KEGG   ENZYME: 3.4.13.22
Entry
EC 3.4.13.22                Enzyme                                 
Name
D-Ala-D-Ala dipeptidase;
D-alanyl-D-alanine dipeptidase;
vanX D-Ala-D-Ala dipeptidase;
VanX
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
Reaction(IUBMB)
D-Ala-D-Ala + H2O = 2 D-Ala [RN:R07651]
Reaction(KEGG)
R07651
Substrate
D-Ala-D-Ala [CPD:C00993];
H2O [CPD:C00001]
Product
D-Ala [CPD:C00133]
Comment
A Zn2+-dependent enzyme [4]. The enzyme protects Enterococcus faecium from the antibiotic vancomycin, which can bind to the -D-Ala-D-Ala sequence at the C-terminus of the peptidoglycan pentapeptide (see diagram). This enzyme reduces the availability of the free dipeptide D-Ala-D-Ala, which is the precursor for this pentapeptide sequence, allowing D-Ala-(R)-lactate (for which vancomycin has much less affinity) to be added to the cell wall instead [2,3]. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates [2]. Belongs in peptidase family M15.
History
EC 3.4.13.22 created 2006
Orthology
K08641  zinc D-Ala-D-Ala dipeptidase
K18866  zinc D-Ala-D-Ala dipeptidase/carboxypeptidase
Genes
ECOb1488(ddpX)
ECJJW1483(ddpX)
ECDECDH10B_1619(ddpX)
EBWBWG_1309(ddpX)
ECOKECMDS42_1200(ddpX)
ECEZ2222
ECSECs_2092(ddpX)
ECFECH74115_2100(ddpX)
ETWECSP_1973(ddpX)
ELXCDCO157_1936
EOIECO111_1878(ddpX)
EOJECO26_2086(ddpX)
ECOOECRM13514_1906
ECOHECRM13516_1852
ESLO3K_13055
ESOO3O_12575
ESMO3M_13020
ECKEC55989_1620(ddpX)
EOKG2583_1851(ddpX)
ELRECO55CA74_09060
ELHETEC_1558
ECWEcE24377A_1677(ddpX)
EUNUMNK88_1893
ECOAAPECO78_11165
ECXEcHS_A1573(ddpX)
ECMEcSMS35_1685(ddpX)
ECYECSE_1578
ECRECIAI1_1498(ddpX)
EUMECUMN_1742(ddpX)
ECTECIAI39_1752(ddpX)
EOCCE10_1678(ddpX)
EBRECB_01446(ddpX)
EBLECD_01446(ddpX)
EBEB21_01458(ddpX)
EBDECBD_2151
ELOEC042_1620(ddpX)
ECLEcolC_2169
EKOEKO11_2332
EDHEcDH1_2159
EDJECDH1ME8569_1431(ddpX)
ELWECW_m1616(ddpX)
ELLWFL_07910(ddpX)
ELPP12B_c1641(ddpX)
STYSTY1465(pcgL)
STTt1508(pcgL)
SEXSTBHUCCB_16060
SENTTY21A_07660
STMSTM1599(pdgL)
SEOSTM14_1936(pdgL)
SEVSTMMW_15941
SEYSL1344_1530(pdgL)
SEMSTMDT12_C16190
SEJSTMUK_1568(pdgL)
SEBSTM474_1612(pcgL)
SEFUMN798_1676(pcgL)
SETUSTU288_04345
SETCCFSAN001921_09100
SENDDT104_15701(pcgL)
SENICY43_08170
SEENSE451236_13910
SPTSPA1269(pcgL)
SEKSSPA1177
SPQSPAB_01685
SEISPC_2136(pcgL)
SECSCH_1596(pdgL)
SEHSeHA_C1779
SHBSU5_02213
SENHCFSAN002069_00965
SEEHSEEH1578_17245
SEESNSL254_A1714
SENNSN31241_26740
SEWSeSA_A1717
SEASeAg_B1561
SENSQ786_07225
SEDSeD_A1742
SEGSG1524(pdgL)
SELSPUL_1410(pdgL)
SEGASPUCDC_1410(pdgL)
SETSEN1456(pdgL)
SENAAU38_07520
SENOAU37_07515
SENVAU39_07525
SENQAU40_08445
SENLIY59_07710
SENJCFSAN001992_03535
SEECCFSAN002050_14400
SEEBSEEB0189_011510
SENBBN855_16460(pdgL)
SENEIA1_07925
SENCSEET0819_14695
SESSARI_01378
SBGSBG_1423(pcgL)
SBZA464_1631
SBVN643_06865
SALZEOS98_11385
SFVSFV_1735
SFESFxv_1947
SFNSFy_2492
SFSSFyv_2548
SFTNCTC1_01885(ddpX)
SSNSSON_1636
SBOSBO_1569
SBCSbBS512_E1751(ddpX)
SHQA0259_11490
ENCECL_01923
ENLA3UG_11620
ECLGEC036_22190
ECLEECNIH2_11750
ECLNECNIH4_11445
ECLIECNIH5_10920
ECLXLI66_11055
ECLYLI62_13200
ECLZLI64_11095
ECLOENC_10100
EHMAB284_13865
EXFBFV63_11310
ECLAECNIH3_10895
ECLCECR091_10835
EAUDI57_07395
EKBBFV64_11685
ENOECENHK_11330
EECEcWSU1_02290(ddpX)
ELGBH714_07615
ERNBFV67_11070
ECLSLI67_014295
ECHGFY206_12810(ddpX)
ESHC1N69_11530
EASEntas_2189
ENXNI40_011510
LNICWR52_00770
EBGFAI37_17855(ddpX)
ENDA4308_16005
ENZG0034_11485(ddpX)
ENSHWQ15_19775(ddpX)
ENKLOC22_21485(ddpX)
EHUD5067_0011520(ddpX)
EMORL6Y89_11085(ddpX)
ENBELK40_11750
EAEEAE_01310
EARCCG33736
RORRORB6_24310
RONTE10_21745
RPLNB1209_05705
RAODSD31_05825
REEelectrica_01068(ddpX)
CKOCKO_01525
CFDCFNIH1_17825
CBRAA6J81_04275
CWECO701_10410
CYOCD187_11880
CPOTFOB25_23415(ddpX)
CFQC2U38_12140
CAMAF384_07120
CAFAL524_15180
CIFAL515_12145
CFARCI104_13075
CIRC2U53_22135
CIEAN232_17980
CPARCUC49_07870
CTELGBC03_17420(ddpX)
CITZE4Z61_05050(ddpX)
CARSE1B03_13300(ddpX)
PGELG71_10080
KRDA3780_20490
LPNUKQ929_09965(ddpX)
LAZA8A57_10980
SYMK6K13_11760(ddpX)
PSTSE05_24640
YRUBD65_2057
YRBUGYR_10565
SPESpro_2346
SRRSerAS9_2306
SRLSOD_c21700(ddpX)
SRYM621_11905
SPLYQ5A_012090(ddpX)
SRSSerAS12_2306
SRASerAS13_2307
SLQM495_11690
SERASer39006_017725
SERQCWC46_17725
SQUE4343_04465(ddpX)
SFJSAMEA4384070_2424(ddpX)
SOFNCTC11214_04342(ddpX)
SENPKHA73_11935(ddpX)
RAHRahaq_2676
RACEJHW33_03790(ddpX)
RAQRahaq2_2009
RAAQ7S_13335
ROXBV494_03470
RVCJ9880_20350(ddpX)
RBADH2866_00210(ddpX)
BGJAWC36_17940
BNGEH206_22040
BIZHC231_22985(ddpX)
SODSant_P0242(ddpX)
EAMEAMY_0704(vanX)
EAYEAM_2736(ddpX)
ETAETA_27580(ddpX)
EPYEpC_28720(ddpX)
EPREPYR_03109(vanX)
ERJEJP617_18630(ddpX)
PAMPANA_3756(ddpX)
PLFPANA5342_0285(ddpX)
