KEGG ENZYME: 3.4.13.20

ENZYME: 3.4.13.20

Entry

EC 3.4.13.20 Enzyme

Name

beta-Ala-His dipeptidase;
serum carnosinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases

Reaction(IUBMB)

Preferential hydrolysis of the beta-Ala!His dipeptide (carnosine), and also anserine, Xaa!His dipeptides and other dipeptides including homocarnosine [RN:R01166 R03288]

Reaction(KEGG)

R01166 R03288 > R01992

Comment

Present in the serum of humans and higher primates, but not in the serum of other mammals. Activated by Cd2+ and citrate. Belongs in peptidase family M20.

History

EC 3.4.13.20 created 1992

Pathway

ec00330

Arginine and proline metabolism

ec00340

Histidine metabolism

ec00410

beta-Alanine metabolism

ec01100

Metabolic pathways

Orthology

K05604

beta-Ala-His dipeptidase

Genes

HSA:	84735(CNDP1)

PTR:	455474(CNDP1)

GGO:	101127378(CNDP1)

PON:	100172721(CNDP1)

NLE:	100583488(CNDP1)

MCC:	695195(CNDP1)

MCF:	102131452(CNDP1)

CSAB:

103244082(CNDP1)

RRO:	104656992(CNDP1)

RBB:	108525057(CNDP1)

CJC:	100395623(CNDP1)

SBQ:	101048509(CNDP1)

MMU:	338403(Cndp1)

MCAL:

110284617(Cndp1)

MPAH:

110333472(Cndp1)

RNO:	307212(Cndp1)

MUN:	110555520(Cndp1)

CGE:	100761203(Cndp1)

NGI:	103748140(Cndp1)

HGL:	101707301(Cndp1)

CCAN:

109681064(Cndp1)

OCU:	100345937(CNDP1)

TUP:	102489508(CNDP1)

CFA:	476165(CNDP1)

VVP:	112919334(CNDP1)

AML:	100467604(CNDP1)

UMR:	103658416(CNDP1)

UAH:	113253529(CNDP1)

ORO:	101378722(CNDP1)

FCA:	101099503(CNDP1)

PTG:	102964440(CNDP1)

AJU:	106982253(CNDP1)

BTA:	614200(CNDP1)

BOM:	102267168(CNDP1)

BIU:	109578014(CNDP1)

BBUB:

102402300(CNDP1)

PHD:	102332890(CNDP1)

CHX:	102180002(CNDP1)

OAS:	101110987(CNDP1)

SSC:	100516053(CNDP1)

CFR:	102512299(CNDP1)

CDK:	105105074(CNDP1)

BACU:

103016948(CNDP1)

LVE:	103084929(CNDP1)

OOR:	101281356(CNDP1)

DLE:	111167305(CNDP1)

ECB:	100061728(CNDP1)

EPZ:	103544994 103561746

EAI:	106832860 106832861

MYB:	102242328(CNDP1)

MYD:	102767022(CNDP1)

MNA:	107537575(CNDP1)

HAI:	109383171(CNDP1)

RSS:	109436700(CNDP1)

DRO:	112322841(CNDP1)

PALE:

102890418(CNDP1)

LAV:	100657615(CNDP1)

TMU:

101356417

MDO:	100619431(CNDP1)

SHR:	100922964(CNDP1)

PCW:	110215824(CNDP1)

OAA:	100076860(CNDP1)

GGA:	421012(CNDP1)

MGP:	100541194(CNDP1)

CJO:	107309982(CNDP1)

APLA:

101791863(CNDP1)

ACYG:

106035949(CNDP1)

TGU:	100232073(CNDP1)

LSR:	110470903(CNDP1)

SCAN:

103815755(CNDP1)

GFR:	102040432(CNDP1)

FAB:	101819344(CNDP1)

PHI:	102111429(CNDP1)

PMAJ:

107200306(CNDP1)

CCAE:

111925250(CNDP1)

CCW:	104685799(CNDP1)

ETL:	114057532(CNDP1)

FPG:	101915873(CNDP1)

FCH:	102045939(CNDP1)

CLV:

102095516

EGZ:	104128655(CNDP1)

NNI:	104018184(CNDP1)

ACUN:

113476758(CNDP1)

AAM:	106482719(CNDP1)

ASN:	102367881(CNDP1)

AMJ:	106737110(CNDP1)

PSS:

102445657

CMY:

102938002

CPIC:

101937111(CNDP1)

ACS:	100554161(cndp1)

PVT:	110083379(CNDP1)

PBI:	103057080 103057919

PMUR:

107291693(CNDP1)

GJA:	107115115(CNDP1)

XLA:	398917(cndp1.L)

XTR:	100135225(cndp1)

NPR:

108799252

IPU:	108261199(Cndp1)

AMEX:

EEE:

NCC:

NFU:

SASA:

100196692(cndp1)

OTW:

SALP:

ELS:

SFM:

PKI:	111844178 111844287

LCM:

102355447

» show all

Reference

1 [PMID:7116644]

Authors

Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS.

Title

Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium.

Journal

Clin Chim Acta 123:221-31 (1982)
DOI:10.1016/0009-8981(82)90166-8

Sequence

[hsa:84735]

Reference

2 [PMID:1903095]

Authors

Jackson MC, Kucera CM, Lenney JF.

Title

Purification and properties of human serum carnosinase.

Journal

Clin Chim Acta 196:193-205 (1991)
DOI:10.1016/0009-8981(91)90073-L

Other DBs

ExplorEnz - The Enzyme Database:

3.4.13.20

IUBMB Enzyme Nomenclature:

3.4.13.20

ExPASy - ENZYME nomenclature database:

3.4.13.20

BRENDA, the Enzyme Database:

3.4.13.20

CAS:	525589-43-9

DBGET integrated database retrieval system