KEGG   ENZYME: 3.4.14.4
Entry
EC 3.4.14.4                 Enzyme                                 
Name
dipeptidyl-peptidase III;
dipeptidyl aminopeptidase III;
dipeptidyl arylamidase III;
enkephalinase B;
red cell angiotensinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
Reaction(IUBMB)
Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.
Comment
A cytosolic peptidase that is active at neutral pH. It has broad activity on peptides, although it is highly selective for Arg-Arg-2-naphthylamide, at pH 9.2. Active in the hydrolysis of enkephalins. A metallopeptidase, the type example of peptidase family M49.
History
EC 3.4.14.4 created 1981, modified 2001
Orthology
K01277  dipeptidyl-peptidase III
Genes
HSA10072(DPP3)
PTR100613456(DPP3)
PPS100971539(DPP3)
GGO101128992(DPP3)
PON100172221(DPP3)
NLE100582608 100595091(DPP3)
MCC721809(DPP3)
MCF102131147(DPP3)
MTHB126935343
CSAB103222490(DPP3) 103228650
CATY105577387(DPP3)
PANU101025917(DPP3) 110742130
TGE112606302(DPP3)
RRO104664772(DPP3)
RBB108518602(DPP3)
TFN117080560(DPP3)
PTEH111522264(DPP3)
CJC100393210(DPP3)
SBQ101027916(DPP3)
CSYR103264996(DPP3)
MMUR105867483(DPP3)
LCAT123642888(DPP3)
OGA100948756(DPP3)
MMU75221(Dpp3)
MCAL110285349(Dpp3)
MPAH110337628(Dpp3)
RNO114591(Dpp3)
MCOC116103357(Dpp3)
MUN110556487(Dpp3)
CGE100760621(Dpp3)
MAUA101841760(Dpp3)
PLEU114709139(Dpp3)
MORG121454079(Dpp3)
MFOT126498452
AAMP119821568(Dpp3)
NGI103725034(Dpp3)
HGL101721371(Dpp3)
CPOC100729344(Dpp3)
CCAN109687068(Dpp3)
DORD105989262(Dpp3)
DSP122105073(Dpp3)
NCAR124958828
OCU100358846(DPP3)
OPI101525549(DPP3)
TUP102493027(DPP3)
CFA476011(DPP3)
CLUD112659494(DPP3)
VVP112924213(DPP3)
VLG121471491(DPP3)
AML100484390(DPP3)
UMR103679495(DPP3)
UAH113244062(DPP3)
UAR123778391(DPP3)
ELK111149678
LLV125078408
MPUF101677123(DPP3)
ORO101367015(DPP3)
EJU114220372(DPP3)
ZCA113914312(DPP3) 118357179
MLX118016098(DPP3)
NSU110576016(DPP3)
FCA101099587(DPP3)
PYU121023916(DPP3)
PBG122484019(DPP3)
LRUF124505121
PTG102962861(DPP3)
PPAD109246801(DPP3)
AJU106971200(DPP3)
HHV120240177(DPP3)
BTA510200(DPP3)
BOM102280041(DPP3)
BIU109554468(DPP3)
BBUB102414486(DPP3)
CHX102177139(DPP3)
OAS101115241(DPP3)
ODA120874742(DPP3)
CCAD122430917(DPP3)
SSC100519350(DPP3)
CFR102506535(DPP3)
CBAI105070304(DPP3)
CDK105104457(DPP3)
VPC102537409(DPP3)
BACU103009087(DPP3)
LVE103074526(DPP3)
OOR101277035(DPP3)
DLE111183703(DPP3)
PCAD102977466(DPP3)
