| Entry |
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| Name |
dipeptidyl-peptidase II;
dipeptidyl aminopeptidase II;
dipeptidyl arylamidase II;
carboxytripeptidase;
dipeptidyl peptidase II;
dipeptidyl arylamidase II;
DAP II;
dipeptidyl(amino)peptidase II;
dipeptidylarylamidase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
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| Reaction(IUBMB) |
Release of an N-terminal dipeptide, Xaa-Yaa!, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides
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| Comment |
A lysosomal serine-type peptidase in family S28 (Pro-X carboxypeptidase family); maximally active at acidic pH
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| History |
EC 3.4.14.2 created 1978
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| Orthology |
| K01276 | dipeptidyl-peptidase II |
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| Genes |
» show all
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| Reference |
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| Authors |
McDonald JK, Leibach FH, Grindeland RE, Ellis S. |
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| Title |
Purification of dipeptidyl aminopeptidase II (dipeptidyl arylamidase II) of the anterior pituitary gland. Peptidase and dipeptide esterase activities. |
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| Journal |
J Biol Chem 243:4143-50 (1968) |
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| Reference |
2 |
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| Authors |
McDonald, J.K. and Schwabe, C. |
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| Title |
Intracellular exopeptidases. |
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| Journal |
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 311-391. |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.14.2 |
| ExPASy - ENZYME nomenclature database: | 3.4.14.2 |
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