KEGG ENZYME: 3.4.14.2

ENZYME: 3.4.14.2

Entry

EC 3.4.14.2                 Enzyme

Name

dipeptidyl-peptidase II;
dipeptidyl aminopeptidase II;
dipeptidyl arylamidase II;
carboxytripeptidase;
dipeptidyl peptidase II;
DAP II;
dipeptidyl(amino)peptidase II;
dipeptidylarylamidase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases

Reaction(IUBMB)

Release of an N-terminal dipeptide, Xaa-Yaa!, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides

Comment

A lysosomal serine-type peptidase in family S28 (Pro-X carboxypeptidase family); maximally active at acidic pH

History

EC 3.4.14.2 created 1978

Orthology

K01276

dipeptidyl-peptidase II

Genes

HSA:	29952(DPP7)

PPS:	100976342(DPP7)

GGO:	101136044(DPP7)

PON:	100174214(DPP7)

PPYG:

129044751(DPP7)

NLE:	100595263(DPP7)

HMH:	116475910(DPP7)

SSYN:

129478647(DPP7)

MCC:	721595(DPP7)

MCF:	101867244(DPP7)

MTHB:

126936964

MNI:	105471964(DPP7)

CSAB:

103239581(DPP7)

CATY:

105580608(DPP7)

PANU:

101009717 116272657

TGE:	112617564(DPP7)

MLEU:

105543279(DPP7)

RRO:	104669635(DPP7)

RBB:	108542890(DPP7)

TFN:	117099114(DPP7)

PTEH:

111553016(DPP7)

CANG:

105522685(DPP7)

CJC:	100413498(DPP7)

SBQ:	101032597(DPP7)

CIMI:

108287260(DPP7)

ANAN:

105712239(DPP7)

CSYR:

103269508(DPP7)

MMUR:

105882253(DPP7)

LCAT:

123645583(DPP7)

PCOQ:

105818711(DPP7)

OGA:	100947897(DPP7)

MMU:	83768(Dpp7)

MCAL:

110285412(Dpp7)

MPAH:

110318817(Dpp7)

RNO:	83799(Dpp7)

MCOC:

116089812(Dpp7)

ANU:	117711512(Dpp7)

ASYL:

127685055(Dpp7)

MUN:	110550552 110557034(Dpp7)

CGE:	100756223(Dpp7)

MAUA:

101826833(Dpp7)

PROB:

127222591(Dpp7)

PLEU:

114692782(Dpp7)

MORG:

121462858(Dpp7)

MFOT:

126509402

AAMP:

119819215(Dpp7)

NGI:	103741174(Dpp7)

HGL:	101724543(Dpp7)

CPOC:

100716276(Dpp7)

CCAN:

109697988(Dpp7)

DORD:

105995573(Dpp7)

DSP:	122099710(Dpp7)

DMER:

138822338(Dpp7)

PLOP:

125345283 125351535(Dpp7)

NCAR:

124964529

MMMA:

107159193(Dpp7)

ITI:	101978622(Dpp7)

OPI:	101527332(DPP7)

TUP:	102470111(DPP7)

GVR:	103593510(DPP7)

CFA:	607003(DPP7)

CLUD:

112677481(DPP7)

VVP:	112911406(DPP7)

VLG:	121473433(DPP7)

NPO:	129509845(DPP7)

AML:	100467965(DPP7)

UMR:	103675309(DPP7)

UAH:	113249879(DPP7)

UAR:	123796321(DPP7)

ELK:

111145784

LLV:

125083758

MPUF:

101685625(DPP7)

MLK:	131813070(DPP7)

NVS:	122917073(DPP7)

ORO:	101379800(DPP7)

EJU:	114201770(DPP7)

ZCA:	113934598(DPP7)

NSU:	110581236(DPP7)

LWW:	102729350(DPP7)

FCA:	101095966(DPP7)

PYU:	121020232(DPP7)

PCOO:

112860948(DPP7)