PSIU116758823(DPP3)
ECB100058485(DPP3)
EPZ103559636(DPP3)
EAI106833526(DPP3)
MYB102240410(DPP3)
MYD102753158(DPP3)
MMYO118665255(DPP3)
MNA107533601(DPP3)
PKL118706976
HAI109384257(DPP3)
DRO112317117(DPP3)
SHON118991780(DPP3)
AJM119041854(DPP3)
PDIC114499729(DPP3)
PHAS123829513(DPP3)
MMF118628041(DPP3)
RFQ117030107(DPP3)
PALE102898581(DPP3)
PGIG120584798(DPP3)
PVP105298006(DPP3)
RAY107497508(DPP3)
MJV108401340(DPP3)
TOD119249936(DPP3)
SARA101543602(DPP3)
LAV100677496(DPP3)
TMU101352046
DNM101413226(DPP3)
MDO100619774(DPP3)
GAS123250965(DPP3)
SHR100928407(DPP3)
PCW110195474(DPP3)
OAA103167151(DPP3)
PSS102460456(DPP3)
CMY102939340(DPP3)
CPIC101933103(DPP3)
TST117880510(DPP3)
CABI116838789(DPP3)
MRV120369424(DPP3)
ACS100562322(dpp3)
PVT110069797(DPP3)
SUND121916032(DPP3)
PBI103049733(DPP3)
PMUR107297103(DPP3)
CTIG120318491(DPP3)
TSR106553365(DPP3)
PGUT117669738(DPP3)
VKO123032599(DPP3)
PMUA114586446(DPP3)
ZVI118076104(DPP3)
GJA107115216(DPP3)
STOW125443403(DPP3)
XLA394413(dpp3.S) 446491(dpp3.L)
XTR101732710(dpp3)
NPR108784144(DPP3)
RTEM120917528(DPP3)
BBUF120980169(DPP3) 120983770
BGAR122920417(DPP3)
DRE322527(dpp3)
SRX107715386 107756175
SANH107669347 107700005
SGH107567923 107568306
CCAR109056653 109056655
CAUA113038500 113064156
PPRM120494531(dpp3)
MAMB125252394(dpp3)
IPU108278869(dpp3)
PHYP113541758(dpp3)
SMEO124397954(dpp3)
TFD113662115(dpp3)
AMEX103042368(dpp3)
EEE113586015(dpp3)
TRU101074134(dpp3)
TNGGSTEN00033806G001
LCO104935082(dpp3)
NCC104966988(dpp3)
CGOB115019140(dpp3)
ELY117261409(dpp3)
EFO125898605(dpp3)
PLEP121953010(dpp3)
SLUC116037041(dpp3)
ECRA117955911(dpp3)
ESP116700759(dpp3)
PFLV114567190(dpp3)
GAT120821751(dpp3)
PPUG119215628(dpp3)
MSAM119896183(dpp3)
CUD121519345(dpp3)
ALAT119030815(dpp3)
MZE101469827(dpp3)
ONL100694869(dpp3)
OAU116319693(dpp3)
OLA101174283(dpp3)
OML112142976(dpp3)
XMA102225547(dpp3)
XCO114153317(dpp3)
XHE116728517(dpp3)
PRET103475408(dpp3)
PFOR103138767(dpp3)
PLAI106940341(dpp3)
PMEI106917149(dpp3)
GAF122844587(dpp3)
CVG107084155(dpp3)
CTUL119795221(dpp3)
GMU124875941(dpp3)
NFU107386740(dpp3)
KMR108238973(dpp3)
ALIM106524015(dpp3)
NWH119419947(dpp3)
AOCE111582686(dpp3)
MCEP125021014(dpp3)
CSEM103395536(dpp3)
POV109635782(dpp3)
SSEN122780127(dpp3)
HHIP117773886(dpp3)
HSP118121954(dpp3)
LCF108893201
SDU111217164(dpp3)
SLAL111672104(dpp3)
XGL120802983(dpp3)
HCQ109512419(dpp3)
BPEC110155883(dpp3)
