KEGG   ENZYME: 3.4.16.5
Entry
EC 3.4.16.5                 Enzyme                                 
Name
carboxypeptidase C;
carboxypeptidase Y;
serine carboxypeptidase I;
cathepsin A;
lysosomal protective protein;
deamidase;
lysosomal carboxypeptidase A;
phaseolin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine-type carboxypeptidases
Reaction(IUBMB)
Release of a C-terminal amino acid with broad specificity
Comment
A carboxypeptidase with optimum pH 4.5--6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). Widely distributed in eukaryotes. Type example of peptidase family S10.
History
EC 3.4.16.5 created 1972 as EC 3.4.12.1, transferred 1978 to EC 3.4.16.1, part transferred 1993 to EC 3.4.16.5 (EC 3.4.16.3 created 1972 as EC 3.4.12.12, transferred 1978 to EC 3.4.16.3, transferred 1992 to EC 3.4.16.1), (EC 3.4.21.13 created 1972, transferred 1978 to EC 3.4.16.1)
Orthology
K13289  cathepsin A (carboxypeptidase C)
Genes
HSA5476(CTSA)
PTR458290(CTSA)
PPS100969338(CTSA)
GGO101150972(CTSA)
PON100173381(CTSA)
NLE100584301(CTSA)
HMH116460900(CTSA)
MCC708592(CTSA)
MCF101866185(CTSA)
MTHB126963826
MNI105496462(CTSA)
CSAB103245139(CTSA)
CATY105588500(CTSA)
PANU101004937(CTSA)
TGE112632909(CTSA)
MLEU105542300(CTSA)
RRO104678820(CTSA)
RBB108533329(CTSA)
TFN117068853(CTSA)
PTEH111530028(CTSA)
CANG105502413(CTSA)
CJC100413773(CTSA)
SBQ101033824(CTSA)
CIMI108313034(CTSA)
CSYR103260268(CTSA)
MMUR105859252(CTSA)
LCAT123622174(CTSA)
PCOQ105807161(CTSA)
OGA100941656(CTSA)
MMU19025(Ctsa)
MCAL110310814(Ctsa)
MPAH110317842(Ctsa)
RNO296370(Ctsa)
MCOC116091373(Ctsa)
ANU117702401(Ctsa)
MUN110549351(Ctsa)
CGE100772055(Ctsa)
MAUA101824576(Ctsa)
PROB127223711(Ctsa)
PLEU114692628(Ctsa)
MORG121460162(Ctsa)
MFOT126506882
AAMP119814374(Ctsa)
NGI103737935(Ctsa)
HGL101720484(Ctsa)
CPOC100720508(Ctsa)
CCAN109689272(Ctsa)
DORD105981670(Ctsa)
DSP122120213(Ctsa)
NCAR124976785
OCU100339600
OPI101531894(CTSA)
TUP102485953(CTSA) 102488508
GVR103589578(CTSA)
CFA611146(CTSA)
CLUD112674045(CTSA)
VVP112931900(CTSA)
VLG121478141(CTSA)
AML100474665(CTSA)
UMR103669857(CTSA)
UAH113258664(CTSA)
UAR123797071(CTSA)
ELK111141795
LLV125108319
MPUF101678325(CTSA)
NVS122916021(CTSA)
ORO101379146(CTSA)
EJU114223138(CTSA)
ZCA113937300(CTSA)
MLX118011546(CTSA)
NSU110579374(CTSA)
LWW102731763(CTSA)
FCA101085538 111559765(CTSA)
PYU121012103(CTSA)
PBG122467332(CTSA)
LRUF124503626
PTG102958713(CTSA)
PPAD109272351(CTSA)
PUC125936523
AJU106969007(CTSA)
HHV120243285(CTSA)