PBG:	122474767(DPP7)

PVIV:

125150299(DPP7)

LRUF:

124522355

LGF:	123593837(DPP7)

AJU:

106989098

PTG:	102948665(DPP7)

PPAD:

109260264(DPP7)

PUC:

125923639

PLEZ:

122205639(DPP7)

HHV:	120227605(DPP7)

BTA:	100125760(DPP7)

BOM:	102277526(DPP7)

BBUB:

102402382(DPP7)

CHX:	102182320(DPP7)

OAS:	105605898(DPP7)

BTAX:

128055114(DPP7)

CSUM:

138081984(DPP7)

MREE:

136162619(DPP7)

OVR:	110134182(DPP7)

MBEZ:

129539520(DPP7)

SSC:	100626630(DPP7)

CFR:	102514636(DPP7)

CBAI:

105073395(DPP7)

CDK:	105106184(DPP7)

VPC:	102533086(DPP7)

BACU:

103002313(DPP7)

BMUS:

118897124(DPP7)

LVE:	103077546(DPP7)

OOR:	101274898(DPP7)

LALB:

132523198(DPP7)

GMF:	115842876(DPP7)

DDP:	132426903(DPP7)

DLE:	111176993(DPP7)

PCAD:

102988127(DPP7)

PSIU:

116756117(DPP7)

PPHC:

136125177(DPP7)

NASI:

112411356(DPP7)

ECB:	100059924(DPP7)

EPZ:	103568010(DPP7)

EAI:	106845520(DPP7)

MYD:	102751478(DPP7)

MMYO:

118655272(DPP7)

MDT:	132212609(DPP7)

MYUM:

139020595(DPP7)

PKL:	118707093(DPP7)

EFUS:

103296100(DPP7)

MNA:	107536150(DPP7)

DRO:	112306462(DPP7)

SHON:

118980097(DPP7)

AJM:	119036098(DPP7)

PDIC:

114507924(DPP7)

PHAS:

123823471(DPP7)

MMF:	118629639(DPP7)

PPAM:

129079518(DPP7)

HAI:	109381795(DPP7)

RFQ:	117032554(DPP7)

PALE:

102890830(DPP7)

PGIG:

120599825(DPP7)

PVP:	105298565(DPP7)

RAY:	107503091(DPP7)

MJV:	108406834(DPP7)

TOD:	119231169(DPP7)

SARA:

101558615(DPP7)

SFUM:

130040885(DPP7)

SETR:

126020952(DPP7)

LAV:	100664342(DPP7)

TMU:

101354737

ETF:	101638848(DPP7)

DNM:	101440624(DPP7)

MDO:	100022760(DPP7)

GAS:	123235145(DPP7)

SHR:	100918941(DPP7)

AFZ:

127549105

PCW:	110205293(DPP7)

TVP:	118844096(DPP7)

PBRV:

138176699(DPP7)

MLAO:

141505099(DPP7)

OAA:	100082054(DPP7)

TACU:

119946589(DPP7)

GGA:	417297(DPP7)

PCOC:

116234099(DPP7)

MGP:	100543847(DPP7)

CJO:	107321630(DPP7)

TPAI:

128079776(DPP7)

LMUT:

125702408(DPP7)

NMEL:

110407015(DPP7)

APLA:

101791397(DPP7)

ACYG:

106037124(DPP7)

CATA:

118260739(DPP7)

AFUL:

116497046(DPP7)

TGU:	100226334(DPP7)

LSR:	110472182(DPP7)

SCAN:

103819204(DPP7)

PMOA:

120507336(DPP7)

OTC:	121336948(DPP7)

PRUF:

121357497(DPP7)

ATRC:

139603160(DPP7)

GFR:	102031390(DPP7)

FAB:	101815871(DPP7)

CCW:	104688194(DPP7)

CBRC:

103625038(DPP7)

ACOE:

138119714(DPP7)

ETL:	114064161(DPP7)

ZAB:	102067383(DPP7)