MALB109959949(dpp3)
BSPL114869522(dpp3)
SASA100195375(dpp3) 106602977
STRU115154840 115204454(dpp3)
OTW112228944 112231170(dpp3)
OMY110510131 110534134
OGO124006222 124007435(dpp3)
ONE115101448(dpp3) 115135495
SALP111950262 111964353(dpp3)
SNH120021437(dpp3) 120057321
CCLU121542102(dpp3) 121579614
ELS105030038(dpp3)
SFM108934058(dpp3)
PKI111860103(dpp3)
AANG118235765(dpp3)
PSPA121310054(dpp3)
ARUT117398506 117967830
LCM102362934(DPP3)
RTP109924421(dpp3)
BFO118418412
BBEL109477139
SCLV120338698
SPU582874
APLC110979282
SKO100367734
DMEDmel_CG7415(DppIII)
DER6552969
DSE6607271
DSIDsimw501_GD18539(Dsim_GD18539)
DYADyak_GE25873
DAN6501123
DSR110186914
DPO4801704
DPE6587550
DMN108156449
DWI6650645
DGR6568393
DMODmoj_GI24885
DAZ108618388
DNV108659233
DHE111602717
DVI6630048
CCAT101455727
BOD106624495
RZE108367473 108381745
MDE101892395
SCAC106088087
LCQ111676137
LSQ119603944
HIS119651147
AGAAgaP_AGAP004394
ACOZ120949862
AARA120904438
ASTE118517614
AAG5576366
AALB109414930
CQUCpipJ_CPIJ005356 CpipJ_CPIJ020236
CNS116342141 116352548
BCOO119084665
AME412232
ACER107997841
ALAB122714806
BIM100747855
BBIF117205071
BVK117231034
BVAN117166121
BTER100644845
BPYO122567336
CCAL108627066
OBB114877382
MGEN117219373
NMEA116433069
CGIG122398733
SOC105203676
MPHA105831090
AEC105147695
ACEP105620272
PBAR105432035
VEM105561834
HST105188320
DQU106751823
CFO105258241
FEX115239918
LHU105677201
PGC109853134
OBO105288215
PCF106787582
PFUC122523519
VPS122632569
NVI100117644
CSOL105360956
TPRE106653842
MDL103572895
CGLO123274648
FAS105265961
DAM107037329
AGIF122853117
LHT122506301
CCIN107262858
TCA661730
DPA109534100
SOY115890403
ATD109597223
CSET123306797
AGB108915455
LDC111503685
NVL108566561
APLN108734414
PPYR116181710
OTU111428717
BMOR101739960
BMAN114247620
MSEX115444897
DPLKGM_207580A KGM_207580B
BANY112055727
NIQ126768427
PMAC106714949
PPOT106100162
PXU106125469
PRAP110995888
ZCE119831142
HAW110384066
HZE124630579
TNL113495042
SLIU111349301
OFU114355086
PXY105385637 105394894
NLU111047212
PHUPhum_PHUM420260
FOC113202925
TPAL117650893
ZNE110837876
CSEC111863064
FCD110859164
DPXDAPPUDRAFT_305996
DMK116936621
PVM113814810 113826435
PJA122257619
PCHN125029513
HAME121854248
PCLA123763706
PTRU123502709
HAZT108671979
EAF111716881
LSM121115635
PPOI119093094 119093102
ISCIscW_ISCW013099
DSV119461602
RSAN119395994
RMP119174451
VDE111246680
VJA111272081
DPTE113799459
DFR124496139
