Entry
Name
carboxypeptidase C;
carboxypeptidase Y;
serine carboxypeptidase I;
cathepsin A;
lysosomal protective protein;
deamidase;
lysosomal carboxypeptidase A;
phaseolin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine-type carboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal amino acid with broad specificity
Comment
A carboxypeptidase with optimum pH 4.5--6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). Widely distributed in eukaryotes. Type example of peptidase family S10.
History
EC 3.4.16.5 created 1972 as EC 3.4.12.1, transferred 1978 to EC 3.4.16.1, part transferred 1993 to EC 3.4.16.5 (EC 3.4.16.3 created 1972 as EC 3.4.12.12, transferred 1978 to EC 3.4.16.3, transferred 1992 to EC 3.4.16.1), (EC 3.4.21.13 created 1972, transferred 1978 to EC 3.4.16.1)
Orthology
K13289 cathepsin A (carboxypeptidase C)
Genes
TUP : 102485953(CTSA) 102488508
FCA : 101085538 111559765(CTSA)
LAV : 100665041(CTSA) 100676352
ETF : 101652615 101655929(CTSA)
DNM : 101417051 101433099(CTSA)
MDO : 100022069(CTSA) 100024941
GAS : 123234560 123237282(CTSA)
SHR : 100915300 100933780(CTSA)
PCW : 110192388 110193676(CTSA)
SVG : 106860883(CTSA) 106861627
ASN : 102368270 102373938(CTSA)
AMJ : 102564952(CTSA) 102572879
CPOO : 109310441 109313296(CTSA)
GGN : 109289682 109292477(CTSA)
ACS : 100559820 100561404(ctsa)
SUND : 121926149 121929867(CTSA)
PBI : 103049522(CTSA) 112541987
PGUT : 117669608(CTSA) 117670332
PMUA : 114599892(CTSA) 114601854
ZVI : 118086888 118089308(CTSA)
RTEM : 120918572 120918573
BGAR : 122940925 122941848(CTSA)
DRE : 321818(ctsa) 792966(si:ch211-122f10.4)
SRX : 107707902 107740260 107744356
SANH : 107666023 107695338 107696438 107702181
SGH : 107560512 107587598 107596457
CAUA : 113051376 113104924(ctsa) 113106308
CGIB : 127959378 127962648 128017744(si:ch211-122f10.4)
PPRM : 120477274(si:ch211-122f10.4) 120494162(ctsa)
MAMB : 125264042(si:ch211-122f10.4) 125273350(ctsa)
CIDE : 127514674 127515385(si:ch211-122f10.4)
MASI : 127444637 127446017 127449570
AMEX : 103027152 103035030(ctsa)
EEE : 113569846 113571584(ctsa)
TRU : 101066746(ctsa) 101077421
LCO : 104927289 104933133(ctsa)
ELY : 117254112(si:ch211-122f10.4) 117256367(ctsa)
EFO : 125889223(ctsa) 125901626(si:ch211-122f10.4)
PLEP : 121940545 121957060(si:ch211-122f10.4)
SLUC : 116060544(si:ch211-122f10.4) 116062611(ctsa)
ECRA : 117941192 117943103(si:ch211-122f10.4)
PFLV : 114554751(ctsa) 114565953
GAT : 120833441(si:ch211-122f10.4) 120834957(ctsa)
PPUG : 119194168(si:ch211-122f10.4) 119230065(ctsa)
MSAM : 119886135(ctsa) 119890104 119890996(si:ch211-122f10.4)
CUD : 121506762(si:ch211-122f10.4) 121507447(ctsa)
ALAT : 119017888(si:ch211-122f10.4) 119020547(ctsa)
MZE : 101480742 101482934(ctsa) 112429970
ONL : 100700252(ctsa) 100706635
OAU : 116312697(ctsa) 116334576(si:ch211-122f10.4)
OLA : 101168356 101173697(ctsa)
OML : 112145598 112145599 112160554(si:ch211-122f10.4)
XMA : 102229123 102234395(ctsa)
XCO : 114135284(ctsa) 114142723
PRET : 103460358(ctsa) 103462555
PFOR : 103131224(ctsa) 103136588
PLAI : 106937032(ctsa) 106948990
PMEI : 106904099(ctsa) 106921974
