Entry
Name
aminopeptidase B;
arylamidase II;
arginine aminopeptidase;
arginyl aminopeptidase;
Cl--activated arginine aminopeptidase;
cytosol aminopeptidase IV;
L-arginine aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys
Comment
Cytosolic or membrane-associated enzyme from mammalian tissues, activated by chloride ions and low concentrations of thiol compounds. This is one of the activities of the bifunctional enzyme EC
3.3.2.6 (membrane alanyl aminopeptidase family) [4,5].
History
EC 3.4.11.6 created 1972, modified 1997
Orthology
Genes
XLA : 443974(rnpep.S) 447741(rnpep.L)
SANH : 107655028 107685703
CCAR : 109098332 109100480(rnpep)
CGIB : 127968416 128022321
MASI : 127426373 127428214
MANU : 129427144 129427145 129427146 129427147
CCLU : 121575134 121578801
ARUT : 117427904 117965989
LPIC : 129277289 129277770
PAO : Pat9b_4350 Pat9b_4973
BSY : I653_16460 I653_18880
BSN : BSn5_07875 BSn5_10235
BAZ : BAMTA208_17260(ywaD)
BAE : BATR1942_14925 BATR1942_17160
BHT : DIC78_11725 DIC78_14115
BTEQ : G4P54_17410 G4P54_19780
BCG : BCG9842_B2848 BCG9842_B5470
BTN : BTF1_09745 BTF1_25285
BWE : BcerKBAB4_5156 BcerKBAB4_5675
BFD : NCTC4823_00241(ywaD_2) NCTC4823_00357(ywaD_3) NCTC4823_02928(ywaD_4) NCTC4823_03454(ywaD_5)
BDA : FSZ17_04175 FSZ17_04265 FSZ17_04490
BBAD : K7T73_02735 K7T73_08925 K7T73_11125
BACA : FAY30_01660 FAY30_04405 FAY30_12495
BON : A361_02110 A361_18250 A361_23385
CFIR : NAF01_02035 NAF01_16365 NAF01_21050
CPSS : M5V91_02775 M5V91_20110 M5V91_25985
BSJ : UP17_02230 UP17_12585
PBUT : DTO10_14080 DTO10_25570 DTO10_25635
PFRI : L8956_02540 L8956_14370
NMK : CHR53_06325 CHR53_06350 CHR53_12415 CHR53_12420 CHR53_13440
NNV : QNH39_06385 QNH39_06440 QNH39_12915
MJO : FOF60_11430 FOF60_11980
SFOR : QNH23_12965 QNH23_16880 QNH23_17435
BCHS : JNE38_02710 JNE38_06260 JNE38_11960
BCOP : JD108_02445 JD108_13325
BHUI : LOK74_13125 LOK74_14605
BBOR : RFB14_15510 RFB14_23385
PPLA : BBI15_10310 BBI15_10315
PLX : CW734_16630 CW734_16635
SPAE : E2C16_03450 E2C16_03455 E2C16_03835
SURL : BI350_07095 BI350_07100
GFE : Gferi_08450 Gferi_23410
BLAB : EYS05_04695 EYS05_15630
TMY : TEMA_23390 TEMA_23440(ywaD)
BPRS : CK3_19810 CK3_26930
MTEU : R3I42_06845 R3I42_09400
AJA : AJAP_07200 AJAP_38040
PGS : CPT03_15355 CPT03_18160
PROE : H9L23_19820 H9L23_26280
SPHE : GFH32_01500 GFH32_14715
MGK : FSB76_04945 FSB76_19560
SBX : CA265_18610 CA265_25320
RHOZ : GXP67_21935 GXP67_27335
MARE : EJ994_02845 EJ994_12650
CIH : ATE47_07035 ATE47_07040
CIO : CEQ15_06020 CEQ15_06025 CEQ15_06030
CHRY : CEY12_02930 CEY12_02935 CEY12_02940
CPIP : CJF12_04900 CJF12_04905
CARH : EGY05_08560 EGY05_08565 EGY05_08570
CNK : EG343_00980 EG343_00985 EG343_00990
CJT : EG359_02730 EG359_02735
CCAU : EG346_19610 EG346_19615 EG346_19620
CBEN : EG339_17670 EG339_17675 EG339_17680
CGLE : NCTC11432_00569(ywaD_1) NCTC11432_00570(ywaD_2) NCTC11432_00571(ywaD_3)
CTAI : NCTC12078_00710(ywaD)
CLAC : EG342_17345 EG342_17350
CCAO : H5J24_10210 H5J24_10215 H5J24_10220
CANT : NCTC13489_00312(ywaD_1)
EVA : EIB75_04015 EIB75_04475
EZE : KI430_07715 KI430_09180
EBV : F0358_01160 F0358_05835
EFAL : FH779_00960 FH779_02885
ESTE : HNV03_01130 HNV03_10730
NMG : Nmag_3990(ywaD4) Nmag_3997(ywaD3)
LOKI : Lokiarch_50010(ywaD_6)
» show all
Taxonomy
Reference
Authors
Gainer H, Russell JT, Loh YP.
Title
An aminopeptidase activity in bovine pituitary secretory vesicles that cleaves the N-terminal arginine from beta-lipotropin60-65.
Journal
Reference
Authors
Belhacene N, Mari B, Rossi B, Auberger P.
Title
Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation.
Journal
Reference
Authors
Cadel S, Pierotti AR, Foulon T, Creminon C, Barre N, Segretain D, Cohen P.
Title
Aminopeptidase-B in the rat testes: isolation, functional properties and cellular localization in the seminiferous tubules.
Journal
Reference
Authors
Fukasawa KM, Fukasawa K, Kanai M, Fujii S, Harada M.
Title
Molecular cloning and expression of rat liver aminopeptidase B.
Journal
Sequence
Reference
Authors
Cadel S, Foulon T, Viron A, Balogh A, Midol-Monnet S, Noel N, Cohen P.
Title
Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase.
Journal
Sequence
Reference
Authors
Orning L, Gierse JK, Fitzpatrick FA.
Title
The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity.
Journal
J Biol Chem 269:11269-73 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.6
ExPASy - ENZYME nomenclature database: 3.4.11.6