CSCU111619617 111619619
PTEP107447605 107447610 107453556
SDM118200272
CELCELE_F02E9.9(dpt-1)
CBRCBG_12727
NAINECAME_14730
LGILOTGIDRAFT_177525
PCAN112570438
BGT106051258
GAE121366310
HRF124145393
HRJ124275596
CRG105348163
MYI110466501
PMAX117323774
MMER123566345
LAK106165474
SMMSmp_019010
SHXMS3_00005472(DPP3_1)
OVIT265_09337
EGLEGR_02960
NVE5500815 5514921
EPA110231277
ATEN116306260
ADF107337643
AMIL114956445
PDAM113667165
SPIS111346360
DGT114532511
XEN124435625
HMG100207511
TADTRIADDRAFT_63309
AQU100634914 100636624 100640601 100641912 105311889
QSU112012788 112014455
PPP112286215
SCEYOL057W
SEUBDI49_2347
SPAOSPAR_O00950
AGOAGOS_AER229C
ERCEcym_5245
KLAKLLA0_C04059g
KMXKLMA_10181
LTHKLTH0F06666g
VPOKpol_1045p49
ZROZYRO0A05346g
CGRCAGL0C05093g
NCSNCAS_0C03640(NCAS0C03640)
TPFTPHA_0P00610(TPHA0P00610)
TDLTDEL_0D04520(TDEL0D04520)
KAFKAFR_0C00980(KAFR0C00980)
KNGKNAG_0K01190(KNAG0K01190)
PPAPAS_chr1-4_0347
DHADEHA2B07194g
PICPICST_88224(DPP3)
PGUPGUG_00748
SPAASPAPADRAFT_143827
LELLELG_04984
CALCAALFM_C603960WA(CaO19.5773)
CTPCTRG_05410
COTCORT_0H02610
CDUCD36_64480 CD36_81860
CTENCANTEDRAFT_114461
YLIYALI0B19580g
CLUCLUG_00118
CLUSA9F13_20g00473
CAURCJI97_003737
PKZC5L36_0B11180
BNNFOA43_003795
BBRXBRETT_000497
OPAHPODL_01024
SLUDSCDLUD_005140
NCRNCU02701
NTENEUTE1DRAFT126368(NEUTE1DRAFT_126368)
SMPSMAC_04358
PANPODANSg2061 PODANSg8339
TTTTHITE_2147951 THITE_67951
MTMMYCTH_114376
CTHRCTHT_0009590
MGRMGG_04445 MGG_05041
PPEIPpBr36_00233 PpBr36_09394
TMNUCRPA7_2423
SSCKSPSK_08655
FGRFGSG_01017 FGSG_11021
FPUFPSE_00290 FPSE_08592
FVRFVEG_01141
FOXFOXG_00376
NHENECHADRAFT_30560
TRETRIREDRAFT_21659
TRRM419DRAFT_136163
MAWMAC_06050 MAC_07084
MAJMAA_04067 MAA_06183
CMTCCM_02475 CCM_03673 CCM_05894 CCM_06407 CCM_08520
PLJVFPFJ_03651 VFPFJ_08065
VALVDBG_04823
VDAVDAG_04363
CFJCFIO01_04728 CFIO01_11162
CLUPCLUP02_05445 CLUP02_16241
CHIGCH63R_00537
SAPOSAPIO_CDS1839 SAPIO_CDS3505
ELAUCREL1_316 UCREL1_592
PFYPFICI_00854
SSLSS1G_01155 SS1G_03755
BFUBCIN_11g05910
MBEMBM_05956
PSCOLY89DRAFT_695045 LY89DRAFT_759760
GLZGLAREA_12297
ANIAN4321.2
AFMAFUA_4G06140 AFUA_5G06940
ACTACLA_045460
NFINFIA_080360 NFIA_110000
AORAO090023000980
ANGANI_1_170184(An04g00410)
ACHEACHE_40373A
APUUAPUU_70345A APUU_70489A
PCSPc22g16760
PDPPDIP_21750
TMFPMAA_028050
TRGTRUGW13939_05109
CIMCIMG_04201
CPWCPC735_002270
UREUREG_05628
PBLPAAG_07467
PBNPADG_05160
ABEARB_02670