ZLE:	135455018(DPP7)

ACHL:

103807246(DPP7)

SVG:	106855973(DPP7)

MMEA:

130584230(DPP7)

HRT:	120761821(DPP7)

SATI:

136369650(DPP7)

CCIC:

134051763(DPP7)

FPG:	101914257(DPP7)

FCH:	102051827(DPP7)

CCRI:

104165546(DPP7)

NNT:	104411381(DPP7)

SHAB:

115616924(DPP7)

ACUN:

113486638(DPP7)

TALA:

104359834(DPP7)

ACHC:

115334794(DPP7)

HALD:

104313580(DPP7)

HLE:	104830002(DPP7)

AGEN:

126052504

HHAR:

128154845(DPP7)

GCL:

127023822

CSTI:

104557095(DPP7)

LDI:	104339998(DPP7)

MNB:	103781849(DPP7)

DPUB:

104300188(DPP7)

AVIT:

104271162(DPP7)

BRHI:

104492971(DPP7)

EGZ:	104123973(DPP7)

NNI:	104018392(DPP7)

PCRI:

104038704(DPP7)

PCAO:

104043330(DPP7)

PADL:

103915511(DPP7)

AFOR:

103908303(DPP7)

FGA:	104081355(DPP7)

GSTE:

104258526(DPP7)

CBOY:

140661322(DPP7)

CLV:	102083967(DPP7)

CNIC:

135996643(DPP7)

MUI:	104547181(DPP7)

PGUU:

104466829(DPP7)

PLET:

104628618(DPP7)

EHS:	104514334(DPP7)

CUCA:

104059114(DPP7)

TEO:

104379968

BREG:

104633500(DPP7)

OHA:	104329736(DPP7)

ACAR:

104526849(DPP7)

CPEA:

104397877(DPP7)

CVF:	104291093(DPP7)

RTD:	128917356(DPP7)

CRID:

134523594(DPP7)

AAM:	106494235(DPP7)

AROW:

112969737(DPP7)

NPD:	112956119(DPP7)

TGT:	104573526(DPP7)

DNE:	112986764(DPP7)

SCAM:

104139733(DPP7)

ASN:	102372722(DPP7)

AMJ:	102571172(DPP7)

CPOO:

109313772(DPP7)

GGN:	109292849(DPP7)

PSS:	102456165(DPP7)

CMY:	102944633(DPP7)

CCAY:

125623276(DPP7)

DCC:	119844068(DPP7)

CPIC:

101946841(DPP7)

TST:	117889406(DPP7)

CABI:

116823286(DPP7)

MRV:	120386612(DPP7)

ACS:	100562590(dpp7)

ASAO:

132763598(DPP7)

PVT:	110078851(DPP7)

SUND:

121937295(DPP7)

PBI:	103050059(DPP7)

PMUR:

107295056(DPP7)

CTIG:

120308659(DPP7)

TSR:	106542599(DPP7)

PGUT:

117676553(DPP7)

PCAE:

139325773(DPP7)

APRI:

131186021(DPP7)

PTEX:

113443867(DPP7)

NSS:	113424258(DPP7)

VKO:	123028192(DPP7)

PMUA:

114589500(DPP7)

PRAF:

128406400(DPP7)

HCG:	128338838(DPP7)

GJA:	107123276(DPP7)

STOW:

125441877(DPP7)

EMC:	129342491(DPP7)

MUO:	115472701(DPP7)

DRE:	503737(dpp7)

SRX:

107709692

SANH:

107681243(dpp7) 107690688

SGH:

107560239

CCAR:

109099025(dpp7)

CAUA:

113049301(dpp7)

CGIB:

127957674

PTET:

122345542(dpp7)

LROH:

127165220(dpp7)

GRF:	141334704(dpp7)

OMC:	131540667(dpp7)

PPRM:

120469502(dpp7)

RKG:	130089822(dpp7)

MAMB:

125266721(dpp7)

CIDE:

127512634

CERY:

