KEGG   ENZYME: 3.4.13.20Help
Entry
EC 3.4.13.20                Enzyme                                 

Name
beta-Ala-His dipeptidase;
serum carnosinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential hydrolysis of the beta-Ala!His dipeptide (carnosine), and also anserine, Xaa!His dipeptides and other dipeptides including homocarnosine [RN:R01166 R03288]
Reaction(KEGG)
Comment
Present in the serum of humans and higher primates, but not in the serum of other mammals. Activated by Cd2+ and citrate. Belongs in peptidase family M20.
History
EC 3.4.13.20 created 1992
Pathway
ec00330  Arginine and proline metabolism
ec00340  Histidine metabolism
ec00410  beta-Alanine metabolism
ec01100  Metabolic pathways
Orthology
K05604  beta-Ala-His dipeptidase
Genes
HSA: 84735(CNDP1)
PTR: 455474(CNDP1)
GGO: 101127378(CNDP1)
PON: 100172721(CNDP1)
NLE: 100583488(CNDP1)
MCC: 695195(CNDP1)
MCF: 102131452(CNDP1)
CSAB: 103244082(CNDP1)
RRO: 104656992(CNDP1)
RBB: 108525057(CNDP1)
CJC: 100395623(CNDP1)
SBQ: 101048509(CNDP1)
MMU: 338403(Cndp1)
MCAL: 110284617(Cndp1)
MPAH: 110333472(Cndp1)
RNO: 307212(Cndp1)
MUN: 110555520(Cndp1)
CGE: 100761203(Cndp1)
NGI: 103748140(Cndp1)
HGL: 101707301(Cndp1)
CCAN: 109681064(Cndp1)
OCU: 100345937(CNDP1)
TUP: 102489508(CNDP1)
CFA: 476165(CNDP1)
VVP: 112919334(CNDP1)
AML: 100467604(CNDP1)
UMR: 103658416(CNDP1)
UAH: 113253529(CNDP1)
ORO: 101378722(CNDP1)
FCA: 101099503(CNDP1)
PTG: 102964440(CNDP1)
PPAD: 109251775(CNDP1)
AJU: 106982253(CNDP1)
BTA: 614200(CNDP1)
BOM: 102267168(CNDP1)
BIU: 109578014(CNDP1)
BBUB: 102402300(CNDP1)
CHX: 102180002(CNDP1)
OAS: 101110987(CNDP1)
SSC: 100516053(CNDP1)
CFR: 102512299(CNDP1)
CDK: 105105074(CNDP1)
BACU: 103016948(CNDP1)
LVE: 103084929(CNDP1)
OOR: 101281356(CNDP1)
DLE: 111167305(CNDP1)
PCAD: 102991690(CNDP1)
ECB: 100061728(CNDP1)
EPZ: 103544994 103561746
EAI: 106832860 106832861
MYB: 102242328(CNDP1)
MYD: 102767022(CNDP1)
MNA: 107537575(CNDP1)
HAI: 109383171(CNDP1)
DRO: 112322841(CNDP1)
PALE: 102890418(CNDP1)
RAY: 107512645(CNDP1)
MJV: 108409039(CNDP1)
LAV: 100657615(CNDP1)
TMU: 101356417
MDO: 100619431(CNDP1)
SHR: 100922964(CNDP1)
PCW: 110215824(CNDP1)
OAA: 100076860(CNDP1)
GGA: 421012(CNDP1)
MGP: 100541194(CNDP1)
CJO: 107309982(CNDP1)
NMEL: 110394441(CNDP1)
APLA: 101791863(CNDP1)
ACYG: 106035949(CNDP1)
TGU: 100232073
LSR: 110470903(CNDP1)
SCAN: 103815755(CNDP1)
GFR: 102040432(CNDP1)
FAB: 101819344(CNDP1)
PHI: 102111429(CNDP1)
PMAJ: 107200306(CNDP1)
CCAE: 111925250(CNDP1)
CCW: 104685799(CNDP1)
ETL: 114057532(CNDP1)
FPG: 101915873(CNDP1)
FCH: 102045939(CNDP1)
CLV: 102095516
EGZ: 104128655(CNDP1)
NNI: 104018184(CNDP1)
ACUN: 113476758(CNDP1)
PADL: 103924881(CNDP1)
AAM: 106482719(CNDP1)
ASN: 102367881(CNDP1)
AMJ: 106737110(CNDP1)
PSS: 102445657
CMY: 102938002
CPIC: 101937111(CNDP1)
ACS: 100554161(cndp1)
PVT: 110083379(CNDP1)
PBI: 103057080 103057919
PMUR: 107291693(CNDP1)
TSR: 106550218
PMUA: 114600793 114600796
GJA: 107115115(CNDP1)
XLA: 398917(cndp1.L)
XTR: 100135225(cndp1)
NPR: 108799252
IPU: 108261199(Cndp1)
AMEX: 103026681
EEE: 113574437
NCC: 104951856
NFU: 107396261
SASA: 100196692(cndp1)
OTW: 112247755
SALP: 111964936 112068906
ELS: 105019194
SFM: 108940582
PKI: 111844178 111844287
LCM: 102355447
 » show all
Taxonomy
Reference
1  [PMID:7116644]
  Authors
Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS.
  Title
Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium.
  Journal
Clin Chim Acta 123:221-31 (1982)
DOI:10.1016/0009-8981(82)90166-8
  Sequence
[hsa:84735]
Reference
2  [PMID:1903095]
  Authors
Jackson MC, Kucera CM, Lenney JF.
  Title
Purification and properties of human serum carnosinase.
  Journal
Clin Chim Acta 196:193-205 (1991)
DOI:10.1016/0009-8981(91)90073-L
Other DBs
ExplorEnz - The Enzyme Database: 3.4.13.20
IUBMB Enzyme Nomenclature: 3.4.13.20
ExPASy - ENZYME nomenclature database: 3.4.13.20
BRENDA, the Enzyme Database: 3.4.13.20
CAS: 525589-43-9

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Pathway (8)   
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Gene (160)   
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Protein sequence (2686)   
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DNA sequence (5133)   
   RefSeq(nuc) (4580)   
   GenBank (277)   
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