PAJPAJ_2977(ddpX)
PAQPAGR_g0277
PVAPvag_0447(vanX)
PAGGAL522_09580
PAOPat9b_5276
PANPPSNIH2_02150
PAGCBEE12_12025
PSTWDSJ_01400
PALHB1H58_11305
PEYEE896_14255(ddpX)
PGZC2E15_17030
PCDC2E16_16920
MTHIC7M52_00273(ddpX)
TCIA7K98_02220
TPTYNCTC11468_00485(ddpX)
XBOXBJ1_0395
XBVXBW1_4382
XNEXNC1_0525
XNMXNC2_0514
XPOXPG1_0572
ANSArsFIN_43010(vanX)
XCCXCC3801
XCBXC_3873
XCAxcc-b100_3985(vanX)
XCPXCR_0495
XCVXCV3977
XAXXACM_3753
XACXAC3859
XCIXCAW_04621(ddpX)
XCTJ151_04038
XCJJ158_04014
XCUJ159_04010
XCNJ169_04035
XCWJ162_04015
XCRJ163_04010
XCMJ164_04011
XCFJ172_04028
XAOXAC29_19615
XOMXOO3875(XOO3875)
XOOXOO4099(DdpX)
XOPPXO_04244
XOYAZ54_03310
XORXOC_0567
XOZBE73_21555
XSASB85_15350
XFRBER92_18165
XVEBJD12_10140
XPEBJD13_19655
XHRXJ27_13300
XGABI317_03250
XPHXppCFBP6546_15110(XppCFBP6546P_15110)
XVAC7V42_19855
XANAC801_19245
XARXB05_14240
XHYFZ025_06840
XCZEBN15_18090
XEUXSP_003660
XHDLMG31886_39940(vanX)
XPRMUG10_12680
SMLSmlt0463
SMTSmal_0344
BUJBurJV3_0374
SMZSMD_0392
SACZAOT14_00970(vanX)
STEKAXG53_16240
SRHBAY15_0557
SLMBIZ42_11315
STENCCR98_01990
STEMCLM74_01910
STESMG068_01750
SINCDAIF1_04000(vanX)
SPAQSTNY_R04150
PSUPsesu_2550
PSUWWQ53_10580
PSDDSC_15610
PJPLAG73_18630
PDDMNQ95_09160
LABLA76x_0750
LAQGLA29479_3920(vanX)
LCPLC55x_4747
LGULG3211_4541
LEZGLE_4596(ddpX)
LEMLEN_0625
LMBC9I47_1378
LUEDCD74_11335
LYJFKV23_06935
LSOLGOY17_12325
LAREHIV01_002290
LHXLYSHEL_01550(ddpX)
LCASLYSCAS_01550(ddpX)
THEHG7079_09485
TBVH9L17_02560
RHDR2APBS1_3415
RGLCS053_15475
RTHLRK53_17055
DJAHY57_05625
DYEEO087_03465
DTLH8F01_12415
DTADYST_03665
LRZBJI69_03405
LPYFIV34_17120
LANHKR767_10825
XBAC7S18_11530
RBDALSL_2071
VBRA6E01_18180
VASGT360_21365
PAEVN297_3907
PAEIN296_3907
PAUPA14_15160
PAPPSPA7_1333
PAFPAM18_1157
PNCNCGM2_4966
PAEBNCGM1900_1198
PDKPADK2_05420
PSGG655_05800
PRPM062_19990
PAEPPA1S_06150
PAERPA1R_gp1646
PAEMU769_05965
PAELT223_05870
PAESSCV20265_1219
PAEUBN889_04203
PAEGAI22_27445
PAECM802_3905
PAEOM801_3773
PCQPcP3B5_55530(vanX)
PMUIG4G71_06700 G4G71_09530
PSAVPSA3335_04905
PASTN015_18545(ddpX)
PFLPFL_4023(ddpX)
PPRCPFLCHA0_c40820(ddpX)
PPROPPC_4119(ddpX)
PPZH045_02080
PMANOU5_1104
PBAPSEBR_a2910
PPUUPputUW4_01861
PDRH681_18785 H681_21470
PKCPKB_1066 PKB_5123(vanX)
PSOSPOS17_4119(ddpX)
PFKPFAS1_24925
PPSLBJP27_22025
PSILPMA3_16850
PYMAK972_2044 AK972_2211
PUMHGP31_20045
PGGFX982_04241
PPSHG5J76_14280(ddpX)
PVKEPZ47_14670
PKHJLK41_19140
PVWHU752_019095(ddpX)
PASGKSS96_12035(ddpX)
PAZEKSS91_18315
PCAVD3880_19745
PIZLAB08_R38940
AVNAvin_39780
AVLAvCA_39780
AVDAvCA6_39780
ACXAchr_10470
MBSMRBBS_3366(ddpX)
MPQABA45_15945
PURAOC03_09230
PALIA3K91_1965
PSYPE5677_03575
ALABFG52_02415
THAPFNC98_10325
PSEOOM33_08855
PLZS4054249_23600
PDJD0907_18515
LALAT746_13205
SALHHMF8227_02390
FBLFbal_2164
CELLCBR65_10205
SAGAM5M_07600
MICCAUP74_02812(vanX)
HJABST95_05525
HALCEY643_02670
RVIRVIR1_12660
ALGAQULUS_13840(ddpX)
ASIPAQUSIP_09590(ddpX) AQUSIP_09710(vanX)
LPNlpg2449 lpg2585(pcgL)
LPHLPV_2773 LPV_2917(vanX)
LPOLPO_2639 LPO_2852(vanX)
LPULPE509_00454 LPE509_00615
LPMLP6_2478(ddpX) LP6_2616(pcgL)
LPFlpl2367 lpl2508
LPPlpp2514 lpp2638
LPCLPC_0560 LPC_2029
LPAlpa_03417 lpa_03568(ddpX) lpa_03780(ddpX)
LPElp12_2440 lp12_2578
LLOLLO_1611 LLO_1639 LLO_2675 LLO_2917
LFALFA_2512(vanX)
LHALHA_0456 LHA_2877(vanX)
LOKLoa_00608 Loa_00711
LSHCAB17_13980
LLG44548918_00346(ddpX_1) 44548918_02386(ddpX_2)
LIBE4T55_02960
LJRNCTC11533_00360(vanX) NCTC11533_02556(ddpX)
LCJNCTC11976_00284(ddpX)
LWASAMEA4504053_0564(ddpX_1) SAMEA4504053_2427(ddpX_2)
LSSNCTC12082_01727(ddpX_1) NCTC12082_01816(ddpX_2)
LADLNCTC12735_01374(ddpX)
LANTTUM19329_06510(pcgL)
LLYJ2N86_04915
TMCLMI_0349(vanX) LMI_1375
MCAMCA2615(vanX)
METUGNH96_00195
MPADKEF85_03395
MAHMEALZ_1780
MBUREQU24_12230
MMOBF6R98_03030
MISZMishRS11D_21770(ddpX)
FRMBBG19_0198
FRCKX01_515
FOOCGC45_00980
PSALPSLF89_566
TUNJ9260_03495
ALVAlvin_0996 Alvin_0999 Alvin_3183
TMBThimo_1865
TSYTHSYN_07360
RHHE0Z06_13670
TTPE6P07_04030
CJAPGWK36_12285
THIMKFB96_22725
TBOGLT988_06925
TKMTK90_0077
TVRTVD_12440
APRSBI364_00885
WOCBA177_04645
CSACsal_0663
HELHELO_4226(ddpX)
HCSFF32_03865
HHUAR456_01040
HCOLOKO_00357(ddpX)
HSIBOX17_06935 BOX17_14560
HHHCLM76_07235
HBEBEI_0158(vanX)
HAFC8233_03495
HALKCUU95_08295
HVNEI420_17870
HOLHORIV_63570
HAXIHAALTHF_13750n
HTTHZS52_08015
HCAMI4484_20330
HSXHNO51_20415
HSVHNO53_20970
HTXEKK97_22885
HPROLMS44_20215
CMAIBFX80_10140
CAMHLCW13_07730
PAURFGL86_03685
MMWMmwyl1_2448
TWANHUF19_12265
MARSA8C75_01115
NIKF5I99_16280
AJPAMJAP_2444(vanX)
ENWMJO57_20065(ddpX) MJO57_20075(ddpX)
EEINX720_21415(ddpX)
ASRWL1483_184
AJDI6H43_08735
OCEGU3_05605
OCMCBP12_06850
OPFCBP31_11545
ZDFAN401_03945 AN401_06745
SUTRL0B52_09390
