KEGG   ENZYME: 3.4.14.10
Entry
EC 3.4.14.10                Enzyme                                 
Name
tripeptidyl-peptidase II;
tripeptidyl aminopeptidase;
tripeptidyl peptidase;
tripeptidyl aminopeptidase II;
tripeptidyl peptidase II;
TPP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
Reaction(IUBMB)
Release of an N-terminal tripeptide from a polypeptide
Comment
A cytosolic enzyme in peptidase family S8 (subtilisin family). Active at neutral pH. Inhibited by diisopropyl fluorophosphate. Formerly included in EC 3.4.14.8
History
EC 3.4.14.10 created 1992 (part of EC 3.4.14.8 created 1989, incorporated 1992)
Orthology
K01280  tripeptidyl-peptidase II
Genes
HSA7174(TPP2)
PTR452645(TPP2)
PPS100979697(TPP2)
GGO101135379(TPP2)
PON100172493(TPP2)
NLE100581612(TPP2) 115835069
MCC701311(TPP2)
MCF101865014(TPP2)
MTHB126940638
CSAB103214737(TPP2)
CATY105574433(TPP2)
PANU100999793(TPP2)
TGE112610801(TPP2)
RRO104654017(TPP2)
RBB108521644(TPP2)
TFN117063538(TPP2)
PTEH111546548(TPP2)
CJC100391991(TPP2)
SBQ101037381(TPP2)
CSYR103274303(TPP2)
MMUR105864245(TPP2)
LCAT123649424(TPP2)
OGA100965190(TPP2)
MMU22019(Tpp2)
MCAL110306791(Tpp2)
MPAH110321160(Tpp2)
RNO81815(Tpp2)
MCOC116089421(Tpp2)
MUN110566898 110566899
CGE100751018(Tpp2)
MAUA101831554(Tpp2)
PLEU114704339(Tpp2)
MORG121442186 121458902
MFOT126511805
AAMP119803834(Tpp2)
NGI103751647(Tpp2)
HGL101700345(Tpp2)
CPOC100720822(Tpp2)
CCAN109693747(Tpp2)
DORD105990569(Tpp2)
DSP122122733(Tpp2)
NCAR124984820
OCU100359134(TPP2)
OPI101531478(TPP2)
TUP102491918(TPP2)
CFA100855853(TPP2)
CLUD112655778(TPP2)
VVP112927485(TPP2)
VLG121477022(TPP2)
AML100472407(TPP2)
UMR103657636(TPP2)
UAH113251515(TPP2)
UAR123802218(TPP2)
ELK111146903
LLV125094799
MPUF101688723(TPP2)
ORO101371298(TPP2)
EJU114215811(TPP2)
ZCA113919883(TPP2)
MLX118009256(TPP2)
NSU110585802(TPP2)
FCA101082370(TPP2)
PYU121037748(TPP2)
PBG122484620(TPP2)
LRUF124513541
PTG102969991(TPP2)
PPAD109264098(TPP2)
AJU106983027(TPP2)
HHV120247696(TPP2)
BTA526052(TPP2)
BOM102273977(TPP2)
BIU109566938(TPP2)
BBUB102391232(TPP2)
CHX102169112(TPP2)
OAS101113507(TPP2)
ODA120883352(TPP2)
CCAD122447211(TPP2)
SSC100511152(TPP2)
CFR102514630(TPP2)
CBAI105071363(TPP2)
CDK105094097(TPP2)
VPC102530808(TPP2)
BACU103006667(TPP2)
LVE103077108(TPP2)
OOR101284092(TPP2)
DLE111176408(TPP2)
PCAD102977159(TPP2)
PSIU116743058(TPP2)
ECB100050973(TPP2)
EPZ103560019(TPP2)
EAI106830041(TPP2)
MYB102261518(TPP2)
MYD102763719(TPP2)
MMYO118649990(TPP2)
MLF102441707(TPP2)
MNA107530146(TPP2)
PKL118728978(TPP2)
HAI109394087(TPP2)
DRO112321410(TPP2)
SHON119000689(TPP2)
AJM119048074(TPP2)
PDIC114508366(TPP2)
PHAS123807595(TPP2)
MMF118622213(TPP2)
RFQ117021424(TPP2)
PALE102878730(TPP2)
PGIG120591774(TPP2)
PVP105294168(TPP2)
RAY107499212(TPP2)
MJV108401615(TPP2)
TOD119259749(TPP2)
SARA101549565(TPP2)
LAV100675866(TPP2)
TMU101341260
DNM101423284(TPP2)
MDO100018913(TPP2)
GAS123242637(TPP2)
SHR100932521(TPP2)
PCW110192677(TPP2)
OAA100082920(TPP2)
GGA428020(TPP2)
PCOC116242776(TPP2)
MGP100540785(TPP2) 104917426
CJO107307969(TPP2)
NMEL110407746(TPP2)
APLA101800618(TPP2)
ACYG106031919(TPP2)
AFUL116502255(TPP2)
TGU100221846(TPP2)
