Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy

The enzyme releases L-Ala-gamma-D-Glu dipeptides from cell wall peptides via cleavage of an L-Ala-gamma-D-Glu!L-Lys bond. [RN:R11190]

R11190
Reaction

The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the recycling of the murein peptide.

EC 3.4.14.13 created 2015

1  [PMID:11747447]

Schmidt DM, Hubbard BK, Gerlt JA

Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases.

Biochemistry 40:15707-15 (2001)
DOI:10.1021/bi011640x

[bsu:BSU12990]

2  [PMID:20944232]

Xu Q, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Das D, Deller MC, Duan L, Ellrott K, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Lam WW, Marciano D, Miller MD, Morse AT, Nigoghossian E, Nopakun A, Okach L, Puckett C, Reyes R, Tien HJ, Trame CB, van den Bedem H, Weekes D, Wooten T, Yeh A, Hodgson KO, Wooley J, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA

Structure of the gamma-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-gamma-D-Glu: insights into substrate recognition by  NlpC/P60 cysteine peptidases.

Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1354-64 (2010)
DOI:10.1107/S1744309110021214

[bca:BCE_2878]