PSPIPS2015_2029
IGNMMG00_07185
NMPNMBB_0474(vanX)
NMDNMBG2136_1669
NMMNMBM01240149_1657
NMZNMBNZ0533_1818
NMCNMC1731(ddpX)
NMINMO_1609(ddpX)
NAQD0T90_08840
NBLGJV52_05975
NSGH3L94_03755
VMSLVJ82_15220
NBACUN60_10585
CVICV_0902(vanX) CV_3935
CVCBKX93_17645
CHROCXB49_17645
CHRIDK842_04860 DK842_12100
CHRBDK843_10385 DK843_17535
CRZD1345_04980 D1345_11845
CHRMFYK34_14585
CHAECH06BL_10760 CH06BL_24310
AQLBXU06_06925
BMABMAA1273(vanX)
BMVBMASAVP1_0246(vanX)
BMLBMA10229_0517(dppX)
BMNBMA10247_A1051(dppX)
BMALDM55_4247(ddpX)
BMAEDM78_3925(ddpX)
BMAQDM76_4947(ddpX)
BMAIDM57_10660
BMAFDM51_4931(ddpX)
BMAZBM44_4210(ddpX)
BMABBM45_3332
BPSBPSS0955
BPMBURPS1710b_A2563(vanX)
BPLBURPS1106A_A1312(ddpX)
BPDBURPS668_A1393(vanX)
BPSEBDL_4245(ddpX)
BPSMBBQ_5181(ddpX)
BPSUBBN_4415(ddpX)
BPSDBBX_6086(ddpX)
BPZBP1026B_II1045
BPQBPC006_II1328
BPKBBK_3481(ddpX)
BPSHDR55_4380(ddpX)
BPSABBU_5075(ddpX)
BPSOX996_4192(ddpX)
BUTX994_6167
BTEBTH_II1441
BTQBTQ_4728(ddpX)
BTJBTJ_5670(ddpX)
BTZBTL_4209(ddpX)
BTDBTI_5768(ddpX)
BTVBTHA_3748(ddpX)
BTHEBTN_3482(ddpX)
BTHMBTRA_4233(ddpX)
BTHADR62_3555
BTHLBG87_4185
BOKDM82_5125(ddpX)
BOCBG90_5469
BUUWS70_22255
BSAVWS86_23520
BHGI6G56_23225(ddpX)
BVIBcep1808_5113
BVEAK36_3780
BURBcep18194_B0891 Bcep18194_B1254
BCMBcenmc03_5471 Bcenmc03_5715
BCHBcen2424_4590 Bcen2424_4812
BCJBCAM1769(ddpX)
BCENDM39_6055(ddpX)
BCEWDM40_4588(ddpX)
BCEOI35_5644(ddpX)
BAMBamb_4016
BACBamMC406_4478
BMUBmul_4059
BMKDM80_5370(ddpX)
BMULNP80_4549
BCEDDM42_6180(ddpX)
BCEPAPZ15_28810 APZ15_30135
BDLAK34_3843
BPYRABD05_27025
BCONNL30_02225 NL30_03290
BUBBW23_5601
BDFWI26_21935
BLATWK25_25375
BTEIWS51_06405
BSEMWJ12_28830 WJ12_30145
BPSLWS57_05120
BMECWJ16_27645 WJ16_28680
BSTGWT74_18245 WT74_27915
BSTLBBJ41_22265
BANNJFN94_27000(ddpX)
BUGBC1001_4495
BGFBC1003_4972
BYIBYI23_A010880
BUKMYA_4100
BUEBRPE67_ACDS11230
BULBW21_5455
BUQAC233_27690
BUDAQ610_25910
BUMAXG89_12165
BUIAX768_05960
BURKDM992_21570 DM992_31705
BXEBxe_B1785 Bxe_C0198
BXBDR64_7091(ddpX) DR64_8229(ddpX)
BPHBphy_4003
BGEBC1002_5696
BPXBUPH_01059
BPYBphyt_6300
BCAIK788_0006343
PARABTO02_11055
PARBCJU94_21995
PHSC2L64_19230
PTERC2L65_17105
PGPCUJ91_28530
PCJCUJ87_27305 CUJ87_30830
PTSCUJ90_09930
PMEGFNZ07_11375(ddpX)
PEWKZJ38_12670(ddpX) KZJ38_33645
PDIOPDMSB3_1278.1(ddpX)
PPULRO07_10090
PLGNCTC10937_02132(ddpX)
HYFDTO96_100586(ddpX)
CABASBC2_15080(ddpX)
BUOBRPE64_ACDS12190
BBROBAU06_07205
BOHAKI39_07035
TEQTEQUI_1219
TEAKUI_0618
TEGKUK_0487
PUDG9Q38_00825
AKATKWG_16505
AMIMMIM_c13380(ddpX)
CDNBN940_18191
BOZDBV39_00360
OURCEQ07_06915
PIGEGT29_04245
PACRFXN63_13630(ddpX)
PARKLSG25_17070(ddpX)
RHYRD110_00885
RHGEXZ61_03510
PNAPnap_3562
POSDT070_04175
POOF7R28_05270(ddpX)
PVACHC248_00360(ddpX)
ACIDCBP33_03690
ACIPCBP36_04110
ACISCBP35_14830
ACIOEAG14_17125
AMONH9L24_11675
ARADKI609_04525
VEIVeis_4116
CTTCtCNB1_4001
CTESO987_24260
CKEB5M06_02740
COFFOZ74_07635
CAQTKAQ61_13120
CODOLAD35_04695(ddpX)
MELMC7H73_04480
MELAC6568_12195
MJELVC68_03305
KIAG8A07_01870
RDPRD2015_276
MIUABE85_21740
JAGGJA_34
JAZYQ44_27140
JALBZG29_00870
JSVCNX70_00915
JASFJQ89_17985
JLVG3257_00860
MNRACZ75_19645
MASWAM586_00720
MASSCR152_01230
MTIMDIR46_14160
MASYDPH57_20730
MANCIV454_07240
MFYHH212_08605
MASZC9I28_01160
MALIEYF70_29545
MUMFCL38_20060
MFLAGO485_15325
MPLIE1742_16645
PKTAT984_19385
XYKGT347_19615
URUDSM104443_01529(ddpX)
UPLDSM104440_01439(ddpX)
ATWC0099_01120
BEBAEM42_12530
BEBABWI17_19415
HHEHH_1855
HCPHCN_1394
HCBHCBAA847_1540
HTYBN2458_PEG1063
ANTArnit_0954
DFLDFE_3051
DSDGD606_15785
DMADMR_05000
DCBC3Y92_17910
DGGDGI_3051
DDEDde_1551
DMSE8L03_08555
DSADesal_0964
DHYDESAM_23199(vanX)
DAFDesaf_3069
DASDaes_2690
DEJAWY79_05810
LIPLI0292
LIRLAW_00301
DSXGD604_03005
DALKDSCA_53210 DSCA_53430
AORYAMOR_17360
MXAMXAN_6416(ddpX)
MSDMYSTI_07018
MYMA176_000470
MFBMFUL124B02_37085
CCXCOCOR_07007(ddpX)
MFULILAB_14475
MMASMYMAC_006124
SURSTAUR_7149(ddpX)
AGEAA314_09004
AVMJQX13_05080(ddpX)
MBDMEBOL_002049
CFUSCYFUS_008802
VINAKJ08_1853
HOHHoch_2451
DTIDesti_1921 Desti_5152
SFUSfum_0509
RFERF_0996
RAMMCE_02250
RABAL573_02100
RTLH6P87_00319(vanXB) H6P87_01163(ddpX)
PTCphytr_9650
MMNmidi_00429(ddpX)
RBTNOVO_05530(vanX)
RENEF513_05820 EF513_07680
PACAID47_08795
CAQIM40_03925
NAFGQ61_07365
EAAI862_05570
MLOmlr1665
MLNA9174_18005
MCIMesci_3069
MOPMesop_3452
MAMMesau_03339
MESWA9K65_016660
MJREB229_18270
MERDEB233_15595
MOHIHQ72_16475
KMNHW532_16225(ddpX)
BJAbll5098(bll5098)
BJUBJ6T_46200
BJPRN69_22415
BRSS23_31200
AOLS58_32420 S58_43880
BRCBCCGELA001_21625
BRADBF49_6481
BICLMTR13_17960
BROBRAD285_4270
BRKCWS35_27060
BOTCIT37_28635
BRQCIT40_17770
BGQX265_21805
BGZXH91_15595
BSYMCIT39_17085
BBETF8237_30400
BARHWN72_28380
