KEGG   ENZYME: 3.4.14.1
Entry
EC 3.4.14.1                 Enzyme                                 
Name
dipeptidyl-peptidase I;
cathepsin C;
dipeptidyl aminopeptidase I;
dipeptidyl transferase;
dipeptide arylamidase I;
DAP I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
Reaction(IUBMB)
Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro
Comment
A Cl--dependent, lysosomal cysteine-type peptidase maximally active at acidic pH. Also polymerizes dipeptide amides, arylamides and esters at neutral pH. In peptidase family C1 (papain family).
History
EC 3.4.14.1 created 1961 as EC 3.4.4.9, transferred 1972 to EC 3.4.14.1
Orthology
K01275  cathepsin C
Genes
HSA1075(CTSC)
PTR451469(CTSC)
PPS100987211(CTSC)
GGO101146804(CTSC)
PON100172530(CTSC)
NLE100599280(CTSC)
MCC705320(CTSC)
MTHB126936633
CSAB103248190(CTSC)
CATY105592961(CTSC)
PANU101017791(CTSC)
TGE112605750(CTSC)
RRO104657430(CTSC)
RBB108539152(CTSC)
TFN117081489(CTSC)
PTEH111540754(CTSC)
CJC100400437(CTSC)
SBQ101042299(CTSC)
CSYR103268799(CTSC)
MMUR105860425(CTSC)
LCAT123642241(CTSC)
OGA100960196(CTSC)
MMU13032(Ctsc)
MCAL110299008(Ctsc)
MPAH110326827(Ctsc)
RNO25423(Ctsc)
MCOC116102536(Ctsc)
MUN110566149(Ctsc)
CGE100769144(Ctsc)
MAUA101839953(Ctsc)
PLEU114710707(Ctsc)
MORG121448727(Ctsc)
MFOT126491508
AAMP119803098(Ctsc)
NGI103742959(Ctsc)
HGL101697606(Ctsc)
CPOC100714387(Ctsc)
CCAN109701576(Ctsc)
DORD105984042(Ctsc)
DSP122114582(Ctsc)
NCAR124958603
OCU100101594(CTSC)
OPI101517575
TUP102488201(CTSC)
CFA403458(CTSC)
CLUD112642043(CTSC) 112662681
VVP112932296(CTSC)
VLG121476282(CTSC)
AML100464355(CTSC)
UMR103675378(CTSC)
UAH113269415(CTSC)
UAR123792342(CTSC)
ELK111154405
LLV125078452
MPUF101681849(CTSC)
ORO101371731(CTSC)
EJU114199708(CTSC)
ZCA113914226(CTSC)
MLX118013461(CTSC)
NSU110581898(CTSC)
FCA101092140(CTSC)
PYU121039392(CTSC)
PBG122483231(CTSC)
LRUF124505770
PTG102956745(CTSC)
PPAD109267324(CTSC)
AJU106967745(CTSC) 106972633
HHV120246242(CTSC)
BTA352958(CTSC)
BOM102272716(CTSC)
BIU109554360(CTSC)
BBUB102399616(CTSC)
CHX102190937(CTSC)
OAS101112686(CTSC)
ODA120874825(CTSC)
CCAD122431180(CTSC)
SSC100522387(CTSC)
CFR102510887(CTSC)
CBAI105083520(CTSC)
BACU103017877(CTSC)
LVE103089091(CTSC)
DLE111184954(CTSC)
PCAD112063205
PSIU116758007(CTSC)
ECB100060401(CTSC)
EPZ103547853(CTSC)
EAI106848234(CTSC)
MYB102242588(CTSC)
MYD102764432(CTSC)
MMYO118664541(CTSC)
MLF102431068(CTSC)
MNA107532450(CTSC)
PKL118713550(CTSC)
HAI109383277(CTSC)
DRO112316040(CTSC)
SHON118984754(CTSC)
AJM119043585(CTSC)
PDIC114499527(CTSC)
PHAS123805588(CTSC)
MMF118627682(CTSC)
RFQ117030085(CTSC)
PALE102893721(CTSC)
PGIG120590510(CTSC)
PVP105294191(CTSC)
RAY107514936(CTSC)
MJV108393107(CTSC)
TOD119255701(CTSC)
SARA101538937(CTSC)
LAV100676360(CTSC)
TMU101360788
DNM101412186(CTSC)
MDO100010333 100010381(CTSC)
GAS123238811 123238812 123238813
SHR100914125(CTSC)
PCW110213388(CTSC)
OAA100081326(CTSC)
GGA419014(CTSC)
PCOC116241909(CTSC)
MGP100551142(CTSC)
CJO107308454(CTSC)
NMEL110390807(CTSC)
APLA101805141(CTSC)
ACYG106034176(CTSC)
AFUL116497991(CTSC)
TGU100230748(CTSC)
LSR110478418(CTSC)
SCAN103812503(CTSC)
PMOA120506624(CTSC)
OTC121340986(CTSC)
PRUF121362284(CTSC)
GFR102035213(CTSC)
FAB101814128(CTSC)