GAF : 122833411(ctsa) 122843268(si:ch211-122f10.4)
CVG : 107102985 107103547(ctsa) 107105074
CTUL : 119788650(ctsa) 119798977(si:ch211-122f10.4)
GMU : 124856607(ctsa) 124866555(si:ch211-122f10.4)
NFU : 107373363 107381336 107384873(ctsa)
KMR : 108250713(ctsa) 108251491(si:ch211-122f10.4)
ALIM : 106531749(ctsa) 106532157
NWH : 119412669(ctsa) 119428549(si:ch211-122f10.4)
AOCE : 111571413(ctsa) 111587671
MCEP : 125005312(si:ch211-122f10.4) 125007094(ctsa)
CSEM : 103378882 103386821(ctsa)
POV : 109636834 109647685(ctsa)
SSEN : 122768165(ctsa) 122772409(si:ch211-122f10.4)
HHIP : 117753376(si:ch211-122f10.4) 117762170(ctsa)
HSP : 118105350(ctsa) 118105939(si:ch211-122f10.4)
LCF : 108877788(si:ch211-122f10.4) 108890718
SDU : 111217614 111219402(ctsa)
SLAL : 111646244 111656535(ctsa)
XGL : 120783358(ctsa) 120804373(si:ch211-122f10.4)
HCQ : 109522647(ctsa) 109525936
SSCV : 125967600(si:ch211-122f10.4) 125977314
MALB : 109964585 109966949(ctsa)
BSPL : 114852309(si:ch211-122f10.4) 114855077(ctsa)
SASA : 100195153(ctsa) 106562245 106587401
STRU : 115150090(ctsa) 115203138
OTW : 112249206 112255041(ctsa) 112263741
OMY : 110506581(si:ch211-122f10.4) 110528562(ctsa)
OGO : 124026161(ctsa) 124033111 124035690
ONE : 115112317 115112318 115144189(ctsa)
SALP : 111969419 111970521(ctsa) 111974269
SNH : 120025180 120056261 120065464(ctsa)
CCLU : 121548264(si:ch211-122f10.4) 121575587 121577970(ctsa)
ELS : 105016109 105016705(ctsa)
SFM : 108936511(ctsa) 108937935
PKI : 111835880(ctsa) 111846630
AANG : 118211793(ctsa) 118226845(si:ch211-122f10.4)
LOC : 102691640(ctsa) 102698583 102698789
PSPA : 121298046(ctsa) 121320200 121325949(si:ch211-122f10.4)
ARUT : 117399404 117425024(si:ch211-122f10.4) 117425942 117431553
PSEX : 120515128(ctsa) 120534856 120535305(si:ch211-122f10.4)
LCM : 102354641(CTSA) 102367606
RTP : 109929856 109938362(ctsa)
BBEL : 109473640 109480593
SCLV : 120326519 120338425
SPU : 588485 589075 594128
AJC : 117107562 117113986 117114027
HAZT : 108665481 108680621 108682879
DSV : 119432355 119432876 119432929 119433908 119434102 119434103 119445287 119445696
RSAN : 119377832 119405002 119405126 119405451 119405538
RMP : 119176385 119180547 119180706 119181713 119181714 119186027
CEL : CELE_F13D12.6(ctsa-1.2) CELE_F41C3.5(ctsa-1.1) CELE_Y16B4A.2(Y16B4A.2) CELE_Y40D12A.2(ctsa-4.2)
CBR : CBG_03132 CBG_04280 CBG_15195
LGI : LOTGIDRAFT_159616 LOTGIDRAFT_206131
HRF : 124131380 124131632 124131700
HRJ : 124254268 124254318 124254319
SMM : Smp_163970 Smp_172590
TDC : 119297522 119304092 119323407
SCE : YBR139W(ATG42) YMR297W(PRC1)
SEUB : DI49_1168 DI49_4384
SPAO : SPAR_B02380 SPAR_M04120
AGO : AGOS_AER022W AGOS_AGL328C
KLA : KLLA0_A09977g KLLA0_C17490g KLLA0_E17821g
KMX : KLMA_10499(PRC1) KLMA_60138
LTH : KLTH0B09328g KLTH0G15950g
VPO : Kpol_1028p72 Kpol_1036p14
ZRO : ZYRO0B05720g ZYRO0D07260g
NCS : NCAS_0F02120(NCAS0F02120) NCAS_0I02290(NCAS0I02290)
NDI : NDAI_0A06870(NDAI0A06870) NDAI_0C03670(NDAI0C03670)
TPF : TPHA_0A05520(TPHA0A05520)
TBL : TBLA_0C06920(TBLA0C06920)
TDL : TDEL_0G00500(TDEL0G00500)
KAF : KAFR_0I02520(KAFR0I02520)
KNG : KNAG_0E01520(KNAG0E01520) KNAG_0K01950(KNAG0K01950)
