KEGG   ENZYME: 3.4.14.2
Entry
EC 3.4.14.2                 Enzyme                                 
Name
dipeptidyl-peptidase II;
dipeptidyl aminopeptidase II;
dipeptidyl arylamidase II;
carboxytripeptidase;
dipeptidyl peptidase II;
DAP II;
dipeptidyl(amino)peptidase II;
dipeptidylarylamidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
Reaction(IUBMB)
Release of an N-terminal dipeptide, Xaa-Yaa!, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides
Comment
A lysosomal serine-type peptidase in family S28 (Pro-X carboxypeptidase family); maximally active at acidic pH
History
EC 3.4.14.2 created 1978
Orthology
K01276  dipeptidyl-peptidase II
Genes
HSA29952(DPP7)
PTR473101(DPP7)
PPS100976342(DPP7)
GGO101136044(DPP7)
PON100174214(DPP7)
NLE100595263(DPP7)
MCC721595(DPP7)
MCF101867244(DPP7)
MTHB126936964
CSAB103239581(DPP7)
CATY105580608(DPP7)
PANU101009717 116272657
TGE112617564(DPP7)
RRO104669635(DPP7)
RBB108542890(DPP7)
TFN117099114(DPP7)
PTEH111553016(DPP7)
CJC100413498(DPP7)
SBQ101032597(DPP7)
CSYR103269508(DPP7)
MMUR105882253(DPP7)
LCAT123645583(DPP7)
OGA100947897(DPP7)
MMU83768(Dpp7)
MCAL110285412(Dpp7)
MPAH110318817(Dpp7)
RNO83799(Dpp7)
MCOC116089812(Dpp7)
MUN110557034(Dpp7)
CGE100756223(Dpp7)
MAUA101826833(Dpp7)
PLEU114692782(Dpp7)
MORG121462858(Dpp7)
MFOT126509402
AAMP119819215(Dpp7)
NGI103741174(Dpp7)
HGL101724543(Dpp7)
CPOC100716276(Dpp7)
CCAN109697988(Dpp7)
DORD105995573(Dpp7)
DSP122099710(Dpp7)
NCAR124964529
OPI101527332(DPP7)
TUP102470111(DPP7)
CFA607003(DPP7)
CLUD112677481(DPP7)
VVP112911406(DPP7)
VLG121473433(DPP7)
AML100467965(DPP7)
UMR103675309(DPP7)
UAH113249877 113249879 113249880 113249881
UAR123796321(DPP7)
ELK111145784
LLV125083758
MPUF101685625(DPP7)
ORO101379800(DPP7)
EJU114201770(DPP7)
ZCA113934598(DPP7)
NSU110581236(DPP7)
FCA101095966(DPP7)
PYU121020232(DPP7)
PBG122474767(DPP7)
LRUF124522355
PTG102948665(DPP7)
PPAD109260264(DPP7)
AJU106989098(DPP7)
HHV120227605(DPP7)
BTA100125760(DPP7)
BOM102277526(DPP7)
BBUB102402382(DPP7)
CHX102182320(DPP7)
OAS105605898(DPP7)
SSC100626630(DPP7)
CFR102514636(DPP7)
CBAI105073395(DPP7)
CDK105106184(DPP7)
VPC102533086(DPP7)
BACU103002313(DPP7)
LVE103077546(DPP7)
OOR101274898(DPP7)
DLE111176993(DPP7)
PCAD102988127(DPP7)
PSIU116756117(DPP7)
ECB100059924(DPP7)
EPZ103568010(DPP7)
EAI106845520(DPP7)
MYD102751478(DPP7)
MMYO118655272(DPP7)
MNA107536150(DPP7)
PKL118707093(DPP7)
HAI109381795(DPP7)
DRO112306462(DPP7)
SHON118980097(DPP7)
AJM119036098(DPP7)
PDIC114507924(DPP7)
PHAS123823471(DPP7)