BVZBRAD3257_3952
BELBE61_50100
BDGLPJ38_27505
BSEPHAP48_0041840
BQBJ4P68_0002050
BSEIKMZ68_15850
RPBRPB_2426
RPCRPC_2248
RPDRPD_3026
RPERPE_3372
RBKE0H22_16290
VGOGJW-30_1_00787(vanX)
TRBHB776_11285
BVVBHK69_01680
BOIBLM15_23945
XAUXaut_0653
XDIEZH22_14935
AZCAZC_1150
LNEFZC33_24545 FZC33_25250
APOLK9D25_10835
MEAMex_1p0607
MDIMETDI0978
MEXMext_0840
MCHMchl_0800
MPOMpop_0763
MZAB2G69_11185
METAY590_03125
METDC0214_03520
METSDK389_23440
MOGMMB17_05230
BIDBind_1206
MSLMsil_2119
MTUNMTUNDRAET4_2033(ddpX)
MLGCWB41_10275
BBARRHAL1_03969(vanX)
RVARvan_3635
RHZRHPLAN_05540
MCGGL4_1677
METGHT051_10685
DEVOH4N61_01675
BVRBVIR_208
BLAGBLTE_28860
MSCBN69_3604
MBRYB1812_17390
MROSEHO51_08260
MHEYH2LOC_008475
MPARF7D14_16040
MTWCQW49_01525
PSINCAK95_07300
LABRCHH27_17790
PHRC6569_00490
PSTGE8M01_17295
LIZLGH83_06405
CCRCC_2273
CCSCCNA_02356
CAKCaul_1410
CSECseg_2929
CHQAQ619_06085
CFHC1707_18360
CAUFCSW63_16290
CAULKCG34_09555
TSVDSM104635_00989(ddpX) DSM104635_02016(vanX)
DSHDshi_3149(ddpX)
HATRC74_12885
NSMJO391_08925
HBAHbal_0940
CBOTATE48_14980
SECHB18_01920
SLANGV829_13260
PORLBG023_112314
PHZCHX26_12715
POTE2E27_09420
GXYGLX_14850
GXLH845_292
KNAB0W47_10880
KEUS101446_02076(vanX)
KSCCD178_01307(ddpX)
KREGWK63_13565
ASZASN_2162(vanX)
ATOCIW82_01870
RGIRGI145_00080
ROSCTJ15_15340
RMUCFOB66_03875(ddpX)
RMTIAI58_00465(ddpX)
KHAIFJ82_08715 IFJ82_10455(ddpX)
SHUMSTHU_52880(ddpX)
SVCSTVA_52770(ddpX)
STELSTAQ_47990(ddpX)
AZLAZL_000450(vanX)
ALIAZOLI_2986(ddpX)
ABSAZOBR_10336(ddpX)
ABQABAZ39_14355
ABFAMK58_00665
ATIAL072_04335
AHUA6A40_11960
AZTTSH58p_11305
AZMDM194_11510
AZZDEW08_27625
AOZHUE56_10190(ddpX)
NAOY958_00100
NCBC0V82_08425
SKTIGS68_27560(ddpX)
SMUCJL100_029660(ddpX)
SROEJL101_028450(ddpX)
RRURru_A3762
RRFF11_19245
RCERC1_2612(vanX)
RPMRSPPHO_01149
MAGamb4456
MGYMGMSRv2__3117(ddpX)
MGRYMSR1_28490(ddpX)
MAGXXM1_0748(ddpX)
MAGNWV31_12100
TMOTMO_3524(ddpX)
HJOAY555_04205
FERFNB15_08040(ddpX)
HTQFRZ44_53510(ddpX)
HADHFRZ61_52350(ddpX)
DEXHWD60_04520(ddpX)
DVNHQ394_05495(ddpX)
TXITH3_20355
THACCSC3H3_19875
TIIDY252_01160
THAIIT893_19580(ddpX)
MAGQMGMAQ_3904(ddpX)
MAIMICA_2297
MANA11S_2245
SNEANBZ79_18760(ddpX)
BBABd2654(aad)
BBATBdt_2577(aad)
BBACEP01_09385
BDCDOE51_13085
BDZDOM22_06820
BDKHW988_06230
SBFJCM31447_12540
AFRAFE_0462
AFELferr_0622
AFIAcife_0851
AFJAFERRID_16970
AFPK1Y48_02335
BKOCKF48_05320
CGOTJ1899_06175
GTNGTNG_1240
PARGPspKH34_18320
ANMGFC28_735 GFC28_787
ANLGFC29_839 GFC29_891
ACAIISX45_02520
ASEDIRT44_16965(vanX)
LSPBsph_2280(ddpX)
LGYT479_09305
LFUHR49_14860
LYSLBYS11_08235
LYZDCE79_12015
LYGC1N55_13150
LPAKGDS87_09350
LAGRFJQ98_10070
FARABE41_005880
BVJI5776_15875
STEAC0679_14830
BBEBBR47_05880 BBR47_12370
BFMBP422_01430 BP422_28595
BAGRBA6348_19175
BCHSJNE38_06570
BCOPJD108_17385
PJDPjdr2_5611
PSABPSAB_13255
PODPODO_13780
PAENP40081_17435
PAEFR50345_13940
PAEQR50912_16235
PAEAR70723_15015
PAEER70331_14570
PAEHH70357_16670
PAEJH70737_13280
PBJVN24_01310 VN24_07225
PIHUB51_09690
PRIPRIO_3225
PSONJI735_32485(vanX)
PDHB9T62_11440
PAIHASL14_17805
PLENEIM92_11790
PPSCEHS13_32635
PRZGZH47_24210
PSOPKP014_14535
PTRIKDC22_15520
PTJJRJ22_12225
PALRHGI30_04875 HGI30_12760
COHNKCTCHS21_36140
CCHLFPL14_01155
CHEBHH215_08165
SOBCSE16_14445
VIJJNUCC6_05545
TVUAB849_010225(vanX)
SANSDK43_03865
LPLlp_0769(aad)
LPJJDM1_0636(aad)
LPTzj316_0829(aad)
LPSLPST_C0597(aad)
LPRLBP_cg0573
LPZLp16_0607
LPBSH83_03090
LPXASU28_04505
LPGBB562_13195
LARGLPA65_03050
LNGBSQ50_02720
LHWBSQ49_03245
LMALLM596_03500
LBHLbuc_1951
LBNLBUCD034_2038(aad)
LPARFAM21731_01459
LCUPL11_005455
LKFDNL43_07460
LHILG8J22_02249(ddpX)
LBRLVIS_2130
LBKLVISKB_2187
LKOABN16_06690
LZYLZ3411_2189
LSUAH3M12_01710
LSLLSL_1373(ddpX)
LSIHN6_01156(ddpX)
LSJLSJ_1436c(ddpX)
LRMLRC_07620(ddpX)
LAGLBEN83_07000
LACALAC1533_2123
LANIFAX13_03760
LMURCPS94_04995
LHOLOOC260_101260
LOLLACOL_1440
LNNF0161_00725 F0161_09345
LPDAYR62_10705 AYR62_15350
LMAEFGL90_04230 FGL90_05415
LGNABM34_05875
LZHD1B17_01695
OOEOEOE_0214
LCILCK_00920(ddpX)
WKOWKK_05410
WCEWS08_0838
WCTWS74_0904
WCIWS105_0902
WCBAO080_09810
WJOFOL01_0633
WPACO680_05150
WCFC6P13_07270
WSOWSWS_01029(vanX)
WHEEFA59_03125
WDIH9L19_01660
WCOG7084_06610
EFAEF2293(vanX)
EFCEFAU004_02774(vanXB)
EFAUEFAU085_00736(vanXB)
ECASECBG_02848
EGAAL523_09460(vanXY)
ESGEsVE80_p1-00090(vanX)
ERAFJ9537_15945
EIEENLAB_26740
VCPH9L18_13850(vanXY)
VFVK5K99_04110(vanXY)
CLBClo1100_0663 Clo1100_2029
CACECACET_c25470(vanY)
CFMBJL90_20405
CARGRSJ17_20560
CMAHC1I91_27095
AOEClos_2859
ASFSFBM_0042
ASMMOUSESFB_0042
ASOSFBmNL_00057
ASBRATSFB_0043
CALEFDN13_12935
CCLClocl_2787
FPLAA4U99_10120
RGVNQ502_10135
OVAOBV_09500
PFAAMM59RIKEN_06550 MM59RIKEN_12800(vanY) MM59RIKEN_24460