PHI102104432(CTSC)
PMAJ107211449(CTSC)
CCAE111922076 111924959(CTSC)
CCW104690321(CTSC)
CBRC103616749(CTSC) 103623078
ETL114063513(CTSC)
ZAB102066301(CTSC)
ACHL103799052(CTSC)
FPG101918722(CTSC)
FCH102058646(CTSC)
CLV102095055(CTSC)
EGZ104128838(CTSC)
NNI104017387(CTSC)
PLET104625081(CTSC)
PCRI104038214(CTSC)
ACUN113483328(CTSC)
TALA104359708(CTSC)
PADL103914925(CTSC)
AFOR103904774(CTSC)
ACHC115353494(CTSC)
HALD104318917(CTSC)
CCRI104163032(CTSC)
CSTI104554318(CTSC)
EHS104511337(CTSC)
CMAC104481621(CTSC)
MUI104546823(CTSC)
FGA104080078
GSTE104256444(CTSC)
MNB103768367(CTSC)
OHA104327661(CTSC)
NNT104408430(CTSC)
DPUB104301167(CTSC)
PGUU104461146(CTSC)
ACAR104522986(CTSC)
AVIT104270832(CTSC)
CVF104283097(CTSC)
AAM106491260(CTSC)
AROW112962635(CTSC)
NPD112951484(CTSC)
TGT104580967(CTSC)
DNE112986680(CTSC)
SCAM104153281(CTSC)
ASN102386282(CTSC)
AMJ102576717(CTSC)
CPOO109305553(CTSC)
GGN109302203(CTSC)
PSS102453891(CTSC)
CMY102935389(CTSC)
CPIC101935953(CTSC)
TST117871234(CTSC)
CABI116818082(CTSC)
MRV120406503(CTSC)
ACS100565042(ctsc)
PVT110071074(CTSC)
SUND121925165(CTSC)
PBI103055898(CTSC)
PMUR107294161(CTSC)
CTIG120307812(CTSC)
PGUT117659762(CTSC)
VKO123029200(CTSC)
PMUA114595610(CTSC)
ZVI118085417(CTSC)
GJA107113356(CTSC)
STOW125431259 125431442
XLA108710023(ctsc.S) 380203(ctsc.L)
XTR407938(ctsc)
NPR108784428(CTSC)
RTEM120928963(CTSC)
BBUF120996451(CTSC)
BGAR122930404 122931039(CTSC)
DRE368704(ctsc)
SRX107731820 107737423
SANH107669915 107670127
SGH107558840 107570111
CCAR109063991 109064009
CAUA113058764 113058774 113114714
PPRM120470732(ctsc)
MAMB125248615(ctsc)
IPU108278259(ctsc)
PHYP113544528(ctsc)
SMEO124394181(ctsc)
TFD113637939(ctsc)
AMEX103046262(ctsc)
EEE113578742(ctsc)
TRU101061497(ctsc)
LCO104920118(ctsc)
CGOB115018232(ctsc)
ELY117259914(ctsc)
EFO125888772(ctsc)
PLEP121943061(ctsc)
SLUC116048242(ctsc)
ECRA117942172(ctsc)
ESP116683060(ctsc)
PFLV114553131(ctsc)
GAT120815703(ctsc)
PPUG119194756(ctsc)
MSAM119882707(ctsc)
CUD121521405(ctsc)
ALAT119010035(ctsc)
MZE101475307(ctsc)
ONL100707260(ctsc)
OAU116322925(ctsc)
OLA101170449(ctsc)
OML112149107(ctsc)
XMA102223206(ctsc)
XCO114133233(ctsc)
XHE116707783(ctsc)
PRET103474488(ctsc)
PFOR103146262(ctsc)
PLAI106958869(ctsc)
PMEI106918012(ctsc)
GAF122833315(ctsc)
CVG107091945(ctsc)
CTUL119771811(ctsc)
GMU124884351(ctsc)
NFU107380452(ctsc)
KMR108244622(ctsc)
ALIM106517256(ctsc)
NWH119411089(ctsc)
AOCE111572660(ctsc)
MCEP125012978(ctsc)
CSEM103378542(ctsc)
POV109634615(ctsc)
SSEN122765550(ctsc)
HHIP117773206(ctsc)
HSP118106176(ctsc)
LCF108886624
SDU111224142(ctsc)
SLAL111655299(ctsc)
XGL120792483(ctsc)
HCQ109525508(ctsc)
BPEC110174272(ctsc)
MALB109971607(ctsc)
BSPL114867489(ctsc)
SASA100196094(catc) 106581413(ctsc) 106613233
STRU115206584 115206587
OTW112267292(ctsc) 112267304
OMY100136230 110503180
OGO124006275 124006475
ONE115142003(ctsc)
SNH120028730 120036499
CCLU121566813 121567808(ctsc)
ELS105024067(ctsc)
SFM108932123(ctsc)
PKI111833927(ctsc)
AANG118209880(ctsc)
LOC102695252(ctsc)
PSPA121320348(ctsc)
ARUT117405993 117973058
LCM102365650(CTSC)
CMK103184353(ctsc)
RTP109912221(ctsc)
BFO118404660 118405126 118414050
BBEL109475624 109476393 109476394
CIN104266675
SCLV120334333