BTA518169(CTSA)
BOM102280027(CTSA)
BIU109567503(CTSA)
BBUB102412556(CTSA)
BBIS104985047(CTSA)
CHX102182324(CTSA)
OAS101113615(CTSA)
ODA120869514(CTSA)
CCAD122448643(CTSA)
SSC100156798(CTSA)
CFR102508708(CTSA)
CBAI105071889(CTSA)
CDK105087842(CTSA)
VPC102529116(CTSA)
BACU103017862(CTSA)
LVE103087262(CTSA)
OOR101276848(CTSA)
DLE111170150(CTSA)
PCAD102975673(CTSA)
PSIU116739727(CTSA)
ECB100071127(CTSA)
EPZ103551923(CTSA)
EAI106843038(CTSA)
MYB102259776(CTSA)
MYD102766118(CTSA)
MMYO118662756(CTSA)
MLF102417614(CTSA)
MNA107530900(CTSA)
PKL118707533(CTSA)
HAI109379946(CTSA)
DRO112304018(CTSA)
SHON118985543(CTSA)
AJM119063319(CTSA)
PDIC114506534(CTSA)
PHAS123814777(CTSA)
MMF118618615(CTSA)
RFQ117016175(CTSA)
PALE102888117(CTSA)
PGIG120603734(CTSA)
PVP105298196(CTSA)
RAY107514542(CTSA)
MJV108392907(CTSA)
TOD119236020(CTSA)
SARA101538669(CTSA)
LAV100665041(CTSA) 100676352
TMU101347053 101358725
ETF101652615 101655929(CTSA)
DNM101417051 101433099(CTSA)
MDO100022069(CTSA) 100024941
GAS123234560 123237282(CTSA)
SHR100915300 100933780(CTSA)
AFZ127547647 127550767
PCW110192388 110193676(CTSA)
OAA100076065
GGA428163(CTSA)
PCOC116225646(CTSA)
MGP100547907(CTSA)
CJO107323140(CTSA)
NMEL110408332(CTSA)
APLA101801880(CTSA)
ACYG106047180(CTSA)
AFUL116495609(CTSA)
TGU100220062(CTSA)
LSR110479786(CTSA)
SCAN103818651(CTSA)
PMOA120497809(CTSA)
OTC121343740(CTSA)
PRUF121359657(CTSA)
GFR102038566(CTSA)
FAB101812393(CTSA)
PHI102113628(CTSA)
PMAJ107213227(CTSA)
CCAE111938164(CTSA)
CCW104687726(CTSA)
CBRC103617329(CTSA)
ETL114063057(CTSA)
ZAB102069291(CTSA)
ACHL103797914
SVG106860883(CTSA) 106861627
FPG101912460(CTSA)
FCH102045880(CTSA)
CLV102087924(CTSA)
EGZ104127960(CTSA)
NNI104018334(CTSA)
PLET104617314(CTSA)
PCAO104051306(CTSA)
PADL103916205(CTSA)
AFOR103899131(CTSA)
ACHC115339744(CTSA)
HLE104832944(CTSA)
CCRI104158518(CTSA)
FGA104074949(CTSA)
SHAB115615005(CTSA)
DPUB104301473(CTSA)
CPEA104385560(CTSA)
CVF104293850(CTSA)
CUCA104060842(CTSA)
AAM106497597(CTSA)
AROW112974167(CTSA)
NPD112949767(CTSA)
TGT104566757(CTSA)
DNE112994566(CTSA)
SCAM104140401(CTSA)
ASN102368270 102373938(CTSA)
AMJ102564952(CTSA) 102572879
CPOO109310441 109313296(CTSA)
GGN109289682 109292477(CTSA)
PSS102460692(CTSA)
CMY102942772(CTSA)
CPIC101938768(CTSA)
TST117885711(CTSA)
CABI116831191(CTSA)
MRV120380977(CTSA)
ACS100559820 100561404(ctsa)
PVT110086236(CTSA)
SUND121926149 121929867(CTSA)
PBI103049522(CTSA) 112541987
PMUR107298445(CTSA)
CTIG120307551(CTSA)