137034221(dpp7)

MASI:

127421085

TROS:

130568071(dpp7)

TDW:	130419198(dpp7)

MANU:

129440147(dpp7)

PDAB:

135732302(dpp7)

IPU:

108255762

IFU:	128625616(dpp7)

PHYP:

113536984(dpp7)

SMEO:

124380547(dpp7)

TFD:	113653305(dpp7)

TVC:	132854353(dpp7)

CGAR:

128509792(dpp7)

NGRA:

132872498(dpp7)

TRN:	134335515(dpp7)

AMEX:

103027831(dpp7)

CMAO:

118826959(dpp7)

EEE:	113577929(dpp7)

CHAR:

105889930(dpp7)

SPIL:

134088878(dpp7)

TRU:	101061692(dpp7)

TFS:	130525558(dpp7)

TNG:	GSTEN00004959G001

LCO:	104925283(dpp7)

NCC:	104966816(dpp7)

TBEN:

117472486(dpp7)

CGOB:

115014171(dpp7)

PGEO:

117451912(dpp7)

GACU:

117541202(dpp7)

EMAC:

134873497(dpp7)

ELY:	117253118(dpp7)

EFO:	125890960(dpp7)

PLEP:

121944093

SLUC:

116050669(dpp7)

ECRA:

117944691(dpp7)

ESP:	116686933(dpp7)

PFLV:

114555184(dpp7)

GAT:	120830401(dpp7)

PPUG:

119225046(dpp7)

AFB:	129101298(dpp7)

CLUM:

117736701(dpp7)

PSWI:

130196897(dpp7)

CANA:

137801454(dpp7)

CVE:	137879824(dpp7)

MSAM:

119892353(dpp7) 119917793

SCHU:

122875945(dpp7)

CUD:	121509537(dpp7)

SPUL:

138610319(dpp7)

LMIX:

132973828(dpp7)

ALAT:

119019036(dpp7)

ASTR:

137592972(dpp7)

MZE:	101469493(dpp7)

ONL:	100690872(dpp7)

OAU:	116311168(dpp7)

OLA:	101156583(dpp7)

OML:	112137702(dpp7)

CSAI:

133450809(dpp7)

XMA:	102233162(dpp7)

XCO:	114155126(dpp7)

XHE:	116729400(dpp7)

PRET:

103469621(dpp7)

PFOR:

103141938(dpp7)

PLAI:

106951547(dpp7)

PMEI:

106904615(dpp7)

PPRL:

129351625(dpp7)

CVG:	107088011(dpp7)

CTUL:

119789278(dpp7)

GMU:	124877757(dpp7)

KMR:	108245624(dpp7)

ALIM:

106528747(dpp7)

NWH:

119413691

AOCE:

111578428(dpp7)

EJA:	138208303(dpp7)

BFRE:

138633707(dpp7)

MCEP:

125012079(dpp7)

CSEM:

103397365(dpp7)

POV:	109639094(dpp7)

SSOE:

131463442(dpp7)

HHIP:

117767913(dpp7)

HSP:	118114998(dpp7)

PPLT:

128439038(dpp7)

SMAU:

118313383(dpp7)

LCF:

108878395

SDU:	111226926(dpp7)

SLAL:

111647981(dpp7)

XGL:	120805355(dpp7)

HCQ:	109510557(dpp7)

PEE:	133400455(dpp7)

PTAO:

133473442(dpp7)

BPEC:

110154650(dpp7)

ENY:	140346577(dpp7)

MALB:

109959747(dpp7)

BSPL:

114845430(dpp7)

SJO:	128364595(dpp7)

SSCO:

133978977(dpp7)

GMH:	115545198(dpp7)

SASA:

106585425(dpp7)

STRU:

115164725(dpp7)

OTW:	112232798(dpp7)

OMY:	110525470(dpp7)

OGO:	124034455(dpp7)

ONE:	115111438(dpp7)

OKI:	109877685(dpp7)

