KEGG   ENZYME: 3.4.14.13
Entry
EC 3.4.14.13                Enzyme                                 

Name
gamma-D-glutamyl-L-lysine dipeptidyl-peptidase;
YkfC
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
Reaction(IUBMB)
The enzyme releases L-Ala-gamma-D-Glu dipeptides from cell wall peptides via cleavage of an L-Ala-gamma-D-Glu!L-Lys bond. [RN:R11190]
Reaction(KEGG)
R11190
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the recycling of the murein peptide.
History
EC 3.4.14.13 created 2015
Orthology
K20742  gamma-D-glutamyl-L-lysine dipeptidyl-peptidase
Genes
SUTK: FG381_04275
BBAY: A4V04_07390
HCP: HCN_0923
HCB: HCBAA847_1055
HTY: BN2458_PEG1065
SUN: SUN_0826
PCA: Pcar_1371
PEF: A7E78_07255
DES: DSOUD_0236
DEU: DBW_1409
BSU: BSU12990(ykfC)
BSR: I33_1462
BSL: A7A1_1443
BSH: BSU6051_12990(ykfC)
BSUT: BSUB_01416(ykfC)
BSUL: BSUA_01416(ykfC)
BSUS: Q433_07425
BSS: BSUW23_06655(ykfC)
BST: GYO_1618
BSO: BSNT_07784(ykfC)
BSQ: B657_12990(ykfC)
BSX: C663_1337
BLI: BL03764(ykfC)
BLD: BLi01399(ykfC)
BLH: BaLi_c15400(ykfC)
BAQ: BACAU_1261(ykfC)
BYA: BANAU_1220(ykfC)
BAMP: B938_06665
BAML: BAM5036_1218(ykfC)
BAMA: RBAU_1261(ykfC)
BAMN: BASU_1240(ykfC)
BAMB: BAPNAU_2482(ykfC)
BAMT: AJ82_07355
BAMY: V529_12320(ykfC)
BMP: NG74_01331(ykfC)
BAO: BAMF_1387(ykfC)
BAZ: BAMTA208_10630(ykfC)
BQL: LL3_01401(ykfC)
BXH: BAXH7_02174(ykfC)
BAMI: KSO_012965
BAMC: U471_12980
BAMF: U722_06855
BAN: BA_2849
BAR: GBAA_2849
BAT: BAS2658
BAI: BAA_2911
BANT: A16_28820
BANR: A16R_29250
BANS: BAPAT_2738
BANV: DJ46_1623(ykfC)
BCE: BC2849
BCA: BCE_2878
BCQ: BCQ_2686
BCX: BCA_2930
BNC: BCN_2709
BCF: bcf_13940
BCER: BCK_20625
BTL: BALH_2557
BTT: HD73_3130
BTHI: BTK_15525
BTM: MC28_2038
BTG: BTB_c29690(ykfC)
BTI: BTG_05100
BTW: BF38_4017(ykfC)
BWW: bwei_2181(ykfC)
BMYO: BG05_3175
BMYC: DJ92_5319(ykfC)
BPU: BPUM_1191
BPUM: BW16_06770
BPUS: UP12_06310
BMEG: BG04_2761 BG04_3771(ykfC)
BCK: BCO26_2254(ykfC)
BAG: Bcoa_2197
BCOA: BF29_1382(ykfC)
BJS: MY9_1424
BMET: BMMGA3_08805(ykfC)
BACW: QR42_06165
BACP: SB24_03285
BACB: OY17_09520
BACY: QF06_05510
BACL: BS34A_14380(ykfC)
BALM: BsLM_1373
BEO: BEH_02635
BGY: BGLY_1392
BHA: BH3007
BCL: ABC0782
BPF: BpOF4_12075(ykfC)
OIH: OB2964
GTN: GTNG_3182
LSP: Bsph_2289
HLI: HLI_15400
VPN: A21D_00920(ykfC)
LIN: lin0198
LWE: lwe0136
LSG: lse_0139
LIV: LIV_0129
LGZ: NCTC10812_00094(ykfC)
BBE: BBR47_01650(ykfC)
ASOC: CB4_00790(ykfC)
SIV: SSIL_0333
JEO: JMA_32900
LBU: LBUL_1667
LDL: LBU_1516
LBR: LVIS_1419
LBH: Lbuc_1248
LPL: lp_2520
LPJ: JDM1_2029
LPZ: Lp16_2002
ECAS: ECBG_02907
CRN: CAR_c00610(ykfC)