PGUT117669608(CTSA) 117670332
VKO123018861(CTSA)
PMUA114599892(CTSA) 114601854
ZVI118086888 118089308(CTSA)
GJA107111356(CTSA)
STOW125433855(CTSA)
XLA494810(ctsa.L)
XTR734066(ctsa)
NPR108793373(CTSA)
RTEM120918572 120918573
BBUF121003650(CTSA)
BGAR122940925 122941848(CTSA)
DRE321818(ctsa) 792966(si:ch211-122f10.4)
SRX107707902 107740260 107744356
SANH107666023 107695338 107696438 107702181
SGH107560512 107587598 107596457
CCAR109052126(ctsa)
CAUA113051376 113104924(ctsa) 113106308
CGIB127959378 127962648 128017744(si:ch211-122f10.4)
PPRM120477274(si:ch211-122f10.4) 120494162(ctsa)
MAMB125264042(si:ch211-122f10.4) 125273350(ctsa)
CIDE127514674 127515385(si:ch211-122f10.4)
MASI127444637 127446017 127449570
IPU108271760(ctsa)
PHYP113532065(ctsa)
SMEO124383934(ctsa)
TFD113642895(ctsa)
AMEX103027152 103035030(ctsa)
EEE113569846 113571584(ctsa)
TRU101066746(ctsa) 101077421
TNGGSTEN00004285G001
LCO104927289 104933133(ctsa)
NCC104945215
CGOB115024929(ctsa)
ELY117254112(si:ch211-122f10.4) 117256367(ctsa)
EFO125889223(ctsa) 125901626(si:ch211-122f10.4)
PLEP121940545 121957060(si:ch211-122f10.4)
SLUC116060544(si:ch211-122f10.4) 116062611(ctsa)
ECRA117941192 117943103(si:ch211-122f10.4)
ESP116673671 116679374
PFLV114554751(ctsa) 114565953
GAT120833441(si:ch211-122f10.4) 120834957(ctsa)
PPUG119194168(si:ch211-122f10.4) 119230065(ctsa)
MSAM119886135(ctsa) 119890104 119890996(si:ch211-122f10.4)
CUD121506762(si:ch211-122f10.4) 121507447(ctsa)
ALAT119017888(si:ch211-122f10.4) 119020547(ctsa)
MZE101480742 101482934(ctsa) 112429970
ONL100700252(ctsa) 100706635
OAU116312697(ctsa) 116334576(si:ch211-122f10.4)
OLA101168356 101173697(ctsa)
OML112145598 112145599 112160554(si:ch211-122f10.4)
XMA102229123 102234395(ctsa)
XCO114135284(ctsa) 114142723
XHE116710825 116718862
PRET103460358(ctsa) 103462555
PFOR103131224(ctsa) 103136588
PLAI106937032(ctsa) 106948990
PMEI106904099(ctsa) 106921974
GAF122833411(ctsa) 122843268(si:ch211-122f10.4)
CVG107102985 107103547(ctsa) 107105074
CTUL119788650(ctsa) 119798977(si:ch211-122f10.4)
GMU124856607(ctsa) 124866555(si:ch211-122f10.4)
NFU107373363 107381336 107384873(ctsa)
KMR108250713(ctsa) 108251491(si:ch211-122f10.4)
ALIM106531749(ctsa) 106532157
NWH119412669(ctsa) 119428549(si:ch211-122f10.4)
AOCE111571413(ctsa) 111587671
MCEP125005312(si:ch211-122f10.4) 125007094(ctsa)
CSEM103378882 103386821(ctsa)
POV109636834 109647685(ctsa)
SSEN122768165(ctsa) 122772409(si:ch211-122f10.4)
