KEGG   ENZYME: 3.4.11.6
Entry
EC 3.4.11.6                 Enzyme                                 
Name
aminopeptidase B;
arylamidase II;
arginine aminopeptidase;
arginyl aminopeptidase;
Cl--activated arginine aminopeptidase;
cytosol aminopeptidase IV;
L-arginine aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
Reaction(IUBMB)
Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys
Comment
Cytosolic or membrane-associated enzyme from mammalian tissues, activated by chloride ions and low concentrations of thiol compounds. This is one of the activities of the bifunctional enzyme EC 3.3.2.6 (membrane alanyl aminopeptidase family) [4,5].
History
EC 3.4.11.6 created 1972, modified 1997
Orthology
K01260  aminopeptidase B
K19701  aminopeptidase YwaD
Genes
HSA6051(RNPEP)
PTR469638(RNPEP)
PPS100974364(RNPEP)
GGO101127560(RNPEP)
PON100456066(RNPEP)
NLE115836679(RNPEP)
MCC706696(RNPEP)
MCF102146949
CSAB103230319(RNPEP)
CATY105575438(RNPEP)
PANU101012547(RNPEP)
TGE112633639(RNPEP)
RRO104674517(RNPEP)
RBB108545095(RNPEP)
TFN117074513(RNPEP)
PTEH111522727(RNPEP)
CJC100400846(RNPEP)
SBQ101049218(RNPEP)
CSYR103269568(RNPEP)
MMUR105860056(RNPEP)
OGA100962482(RNPEP)
MMU215615(Rnpep)
MCAL110291497(Rnpep)
MPAH110321199(Rnpep)
RNO81761(Rnpep)
MCOC116099711(Rnpep)
MUN110548421(Rnpep)
CGE100755451(Rnpep)
PLEU114698122
NGI103731828(Rnpep)
HGL101712935(Rnpep)
CPOC100724495(Rnpep)
CCAN109684759(Rnpep)
DORD105986535(Rnpep)
DSP122126758
OCU100342982(RNPEP)
OPI101535169
TUP102475581(RNPEP)
CFA490236(RNPEP)
VVP112934502(RNPEP)
VLG121493844
AML100471332(RNPEP)
UMR103657779(RNPEP)
UAH113242543(RNPEP)
UAR123785746
ELK111151108
LLV125085802
MPUF101671932(RNPEP)
ORO101367496(RNPEP)
EJU114221918(RNPEP)
ZCA113931828
MLX118014200(RNPEP)
FCA101100613(RNPEP)
PYU121021695
PBG122476341
PTG102952170(RNPEP)
PPAD109256296(RNPEP)
AJU106974256(RNPEP)
HHV120228913
BTA282040(RNPEP)
BOM102286299(RNPEP)
BBUB102409731(RNPEP)
CHX102170601(RNPEP)
OAS101114205(RNPEP)
ODA120880081
CCAD122451953
SSC100524577(RNPEP)
CFR102505914(RNPEP)
CBAI105069995(RNPEP)
CDK105103112(RNPEP)
VPC102537090(RNPEP)
BACU103013646(RNPEP)
LVE103076101(RNPEP)
OOR101290438(RNPEP)
DLE111168315(RNPEP)
PCAD102985050(RNPEP)
PSIU116750688(RNPEP)
ECB100063775(RNPEP)
EPZ103567457(RNPEP)
EAI106832344
MYB102246228(RNPEP)
MYD102760506(RNPEP)
MMYO118678826
MNA107536014(RNPEP)
PKL118710533
HAI109380478(RNPEP)
DRO112318852(RNPEP)
SHON119003946
AJM119060745
PDIC114512248
PHAS123832305
MMF118640618
RFQ117018493(RNPEP)
PGIG120619323
PVP105296944(RNPEP)
MJV108405428(RNPEP)
TOD119233840
SARA101557066(RNPEP)
LAV100673954(RNPEP)
TMU101342405
DNM101412539(RNPEP)
MDO100014545(RNPEP)
GAS123244144
SHR100923693(RNPEP)
PCW110219603(RNPEP)
OAA100093099
GGA421165(RNPEP)
PCOC116238698(RNPEP)
MGP100549291(RNPEP)