LSR110470533(TPP2)
SCAN103812621(TPP2)
PMOA120512290(TPP2)
OTC121345970(TPP2)
PRUF121359353(TPP2)
GFR102037153(TPP2)
FAB101820047(TPP2)
PHI102108612(TPP2)
PMAJ107207308(TPP2)
CCAE111944484(TPP2)
CCW104685991(TPP2)
CBRC103611750(TPP2)
ETL114058362(TPP2)
ZAB102074652(TPP2)
ACHL103804526(TPP2)
FPG101917191(TPP2)
FCH102051260(TPP2)
CLV102092306(TPP2)
EGZ104131382(TPP2)
NNI104017390(TPP2)
PLET104614197(TPP2)
PCRI104035754(TPP2)
ACUN113481662(TPP2)
TALA104361436(TPP2)
PADL103924785(TPP2)
AFOR103906522(TPP2)
ACHC115350623(TPP2)
CCRI104163701(TPP2)
CSTI104560721(TPP2)
EHS104514215(TPP2)
CMAC104476175(TPP2)
MUI104538999(TPP2)
FGA104074935(TPP2)
LDI104345872
MNB103780812(TPP2)
OHA104328462(TPP2)
NNT104405811(TPP2)
DPUB104304506(TPP2)
PGUU104459079(TPP2)
ACAR104531116(TPP2)
AVIT104268057(TPP2)
CVF104282483(TPP2)
AAM106493913(TPP2)
AROW112977358(TPP2)
NPD112951367(TPP2)
TGT104567300(TPP2)
DNE112996236(TPP2)
SCAM104147440(TPP2)
ASN102383303(TPP2)
AMJ102568353(TPP2)
CPOO109306355(TPP2)
GGN109302873(TPP2)
PSS102443431(TPP2)
CMY102932230(TPP2)
CPIC101932912(TPP2)
TST117870820(TPP2)
CABI116836926(TPP2)
MRV120407697(TPP2)
ACS100552517(tpp2)
PVT110080003(TPP2)
SUND121925511(TPP2)
PBI103065222(TPP2)
PMUR107293862
CTIG120305609(TPP2)
PGUT117665799(TPP2)
VKO123022493(TPP2)
PMUA114596511(TPP2)
ZVI118084865(TPP2)
GJA107115732(TPP2)
STOW125431104(TPP2)
XLA108709744(tpp2.S) 443806(tpp2.L)
XTR100101674(tpp2)
NPR108804747(TPP2)
RTEM120926342(TPP2)
BBUF120995819(TPP2)
BGAR122930931(TPP2)
DRE100331669(tpp2)
SRX107748328 107751091
SANH107665822 107694479
SGH107557266(tpp2) 107593811
CCAR109082630 109085586
CAUA113083493(tpp2)
PPRM120459063(tpp2)
MAMB125273000(tpp2)
IPU108258999(tpp2)
PHYP113537510(tpp2)
SMEO124378631(tpp2)
TFD113648888(tpp2)
AMEX103046829(tpp2)
EEE113576661(tpp2)
TRU101077190(tpp2)
TNGGSTEN00017928G001
LCO104922536(tpp2)
NCC104958875(tpp2)
CGOB115027702(tpp2)
ELY117252131(tpp2)
EFO125901057(tpp2)
PLEP121947503(tpp2)
SLUC116067690(tpp2)
ECRA117948746(tpp2)
ESP116699435(tpp2)
PFLV114557008(tpp2)
GAT120835060(tpp2)
PPUG119228725(tpp2)
MSAM119889924(tpp2)
CUD121506849(tpp2)
ALAT119017896(tpp2)
MZE101481116(tpp2)
ONL100697515(tpp2)
OAU116312228(tpp2)
OLA101174009(tpp2)
OML112160799(tpp2)
XMA102234712(tpp2)
XCO114142932(tpp2)
XHE116718502(tpp2)
PRET103461961(tpp2)
PFOR103139378(tpp2)
PLAI106955604(tpp2)
PMEI106930428(tpp2)
GAF122822789(tpp2)
CVG107103565(tpp2)
CTUL119782732(tpp2)
GMU124866902(tpp2)
NFU107381138(tpp2)
KMR108251528(tpp2)
ALIM106513975(tpp2)
NWH119422661 119422671
AOCE111573064(tpp2)
MCEP125005303(tpp2)
CSEM103378933(tpp2)
POV109625021(tpp2)
SSEN122772844(tpp2)
HHIP117759597(tpp2)
HSP118112451(tpp2)
LCF108888019
SDU111238357(tpp2)
SLAL111668285(tpp2)
XGL120788605(tpp2)
HCQ109519672(tpp2)
BPEC110173024(tpp2)
MALB109964275(tpp2)
BSPL114851754(tpp2)
SASA106575025(tpp2)
STRU115181157(tpp2)
OTW112240281(tpp2) 121843881
OMY110519261(tpp2)
OGO124018317 124027342
CCLU121563375 121565831
ELS105020121(tpp2)
SFM108938473(tpp2)
PKI111855759(tpp2)
AANG118214241(tpp2)
LOC102687917(tpp2)
PSPA121320891 121327866
ARUT117406138 117407311
LCM102350093(TPP2)
CMK103177578(tpp2) 103178210