HHIP117753376(si:ch211-122f10.4) 117762170(ctsa)
HSP118105350(ctsa) 118105939(si:ch211-122f10.4)
LCF108877788(si:ch211-122f10.4) 108890718
SDU111217614 111219402(ctsa)
SLAL111646244 111656535(ctsa)
XGL120783358(ctsa) 120804373(si:ch211-122f10.4)
HCQ109522647(ctsa) 109525936
SSCV125967600(si:ch211-122f10.4) 125977314
BPEC110175414(ctsa)
MALB109964585 109966949(ctsa)
BSPL114852309(si:ch211-122f10.4) 114855077(ctsa)
SASA100195153(ctsa) 106562245 106587401
STRU115150090(ctsa) 115203138
OTW112249206 112255041(ctsa) 112263741
OMY110506581(si:ch211-122f10.4) 110528562(ctsa)
OGO124026161(ctsa) 124033111 124035690
ONE115112317 115112318 115144189(ctsa)
SALP111969419 111970521(ctsa) 111974269
SNH120025180 120056261 120065464(ctsa)
CCLU121548264(si:ch211-122f10.4) 121575587 121577970(ctsa)
ELS105016109 105016705(ctsa)
SFM108936511(ctsa) 108937935
PKI111835880(ctsa) 111846630
AANG118211793(ctsa) 118226845(si:ch211-122f10.4)
LOC102691640(ctsa) 102698583 102698789
PSPA121298046(ctsa) 121320200 121325949(si:ch211-122f10.4)
ARUT117399404 117425024(si:ch211-122f10.4) 117425942 117431553
PSEX120515128(ctsa) 120534856 120535305(si:ch211-122f10.4)
LCM102354641(CTSA) 102367606
CMK103191463
RTP109929856 109938362(ctsa)
BFO118417927 118418097
BBEL109473640 109480593
CIN100176903 100183589
SCLV120326519 120338425
SPU588485 589075 594128
APLC110988405
AJC117107562 117113986 117114027
SKO100370840
RZE108379800
PJA122263679
HAME121873139
PCLA123769361
PTRU123507780
HAZT108665481 108680621 108682879
DSV119432355 119432876 119432929 119433908 119434102 119434103 119445287 119445696
RSAN119377832 119405002 119405126 119405451 119405538
RMP119176385 119180547 119180706 119181713 119181714 119186027
TUT107366517
DPTE113799250
DFR124492251 124498282
CSCU111633317
PTEP107456912
SDM118195456
CELCELE_F13D12.6(ctsa-1.2) CELE_F41C3.5(ctsa-1.1) CELE_Y16B4A.2(Y16B4A.2) CELE_Y40D12A.2(ctsa-4.2)
CBRCBG_03132 CBG_04280 CBG_15195
BMYBM_BM3985(Bm3985)
LOALOAG_04094
HROHELRODRAFT_185271
LGILOTGIDRAFT_159616 LOTGIDRAFT_206131
PCAN112568668
BGT106055601
GAE121388303
HRF124131380 124131632 124131700
HRJ124254268 124254318 124254319
MYI110453620
PMAX117338455
MCAF127702385
MMER123548864
DPOL127844770
OBI106874211
OSN115226095
LAK106171672
SMMSmp_163970 Smp_172590
XEN124436910
TADTRIADDRAFT_38444
QSU111983446 112029519
TWL120002954 120010451
TDC119297522 119304092 119323407
NCOL116245239
SCEYBR139W(ATG42) YMR297W(PRC1)
SEUBDI49_1168 DI49_4384
SPAOSPAR_B02380 SPAR_M04120