CJO107324639(RNPEP)
NMEL110388359(RNPEP)
APLA101802986(RNPEP)
ACYG106045854(RNPEP)
AFUL116498667(RNPEP)
TGU100224003(RNPEP)
LSR110469199(RNPEP)
SCAN103822440(RNPEP)
PMOA120497284
OTC121345540
PRUF121365435
GFR102036435(RNPEP)
FAB101813510(RNPEP)
PHI102112448(RNPEP)
PMAJ107214916(RNPEP)
CCAE111939603(RNPEP)
CCW104692573
ETL114064786(RNPEP)
ZAB102070961(RNPEP)
FPG101914529(RNPEP)
FCH102048572(RNPEP)
CLV102090773(RNPEP)
EGZ104122020(RNPEP)
NNI104011102(RNPEP)
TALA116963905
PADL103913823(RNPEP)
ACHC115334985
AAM106500249(RNPEP)
AROW112965099(RNPEP)
NPD112959241(RNPEP)
DNE112983877(RNPEP)
ASN102369662(RNPEP)
AMJ102561220(RNPEP)
CPOO109317603(RNPEP)
PSS102450932(RNPEP)
CMY102931368
CPIC101946561
TST117875969(RNPEP)
CABI116831702(RNPEP)
MRV120404495
ACS100554554(rnpep)
PVT110073333(RNPEP)
SUND121928799
PBI103063102(RNPEP)
PMUR107295845(RNPEP)
TSR106544931(RNPEP)
PGUT117663761(RNPEP)
VKO123032007
PMUA114599423(RNPEP)
ZVI118089090(RNPEP)
GJA107121706(RNPEP)
XLA443974(rnpep.S) 447741(rnpep.L)
XTR407876(rnpep)
NPR108795716(RNPEP)
RTEM120927302
DRE437014(rnpep)
SRX107727878 107749494
SANH107655028 107685703
SGH107560645 107600956
CCAR109098332 109100480(rnpep)
CAUA113055188(rnpep)
AMEX103045130(rnpep)
EEE113578925(rnpep)
SASA100195514(rnpep)
OTW112216049
OMY110494181
OGO124003672
ONE115143052(rnpep)
SALP111965278(rnpep)
SNH120062260
ELS105016934(rnpep)
PKI111839897(rnpep)
AANG118210517(rnpep)
LOC102682358(rnpep)
PSPA121299903
ARUT117427904 117965989
LCM102364673(RNPEP)
CMK103179129(rnpep)
RTP109916000(rnpep)
BFO118421446
BBEL109484642
SPU115929028 588993
SKO100372225
LGILOTGIDRAFT_222314
PCAN112575395
BGT106073241
HRF124141823
HRJ124273995
MYI110440307
PMAX117329886
LAK106177534
PIFPITG_03837
PSOJPHYSODRAFT_309500
RAHRahaq_3473
RACEJHW33_11585
RAQRahaq2_3549
RAAQ7S_17485
SODSant_0686 Sant_0867
PAOPat9b_4350 Pat9b_4973
CPSCPS_2188
COZA3Q34_03215
COVEKO29_08790
WOCBA177_13380
BUOBRPE64_ECDS03080
BBROBAU06_01895
BFZBAU07_01815
BOHAKI39_01755
BGMCAL15_11190
ODIODI_R3657
PIGEGT29_25965
XYKGT347_21035
MSDMYSTI_06036
MYMA176_000537
CCXCOCOR_04740(iap)
MMASMYMAC_006098
SURSTAUR_0723
RHRCKA34_33010
RLNJ0663_21320
SHZshn_24285
ABAWD5400_18035
MMESMMSR116_04670
MIVC4E04_14740
AALAIGS74_14160
AALMLUX29_16065
BRLBZG35_04910
KVLKVU_PB0137
KVUEIO_3327
THAACFI11_19550
SPHITS85_12010
SPHCCVN68_00885
SDHH9L15_03195
SPAIFPZ24_06280
SPHSETR14_04035
AEPAMC99_01343
ERKCD351_10985
ERFFIU90_11045(ywaD2)
PHZCHX26_11765
BSUBSU38470(ywaD)
BSRI33_4001
BSLA7A1_2084
BSHBSU6051_38470(ywaD)
BSYI653_16460 I653_18880
BSUTBSUB_04085(ywaD)
BSULBSUA_04085(ywaD)
BSUSQ433_21180
BSOBSNT_10509(ywaD)
BSNBSn5_07875 BSn5_10235
BSQB657_38470(ywaD)
BSXC663_3758(ywaD)
BSPU712_19420
BSSBSUW23_19060(ywaD)
BSTGYO_4245
BLIBL03935(ywaD)
BLDBLi04074(ywaD)