VCOPMM50RIKEN_08110(vanY)
CFEMHCR03_19245
LASAL9O85_05965
BPBbpr_I0244(vanX)
CLEClole_1512
CSCIHDCHBGLK_00826(ddpX)
CSOCLS_04650
HSDSD1D_0542
ACELacsn021_25820(vanY)
ACHTbsdcttw_22900(vanY_1) bsdcttw_27600(vanY_2)
SSUNH9Q77_03160
QDOH9Q78_03825
WHJH9Q79_01755
CDFCD630_16270(vanY)
PDCCDIF630_01804(vanY1)
CDCCD196_1550
CDLCDR20291_1525
PDFCD630DERM_16270(vanY)
SALQSYNTR_0793
CALKHUE98_13535
DSYDSY3694
DHDDhaf_1661
DDLDesdi_1474
DAUDaud_1902
FWADCMF_01545 DCMF_02705
DGIDesgi_0993
ELMELI_0380
EMTCPZ25_011905
ELIMB2M23_04885
AWOAwo_c09350(pdgL)
AWICHL1_002839
VGUHYG85_23275
IBUIB211_00655 IB211_01761
AMIJEQM06_03915
AMICAmi3637_03095 Ami3637_13570(vanX)
ABUTAmi103574_02980 Ami103574_06130 Ami103574_07965
ETMCE91St48_02950(vanY) CE91St48_40230(ddpX)
EUUADJ67_01660 ADJ67_03765
TTETTE2535(DdpX)
HALSD7D81_06425
IFNGM661_04070
CADCuri_c05070(vanXY)
SRISELR_pSRC101300(vanX)
AFNAcfer_0822
AINAcin_1290
PFACPFJ30894_02013(ddpX)
ERMEYR00_02860
LCGL3BBH23_19230(vanXB)
CMITNQ499_13340
MTURv0838(lpqR)
MTVRVBD_0838
MTCMT0860(vanX)
MRAMRA_0846(lpqR)
MTFTBFG_10856
MTBTBMG_03152
MTKTBSG_03172
MTZTBXG_003130
MTGMRGA327_05285
MTIMRGA423_05255
MTECCDC5079_0774
MTURCFBS_0880(lpqR)
MTLCCDC5180_0767
MTOMTCTRI2_0861(lpqR)
MTDUDA_0838(lpqR)
MTNERDMAN_0929(lpqR)
MTJJ112_04505
MTUBMT7199_0857(lpqR)
MTUCJ113_05860
MTUEJ114_04465
MTXM943_04395
MTUHI917_05905
MTULTBHG_00826
MTUTHKBT1_0880(lpqR)
MTUUHKBT2_0881(lpqR)
MTQHKBS1_0880(lpqR)
MBOBQ2027_MB0861(lpqR)
MBBBCG_0890(lpqR)
MBTJTY_0860(lpqR)
MBMBCGMEX_0861(lpqR)
MBKK60_008950
MBXBCGT_0642
MAFMAF_08470(lpqR)
MMICRN08_0935
MCEMCAN_08401(lpqR)
MCQBN44_10917
MCVBN43_20287
MCXBN42_20614
MCZBN45_20124
MPAMAP_0670(lpqR)
MAOMAP4_3194
MAVIRC58_15825
MAVURE97_15855
MAVMAV_0853(ddpX)
MITOCO_07050
MIAOCU_07050
MIDMIP_01229
MYOOEM_07120
MCHIAN480_04685
MIROCQ_07200
MMALCKJ54_03540
MMANMMAN_50110(lpqR)
MSAMycsm_05715
MULMUL_0369(lpqR)
MMIMMAR_4800(lpqR)
MMAEMMARE11_46300(lpqR)
MLIMULP_05030(lpqR)
MSHOMSHO_58170(lpqR)
MMCMmcs_4186
MKMMkms_4252
MJLMjls_4413
MMMW7S_03445
MKNMKAN_10430
MYVG155_05025
MYEAB431_09665
MGOAFA91_11335
MHADB586_05625 B586_10005
MDXBTO20_30920
MSHGMSG_04338(lpqR)
MFJMFLOJ_42770(lpqR)
MSTOMSTO_46880(lpqR)
MSIMMSIM_31300(lpqR)
MSAKMSAS_26800(lpqR)
MKUI2456_22980
MGROFZ046_11025
MXEMYXE_09730(lpqR)
MNVMNVI_10450(lpqR)
MPAGC0J29_02835 C0J29_03365 C0J29_26410
MNMMNVM_40600
MGORH0P51_24675
MCOOMCOO_24810(lpqR)
MBAIMB901379_04211(ddpX)
MSEOMSEO_32450(lpqR)
MHEKJMUB5695_00932(lpqR)
MGAUMGALJ_37400
MLJMLAC_01900(lpqR)
MBRDMBRA_22760(lpqR)
MSHJMSHI_40650(lpqR)
MKRMKOR_37880(lpqR)
MDFK0O62_05835
MMAMK3U93_21335
MHOLK3U96_03575
MHERK3U94_11415
MSENK3U95_24810
MPAEK0O64_09060
MSPGF6B93_01905 F6B93_19210
MOTLTS72_01215
MVMMJO54_11400
MRFMJO55_21375
MCROMI149_09890
MSMMSMEG_5879
MSGMSMEI_5720(vanX)
MSBLJ00_29075
MSNLI99_29080
MSHLI98_29085
MVAMvan_4724 Mvan_5181
MGIMflv_1575
MSPMspyr1_09590
MCBMycch_4543
MNED174_06505
MYNMyAD_06375
MFTXA26_09680
MPHLMPHLCCUG_00631(ddpX)
MVQMYVA_1601 MYVA_5064(lpqR)
MLLB1R94_13245 B1R94_19660
MRHMycrhN_2361
MHASMHAS_03668(ddpX)
MCHTMCHIJ_01590(lpqR)
MAUUNCTC10437_04942(ddpX)
MMAGMMAD_10360
MMORMMOR_12880
MFXMFAL_21680
MAICMAIC_16440
MIJMINS_12860
MALVMALV_43390(vanX)
MTYMTOK_23400(lpqR)
MPSCMPSYJ_21410
MARZMARA_28690 MARA_52960
MGADMGAD_36550
MHEVMHEL_40980
MSARMSAR_01210
MANYMANY_02580 MANY_14070
MAUBMAUB_22660
MPOFMPOR_48040 MPOR_52810
MPHUMPHO_47910
MMUCC1S78_023285
MMATMMAGJ_35420
MBOKMBOE_20730(vanX)
MFGK6L26_06020
MSEIMSEDJ_23120 MSEDJ_57000
MFLVNCTC10271_00574(ddpX)
MCEEMCEL_38890
MABMAB_1843
MMVMYCMA_0951
MABBMASS_1830
MABLMMASJCM_1760
MCHEBB28_09515
MIZBAB75_09970
MSTEMSTE_01768
MSAOMYCSP_07985
MSALDSM43276_01605(ddpX)
MJDJDM601_1992(lpqR)
MTER4434518_01943(ddpX)
MMINMMIN_36310
MHIBMHIB_14640
MPAKMIU77_03090
CGVCGLAU_00350(ddpX)
CEECENDO_00370(ddpX)
NBRO3I_008265
NTPCRH09_30835
NOZDMB37_28960
NWLNWFMUON74_45710(vanA)
NIEKV110_08865
RHWBFN03_17280
GBRGbro_0051
GPOGPOL_c02420
GORKTR9_0356
GTABCM27_02305
GAVC5O27_03010
GODGKZ92_01915
GAMGII34_10265
GPDGII33_09835
GJIH1R19_01905
GAMIIHQ52_02615
TPRTpau_0522
TOYFO059_01070(vanX)
SCOSCO1396(SC1A8A.16c) SCO2328(SCC53.19) SCO3596(SC66T3.07)
SALBXNR_5444
SMASAVERM_1809
SGRSGR_6133
SGBWQO_04765
SCBSCAB_61891
SSXSACTE_0818
SVLStrvi_1426 Strvi_5702 Strvi_9340
SHYSHJG_1314
SHOSHJGH_1148
SRCM271_18335 M271_25650 M271_43685
SMALSMALA_0671 SMALA_5061
SSOII1A49_06950
SFASfla_5472
SBHSBI_01991
SVESVEN_0985
SALSSLNWT_6542
STRPF750_1141 F750_6452
SFISFUL_918
SALUDC74_1682 DC74_6104
SALLSAZ_08945 SAZ_31455
SLVSLIV_20315(vanX) SLIV_26040 SLIV_30780
SGUSGLAU_05590
SVTSVTN_03045 SVTN_06350
STREGZL_02161 GZL_07463
SLDT261_07487 T261_5666
SLCSL103_06905 SL103_13690