ZMK : HG535_0C03120 HG535_0E00490
DHA : DEHA2C13112g DEHA2D02244g
PIC : PICST_31676 PICST_36810 PICST_38351(CPY2)
PGU : PGUG_05015 PGUG_05150
SPAA : SPAPADRAFT_48326 SPAPADRAFT_63508
LEL : LELG_04484 LELG_04485 LELG_05162
CAL : CAALFM_C105770CA(PRC3) CAALFM_C501450WA(PRC2) CAALFM_C703360WA(CPY1)
CTP : CTRG_00505 CTRG_04821 CTRG_05137
COT : CORT_0B08710 CORT_0E03430 CORT_0G03840
CDU : CD36_05440(CPY2) CD36_50900 CD36_73010
CTEN : CANTEDRAFT_112550 CANTEDRAFT_98952
YLI : YALI0A18810g YALI0B01408g YALI0B20812g YALI0C00803g YALI0C21604g YALI0C23661g YALI0D08052g YALI0D09042g YALI0F11803g
CLU : CLUG_00466 CLUG_02976
CLUS : A9F13_08g02750 A9F13_18g00847
CAUR : CJI97_003865 CJI97_004880
PKZ : C5L36_0A05800 C5L36_0B00410
OPA : HPODL_02015 HPODL_04650
SLUD : SCDLUD_002512 SCDLUD_004850
NTE : NEUTE1DRAFT82484(NEUTE1DRAFT_82484)
FGR : FGSG_03769 FGSG_06895
FPU : FPSE_03477 FPSE_11764
NHE : NECHADRAFT_100110 NECHADRAFT_44892
CLUP : CLUP02_03399 CLUP02_09266
CHIG : CH63R_02503 CH63R_07060 CH63R_14020 CH63R_14024
BFU : BCIN_10g04320(Bccp4)
AFM : AFUA_3G12210 AFUA_5G14610 AFUA_6G13540
ACT : ACLA_040070 ACLA_086840 ACLA_098670
NFI : NFIA_059500 NFIA_065090 NFIA_072360
ANG : ANI_1_1208074(An08g08750) ANI_1_238044(An05g01870)
ALUC : AKAW2_11962A AKAW2_51701A AKAW2_81337S
ACHE : ACHE_10104S ACHE_20311S
CIM : CIMG_02815 CIMG_09968
CPW : CPC735_011420 CPC735_036210
URE : UREG_03020 UREG_06044
PNO : SNOG_02053 SNOG_08837
BZE : COCCADRAFT_104639 COCCADRAFT_33067
BSC : COCSADRAFT_106369 COCSADRAFT_41809
BOR : COCMIDRAFT_38160 COCMIDRAFT_5305
NPA : UCRNP2_8337 UCRNP2_9391
CNG : CNAG_01879 CNAG_06640
CGI : CGB_F1460W CGB_K1610W
TMS : TREMEDRAFT_33109 TREMEDRAFT_45442
LBC : LACBIDRAFT_189535(LbPR_S3) LACBIDRAFT_295014(LbPR_S2)
CCI : CC1G_09180 CC1G_12159
PCUB : JR316_0001407 JR316_0001463 JR316_0003113
MORE : E1B28_002378 E1B28_009549
SCM : SCHCO_02485498(SCHCODRAFT_02485498) SCHCO_02521311(SCHCODRAFT_02521311)
TET : TTHERM_00249550 TTHERM_00249560 TTHERM_00249570 TTHERM_00249680 TTHERM_00249710 TTHERM_00249800 TTHERM_00346900 TTHERM_00448920 TTHERM_00448930 TTHERM_00448980 TTHERM_00927190 TTHERM_00927200 TTHERM_00927210 TTHERM_00927220 TTHERM_01141610
PTI : PHATRDRAFT_11204 PHATR_18551
PIF : PITG_01447 PITG_11525
TBR : Tb10.70.7080 Tb10.70.7090 Tb10.70.7100
TBG : TbgDal_X1360 TbgDal_X1380 TbgDal_X1400 TbgDal_X1410
TCR : 508671.20 509695.210 509695.220 509695.230
» show all
Taxonomy
Reference
1
Authors
Breddam, K.
Title
Serine carboxypeptidases. A review.
Journal
Carlsberg Res Commun 51:83-128 (1986)
Reference
Authors
Valls LA, Hunter CP, Rothman JH, Stevens TH
Title
Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide.
Journal
Sequence
Reference
Authors
Jackman HL, Morris PW, Deddish PA, Skidgel RA, Erdos EG.
Title
Inactivation of endothelin I by deamidase (lysosomal protective protein).
Journal
J Biol Chem 267:2872-5 (1992)
Reference
Authors
Miller JJ, Changaris DG, Levy RS.
Title
Purification, subunit structure and inhibitor profile of cathepsin A.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.4.16.5
ExPASy - ENZYME nomenclature database: 3.4.16.5