RTP109917224 109920506 109930320
BFO118427335
BBEL109485049
CIN100177474
SCLV120328246
SPU583848
APLC110983628
SKO102807403
DMEDmel_CG3991(TppII)
DER6549523
DSE6608943
DSIDsimw501_GD25789(Dsim_GD25789)
DYADyak_GE13397
DAN6494840
DSR110189246
DPO4804053
DPE6590900
DMN108158462
DWI6640133
DGR6559741
DMODmoj_GI19561
DAZ108615539
DNV108653662
DHE111595328
DVI6626644
CCAT101455255
BOD106622108
RZE108375782
MDE101889276
SCAC106086504
LCQ111686536
LSQ119610784
HIS119660457
AGAAgaP_AGAP004870
ACOZ120949518
AARA120894191
ASTE118512254 118517165
AAG5572106
AALB109406409 115262474
CQUCpipJ_CPIJ013852
CPII120414122
CNS116336966
BCOO119084824
AME412055
ACER108001562
ALAB122711815
BIM100749640
BTER100647107
BPYO122571850
CCAL108622953
CGIG122401003
SOC105200904
MPHA105838725
AEC105154625
ACEP105622872
PBAR105433561
VEM105564965
HST105185706
DQU106745676
CFO105251650
LHU105674024
PGC109854061
OBO105288158
PFUC122522563
VPS122638113
NVI100122357
CSOL105361100
TPRE106648189
MDL103568194
CGLO123264343
FAS105268807
DAM107046750
AGIF122860717
LHT122509429
CCIN107265771
TCA657622
DPA109540902
SOY115882188
ATD109596308
CSET123321446
AGB108916911
NVL108556611
APLN108732400 108739114
PPYR116170457
OTU111425147
BMOR101742969
BMAN114247434
MSEX115448319
DPLKGM_202963
BANY112047985
NIQ126769911
PMAC106716063
PPOT106099279
PXU106124484
PRAP111001663
ZCE119838779
HAW110380302
HZE124645259
TNL113501996
SLIU111353502
OFU114359141
PXY105393364 105395944
CFEL113376614
API100159456 100161895
DNX107165447
AGS114127309
RMD113560432
BTAB109034493
CLEC106660826
HHAL106685076
NLU111047027
PHUPhum_PHUM454920
FOC113207545
TPAL117652844
ZNE110835281
CSEC111875029
FCD110856131
DPXDAPPUDRAFT_186919
DMK116918328
PVM113823290
PJA122265262
PCHN125033383
HAME121859724
PCLA123757481
PTRU123506362
HAZT108679011
EAF111704279 111718279
LSM121120694
PPOI119096299
ISCIscW_ISCW006099
DSV119441413
RSAN119386556
VDE111244812
VJA111264435
TUT107366136
DPTE113788742
DFR124496920
CSCU111634632
PTEP107453821
SDM118184623
CELCELE_F21H12.6(tpp-2)
CBRCBG_02572
BMYBM_BM3501(Bma-tpp-2)
LOALOAG_08100
NAINECAME_01499
TSPTsp_09238
HROHELRODRAFT_107485
LGILOTGIDRAFT_129137
PCAN112555061
BGT106056392
GAE121372682
HRF124121003 124121005
HRJ124281114
CRG105320486
MYI110462454
PMAX117342816
OBI106874742
OSN115216390
LAK106161240 106179437
SMMSmp_131220
OVIT265_15389
EGLEGR_08923
NVE5500974
EPA110246127
ATEN116291795
ADF107332456
AMIL114956331
PDAM113675300
SPIS111320720
DGT114528232
XEN124445257
HMG101241465
TADTRIADDRAFT_61672
AQU100631430 109589028
ATHAT4G20850(TPP2)
ALY9305994
CRB17879953
CSAT104722978 104733446 109124484
EUSEUTSA_v10024222mg
BRP103858419 103861204
BNA106358188 106375690 106421156
BOE106303335 106307134
RSZ108842708 108854676
THJ104812206 104824854 104824860
CPAP110810280
CIT102615091
CICCICLE_v10004167mg
PVY116139553
MINC123197787 123225015
TCC18605576
GRA105791164 105801784
GHI107904614 107923906 107952372
GAB108456728 108469616
DZI111281175 111289774
EGR104448732
GMX100777892 100787184 100798235
GSJ114368059 114371157 114390579
PVUPHAVU_004G114200g PHAVU_007G071600g
VRA106770186 106771922
VAR108326206 108345579