SXISXIM_06730 SXIM_54610
STRMM444_07150 M444_35025
STRCAA958_01615 AA958_28370
SAMBSAM23877_0338 SAM23877_1454
SPRISPRI_6164
SCZABE83_31015
SCXAS200_06585 AS200_36705 AS200_44880
SRWTUE45_pSRc_0325(ddpX)
STRFASR50_06595
SLEsle_01160(sle_01160) sle_57010(sle_57010)
SRNA4G23_00646(vanX)
SPAVSpa2297_03320 Spa2297_05150
STRTA8713_04685
STSIA4E84_06855
SKYD0C37_29265
SALWCP975_02235 CP975_05035
SGMGCM10017557_69360
SCADDN051_07295 DN051_31785
SPHWNFX46_27415
SLSSLINC_1579 SLINC_1843 SLINC_7674
SNRSNOUR_09685 SNOUR_34330
SPLULK06_028350
STRDNI25_32210
SNWBBN63_29755 BBN63_34025
SAUOBV401_07205
SSIAA7J05_30080
SVUB1H20_03925
SPUNBFF78_34645
SGVB1H19_07740 B1H19_14140
SLAUSLA_0896
SALFSMD44_00245(vanX) SMD44_01409(vanX)
SALJSMD11_5696(vanX) SMD11_6976
SLXSLAV_03520 SLAV_30760(vanX)
STROSTRMOE7_06310
SFKKY5_0472c KY5_1125 KY5_7836
SGEDWG14_00988(ddpX)
SRJSRO_1032
SDXC4B68_39230
SGDELQ87_04485 ELQ87_32845
SASTCD934_28760
SNQCP978_33975
STIRDDW44_10980
SKACP970_00250 CP970_37195 CP970_40415
SGZC0216_20400
SNKCP967_29595
SHAWCEB94_07250 CEB94_33725
SRKFGW37_04840
SFICEIZ62_28260
SGALCP966_05295
SPADDVK44_02940
SFYGFH48_33630
SAQUEJC51_03790(vanX) EJC51_09505 EJC51_16710
SGFHEP81_00997
SCAVCVT27_03605
SSEOD0Z67_02465 D0Z67_03070
SBYH7H31_02100 H7H31_16170(vanX) H7H31_16470
SRIMCP984_35635 CP984_39915(vanX)
SSUBCP968_27655
SPHVF9278_13670 F9278_43130
SCINCP977_05985
SFUGCNQ36_05540
SPACB1H29_30665
SCHACP983_36275 CP983_39425
SGXH4W23_03855 H4W23_06865
SBATG4Z16_14910 G4Z16_30590
SSPBCP982_05345 CP982_08220 CP982_31315(vanX) CP982_40590
SNFJYK04_07424(vanX)
SPLACP981_04965 CP981_12390
SBROGQF42_43620
STUIGCM10017668_09700
SATAC5746_07385
SHARHUT13_03980
SFEUIM697_03220
SLIAHA039_29210
SDWK7C20_04350
SVDCP969_07945
SCALI6J39_04110
SAUHSU9_010010
SFBCP974_03405
SMOBJ7W19_32215
SPRACP972_06080 CP972_31600
SPEUCGZ69_05450
SROIIAG44_02355 IAG44_33580 IAG44_39580(vanX)
SXNIAG42_01120 IAG42_30120
SGJIAG43_04355
SHKJ2N69_02430 J2N69_04970
SANUK7396_24870 K7396_31120
SACTDMT42_05905
SGOBtest1122_25685
SINEKI385_07375 KI385_15215
SLFJEQ17_38905
SDECL3078_03285 L3078_15130
SAOVG3H79_31865 G3H79_33180
SDURM4V62_35185 M4V62_38720 M4V62_40790
SYANNRK68_05895 NRK68_29235
SCTSCAT_0154
SCYSCATT_01600
KABB7C62_03420
YIALO772_06595(vanX)
STRHGXP74_02660
ABRYNYE86_14505
PSICJ4E96_04775 J4E96_04945 J4E96_14340
MCAWF6J84_00740
RTXTI83_01665
RTCAPU90_04825
RTNA6122_0298
RRYC1O28_00075
RIAC7V51_10860
MSPOKXZ72_08445
ACITHPK19_19130
ASUNKG104_11145(vanX)
KSEKsed_22940
CFLCfla_0533
CFICelf_0507
CIRALFM56_15950
CDONKKR89_02715
CWANKG103_02675
OEKFFI11_014115
AUSIPK37_00825
NOOFE634_07190 FE634_17695
NANOG5V58_22155
NAQUENKNEFLB_02182(vanXB)
NROK8W59_03060
PSIMKR76_27180
MGGMPLG2_1043
KFLKfla_3621
KQIF1D05_24240 F1D05_26440(vanX)
ACTWF7P10_09885(vanX)
SROSros_2196
NOABKM31_13725 BKM31_33780
NOWGBF35_10875
NCXNocox_10295(ddpX1) Nocox_20140(ddpX2)
NGNLCN96_11630 LCN96_29460
FREFranean1_7136
SACGFDZ84_33825
AMDAMED_0659(vanA) AMED_8288(vanA)
AMNRAM_03365 RAM_42560
AMMAMES_0657(vanA) AMES_8160(vanA)
AMZB737_0658(vanA) B737_8161(vanA)
AOIAORI_1473(vanX) AORI_2227(vanX)
AJAAJAP_27755 AJAP_32165(vanX)
AMYCCU254_05725 CU254_15950
AMYBBKN51_37400 BKN51_41400
AABA4R43_21430 A4R43_33690
AMYYYIM_33815(ddpX) YIM_36540(vanX1) YIM_44415(vanX2)
AORISD37_33755 SD37_37960
AACDLWP59_12325
APRTMUY14_04910(vanX) MUY14_33495
AROONQK81_15535(vanX)
SESPBN6_49750(vanX)
SSYIEKG83_05360(vanX)
KALKALB_1171
KPHYAOZ06_08685 AOZ06_28870
LEDBBK82_32725
ALOCRK56506
ACTUActkin_02322(vanX)
MAUMicau_3391
MILML5_1228 ML5_5003
MICBMicB006_1026 MicB006_2451
MTUACSH63_08095 CSH63_19590
MICHFJK98_16855
MTEMGCE86_12920 GCE86_30420
MCABHXZ27_18685
VMAVAB18032_09600 VAB18032_19945
MCRAID554_07975
ACTNL083_3595
ACTRAsp14428_23750
PLKCIK06_10115
PFLAPflav_001160 Pflav_014270 Pflav_032710
PSUUPsuf_054830(vanA) Psuf_064030 Psuf_064040
VERHUT12_05755 HUT12_17545
ATLAthai_15810(vanX)
ASERAsera_58750(vanX)
CATICS0771_16710
DVCDvina_26160(vanX)
DFUDfulv_23780
DROSDrose_19525
CCAZCOUCH_28885
CAICaci_5792
SNASnas_5357
GLYK3N28_22510(vanX)
BSUEBS3272_00605
JTLM6D93_18485
CWOCwoe_1415
AFOAfer_1324
SHIShel_25870
DDTAAY81_09795
SYNslr1679
SYZMYO_118050
SYYSYNGTS_1787(slr1679)
SYTSYNGTI_1787(slr1679)
SYSSYNPCCN_1786(slr1679)
SYQSYNPCCP_1786(slr1679)
SYJD082_24400(ddpX)
SYOC7I86_09300
SYCsyc1085_c
SYUM744_00810
SYFSynpcc7942_0432
SYDSyncc9605_1226
SYESyncc9902_1243
SYGsync_1279
SYRSynRCC307_1270(ddpX)
SYXSynWH7803_1320(ddpX)
SYPSYNPCC7002_A2266(ddpX)
SYNESyn6312_0181
SYNPSyn7502_02784
SYNKKR100_09520
SYNRKR49_02810
SYNDKR52_10500
SYHSyncc8109_1454
SYNWSynWH8103_01237(ddpX)
SYVAWQ23_11295
SYLAWQ21_13200
SYNCCB0101_03240
SYNYBM449_10965