AGOAGOS_AER022W AGOS_AGL328C
ERCEcym_5321 Ecym_5642
KLAKLLA0_A09977g KLLA0_C17490g KLLA0_E17821g
KMXKLMA_10499(PRC1) KLMA_60138
LTHKLTH0B09328g KLTH0G15950g
VPOKpol_1028p72 Kpol_1036p14
ZROZYRO0B05720g ZYRO0D07260g
CGRCAGL0M13651g
NCSNCAS_0F02120(NCAS0F02120) NCAS_0I02290(NCAS0I02290)
NDINDAI_0A06870(NDAI0A06870) NDAI_0C03670(NDAI0C03670)
TPFTPHA_0A05520(TPHA0A05520)
TBLTBLA_0C06920(TBLA0C06920)
TGBHG536_0A00500
TDLTDEL_0G00500(TDEL0G00500)
KAFKAFR_0I02520(KAFR0I02520)
KNGKNAG_0E01520(KNAG0E01520) KNAG_0K01950(KNAG0K01950)
ZMKHG535_0C03120 HG535_0E00490
PPAPAS_chr1-4_0013
DHADEHA2C13112g DEHA2D02244g
PICPICST_31676 PICST_36810 PICST_38351(CPY2)
PGUPGUG_05015 PGUG_05150
SPAASPAPADRAFT_48326 SPAPADRAFT_63508
LELLELG_04484 LELG_04485 LELG_05162
CALCAALFM_C105770CA(PRC3) CAALFM_C501450WA(PRC2) CAALFM_C703360WA(CPY1)
CTPCTRG_00505 CTRG_04821 CTRG_05137
COTCORT_0B08710 CORT_0E03430 CORT_0G03840
CDUCD36_05440(CPY2) CD36_50900 CD36_73010
CTENCANTEDRAFT_112550 CANTEDRAFT_98952
YLIYALI0A18810g YALI0B01408g YALI0B20812g YALI0C00803g YALI0C21604g YALI0C23661g YALI0D08052g YALI0D09042g YALI0F11803g
CLUCLUG_00466 CLUG_02976
CLUSA9F13_08g02750 A9F13_18g00847
CAURCJI97_003865 CJI97_004880
SLBAWJ20_4686(PRC1)
PKZC5L36_0A05800 C5L36_0B00410
BNNFOA43_003909(CPY1)
BBRXBRETT_000630(CPY1)
OPAHPODL_02015 HPODL_04650
SLUDSCDLUD_002512 SCDLUD_004850
NCRNCU00477
NTENEUTE1DRAFT82484(NEUTE1DRAFT_82484)
SMPSMAC_01911
PANPODANSg5071
TTTTHITE_2118436
MTMMYCTH_2304704
CTHRCTHT_0026440
MGRMGG_05663
PPEIPpBr36_05150
TMNUCRPA7_6348
SSCKSPSK_07330
FGRFGSG_03769 FGSG_06895
FPUFPSE_03477 FPSE_11764
FVRFVEG_14045
FOXFOXG_16811
NHENECHADRAFT_100110 NECHADRAFT_44892
TRETRIREDRAFT_120998
TRRM419DRAFT_122545
MAWMAC_06140
MAJMAA_05766
CMTCCM_05858
PLJVFPFJ_05416
CFJCFIO01_03200
CLUPCLUP02_03399 CLUP02_09266
CHIGCH63R_02503 CH63R_07060 CH63R_14020 CH63R_14024
ELAUCREL1_5921
PFYPFICI_08037
SSLSS1G_12500
BFUBCIN_10g04320(Bccp4)
MBEMBM_01234
PSCOLY89DRAFT_681515
GLZGLAREA_04424
ANIAN5442.2
AFMAFUA_3G12210 AFUA_5G14610 AFUA_6G13540
ACTACLA_040070 ACLA_086840 ACLA_098670
NFINFIA_059500 NFIA_065090 NFIA_072360
AORAO090103000332
ANGANI_1_1208074(An08g08750) ANI_1_238044(An05g01870)
AFVAFLA_013196
ALUCAKAW2_11962A AKAW2_51701A AKAW2_81337S
ACHEACHE_10104S ACHE_20311S
APUUAPUU_40790A
PCSPc22g00890
PDPPDIP_46070
TMFPMAA_064090
TRGTRUGW13939_06573
CIMCIMG_02815 CIMG_09968
CPWCPC735_011420 CPC735_036210
UREUREG_03020 UREG_06044
PBLPAAG_03512
PBNPADG_06314
ABEARB_01491 ARB_05721