VUN114180988 114191906
CCAJ109803113 109819233
APRC113867996 113871116
MTR11429200 25479754
CAM101494371 101512687
LJALj0g3v0190979.1(Lj0g3v0190979.1) Lj2g3v0391790.1(Lj2g3v0391790.1)
ADU107466965 107491142
AIP107617711 107644848
AHF112711638
LANG109335589 109354856
FVE101291383
RCN112178396
PPER18787294
PMUM103333208
PAVI110767759
PDUL117617799
MDM103437393 103439777
PXB103932208 103934922
ZJU107414512
MNT21389931
CSV101220162
CMO103482548
BHJ120092870
MCHA111025404
CMAX111471490
CMOS111430230
CPEP111808490
RCU8281007
JCU105648461
HBR110662206
MESC110617460
POP7474052 7482079
PEU105129661 105142679
PALZ118056266 118060500
JRE108996808
QSU112026441
TWL119985179
VVI100248019(TPP2)
VRI117933519
SLY101244555
SPEN107013102 107013676 107013677
SOT102591471
SSTN125858032
CANN107863279
NTA107784804 107798947
NSY104243251
NTO104109952
NAU109244566
INI109146488
ITR115999002
SIND105160468
OEU111402996
EGT105971755
SSPL121747630
HAN110885815
ECAD122585892
LSV111900783
CCAV112526125
DCR108203289
CSIN114284773
BVG104888547
SOE110784171
CQI110697052 110729648
NNU104596074
MING122082247 122085828
TSS122666164
PSOM113274574 113304239
NCOL116265646
OSA4330237
DOSAOs02t0664300-01(Os02g0664300)
OBR102701235
BDI100840642
ATS109732424
TDC119317342 119322265
TAES123127922 123137711 123145014
TUA125513974
SBI8076065
ZMA103627523
SITA101765055
SVS117865760
PVIR120656725 120711844
PHAI112878858
PDA103719383 120105981
EGU105042882
MUS103970347
DCT110099325
AOF109837263
ATR18423030
SMOSELMODRAFT_144433 SELMODRAFT_74857
PPP112278876 112284251
CRECHLRE_16g675350v5
VCNVOLCADRAFT_93498
CSLCOCSUDRAFT_27430
CVRCHLNCDRAFT_58768
APROF751_2683
CCPCHC_T00004817001
SPOSPAP8A3.12c(tpp2)
UMAUMAG_12106
PFPPFL1_06234
MGLMGL_0154
MRTMRET_1162
MSYMMSY001_0534
MBRMONBRDRAFT_34612
SREPTSG_10288
ACANACA1_149240
PTIPHATRDRAFT_26948
FCYFRACYDRAFT_262448
AAFAURANDRAFT_62802
PIFPITG_04457
PSOJPHYSODRAFT_565047
SPARSPRG_02495 SPRG_22108
EHXEMIHUDRAFT_121183 EMIHUDRAFT_447922 EMIHUDRAFT_454415
GTTGUITHDRAFT_99926
NGRNAEGRDRAFT_78168
SALQSYNTR_1853
TFRBR63_12340
TJRTherJR_2829
CTHMCFE_0399
LCREPla8534_66090(aprX)
BVOPan97_02340(apr)
PBSPlabr_2899
GMRGmarT_48060(aprX)
GIMF1728_21230
GPNPan110_47930(aprX)
THYDTTHT_0279
CTSCtha_2103
IALIALB_3165
CABYCabys_3886
 » show all
Reference
1  [PMID:6352701]
  Authors
Balow RM, Ragnarsson U, Zetterqvist O.
  Title
Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver.
  Journal
J Biol Chem 258:11622-8 (1983)
Reference
2  [PMID:3511062]
  Authors
Balow RM, Tomkinson B, Ragnarsson U, Zetterqvist O.
  Title
Purification, substrate specificity, and classification of tripeptidyl peptidase II.
  Journal
J Biol Chem 261:2409-17 (1986)
Reference
3  [PMID:1691635]
  Authors
Tomkinson B, Zetterqvist O
  Title
Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin.
  Journal
Biochem J 267:149-54 (1990)
DOI:10.1042/bj2670149
  Sequence
[hsa:7174]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.10
IUBMB Enzyme Nomenclature: 3.4.14.10
ExPASy - ENZYME nomenclature database: 3.4.14.10
BRENDA, the Enzyme Database: 3.4.14.10
CAS: 101149-94-4

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