DSLDacsa_3452
SYWSYNW1094
CGCCyagr_0498
CYICBM981_0625(ddpX)
PMAPro_0829(ddpX)
PMMPMM0757
PMTPMT_0580
PMNPMN2A_0161
PMIPMT9312_0765
PMFP9303_16701(ddpX)
PMGP9301_08171(ddpX)
PMHP9215_08511(ddpX)
PMJP9211_10061(ddpX)
PMENATL1_07931(ddpX)
PRCEW14_0846
CMPCha6605_2651
AMRAM1_2367
WNAKA717_38820
TVNNIES2134_125260
SLWBRW62_05295
TELtll2463
THECFFX45_06385
LEPLepto7376_3662
LENLEP3755_00070 LEP3755_56150
LETO77CONTIG1_04608(ddpX)
LBOLBWT_44490 LBWT_51470
KOVK9N68_07130 K9N68_08080
LSCKIK02_06510
LSKJ5X98_13360
HHGXM38_031670(ddpX)
PSEUPse7367_2249
PSERABRG53_1856
THEUHPC62_18605
GLPGlo7428_3529
GENGM3709_186
GEEGM3708_3033
CHONNIES4102_00830
MARMAE_59910
MPKVL20_6369
MIQB5D77_23755
MVZmyaer102_32080
CANCyan10605_2128
CSNCyast_0586
CYLAA637_09005(vanX)
HAOPCC7418_2980
ENNFRE64_00830
CYUUCYN_08040
CYTcce_2981
CWACwatDRAFT_1382
CYPPCC8801_1391
CYHCyan8802_1425
CYCPCC7424_4557
CYJCyan7822_3187
CYNCyan7425_4490
TERTery_2224
ARPNIES39_A06450 NIES39_D02990
PAGHNIES204_30840 NIES204_43110
PPSUNO713_00726(ddpX) NO713_00796(ddpX)
OXYHCG48_20330
MVAGD0A34_15285 D0A34_21720
LFSHFV01_20395 HFV01_30460
MICMic7113_1328 Mic7113_2213
GEIGEI7407_1237
OACOscil6304_0331 Oscil6304_0629
ONIOsc7112_0237 Osc7112_1789
MPROBJP34_34800
PHORJWS08_01990
PYHNEA10_10570
CEPCri9333_2538 Cri9333_4462
GVIgll1805 gll1924
GLJGKIL_1509(vanX) GKIL_1879(vanX)
GMLISF26_00140 ISF26_08475
ANAall4116
NPUNpun_R0488
NOSNos7107_1666
NOPNos7524_1568
NONNOS3756_05750
NFLCOO91_05702
NOECLI64_06505 CLI64_16205
NSHGXM_02020
NEDHUN01_22385
AVAAva_0787
NAZAazo_0087
ANBANA_C13557(vanX)
ACYAnacy_0423
AWAAA650_03150
ANNEH233_04380
CSGCylst_0054 Cylst_5626
RSINB6N60_04631
CALOCal7507_2143
CALTCal6303_0676
CALHIJ00_16565
CALNNIES2098_60440
RIVRiv7116_6463
FISFIS3754_26830
NSPBMF81_01121(vanX)
NSPHBDGGKGIB_03377(ddpX)
DOUBMF77_01915(ddpX_1)
DFSHGD76_02545
DHTNG743_13775
CCURIAR63_09610
CRKL3I90_14005
AFLOHEQ12_19405
TOQHCG51_07900 HCG51_23885
NCNBZZ01_29810
CTHEChro_5071
PLPPle7327_4541
SCSSta7437_0186
STANSTA3757_14070
CEOETSB_1170
CERRGRSB_1841
KBSEPA93_09975
CCZCCALI_01827
FGIOP10G_0233 OP10G_0542 OP10G_3162
NPYNPRO_15330 NPRO_24970
AMUAmuc_1627
ROOG5S37_14800 G5S37_19455
LAMBKBB96_13885
ROLCA51_22610(vanX)
LCREPla8534_39890(ddpX)
AAGGETAA8_00330
AMOBHG15A2_20400(vanX)
PLHVT85_00835(ddpX)
MCADPan265_28630(ddpX)
BHCJFL75_10445
LBILEPBI_I3170
LBFLBF_3060(ddpX)
ABAAcid345_2745
TALBFTW19_01865
SUSAcid_7552
PFERIRI77_30995
CTMCabther_B0704
CVLJ8C06_11810
CHLOJ8C02_12700
EMIEmin_0835
ACOAmico_1339
TLITlie_1539
AMOAnamo_1971
PPIOCE91St28_21600(vanA)
FSUFisuc_0416
FSCFSU_0830(ddpX)
GBAJ421_1157
BTHBT_3007
BTHOBtheta7330_00113(ddpX)
BFRBF4523
BFSBF9343_4205
BFGBF638R_4476
BFBVU15_21015
BHLBache_0830
BXYBXY_21000
BOABovatus_03040(ddpX)
BCELBcellWH2_03030(ddpX)
BCACCGC64_03000
BCAEA4V03_17735
BISDXK01_005910
BUNBun01g_06280
BEGINE88_01867
BFEK6V30_03730
BNOK8P02_17575
BHUMJXR92_003455
BVUBVU_1311
BDOEL88_01545
BDHGV66_04875
PGIPG_1654
PGNPGN_0461
PGTPGTDC60_0646
PCRENCTC12858_01521(ddpX)
PCAGNCTC12856_00777(ddpX)
PENDLA319_02880
PSOECE91St14_04250
DYSG7050_06170
PGOLK6V26_17760
TFOBFO_1449
TOHBCB71_06945
DUNFDZ78_01230
OSPOdosp_0438
PRUPRU_1817
PMZHMPREF0659_A5051(ddpX)
PDNHMPREF9137_0631(ddpX)
PITPIN17_A0507(ddpX)
PROHMPREF0669_00787
PFUSADJ77_06215
PEOAS203_11960
PJECRM71_00105
POCNCTC13071_00388(ddpX)
PNIJ5A59_04850
PHISJ5A62_08125
PVFJ5A55_08000
PBYL6471_02350
PSCJJ4856_05675
ALQC7Y71_010730
AFDAlfi_0363
ALDGFH31_11680
AITAI2BBH_15120
RBCBN938_2945
BACCBRDCF_p310(ddpX)
DRCG0Q07_14645
MCOSGM418_25250
RBARAWN76_012275
CPICpin_1987
CBAECOR50_21155
CHITFW415_09640
CHIHGWR21_25385
COYHF329_32125
CFILMYF79_09890
NKONiako_4501
NSONIASO_06520
NIAA8C56_06815
FGGFSB75_20770
ARBA9P82_00895
ARKD6B99_11130
AGIFSB73_18900
ARACE0W69_012925
ATEEK9M52_17490
FLNFLA_4506
PSEGD3H65_31045
PGINFRZ67_02465
PGOFSB84_28750
FLSGLV81_04545
LACSH4075_16385
FLVKJS94_02350(ddpX)
HHYHalhy_1691 Halhy_3604
SGNSGRA_2881(vanX)
PHEPhep_4285
PEPAQ505_00500
PCMAY601_1867
PSTYBFS30_05310
PGSCPT03_18565
PEKFFJ24_022235
PROEH9L23_22500
PEXIZT61_12935
PMUOLOK61_17230
SHTKO02_06065
SPHNBV902_10780
SMIZ4412673_03003(vanX)
SPHZE3D81_07295
SPDRG6053_20000
SDJNCTC13534_04257(vanX)
STHANCTC11429_03438(vanX)
SSPII6J01_13190
SMUII6J00_00240
SSIYJVX97_22065
SCNSolca_3988
MUCMuYL_4620
MGOTMgSA37_00683(ddpX)
MUHHYN43_024315
MGKFSB76_15665
MRUBDEO27_025640
MGOSDIU38_027040
MMABHQ865_18905
MGIKGO620_011705
MDJLLH06_04530
MROBHH214_05230
SBXCA265_21520
CMRCycma_1819
CAMUCA2015_1733
BBDBelba_0734
EVIEchvi_1819
ESTDN752_14965
ECHIFKX85_08870
ALMAO498_05230
MDAIPZ59_09040
SLISlin_4461
SRDSD10_24055
SMONAWR27_15715
SPIRCWM47_04995 CWM47_18980
SPIKEXU85_07170 EXU85_29195