MMF118629639(DPP7)
RFQ117032554(DPP7)
PALE102890830(DPP7)
PGIG120599825(DPP7)
PVP105298565(DPP7)
RAY107503091(DPP7)
MJV108406834(DPP7)
TOD119231169(DPP7)
SARA101558615(DPP7)
LAV100664342(DPP7)
TMU101354737
DNM101440624(DPP7)
MDO100022760(DPP7)
GAS123235145(DPP7)
SHR100918941(DPP7)
PCW110205293(DPP7)
OAA100082054(DPP7)
GGA417297(DPP7)
PCOC116234099(DPP7)
MGP100543847(DPP7)
CJO107321630(DPP7)
NMEL110407015(DPP7)
APLA101791397(DPP7)
ACYG106037124(DPP7)
AFUL116497046(DPP7)
TGU100226334(DPP7)
LSR110472182(DPP7)
SCAN103819204(DPP7)
PMOA120507336(DPP7)
OTC121336948(DPP7)
PRUF121357497(DPP7)
GFR102031390(DPP7)
FAB101815871(DPP7)
CCW104688194(DPP7)
CBRC103625038(DPP7)
ETL114064161(DPP7)
ZAB102067383(DPP7)
ACHL103807246(DPP7)
FPG101914257(DPP7)
FCH102051827(DPP7)
CLV102083967(DPP7)
EGZ104123973(DPP7)
NNI104018392(DPP7)
PLET104628618(DPP7)
PCRI104038704(DPP7)
ACUN113486638(DPP7)
TALA104359834(DPP7)
PADL103915511(DPP7)
AFOR103908303(DPP7)
ACHC115334794(DPP7)
HALD104313580(DPP7)
CCRI104165546(DPP7)
CSTI104557095(DPP7)
EHS104514334(DPP7)
MUI104547181(DPP7)
FGA104081355(DPP7)
GSTE104258526(DPP7)
LDI104339998(DPP7)
MNB103781849(DPP7)
OHA104329736(DPP7)
NNT104411381(DPP7)
DPUB104300188(DPP7)
PGUU104466829(DPP7)
ACAR104526849(DPP7)
AVIT104271162(DPP7)
CVF104291093(DPP7)
AAM106494235(DPP7)
AROW112969737(DPP7)
NPD112956119(DPP7)
TGT104573526(DPP7)
DNE112986764(DPP7)
SCAM104139733(DPP7)
ASN102372722(DPP7)
AMJ102571172(DPP7)
CPOO109313772(DPP7)
GGN109292849(DPP7)
PSS102456165(DPP7)
CMY102944633(DPP7)
CPIC101946841(DPP7)
TST117889406(DPP7)
CABI116823286(DPP7)
MRV120386612(DPP7)
ACS100562590(dpp7)
PVT110078851(DPP7)
SUND121937295(DPP7)
PBI103050059(DPP7)
PMUR107295056(DPP7)
CTIG120308659(DPP7)
TSR106542599(DPP7)
PGUT117676553(DPP7)
VKO123028192(DPP7)
PMUA114589500(DPP7)
GJA107123276(DPP7)
STOW125441877(DPP7)
DRE503737(dpp7)
SRX107709692
SANH107681243(dpp7) 107690688
SGH107560239
CCAR109099025
CAUA113049301(dpp7)
PPRM120469502(dpp7)
MAMB125266721(dpp7)
IPU108255762(dpp7)
PHYP113536984(dpp7)
SMEO124380547(dpp7)
TFD113653305(dpp7)
AMEX103027831(dpp7)
EEE113577929(dpp7)
TRU101061692(dpp7)
TNGGSTEN00004959G001
LCO104925283(dpp7)
NCC104966816(dpp7)
CGOB115014171(dpp7)
ELY117253118(dpp7)
EFO125890960(dpp7)
PLEP121944093
SLUC116050669(dpp7)
ECRA117944691(dpp7)
ESP116686933(dpp7)
PFLV114555184(dpp7)
GAT120830401(dpp7)
PPUG119225046(dpp7)
MSAM119892353(dpp7) 119917793
CUD121509537(dpp7)
ALAT119019036(dpp7)
MZE101469493(dpp7)
ONL100690872(dpp7)
OAU116311168(dpp7)
