KEGG   ENZYME: 3.4.13.18Help
Entry
EC 3.4.13.18                Enzyme                                 

Name
cytosol nonspecific dipeptidase;
N2-beta-alanylarginine dipeptidase;
glycyl-glycine dipeptidase;
glycyl-leucine dipeptidase;
iminodipeptidase;
peptidase A;
Pro-X dipeptidase;
prolinase;
prolyl dipeptidase;
prolylglycine dipeptidase;
iminodipeptidase;
prolinase;
L-prolylglycine dipeptidase;
prolylglycine dipeptidase;
diglycinase;
Gly-Leu hydrolase;
glycyl-L-leucine dipeptidase;
glycyl-L-leucine hydrolase;
glycyl-L-leucine peptidase;
L-amino-acyl-L-amino-acid hydrolase;
glycylleucine peptidase;
glycylleucine hydrolase;
glycylleucine dipeptide hydrolase;
non-specific dipeptidase;
human cytosolic non-specific dipeptidase;
glycyl-L-leucine hydrolase;
glycyl-glycine dipeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids
Reaction(KEGG)
(other) R01166 R01992
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Comment
A zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine.
History
EC 3.4.13.18 created 1961 as EC 3.4.3.1 and EC 3.4.3.2, transferred 1972 to EC 3.4.13.1 and EC 3.4.13.2, transferred 1978 to EC 3.4.13.11, part transferred 1992 to EC 3.4.13.18, modified 2000 (EC 3.4.13.15 created 1989, incorporated 1992)
Pathway
ec00330  Arginine and proline metabolism
ec00340  Histidine metabolism
ec00410  beta-Alanine metabolism
ec01100  Metabolic pathways
Orthology
K08660  cytosolic nonspecific dipeptidase
Genes
HSA: 55748(CNDP2)
PTR: 455473(CNDP2)
PPS: 100970514(CNDP2)
GGO: 101126755(CNDP2)
PON: 100174694(CNDP2)
NLE: 100583155(CNDP2)
MCC: 695080(CNDP2)
MCF: 101865174(CNDP2)
CSAB: 103244083(CNDP2)
RRO: 104656990(CNDP2)
RBB: 108525047(CNDP2)
CJC: 100393355(CNDP2)
SBQ: 101053821(CNDP2)
MMU: 66054(Cndp2)
MCAL: 110284520(Cndp2)
MPAH: 110332928(Cndp2)
RNO: 291394(Cndp2)
MUN: 110555521(Cndp2)
CGE: 100760626(Cndp2)
NGI: 103748118(Cndp2)
HGL: 101709694(Cndp2)
CCAN: 109700927(Cndp2)
OCU: 100347984(CNDP2)
TUP: 102489914(CNDP2)
CFA: 476166(CNDP2)
VVP: 112919332(CNDP2)
AML: 100466673(CNDP2)
UMR: 103658414(CNDP2)
UAH: 113253527(CNDP2)
ORO: 101378244(CNDP2)
FCA: 101095774(CNDP2)
PTG: 102964722(CNDP2)
PPAD: 109251777(CNDP2)
AJU: 106982249(CNDP2)
BTA: 512626(CNDP2)
BOM: 102267439(CNDP2)
BIU: 109577882(CNDP2)
BBUB: 102400679(CNDP2)
CHX: 102189261(CNDP2)
OAS: 101111244(CNDP2)
SSC: 100158127(CNDP2)
CFR: 102510239(CNDP2)
CDK: 105105096(CNDP2)
BACU: 103016660(CNDP2)
LVE: 103085206(CNDP2)
OOR: 101280936(CNDP2)
DLE: 111167306(CNDP2)
PCAD: 102990839(CNDP2)
ECB: 100061697(CNDP2)
EPZ: 103561747(CNDP2)
EAI: 106832864
MYB: 102242032(CNDP2)
MYD: 102767302(CNDP2)
MNA: 107537573(CNDP2)
HAI: 109383204(CNDP2)
DRO: 112322720(CNDP2)
PALE: 102880342(CNDP2)
RAY: 107512646(CNDP2)
MJV: 108409041(CNDP2)
LAV: 100668146(CNDP2)
