KEGG   ENZYME: 3.4.11.3
Entry
EC 3.4.11.3                 Enzyme                                 
Name
cystinyl aminopeptidase;
cystyl-aminopeptidase;
oxytocinase;
cystine aminopeptidase;
L-cystine aminopeptidase;
oxytocin peptidase;
vasopresssinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
Reaction(IUBMB)
Release of an N-terminal amino acid, Cys!Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however [4]
Comment
A zinc-containing sialoglycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family)
History
EC 3.4.11.3 created 1972
Orthology
K01257  cystinyl aminopeptidase
Genes
HSA4012(LNPEP)
PTR461960(LNPEP)
PPS100975663(LNPEP)
GGO101139054(LNPEP)
PON100439455(LNPEP)
NLE100603383(LNPEP)
MCC703949(LNPEP)
MCF102115644
CSAB103225023(LNPEP)
CATY105580982(LNPEP)
PANU101013078(LNPEP)
TGE112625855(LNPEP)
RRO104657441(LNPEP)
RBB108519674(LNPEP)
TFN117064881(LNPEP)
PTEH111542652(LNPEP)
CJC100391174(LNPEP)
SBQ101040288(LNPEP)
CSYR103257321(LNPEP)
MMUR105876112(LNPEP)
LCAT123648582
OGA100958484(LNPEP)
MMU240028(Lnpep)
MCAL110312590(Lnpep)
MPAH110338032(Lnpep)
RNO171105(Lnpep)
MCOC116078963(Lnpep)
MUN110559507(Lnpep)
CGE100759698(Lnpep)
MAUA101826656
PLEU114691312
MORG121466643
AAMP119820551
NGI103732022(Lnpep)
HGL101709446(Lnpep)
CPOC100718730(Lnpep)
CCAN109695473(Lnpep)
DORD105989819(Lnpep)
DSP122117366
NCAR124986562
OCU100353022(LNPEP)
OPI101528559
TUP102474416(LNPEP)
CFA488896(LNPEP)
VVP112915468(LNPEP)
VLG121489040
AML100473699(LNPEP)
UMR103672209(LNPEP)
UAH113255059(LNPEP)
UAR123799294
ELK111148261
LLV125100824
MPUF101682451(LNPEP)
ORO101372794(LNPEP)
EJU114200055(LNPEP)
ZCA113929649
MLX118017034(LNPEP)
FCA101083321(LNPEP)
PYU121012608
PBG122491501
PTG102969445(LNPEP)
PPAD109254719(LNPEP)
AJU106969070(LNPEP)
HHV120236530
BTA521633(LNPEP)
BOM102267303(LNPEP)
BIU109562347(LNPEP)
BBUB102393847
CHX102186394(LNPEP)
OAS101102729(LNPEP)
ODA120863263
CCAD122439506
SSC100125826(LNPEP)
CFR102509485(LNPEP)
CBAI105064569(LNPEP)
CDK105100897(LNPEP)
VPC102541002(LNPEP)
BACU103014830(LNPEP)
LVE103071064(LNPEP)
OOR101286074(LNPEP)
DLE111184087(LNPEP)
PCAD102992893(LNPEP)
PSIU116750716(LNPEP)
ECB100073222(LNPEP)
EPZ103560188(LNPEP)
EAI106847763
MYB102260924(LNPEP)
MYD102768292(LNPEP)
MMYO118656789
MLF102425594(LNPEP)
MNA107539602(LNPEP)
PKL118702709
HAI109390161(LNPEP)
DRO112307209(LNPEP)
SHON118977438
AJM119055587
PDIC114496094
PHAS123824824
MMF118641862
RFQ117025328(LNPEP)
PALE102892183(LNPEP)
PGIG120612567
PVP105304796(LNPEP)
RAY107518277(LNPEP)
MJV108392001(LNPEP)
TOD119260432
SARA101548854(LNPEP)
LAV100664517(LNPEP)
TMU101354580
DNM101433270(LNPEP)
MDO100015080(LNPEP)
GAS123236302
SHR100925233(LNPEP)
PCW110223535(LNPEP)
OAA100081694
GGA427279(LNPEP)
PCOC116239038(LNPEP)
MGP104915194
CJO107306379(LNPEP)
NMEL110389598(LNPEP)
APLA101792280(LNPEP)
ACYG106046475(LNPEP)
AFUL116500756(LNPEP)
TGU100218959(LNPEP)
LSR110473200(LNPEP)
SCAN103821215(LNPEP)
PMOA120509472
OTC121338542
PRUF121355019
GFR102036062(LNPEP)
FAB101815820(LNPEP)
PHI102109326(LNPEP)
PMAJ107198251(LNPEP)
CCW104689772
ETL114056953(LNPEP)
ZAB102066074(LNPEP)
FPG101921722(LNPEP)
FCH102053784(LNPEP)
CLV102089254(LNPEP)
EGZ104135054(LNPEP)
NNI104014064(LNPEP)
PLET104622895
ACUN113489982(LNPEP)
TALA104362884
PADL103915039(LNPEP)