OLA101156583(dpp7)
OML112137702(dpp7)
XMA102233162(dpp7)
XCO114155126(dpp7)
XHE116729400(dpp7)
PRET103469621(dpp7)
PFOR103141938(dpp7)
PLAI106951547(dpp7)
PMEI106904615(dpp7)
CVG107088011(dpp7)
CTUL119789278(dpp7)
GMU124877757(dpp7)
KMR108245624(dpp7)
ALIM106528747(dpp7)
NWH119413691
AOCE111578428(dpp7)
MCEP125012079(dpp7)
CSEM103397365(dpp7)
POV109639094(dpp7)
HHIP117767913(dpp7)
HSP118114998(dpp7)
LCF108878395
SDU111226926(dpp7)
SLAL111647981(dpp7)
XGL120805355(dpp7)
HCQ109510557(dpp7)
BPEC110154650(dpp7)
MALB109959747(dpp7)
BSPL114845430(dpp7)
SASA106585425(dpp7)
STRU115164725(dpp7)
OTW112232798(dpp7)
OMY110525470(dpp7)
OGO124034455(dpp7)
ONE115111438(dpp7)
SALP111974867(dpp7)
SNH120058212(dpp7)
CCLU121584693(dpp7)
ELS105014134(dpp7)
SFM108938628(dpp7)
PKI111857532(dpp7)
AANG118237522(dpp7)
LOC102690439(dpp7)
PSPA121309602(dpp7)
ARUT117397025 117964682
LCM102363610(DPP7)
CMK103180401
RTP109927300
BFO118410424 118420834
BBEL109469775 109484650
CIN100179268
SCLV120330153
SPU592836
APLC110981392 110981393 110981416 110989449
SKO100367899 102804416
CSCU111618526
PTEP107437402
SDM118192721
LGILOTGIDRAFT_235397
PCAN112575816
BGT106058014
GAE121383224 121392435
HRF124142808
HRJ124262957
CRG105320441
MYI110466518
PMAX117344579
MMER123550371
OBI106877801
OSN115222860
LAK106179479
SMMSmp_071610
SHXMS3_00004349(DPP7)
EGLEGR_02544
NVE5500388 5520418
EPA110231171
ATEN116302681
ADF107327616 107347449
AMIL114956094
PDAM113673001 113673003
SPIS111340021
DGT114524658
XEN124445785 124445786
HMG100200663
TADTRIADDRAFT_21030
TRETRIREDRAFT_108012
TRRM419DRAFT_5451
ACANACA1_116140
SMINv1.2.018349.t1(symbB.v1.2.018349.t1) v1.2.019631.t1(symbB.v1.2.019631.t1)
FCYFRACYDRAFT_247575
AAFAURANDRAFT_2013 AURANDRAFT_28266
EHXEMIHUDRAFT_204576 EMIHUDRAFT_241178 EMIHUDRAFT_352686
 » show all
Reference
1  [PMID:4969969]
  Authors
McDonald JK, Leibach FH, Grindeland RE, Ellis S.
  Title
Purification of  dipeptidyl aminopeptidase II (dipeptidyl arylamidase II) of the anterior pituitary gland. Peptidase and dipeptide esterase activities.
  Journal
J Biol Chem 243:4143-50 (1968)
Reference
2
  Authors
McDonald, J.K. and Schwabe, C.
  Title
Intracellular exopeptidases.
  Journal
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 311-391.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.2
IUBMB Enzyme Nomenclature: 3.4.14.2
ExPASy - ENZYME nomenclature database: 3.4.14.2
BRENDA, the Enzyme Database: 3.4.14.2
CAS: 76199-23-0

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