BLHBaLi_c40830(ywaD)
BAYRBAM_031250
BAQBACAU_3151(ywaD1)
BAMPB938_16010
BAMLBAM5036_3039(ywaD)
BAMARBAU_3260(ywaD)
BAMNBASU_3041(ywaD)
BAMTAJ82_17655
BAMYV529_33860
BAOBAMF_3251(ywaD)
BAZBAMTA208_17260(ywaD)
BQLLL3_03534(ywaD)
BXHBAXH7_03525(ywaD)
BAMIKSO_003505
BAMCU471_32420
BAMFU722_16775
BAEBATR1942_14925 BATR1942_17160
BVMB9C48_15985
BSONS101395_00319
BHTDIC78_11725 DIC78_14115
BMOJHC660_37590(eapD)
BTEQG4P54_17410 G4P54_19780
BIQAN935_19460
BANBA_5606
BARGBAA_5606
BATBAS5208
BAHBAMEG_5650
BAIBAA_5632
BAXH9401_5347
BANTA16_56160
BANRA16R_56850
BANSBAPAT_5374
BANHHYU01_27365
BANVDJ46_4254
BCEBC5359
BCABCE_5488
BCZBCE33L5056
BCRBCAH187_A5537
BCBBCB4264_A5481
BCUBCAH820_5450
BCGBCG9842_B2848 BCG9842_B5470
BCQBCQ_5199
BCXBCA_5508
BALBACI_c53540
BNCBCN_5287
BCFbcf_26900
BCERBCK_08560
BCEFBcrFT9_04302
BCYBcer98_3876
BTKBT9727_5040
BTLBALH_4856
BTBBMB171_C4954
BTTHD73_5768
BTHRYBT1520_28590
BTHIBTK_28440
BTCCT43_CH5398
BTFYBT020_26730
BTMMC28_4594
BTGBTB_c55600(ywaD)
BTIBTG_07585 BTG_21585
BTNBTF1_09745 BTF1_25285
BTHTH175_ch5489
BTHUYBT1518_30160
BTWBF38_1082
BTHYAQ980_02505
BWEBcerKBAB4_5156 BcerKBAB4_5675
BWWbwei_4420(ywaD)
BMYOBG05_646
BTYBtoyo_2559
BMYCDJ92_2450(ywaD)
BBYCY96_25920
BWDCT694_28800
BTROFJR70_20940
BMOBMLA2C4_27735
BNTGSN03_25685
BPACLMD38_00025
BJSMY9_3952
BIFN288_10950
BACPSB24_13125
BACYQF06_17685
BACLBS34A_41670(ywaD)
BALMBsLM_3881
BGYBGLY_4528(ywaD)
BITBIS30_09000
BFDNCTC4823_00241(ywaD_2) NCTC4823_00357(ywaD_3) NCTC4823_02928(ywaD_4) NCTC4823_03454(ywaD_5)
BDAFSZ17_04175 FSZ17_04265 FSZ17_04490
BBADK7T73_02735 K7T73_08925 K7T73_11125
BCIRC2I06_21480
BMQBMQ_2033(ywaD)
BMDBMD_1989(ywaD)
BMHBMWSH_3244(ywaD)
BMEGBG04_4334(amp)
BEOBEH_16595
BFXBC359_13060
BHABH3861
BGIBGM20_13490
BPFBpOF4_12740
BONA361_02110 A361_18250 A361_23385
BKOCKF48_05110
ASEDIRT44_13595
LMACI6G82_03615
HMNHM131_02395
VHLBME96_18855
VILCFK37_06165
VNECFK40_01660
VIMGWK91_03310
BSJUP17_02230 UP17_12585
BMURABE28_002155
PBUTDTO10_14080 DTO10_25570 DTO10_25635
NMKCHR53_06325 CHR53_06350 CHR53_12415 CHR53_12420 CHR53_13440
MDGK8L98_02210
RMFD5E69_18080
BOUI5818_04385
BAGRBA6348_17575
BCHSJNE38_02710 JNE38_06260 JNE38_11960
BCOPJD108_02445 JD108_13325
ANXACH33_09800
ATHEK3F53_09225
SOBCSE16_02625
PPLABBI15_10310 BBI15_10315
PLXCW734_16630 CW734_16635
JEOJMA_03500
KURASO14_2206
KZONCTC404_00115
SPSYAZE41_05725
SURESporoP32a_05070
SPOSDV702_16695
SPAEE2C16_03450 E2C16_03455 E2C16_03835
PANCE2636_17475
NTRB0W44_08560
LFBC1X05_08640
KPULGXN76_03915
KEBGXN75_04460
WCFC6P13_09595
EAVEH197_23430
CLJCLJU_c40100
CAHCAETHG_1859
CCKCcar_11910
CARGRSJ17_01140
CDRKB9W14_03175
CLOSDMR38_02620
ASFSFBM_1324
ASMMOUSESFB_1234
ASOSFBmNL_01395
ASBRATSFB_1153
GFEGferi_08450 Gferi_23410
RUKA4V00_12210
CTHDCDO33_01085
CEWEKH84_01400