OKE:	118393040(dpp7)

OMM:	135539447(dpp7)

OCLA:

139410779

SALP:

111974867(dpp7)

SNH:	120058212(dpp7)

CCLU:

121584693(dpp7)

ELS:	105014134(dpp7)

OEP:	134014982(dpp7)

SFM:	108938628(dpp7)

PKI:	111857532(dpp7)

AANG:

118237522(dpp7)

AROT:

135265147(dpp7)

CCOG:

133140197(dpp7)

LOC:	102690439(dpp7)

PSPA:

121309602(dpp7)

ARUT:

117397025 117964682

PSEX:

120542394(dpp7)

LCM:	102363610(DPP7)

CMK:

103180401

RTP:

109927300

LERI:

129711931

HAKA:

140730153(dpp7)

PMRN:

116953141(DPP7)

LRJ:	133354589(DPP7)

BFO:	118410424 118420834

BBEL:

109469775 109484650

CIN:

100179268

SCLV:

120330153

SPU:

592836

LPIC:

129277712 129277715

AJJ:

139964148

APLC:

110981392 110981393 110981416 110989449

ARUN:

117303011

AAMU:

139948056

AJC:

117100014

SKO:	100367899 102804416

PFLL:

139114478

CSCU:

111618526

CVS:

136987134

PTEP:

107437402

ABRU:

129969501

UDV:

129230484

SDM:

118192721

LPOL:

106477653

PMEO:

129599795

LGI:	LOTGIDRAFT_235397

PVUL:

126820270 130010450

PCAN:

112575816

LSAX:

138949150

BGT:

106058014

GAE:	121383224 121392435

HRF:

124142808

HRJ:

124262957

HASI:

137273593

HCRA:

139459630

CRG:

105320441

CANU:

128192600

CVN:

111124640

OED:

125679045

MYI:

110466518

PMAX:

117344579

AIRR:

138321940

MCAF:

127699850

MMER:

123550371

RPHI:

132747440

DPOL:

127837373

MAEA:

128224073

OBI:

106877801

OSN:

115222860

LJP:

135480210

LAK:

106179479

SMM:	Smp_071610

SHX:	MS3_00004349(DPP7)

EGL:

EGR_02544

NVE:	5500388 5520418

EPA:

110231171

ATEN:

116302681

ADF:	107327616 107347449

AMIL:

114956094

MCAZ:

138025093

MFOO:

137973798

PDAM:

113673001 113673003

SPIS:

111340021

DGT:

114524658

XEN:	124445785 124445786

HMG:

100200663

HSY:

130636248

RES:

135684371

TAD:	TRIADDRAFT_21030

TRE:	TRIREDRAFT_108012

TRR:	M419DRAFT_5451

ACAN:

ACA1_116140

FCY:	FRACYDRAFT_247575

AAF:	AURANDRAFT_2013 AURANDRAFT_28266

EHX:	EMIHUDRAFT_204576 EMIHUDRAFT_241178

» show all

Reference

1 [PMID:4969969]

Authors

McDonald JK, Leibach FH, Grindeland RE, Ellis S.

Title

Purification of dipeptidyl aminopeptidase II (dipeptidyl arylamidase II) of the anterior pituitary gland. Peptidase and dipeptide esterase activities.

Journal

J Biol Chem 243:4143-50 (1968)

Reference

Authors

McDonald JK, Schwabe C.

Title

Intracellular exopeptidases.

Journal

In: Barrett AJ (ed). Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.; 1977. p. 311-391.

Other DBs

ExplorEnz - The Enzyme Database:

3.4.14.2

IUBMB Enzyme Nomenclature:

3.4.14.2

ExPASy - ENZYME nomenclature database:

3.4.14.2

BRENDA, the Enzyme Database:

3.4.14.2

CAS:	76199-23-0

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DNA sequence (67)   
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   EMBL (8)   
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   PDB (3)   
Protein domain (3)   
   InterPro (3)   
All databases (2578)   

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