 2:173-179 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.3
IUBMB Enzyme Nomenclature: 3.4.11.3
ExPASy - ENZYME nomenclature database: 3.4.11.3
BRENDA, the Enzyme Database: 3.4.11.3
CAS: 9031-41-8

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