TVETRV_05416
AJEHCAG_08942
BGHBDBG_04780
PNOSNOG_06713
PTEPTT_07261 PTT_17182
BZECOCCADRAFT_105840
BSCCOCSADRAFT_204418
BORCOCMIDRAFT_3567
AALTCC77DRAFT_931943
ZTRMYCGRDRAFT_66700
PFJMYCFIDRAFT_48690
FFUCLAFUR5_00800
BCOMBAUCODRAFT_62079
NPAUCRNP2_7203
TMLGSTUM_00009940001
TASAA1Q1_03341
TVSTRAVEDRAFT_56726
DSQDICSQDRAFT_104514
PCOPHACADRAFT_256057
SHSSTEHIDRAFT_145190
HIRHETIRDRAFT_60392
PSQPUNSTDRAFT_144875
ADLAURDEDRAFT_114377
FMEFOMMEDRAFT_18161
GTRGLOTRDRAFT_72206
LBCLACBIDRAFT_244681
CCICC1G_13912
ABPAGABI1DRAFT118131(AGABI1DRAFT_118131)
ABVAGABI2DRAFT64000(AGABI2DRAFT_64000)
PCUBJR316_0003766
MRRMoror_12969
MOREE1B28_000342
SCMSCHCO_02607736(SCHCODRAFT_02607736)
CPUTCONPUDRAFT_79874
SLASERLADRAFT_353218
PGRPGTG_21981
MLRMELLADRAFT_37623
MBRMONBRDRAFT_34290
DDIDDB_G0273471(dpp3-1) DDB_G0273563(dpp3-2)
DPPDICPUDRAFT_58624
DFADFA_06511(dpp3-2)
EHIEHI_110750(58.t00023)
EDIEDI_340680
EIVEIN_372120
TETTTHERM_00011440 TTHERM_00313320
PTMGSPATT00003396001 GSPATT00007720001 GSPATT00021484001
GTTGUITHDRAFT_109941
LMALMJF_05_0960
LIFLINJ_05_0960
LDOLDBPK_050960
LMILMXM_05_0960
LBZLBRM_05_0940
LPANLPMP_050940
NGRNAEGRDRAFT_38279
TVATVAG_2v0040270 TVAG_2v0844830
GLAGL50803_0033689 GL50803_003822
COZA3Q34_04020
KIMG3T16_17570
CCXCOCOR_01611
SURSTAUR_2351
AGEAA314_01356
SCUSCE1572_46375
OTEOter_3045
RULUC8_25980
ROLCA51_12990
SACISinac_4683
SUSAcid_0377
ABACLuPra_06225
BTHBT_1846
BTHOBtheta7330_01164
BFRBF3425
BFSBF9343_3161
BFGBF638R_3279
BFBVU15_15295
BHLBache_3162
BXYBXY_14930
BOABovatus_01906
BCELBcellWH2_01460
BCACCGC64_17155
BCAEA4V03_12840
BZGC4H11_05310
BHFC3V43_11965
BISDXK01_021460
BUNBun01g_17870
BEGINE88_00718
BSTEK6V31_06430
BFEK6V30_22635
BNOK8P02_12950
BHUMJXR92_008510
BVUBVU_2015
BSABacsa_1792
BDOEL88_03045
BDHGV66_10385
PCOPI6J50_12025
PGIPG_0317
PGNPGN_1645
PGTPGTDC60_1437
PCRENCTC12858_01148
PCAGNCTC12856_01260
PBTING2E5B_1214
PMUCING2E5A_1809(dpp3-1)
PETPEIBARAKI_5799
PSACPSM36_2003
PROJKDN43_13885
DYSG7050_02140
APSCFPG_728
PPNPalpr_0845
PDIBDI_3779
PARCCI960_02355
PMERINE87_03497
PGOLK6V26_16875
PJOLK449_12810
TFOBFO_1524
TOHBCB71_10165
PARYA4V02_00650
DUNFDZ78_02585
BVSBARVI_00495
COPRCop2CBH44_04790
OSPOdosp_1122
BUYD8S85_03330
BVIRI6J59_10295
PRUPRU_0989
PMZHMPREF0659_A6864
PDNHMPREF9137_1294
PITPIN17_A1705
PDTPrede_2307
PROHMPREF0669_01283
PFUSADJ77_10075
PEOAS203_02585
PJECRM71_10160
POCNCTC13071_01668
PNIJ5A59_09585