CCTCC1_13170
BLABEYS05_04695 EYS05_15630
BLIQINP51_10330
LACYA4V08_26335
ACHTbsdcttw_37200
ROCHF520_00940 HF520_14740
TEMJW646_04590
TEBT8CH_1700(ywaD)
SALQSYNTR_2070
DSYDSY3034
DHDDhaf_4201
DDHDesde_3560
DDLDesdi_2914
DAIDesaci_3863
DEDDHBDCA_p1576
DECDCF50_p1586
DRSDEHRE_11680
HMOHM1_2047
HCVFTV88_1743
THEFE1B22_02055
BPRSCK3_19810 CK3_26930
TPZTph_c12530
GEKkuro4_23370
NTHNther_1155
KMEH0A61_00615(ywaD)
SEDZJYG23_12995
ERLAOC36_09130
TURAT726_05935
TSGHLK68_04755
AAXANCTC10138_00933
TBMBK010_03940
TBZBK011_03280
SFISFUL_459
SPADDVK44_27520
SCAVCVT27_01200
LVIG7068_10285
LLUTK1X41_08505
NOYEXE57_00530
NOOFE634_19485
KQIF1D05_28020
ACTWF7P10_19790
AGRAAGRA3207_007850
SROSros_4970
NOABKM31_18440
NOWGBF35_24185
AJAAJAP_07200 AJAP_38040
AMYBBKN51_27565
AABA4R43_28710
AMYYYIM_00620(ywaD)
AORISD37_06360
APRECNX65_25955
SSYIEKG83_35795
KPHYAOZ06_06510
LEDBBK82_44220
AHMTL08_17870
ACTIUA75_21805
ACADUA74_21325
AHGAHOG_18820(ywaD)
ACTAC1701_03880
MICBMicB006_3634
MTEMGCE86_15035
PLABC6361_05005
PLATC6W10_01540
VERHUT12_06715
PRYPrubr_54060
LENLEP3755_57830
LBOLBWT_51440
MIQB5D77_04965
MVZmyaer102_14990
CWACwatDRAFT_1011
NCNBZZ01_18435
DMCbtf_974
ATMANT_03690
PSUBPelsub_P0342
PBFCFX0092_A3303
KBSEPA93_07435
TBHTbon_09810
DPDDeipe_1280
DABAUC44_09635
DFCDFI_03030 DFI_05120 DFI_08235
DEINDAAJ005_15560
DGADEGR_18760
MTAIMtai_v1c23810
VBHCMV30_11965
VBSEGM51_18010 EGM51_18015
TTFTHTE_3308
PLMPlim_0862
PEHSpb1_15600(ywaD_2)
STASTHERM_c18080
STQSpith_0453
SUSAcid_1517 Acid_4400
STRSterm_3109
GAUGAU_3038 GAU_3847
PMUCING2E5A_2770
PRUPRU_2865
PMZHMPREF0659_A5088
NKONiako_7010
FLNFLA_3919
PSEGD3H65_19815
PGOFSB84_03495
FLSGLV81_13460
PHEPhep_1583
PCMAY601_4302
PSTYBFS30_05730
PGSCPT03_15355 CPT03_18160
PEKFFJ24_025780
PROEH9L23_19820 H9L23_26280
PEXIZT61_17320
SPHEGFH32_01500 GFH32_14715
MUHHYN43_013715
MGINFRZ54_23525
MGKFSB76_04945 FSB76_19560
MMABHQ865_02935
SBXCA265_18610 CA265_25320
RHOZGXP67_21935 GXP67_27335
HYEAM218_00205
HYGAUC43_05345
HYPA0257_18240
HYHD3Y59_10830
HYJFHG12_11020
HQIH9L05_09580
HRSHER32_08510
HBNGUY19_11165
PACTCA264_14565
RTIDC20_10525
RUDTH61_03925
NIBGU926_09705
FLMMY04_2733
FLLEI427_14825
FBTD770_08110
GFLGRFL_2045
FKIFK004_16300
MARMYQ22_08760
MARTBTR34_08900
MARBCJ263_07705
MAREEJ994_02845 EJ994_12650
CLYCelly_1188
CLHIX49_05815
NOMAAT17_09285
NSDBST91_09550
PRNBW723_06090
POLABXQ17_12410
POACW731_12405
PHALH9I45_08855
AALGAREALGSMS7_01479
AUEC5O00_02090
AQAD1815_00415
MGELG5B37_06280
BIAGMA17_00870
FBEFF125_05610 FF125_19850
CHZCHSO_2503
CIHATE47_07035 ATE47_07040
CHHA0O34_19510
CIOCEQ15_06020 CEQ15_06025 CEQ15_06030
CHRYCEY12_02930 CEY12_02935 CEY12_02940
CPIPCJF12_04900 CJF12_04905
CHRSEAG08_21115
CHRZCO230_05620
CARHEGY05_08560 EGY05_08565 EGY05_08570
CSHAEG350_10265