TMU: 101353090
MDO: 100016094(CNDP2)
SHR: 100920874(CNDP2)
PCW: 110215842(CNDP2)
OAA: 100076934
GGA: 421013(CNDP2)
MGP: 100541349(CNDP2)
CJO: 107309961(CNDP2)
NMEL: 110394204(CNDP2)
APLA: 101791366(CNDP2)
ACYG: 106036016(CNDP2)
TGU: 100229152(CNDP2)
LSR: 110470875(CNDP2)
SCAN: 103826354(CNDP2)
GFR: 102034558(CNDP2)
FAB: 101807367(CNDP2)
PHI: 102114713(CNDP2)
PMAJ: 107200307(CNDP2)
CCAE: 111925251(CNDP2)
CCW: 104685798(CNDP2)
ETL: 114057531(CNDP2)
FPG: 101914717(CNDP2)
FCH: 102052576(CNDP2)
CLV: 102092467(CNDP2)
EGZ: 104128656(CNDP2)
NNI: 104018185(CNDP2)
ACUN: 113477172(CNDP2)
PADL: 103924880(CNDP2)
AAM: 106484108(CNDP2)
ASN: 102368140
AMJ: 102560010 102563504(CNDP2)
PSS: 102446043(CNDP2)
CMY: 102938228(CNDP2)
CPIC: 101937378(CNDP2)
ACS: 100553967(cndp2) 100556028
PVT: 110083373 110083377(CNDP2)
PBI: 103052866(CNDP2)
PMUR: 107291689(CNDP2)
TSR: 106538260(CNDP2)
PMUA: 114600794(CNDP2)
GJA: 107115121(CNDP2)
XLA: 108695220 380001(cndp2.S) 398689(darmin.L) 446978(cndp2.L)
XTR: 394907(cndp2)
DRE: 327288(cndp2)
IPU: 108257136(cndp2)
PHYP: 113536259(cndp2)
AMEX: 103024590(cndp2)
EEE: 113585121(cndp2)
TRU: 101066809
LCO: 104927574(cndp2)
NCC: 104949438 104962947(cndp2)
OLA: 101158501(cndp2)
PRET: 103472482 103472483(cndp2)
NFU: 107394616(cndp2)
KMR: 108237889(cndp2)
AOCE: 111585218(cndp2)
CSEM: 103394277(cndp2)
LCF: 108879475(cndp2)
SDU: 111223447(cndp2)
SLAL: 111649520 111657615(cndp2)
HCQ: 109512013(cndp2)
BPEC: 110161127(cndp2)
MALB: 109958636(cndp2)
ELS: 105012659(cndp2) 105019195
PKI: 111852260(cndp2)
LCM: 102355182(CNDP2)
CMK: 103184951(cndp2)
SPU: 594228
DME: Dmel_CG17337(CG17337)
DSI: Dsimw501_GD10382(Dsim_GD10382)
DSR: 110189385
MDE: 101898638
AAG: 5571265
AALB: 109423371
AME: 412393
BIM: 100743679
BTER: 100648827
OBB: 114878059
SOC: 105196148
MPHA: 105834920
AEC: 105147021
ACEP: 105622856
PBAR: 105423960
VEM: 105564520
HST: 105184854
DQU: 106745289
CFO: 105259365
LHU: 105675762
PGC: 109859585
OBO: 105278212
PCF: 106789699
NVI: 100121200
MDL: 103573504
BMOR: 101736010
PMAC: 106712293
HAW: 110371138
TNL: 113492664
API: 100166238
BTAB: 109044429
CLEC: 106663411
ZNE: 110827434
CSCU: 111636340
PTEP: 107451720
TSP: Tsp_11047
PCAN: 112560591
MYI: 110440951
LAK: 106176476
EGL: EGR_00983
EPA: 110248653
PDAM: 113664778
SPIS: 111320177
DGT: 114517120
HMG: 100210621(cndp2) 100211929
 » show all
Taxonomy
Reference
1
  Authors
Bauer, K.
  Title
Cytosol non-specific dipeptidase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 1520-1522.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.13.18
IUBMB Enzyme Nomenclature: 3.4.13.18
ExPASy - ENZYME nomenclature database: 3.4.13.18
BRENDA, the Enzyme Database: 3.4.13.18
CAS: 9025-31-4

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