PMUFJ4864_07445
PHISJ5A62_09520
PCOILK433_10840
PHERprwr041_25470
PVFJ5A55_11640
PBYL6471_08745
PSCJJ4856_02130
ALQC7Y71_004185
AFDAlfi_2483
ASHAL1_29480
ALDGFH31_02165
AOKA3BBH6_02830
ACOUA5CBH24_00280
ADAA5CPEGH6_18620
AITAI2BBH_07710
ASENNQ519_02115
AIUNQ491_08410
RBCBN938_1441
TTZFHG85_07700
BACCBRDCF_p710
MBASALGA_0376
PSNPedsa_1437
SHGSph21_5218
OLIFKG96_23655
FLIFleli_2474
HSWHsw_2933
HYMN008_14550
HYDPK28_12880
HYEAM218_03540
HYHD3Y59_01550
HRSHER32_04615
HBNGUY19_20445
HMTMTP16_21425
RUFTH63_06575
RTIDC20_17450
RUDTH61_15835
NIBGU926_03540
REKN6H18_12930
GFOGFO_0057
GRLLPB144_08875
FGLEM308_10085
FFAFFWV33_08455
FKIFK004_11850
FPALHYN49_10865
FMGHYN48_11825
FNKE1750_03625
CATCA2559_07015
FBCFB2170_13983
KDIKrodi_0028
DOKMED134_03964
DDOI597_2396
DODDCS32_12225
ASLAeqsu_0382
AEVEI546_04200
AICJK629_00950
NDODDD_3018
PPECH9W90_00375
PUNNQP51_14880
MYRMYRA21_0375
MPWMPR_2908
MODAS202_01305
MYZBK054_01410
MOAI6I89_12930
MALSNWE55_03430
WINWPG_0345
WIJBWZ20_12875
TDIAUW17_10520
TMARMARIT_0621
TMPF9Y86_10575
LUTLupro_05960
FORFORMB_20750
FOHFORMA_03830
SALTAO058_07800
SMISLDL76_01875
SEONBWZ22_02310
OLLCW732_17355
OAQDZC78_06215
FEKC1H87_20760
TAJC1A40_16370
AUEC5O00_09365
KOSKORDIASMS9_04428
KANIMCC3317_15580
MARFCJ739_2793
AQBD1818_21300
AQAD1815_10620
AQDD1816_23935
MUREQY75_07990
PSYNE9099_11725
ANPFK178_08855
MGELG5B37_13590
MESQC7H62_1800
ALTIALE3EI_0187
MARXINR76_00575
SINHLS482_16370
SABUMBM09_12605
BIAGMA17_01660
FBEFF125_04585
SAHNJRG66_11615
FBUUJ101_02005(DPP3)
CFAELL667_00545
CCASEIB73_04090
CANTNCTC13489_00999
KDAEIB71_09095
APIBG8C43_00385
FTEFluta_3601
FLUCHH17_07705
CRMK6119_19200
OHOOweho_0781
CHYDH4K34_17990
BBAUAEM51_11080
MROMROS_1275
 » show all
Reference
1
  Authors
McDonald, J.K.
  Title
Dipeptidyl-peptidase III.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Handbook of Proteolytic Enzymes, London, 1998, p. 536-538.
Reference
2  [PMID:10387075]
  Authors
Fukasawa K, Fukasawa KM, Iwamoto H, Hirose J, Harada M.
  Title
The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme.
  Journal
Biochemistry 38:8299-303 (1999)
DOI:10.1021/bi9904959
  Sequence
[rno:114591]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.4
IUBMB Enzyme Nomenclature: 3.4.14.4
ExPASy - ENZYME nomenclature database: 3.4.14.4
BRENDA, the Enzyme Database: 3.4.14.4
CAS: 77464-87-0

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