CNKEG343_00980 EG343_00985 EG343_00990
CJTEG359_02730 EG359_02735
CILEG358_12020
CCAUEG346_19610 EG346_19615 EG346_19620
CBENEG339_17670 EG339_17675 EG339_17680
CGLENCTC11432_00569(ywaD_1) NCTC11432_00570(ywaD_2) NCTC11432_00571(ywaD_3)
CTAINCTC12078_00710(ywaD)
CLACEG342_17345 EG342_17350
CBPEB354_07830
CCASEIB73_01235
CANTNCTC13489_00312(ywaD_1)
KHIEG338_09105
KBEJ4771_04615
EVAEIB75_04015 EIB75_04475
CNREB819_08475
EBVF0358_01160 F0358_05835
EFALFH779_00960 FH779_02885
ESTEHNV03_01130 HNV03_10730
FLUCHH17_17565
BBAUAEM51_10985
TALThal_0471
TRDTHERU_07810
PMOPmob_1107
KPFIX53_02055
MPGTheba_2060
MINFMESINF_0456
ASACATHSA_0108
ALAMRT761_02325(ywaD)
METZMETMT2_0095
MFVMfer_0068
MKAMK0503
MPYMpsy_0296
MCJMCON_0516
MRTJKHC33_06605
RCIRCIX872
HALMFCF25_01745
HALBEKH57_14180
HEZZEO776_12130
HALQHrr1229_012320
HSSJ7656_04705
NMGNmag_3990(ywaD4) Nmag_3997(ywaD3)
HLCCHINAEXTREME12045
THELIG193_05870
ASCASAC_1452
ACIASE86_04005
CLGCalag_0999
LOKILokiarch_50010(ywaD_6)
 » show all
Reference
1  [PMID:6434344]
  Authors
Gainer H, Russell JT, Loh YP.
  Title
An aminopeptidase activity in bovine pituitary secretory vesicles that cleaves the N-terminal arginine from beta-lipotropin60-65.
  Journal
FEBS Lett 175:135-9 (1984)
DOI:10.1016/0014-5793(84)80586-4
Reference
2  [PMID:8344358]
  Authors
Belhacene N, Mari B, Rossi B, Auberger P.
  Title
Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation.
  Journal
Eur J Immunol 23:1948-55 (1993)
DOI:10.1002/eji.1830230833
Reference
3  [PMID:7672445]
  Authors
Cadel S, Pierotti AR, Foulon T, Creminon C, Barre N, Segretain D, Cohen P.
  Title
Aminopeptidase-B in the rat testes: isolation, functional properties and cellular localization in the seminiferous tubules.
  Journal
Mol Cell Endocrinol 110:149-60 (1995)
DOI:10.1016/0303-7207(95)03529-g
Reference
4  [PMID:8940051]
  Authors
Fukasawa KM, Fukasawa K, Kanai M, Fujii S, Harada M.
  Title
Molecular cloning and expression of rat liver aminopeptidase B.
  Journal
J Biol Chem 271:30731-5 (1996)
DOI:10.1074/jbc.271.48.30731
  Sequence
[rno:81761]
Reference
5  [PMID:9096329]
  Authors
Cadel S, Foulon T, Viron A, Balogh A, Midol-Monnet S, Noel N, Cohen P.
  Title
Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase.
  Journal
Proc Natl Acad Sci U S A 94:2963-8 (1997)
DOI:10.1073/pnas.94.7.2963
  Sequence
[rno:81761]
Reference
6  [PMID:8157657]
  Authors
Orning L, Gierse JK, Fitzpatrick FA.
  Title
The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity.
  Journal
J Biol Chem 269:11269-73 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.6
IUBMB Enzyme Nomenclature: 3.4.11.6
ExPASy - ENZYME nomenclature database: 3.4.11.6
BRENDA, the Enzyme Database: 3.4.11.6
CAS: 9073-92-1

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