KEGG   ENZYME: 3.4.13.23
Entry
EC 3.4.13.23                Enzyme                                 

Name
cysteinylglycine-S-conjugate dipeptidase;
tpdA (gene name);
LAP3 (gene name)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
Sysname
cysteinylglycine-S-conjugate dipeptide hydrolase
Reaction(IUBMB)
an [L-cysteinylglycine]-S-conjugate + H2O = an L-cysteine-S-conjugate + glycine [RN:R12514]
Reaction(KEGG)
R12514
Substrate
[L-cysteinylglycine]-S-conjugate [CPD:C05729];
H2O [CPD:C00001]
Product
L-cysteine-S-conjugate [CPD:C02882];
glycine [CPD:C00037]
Comment
The enzyme participates in a widespread glutathione-mediated detoxification pathway. In animals the activity is usually catalysed by enzymes that have numerous additional activities, such as EC 3.4.11.1, leucyl aminopeptidase, EC 3.4.11.2, membrane alanyl aminopeptidase, and EC 3.4.13.19, membrane dipeptidase. However, in the bacterium Corynebacterium sp. Ax20, which degrades axillary secretions, the enzyme appears to be specific for this task.
History
EC 3.4.13.23 created 2019
Orthology
K23980  cysteinylglycine-S-conjugate dipeptidase
Genes
ESA: ESA_01896
CSK: ES15_2053
CSJ: CSK29544_03175
CDM: AFK67_09660
CSI: P262_02997
CMJ: AFK66_009970
CMW: AFK63_09070
CEN: LH86_15745
RAH: Rahaq_2316
RAQ: Rahaq2_2421
RAA: Q7S_11725
ADE: Adeh_0863
CCX: COCOR_06542(dapE4)
MALU: KU6B_34360
CGL: Cgl2726(Cgl2726)
CGB: cg3021
CGU: WA5_2631
CGT: cgR_2629
CGM: cgp_3021(tpdA)
CGJ: AR0_13230
CEF: CE2564
CDI: DIP2037
CDP: CD241_1936(tpdA)
CDH: CDB402_1895(tpdA)
CDT: CDHC01_1936(tpdA)
CDE: CDHC02_1943(tpdA)
CDR: CDHC03_1920(tpdA)
CDA: CDHC04_1962(tpdA)
CDZ: CD31A_2030(tpdA)
CDB: CDBH8_2002(tpdA)
CDS: CDC7B_1990(tpdA)
CDD: CDCE8392_1915(tpdA)
CDW: CDPW8_2009(tpdA)
CDV: CDVA01_1867(tpdA)
CDIP: ERS451417_02043(tpdA)
CJK: jk0266
CUR: cu1717
CAR: cauri_2265(tpdA)
CPL: Cp3995_1857(tpdA)
CPP: CpP54B96_1838(tpdA)
CPZ: CpPAT10_1810(tpdA)
COR: Cp267_1878(tpdA)
COD: Cp106_1767(tpdA)
COS: Cp4202_1799(tpdA)
CPSE: CPTA_00189
CPSU: CPTB_01340
CPSF: CPTC_01010
CRD: CRES_0164(tpdA)
CUN: Cul210932_2012(tpdA)
CUS: CulFRC11_1902(tpdA)
CUQ: Cul210931_1959(tpdA)
CUZ: Cul05146_1997(tpdA)
CUJ: CUL131002_1921(tpdA)
CVA: CVAR_0473
CTER: A606_01890
COA: DR71_821
CSX: CSING_11745(tpdA)
CKU: UL82_02505(tpdA)
CSP: WM42_1733
CPHO: CPHO_10790
CGV: CGLAU_10890(dapE3)
CAQU: CAQU_11190
CMIN: NCTC10288_00303(tpdA)
CPEG: CPELA_01560(dapE2)
CEE: CENDO_10075(dapE3) CENDO_10080(dapE4)
CGK: CGERO_01555(dapE1)
CRL: NCTC7448_00466(tpdA)
CCHO: CCHOA_01490(dapE1)
CPRE: Csp1_22730(argE)
CPSO: CPPEL_01460(dapE2)
CSUR: N24_2820
CCYS: SAMEA4530656_0144(tpdA)
CUO: CUROG_01650(dapE1)
NFA: NFA_5650
REY: O5Y_17920
ROP: ROP_35530
REQ: REQ_30750
RHB: NY08_304
RFA: A3L23_03595(dapE_3)
RHS: A3Q41_04631(dapE_5)
RHU: A3Q40_00860(dapE_1)
RRT: 4535765_01749(dapE_2)
RCR: NCTC10994_01121(dapE_2)
GBR: Gbro_0480
GOR: KTR9_0398
GRU: GCWB2_02410(dapE1)
GOM: D7316_04011(ylmB_2)
TPR: Tpau_3706
SCO: SCO1074(SCG22.20)
SALB: XNR_0080
SGR: SGR_6533
SGB: WQO_02410
SHY: SHJG_2522
SMAL: SMALA_0783
SCT: SCAT_0798
SFA: Sfla_5763
SBH: SBI_02014
SALS: SLNWT_0361
STRP: F750_0823
SFI: SFUL_600
SLD: T261_6924
STRM: M444_06405
SPRI: SPRI_6429
SRW: TUE45_01421(dapE_1)
SLE: sle_60360(sle_60360)
SRN: A4G23_00382(dapE_1)
STRD: NI25_33815