ACHC115336548
AROW112976935(LNPEP)
NPD112951436(LNPEP)
DNE112980261(LNPEP)
ASN102376681(LNPEP)
AMJ106736966(LNPEP)
CPOO109308132(LNPEP)
GGN109297449(LNPEP)
PSS102451133
CMY102930761
CPIC101948346
TST117878811(LNPEP)
CABI116835677(LNPEP)
MRV120407783
ACS100565555(lnpep)
PVT110078770(LNPEP)
SUND121920968
PBI103049159(LNPEP)
PMUR107302784(LNPEP)
TSR106540963(LNPEP)
PGUT117679086(LNPEP)
VKO123031173
PMUA114606174(LNPEP)
ZVI118076743(LNPEP)
GJA107107285(LNPEP)
STOW125436421
XLA379719(lnpep.S) 495293(lnpep.L)
XTR100216271(lnpep)
NPR108790051(LNPEP)
RTEM120931284
BBUF120992535
BGAR122924659
DRE322814(lnpep)
SRX107720271 107756310
SANH107699734 107703263
SGH107555501 107587503
CCAR109082479
CAUA113049633 113080511
PPRM120472049
MAMB125267531
IPU108255525
PHYP113537004(lnpep)
SMEO124380905
TFD113637661
AMEX103042675(lnpep)
EEE113574970(lnpep)
TRU101075332(lnpep)
TNGGSTEN00028656G001
LCO104921214(lnpep)
NCC104943771
CGOB115013600(lnpep)
ELY117252398(lnpep)
PLEP121944168
SLUC116056647
ECRA117945190(lnpep)
PFLV114555125(lnpep)
GAT120830366
PPUG119225218
MSAM119892233
CUD121509809
ALAT119019277
MZE101464558
ONL100692735(lnpep)
OAU116332525
OLA101154957
OML112148247
XMA102233247
XCO114154379
XHE116729613
PRET103470390
PFOR103142937
PLAI106944598(lnpep)
PMEI106920931
GAF122828809
CVG107083671(lnpep)
CTUL119786572
GMU124877870
NFU107393919(lnpep)
KMR108234607
ALIM106521748(lnpep)
NWH119413091
AOCE111587793(lnpep)
CSEM103398275
POV109638180(lnpep)
SSEN122769635
HHIP117767225(lnpep)
HSP118114816
LCF108878318(lnpep)
SDU111227707(lnpep)
SLAL111660327(lnpep)
XGL120804849
HCQ109514097
BPEC110156743(lnpep)
MALB109956957(lnpep)
BSPL114862642
SASA106580282(lnpep) 106585016
OTW112248569 112262802
OMY110525774(lnpep) 110535084
OGO124034239 124036411
ONE115117285 115117953
SALP111958167 111974780
SNH120029584 120062898
ELS105007007
SFM108938375(lnpep)
PKI111839226(lnpep)
AANG118206239(lnpep)
LOC102683571(lnpep)
PSPA121299611 121313833
ARUT117403961(lnpep)
LCM102360095(LNPEP)
CMK103178390
RTP109933513(lnpep)
BBEL109468396
AARA120898825
ASTE118502692
SOY115886622
MSEX115449147
TNL113500536
DSV119463958
CSCU111624120
NVE116619102
 » show all
Reference
1  [PMID:6041057]
  Authors
Sjoholm I.
  Title
Biochemical studies on oxytocin and oxytocinase.
  Journal
Acta Pharm Suec 4:81-96 (1967)
Reference
2  [PMID:4292447]
  Authors
Sjoholm I, Yman L.
  Title
Degradation of oxytocin, lysine-vasopressin, angiotensin II and angiotensin-II-amide by oxytocinase (cystine aminopeptidase).
  Journal
Acta Pharm Suec 4:65-76 (1967)
Reference
3  [PMID:5421622]
  Authors
Yman L.
  Title
Studies on human serum aminopeptidases. Some properties of oxytocinase, human serum aminopeptidase A and leucine aminopeptidase and their purification from retroplacental serum.
  Journal
Acta Pharm Suec 7:75-86 (1970)
Reference
4
  Authors
Sakura, H., Lin, T.Y., Doi, M., Mizutani, S. and Kawashima, Y.
  Title
Purification and properties of oxytocinase, a metalloenzyme.
  Journal
Biochem Int 2:173-179 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.3
IUBMB Enzyme Nomenclature: 3.4.11.3
ExPASy - ENZYME nomenclature database: 3.4.11.3
BRENDA, the Enzyme Database: 3.4.11.3
CAS: 9031-41-8

DBGET integrated database retrieval system