SPIBG8759_27870
STAEHNV11_04275
SRHOHH216_10835
PSEZHME7025_00025(vanX)
AANHG9X63_05170
ALENG9X62_05560
RHOZGXP67_19765
DFEDfer_2827
DSNHWI92_23495
LBYLbys_1708
RSIRunsl_2040 Runsl_2386
RUNDR864_20740
RUPDTQ70_26875
EOLEmtol_3054
FAEFAES_0548
FIBA6C57_06095
ALSDJ013_08085
FLIFleli_0978
HSWHsw_1025
HYMN008_13960
HYGAUC43_01330
HYHD3Y59_00870
HYJFHG12_14330
HQIH9L05_12655
HRSHER32_03315
HTSHMJ29_01345
HMTMTP16_09880
HTBMTX78_16625
RUFTH63_17855
RTIDC20_08610
ADDHUW48_14805
ASWUHUW51_23070
MTTFtrac_2776
FPFDCC35_10515
FLMMY04_0551
FLLEI427_04995
FYAKMW28_13480
FKAKM029_05520
CHKD4L85_05805
FUVJR347_08840
GFOGFO_0641(vanX)
FPSFP1623(ddpX)
FPCFPSM_01189
FPYFPG101_05820
FPOFPG3_09935
FPQIB65_08055
FPVIA03_07835
FPWIA04_07770
FPKIA06_07775
FPSZAMR72_14830
FJOFjoh_4601
FJGBB050_02989(ddpX)
FBRFBFL15_1287(ddpX)
FCOFCOL_06615
FGLEM308_13525
FCMBIW12_15160
FFAFFWV33_12275
FATDVK85_00220
FKIFK004_14995
FPALHYN49_11150
FMGHYN48_11545
FALBHYN59_17850
FCRHYN56_22180
FSNGS03_01743(ddpX)
FNKE1750_16330
FAKFUA48_18015
FFLHYN86_18605
FENJ0383_18355
FCVAWN65_06935
FSDLXD69_05265
FPBNLJ00_22185
COCCoch_2133
CCMCcan_02460
COLAM608_03195
CHGAXF12_03095 AXF12_10870
CAPNCBG49_07780
CGHCGC50_05180
CLKCGC53_02315
CSPUCGC55_03650
CCYNCGC48_07940
CAPHCGC49_05580
CSTOCGC58_04250
CAPQCGC52_05340
CAPFFOC45_08080
RBIRB2501_13189
ZPRZPR_3697
CATCA2559_11948
FBCFB2170_14738
MARMYQ22_01520
MARTBTR34_02145
MARBCJ263_16560
MAREEJ994_02600
CAOCelal_3095
CLYCelly_2590
CLHIX49_13020
CBALM667_12165
CBATM666_12085
KDIKrodi_0057
DOKMED134_03814(vanX)
DDOI597_2426(ddpX)
DODDCS32_12085
LANLacal_1844
LVNBWR22_11105
LACICW733_01345
ZGAZOBELLIA_3181(ddpX)
MRSMurru_2287
MLTVC82_2463
MUTGVT53_05570
MAQILDL77_16900
SPONHME9304_00728(vanX) HME9304_02789
ASLAeqsu_0034
AEVEI546_02760
AICJK629_13240
POMMED152_03330(vanX)
POBLPB03_03850
PRNBW723_15645
POLABXQ17_00350
POACW731_07365
PHALH9I45_05485
PLITK8354_07750
PPECH9W90_07570
PBATJL193_02680
PCEAJ3359_00440
PUNNQP51_07780
WINWPG_2467
WIJBWZ20_04785
SZEAW14_06970
AHZAPS56_05480
SYISB49_02235
TDIAUW17_09965
TENLPB136_06245
TJETJEJU_3330(vanX)
TMARMARIT_2040(vanX)
TMPF9Y86_02920
LUTLupro_05380
LULLPB138_04195
FOPFNB79_08355
SALTAO058_01180
SMISLDL76_08045
SEONBWZ22_01780
AALGAREALGSMS7_00187(ddpX)
OLLCW732_07760
OAQDZC78_14255
FEKC1H87_05720
TAJC1A40_10780
AUEC5O00_12935
KOSKORDIASMS9_02421(vanX)
KANIMCC3317_41860(vanXB)
MARFCJ739_2722
AQBD1818_17435
AQAD1815_14100
AQDD1816_20385
EMARD1013_08665
MUREQY75_04420
PSYNE9099_02390
AFLAFHG64_13375
ANPFK178_09685
OCIFEZ18_09575
MGELG5B37_02360
MESQC7H62_0246
GAAHX109_01535
CAGGHYG79_15300
ALTIALE3EI_2172
MARXINR76_10470
LPALLDL79_16865
SINHLS482_02245
ASAGFGM00_05120
FLGLV716_18195
FLBLV704_00185
SABUMBM09_13615
ZSPMQE36_15225
BIAGMA17_08580
FBEFF125_06620
FBMMQE35_15600
EVAEIB75_13260
FTEFluta_3930
FLUCHH17_07035
CRMK6119_17590
CPHCpha266_1343
CLIClim_1272
PPHPpha_2018
CTSCtha_1444
IALIALB_1434(vanX)
GTLEP073_01145
CABYCabys_655
VPMKG892_01170
FFOFFONT_0879
 » show all
Reference
1  [PMID:7854121]
  Authors
Reynolds PE, Depardieu F, Dutka-Malen S, Arthur M, Courvalin P
  Title
Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine.
  Journal
Mol Microbiol 13:1065-70 (1994)
DOI:10.1111/j.1365-2958.1994.tb00497.x
  Sequence
Reference
2  [PMID:7873524]
  Authors
Wu Z, Wright GD, Walsh CT
  Title
Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147.
  Journal
Biochemistry 34:2455-63 (1995)
DOI:10.1021/bi00008a008
  Sequence
Reference
3  [PMID:9265630]
  Authors
McCafferty DG, Lessard IA, Walsh CT.
  Title
Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX.
  Journal
Biochemistry 36:10498-505 (1997)
DOI:10.1021/bi970543u
Reference
4  [PMID:9702193]
  Authors
Bussiere DE, Pratt SD, Katz L, Severin JM, Holzman T, Park CH.
  Title
The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance.
  Journal
Mol Cell 2:75-84 (1998)
DOI:10.1016/S1097-2765(00)80115-X
Reference
5  [PMID:11881895]
  Authors
Tan AL, Loke P, Sim TS
  Title
Molecular cloning and functional characterisation of VanX, a D-alanyl-D-alanine dipeptidase from Streptomyces coelicolor A3(2).
  Journal
Res Microbiol 153:27-32 (2002)
DOI:10.1016/S0923-2508(01)01282-7
  Sequence
[sco:SCO3596]
Reference
6  [PMID:17017774]
  Authors
Matthews ML, Periyannan G, Hajdin C, Sidgel TK, Bennett B, Crowder MW.
  Title
Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme.
  Journal
J Am Chem Soc 128:13050-1 (2006)
DOI:10.1021/ja0627343
Other DBs
ExplorEnz - The Enzyme Database: 3.4.13.22
IUBMB Enzyme Nomenclature: 3.4.13.22
ExPASy - ENZYME nomenclature database: 3.4.13.22
BRENDA, the Enzyme Database: 3.4.13.22

DBGET integrated database retrieval system