CARC: NY10_1815
CBE: Cbei_2533
CBZ: Cbs_2533
CBEI: LF65_02992
CTH: Cthe_2413
HSC: HVS_00210(ykfC)
CCE: Ccel_0033
CPY: Cphy_2849
DRM: Dred_2321
PTH: PTH_2675
HMO: HM1_2114
TMR: Tmar_1703
ADG: Adeg_0433
TOC: Toce_0616
PFT: JBW_03658
MANA: MAMMFC1_02901(ykfC)
SLX: SLAV_01950(ykfC)
LMOI: VV02_14500
BLIN: BLSMQ_3306
KFL: Kfla_3115
PSEA: WY02_28255
PSEE: FRP1_14455
PSEH: XF36_14700
PAUT: Pdca_27110
MIL: ML5_3938
GLJ: GKIL_0347(spr)
HAU: Haur_3592
PNL: PNK_0299
SUS: Acid_3421
GAU: GAU_0611
GBA: J421_2549
PGI: PG_0721
PGN: PGN_0754
PMUC: ING2E5A_0777(ykfC19)
PSAC: PSM36_3139
BACC: BRDCF_p333(ykfC)
BLQ: L21SP5_01034(ykfC)
CPI: Cpin_5440
FLN: FLA_1232
PHE: Phep_3201
SMIZ: 4412673_00944(ykfC)
SDJ: NCTC13534_01320(ykfC)
MUC: MuYL_2652
MGOT: MgSA37_02397(ykfC)
CHU: CHU_1954(nlpC)
HSW: Hsw_3077
FLM: MY04_1105
FJO: Fjoh_4613
FJG: BB050_02976(ykfC)
FIN: KQS_06195
COC: Coch_1813
DDO: I597_2090(ykfC)
MLT: VC82_2447
NDO: DDD_2602
MPW: MPR_2815
WIN: WPG_3317
TMAR: MARIT_2189
SPON: HME9304_02769(lytE)
KOS: KORDIASMS9_04245(ykfC)
KAN: IMCC3317_13270(ykfC)
MARF: CJ739_2954
MESQ: C7H62_2361
FBA: FIC_00407
RAI: RA0C_1633
RAR: RIA_0858
RAG: B739_0526
RAE: G148_0246
RAT: M949_0979
EAO: BD94_0285
ELB: VO54_02314(ykfC)
CHZ: CHSO_4514
CTAK: 4412677_01295(ykfC_2)
IAL: IALB_0981
CPRV: CYPRO_1624
TLE: Tlet_0253
FNO: Fnod_1049
ASAC: ATHSA_1721
PTO: PTO0017
CDIV: CPM_1645
 » show all
Reference
1  [PMID:11747447]
  Authors
Schmidt DM, Hubbard BK, Gerlt JA
  Title
Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases.
  Journal
Biochemistry 40:15707-15 (2001)
DOI:10.1021/bi011640x
  Sequence
[bsu:BSU12990]
Reference
2  [PMID:20944232]
  Authors
Xu Q, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Das D, Deller MC, Duan L, Ellrott K, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Lam WW, Marciano D, Miller MD, Morse AT, Nigoghossian E, Nopakun A, Okach L, Puckett C, Reyes R, Tien HJ, Trame CB, van den Bedem H, Weekes D, Wooten T, Yeh A, Hodgson KO, Wooley J, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA
  Title
Structure of the gamma-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-gamma-D-Glu: insights into substrate recognition by  NlpC/P60 cysteine peptidases.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1354-64 (2010)
DOI:10.1107/S1744309110021214
  Sequence
[bca:BCE_2878]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.13
IUBMB Enzyme Nomenclature: 3.4.14.13
ExPASy - ENZYME nomenclature database: 3.4.14.13
BRENDA, the Enzyme Database: 3.4.14.13

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