SLAU: SLA_0571
SALJ: SMD11_0653
SLX: SLAV_32395(dapE5)
SGE: DWG14_07568(ylmB_1)
SRJ: SRO_6480
SNF: JYK04_00996(dapE_1) JYK04_01484(argE)
SHUN: DWB77_06572(dapE_6)
SCYG: S1361_05540(dapE1)
KSK: KSE_36480
LXX: Lxx15080
CMI: CMM_1844
CMS: CMS1388
CMC: CMN_01822
ART: Arth_2219
ARR: ARUE_c23720(cNDP)
ARM: ART_0884
AAGI: NCTC2676_1_01417(dapE_1)
AAU: AAur_2217
ACH: Achl_1956
KRH: KRH_12880
KVR: CIB50_0001839(ylmB)
JDE: Jden_1460
XCE: Xcel_2021
IDO: I598_0074 I598_0367(dapE_1)
CFL: Cfla_2089
CFI: Celf_2198
SERJ: SGUI_0837
DCO: SAMEA4475696_1925(dapE_1)
PAC: PPA1972
PAW: PAZ_c20600(cndP)
PACC: PAC1_10080
PACH: PAGK_1886
CACN: RN83_10160
CGRN: 4412665_00150(dapE_1)
PFRE: RM25_0436
PAUS: NCTC13651_02036(dapE_2)
ACIJ: JS278_00777(dapE_2) JS278_02965(cpg2)
TLA: TLA_TLA_02296(dapE_2)
NDK: I601_0888(dapE_1)
SRO: Sros_1518
NCX: Nocox_06615(dapE2)
TBI: Tbis_0820
NML: Namu_3301
MMAR: MODMU_2775
KRA: Krad_3262
AMN: RAM_19840
AMM: AMES_3851
AMZ: B737_3851
PDX: Psed_4253
SESP: BN6_59070
MIL: ML5_3327
ASE: ACPL_1295(argE) ACPL_4018
ACTN: L083_1426
AFS: AFR_07305
SNA: Snas_4666
AHE: Arch_0744
TPYO: X956_06265
TBW: NCTC13354_00220(dapE)
BLJ: BLD_0824(argE1)
BLN: Blon_1889
BLON: BLIJ_1955
BLF: BLIF_0563
BLL: BLJ_0628
BLB: BBMN68_823(argE1)
BLM: BLLJ_0552
BLG: BIL_13000
BAD: BAD_0947
BADL: BADO_1003
BLA: BLA_1230
BBB: BIF_00131
BBC: BLC1_0675
BLV: BalV_0679
BLW: W7Y_0706
BLS: W91_0729
BANI: Bl12_0659
BANL: BLAC_03585
BANM: EN10_03570
BDE: BDP_1303
BDN: BBDE_1244
BBP: BBPR_0692
BBI: BBIF_0723
BBF: BBB_0684(argE)
BBRU: Bbr_0674
BBRE: B12L_0592
BBRV: B689b_0685
BBRJ: B7017_0636
BBRC: B7019_0647
BBRN: B2258_0642
BBRS: BS27_0676
BBRD: BBBR_0622
BAST: BAST_1060
BTP: D805_1777
BCOR: BCOR_0899
BKS: BBKW_1181
BCAT: BBCT_1057
BANG: BBAG_1108
BPSC: BBPC_1059
BSCA: BBSC_1076
SIJ: SCIP_1323
PDO: PSDT_0101
GES: VT84_20185(dapE)
FTJ: FTUN_8187
KOS: KORDIASMS9_03057(ylmB)
MBN: Mboo_0261
 » show all
Reference
1  [PMID:13436444]
  Authors
SEMENZA G
  Title
Chromatographic purification of cysteinyl-glycinase.
  Journal
Biochim Biophys Acta 24:401-13 (1957)
DOI:10.1016/0006-3002(57)90212-3
Reference
2  [PMID:6108111]
  Authors
Rankin BB, McIntyre TM, Curthoys NP
  Title
Brush border membrane hydrolysis of S-benzyl-cysteine-p-nitroanilide, and activity of aminopeptidase M.
  Journal
Biochem Biophys Res Commun 96:991-6 (1980)
DOI:10.1016/0006-291x(80)90050-9
Reference
3  [PMID:2865778]
  Authors
Hirota T, Nishikawa Y, Takahagi H, Igarashi T, Kitagawa H
  Title
Simultaneous purification and properties of dehydropeptidase-I and aminopeptidase-M from rat kidney.
  Journal
Res Commun Chem Pathol Pharmacol 49:435-45 (1985)
Reference
4  [PMID:12675513]
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
5  [PMID:18515361]
  Authors
Emter R, Natsch A
  Title
The sequential action of a dipeptidase and a beta-lyase is required for the release of the human body odorant 3-methyl-3-sulfanylhexan-1-ol from a secreted Cys-Gly-(S) conjugate by Corynebacteria.
  Journal
J Biol Chem 283:20645-52 (2008)
DOI:10.1074/jbc.M800730200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.13.23
IUBMB Enzyme Nomenclature: 3.4.13.23
ExPASy - ENZYME nomenclature database: 3.4.13.23
BRENDA, the Enzyme Database: 3.4.13.23

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