SPU115919030 586157 764711
APLC110975353 110986457
SKO100378978
FOC113203984
TPAL117649276
ZNE110840885
CSEC111869219
DPXDAPPUDRAFT_221708
DMK116921754
PVM113824311 113827608 113827616 113827622 113827638
PJA122243119 122251070 122264789 122264790 122264791 122264792 122264793
PCHN125026766 125027227 125027228 125027640 125027641 125047871
HAME121863392 121863393 121863395 121863396 121863397 121868723 121874598
PCLA123749605 123749606 123752289 123763955 123772472
PTRU123508001 123508571 123512275
HAZT108669401 108678133
EAF111708638
PPOI119089752 119090287 119092275
ISCIscW_ISCW003494
DSV119465131 119465154
RSAN119402464
RMP119166691
DPTE113797519
DFR124490781
PTEP107450228 107450247
SDM118181606 118181607
TSPTsp_02997 Tsp_02998 Tsp_13095
HROHELRODRAFT_91967
LGILOTGIDRAFT_203670 LOTGIDRAFT_221343
PCAN112571494
BGT106053063
GAE121369412 121377090
HRF124122018 124122041
HRJ124283287
CRG105339566
MYI110449444
PMAX117331605
MMER123528583 123539634
LAK106172182
SMMSmp_019030
SHXMS3_00005822
OVIT265_10719
ADF107355896
AMIL114955731
PDAM113685567 113685587
SPIS111344749 111344752
DGT114528914 114537470
HMG100205671 100207605
TADTRIADDRAFT_28083
QLO115971828
PFAPF3D7_1116700 PF3D7_1247800
PFDPFDG_01282 PFDG_02904
PFHPFHG_03743 PFHG_04038
PREIPRSY57_1115100 PRSY57_1247200
PGABPGSY75_1116700 PGSY75_1247800
PYOPY17X_0933300 PY17X_1463300
PCBPCHAS_0913000 PCHAS_1463000
PBEPBANKA_0931300 PBANKA_1460700
PVVPVVCY_0901490 PVVCY_0901500 PVVCY_1406280
PKNPKNH_0914400 PKNH_1467500
PVXPVX_091465 PVX_101280
PCYPCYB_092280 PCYB_147220
TANTA04105 TA15665
TPVTP02_0883 TP03_0357
TOTTOT_020000865 TOT_030000923
BEQBEWA_014540 BEWA_035230
BBOBBOV_I000540(16.m00694) BBOV_II000170(18.m05995)
BMICBMR1_03g02385
BBIGBBBOND_0212020 BBBOND_0300890
CPVcgd4_2110
CHOChro.40239
TGOTGME49_267490 TGME49_289620(CPC1)
TETTTHERM_00445920 TTHERM_00502690
PTMGSPATT00003347001 GSPATT00016000001 GSPATT00020193001 GSPATT00022413001 GSPATT00024351001 GSPATT00031929001 GSPATT00033761001
SMINv1.2.031841.t1(symbB.v1.2.031841.t1)
NGRNAEGRDRAFT_37577 NAEGRDRAFT_75630 NAEGRDRAFT_79989 NAEGRDRAFT_80477 NAEGRDRAFT_81796
GLAGL50803_0014566 GL50803_0022553 GL50803_0028651 GL50803_008741
 » show all
Reference
1  [PMID:14209333]
  Authors
PLANTA RJ, GORTER J, GRUBER M.
  Title
THE CATALYTIC PROPERTIES OF CATHEPSIN C.
  Journal
Biochim Biophys Acta 89:511-9 (1964)
DOI:10.1016/0926-6569(64)90077-x
Reference
2  [PMID:5961281]
  Authors
Metroione RM, Neves AG, Fruton JS.
  Title
Purification and properties of dipeptidyl transferase (Cathepsin C).
  Journal
Biochemistry 5:1597-604 (1966)
DOI:10.1021/bi00869a021
Reference
3  [PMID:4306035]
  Authors
McDonald JK, Zeitman BB, Reilly TJ, Ellis S.
  Title
New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones.
  Journal
J Biol Chem 244:2693-709 (1969)
Reference
4
  Authors
McDonald, J.K. and Schwabe, C.
  Title
Intracellular exopeptidases.
  Journal
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 311-391.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.1
IUBMB Enzyme Nomenclature: 3.4.14.1
ExPASy - ENZYME nomenclature database: 3.4.14.1
BRENDA, the Enzyme Database: 3.4.14.1
CAS: 9032-68-2

DBGET integrated database retrieval system