TVETRV_02994 TRV_08055
AJEHCAG_08666
BGHBDBG_08833
PNOSNOG_02053 SNOG_08837
PTEPTT_15015 PTT_19384
BZECOCCADRAFT_104639 COCCADRAFT_33067
BSCCOCSADRAFT_106369 COCSADRAFT_41809
BORCOCMIDRAFT_38160 COCMIDRAFT_5305
AALTCC77DRAFT_1037795
ZTRMYCGRDRAFT_103135
PFJMYCFIDRAFT_72243
FFUCLAFUR5_02458
BCOMBAUCODRAFT_38207
NPAUCRNP2_8337 UCRNP2_9391
TMLGSTUM_00004304001
SPOSPAC19G12.10c(cpy1)
CNECNF03760 CNK02200
CNBCNBF1060 CNBK1340
CNGCNAG_01879 CNAG_06640
CGICGB_F1460W CGB_K1610W
TMSTREMEDRAFT_33109 TREMEDRAFT_45442
TASAA1Q1_00190
PPLPOSPLDRAFT_92386
LBCLACBIDRAFT_189535(LbPR_S3) LACBIDRAFT_295014(LbPR_S2)
CCICC1G_09180 CC1G_12159
PCUBJR316_0001407 JR316_0001463 JR316_0003113
MOREE1B28_002378 E1B28_009549
SCMSCHCO_02485498(SCHCODRAFT_02485498) SCHCO_02521311(SCHCODRAFT_02521311)
UMAUMAG_01886
MSYMMSY001_0224
PGRPGTG_02777
MBRMONBRDRAFT_38492
DDIDDB_G0291912
TETTTHERM_00249550 TTHERM_00249560 TTHERM_00249570 TTHERM_00249680 TTHERM_00249710 TTHERM_00249800 TTHERM_00346900 TTHERM_00448920 TTHERM_00448930 TTHERM_00448980 TTHERM_00927190 TTHERM_00927200 TTHERM_00927210 TTHERM_00927220 TTHERM_01141610
PTIPHATRDRAFT_11204 PHATR_18551
FCYFRACYDRAFT_277512
TPSTHAPSDRAFT_15093
PIFPITG_01447 PITG_11525
TBRTb10.70.7080 Tb10.70.7090 Tb10.70.7100
TBGTbgDal_X1360 TbgDal_X1380 TbgDal_X1400 TbgDal_X1410
TCR508671.20 509695.210 509695.220 509695.230
LMALMJF_18_0450
LIFLINJ_18_0450
LDOLDBPK_180450
LMILMXM_18_0450
LBZLBRM_18_0510
LPANLPMP_180690
 » show all
Reference
1
  Authors
Breddam, K.
  Title
Serine carboxypeptidases. A review.
  Journal
Carlsberg Res Commun 51:83-128 (1986)
Reference
2  [PMID:3028649]
  Authors
Valls LA, Hunter CP, Rothman JH, Stevens TH
  Title
Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide.
  Journal
Cell 48:887-97 (1987)
DOI:10.1016/0092-8674(87)90085-7
  Sequence
[sce:YMR297W]
Reference
3  [PMID:1737744]
  Authors
Jackman HL, Morris PW, Deddish PA, Skidgel RA, Erdos EG.
  Title
Inactivation of endothelin I by deamidase (lysosomal protective protein).
  Journal
J Biol Chem 267:2872-5 (1992)
Reference
4  [PMID:1487525]
  Authors
Miller JJ, Changaris DG, Levy RS.
  Title
Purification, subunit structure and inhibitor profile of cathepsin A.
  Journal
J Chromatogr 627:153-62 (1992)
DOI:10.1016/0021-9673(92)87195-e
Other DBs
ExplorEnz - The Enzyme Database: 3.4.16.5
IUBMB Enzyme Nomenclature: 3.4.16.5
ExPASy - ENZYME nomenclature database: 3.4.16.5
BRENDA, the Enzyme Database: 3.4.16.5
CAS: 9046-67-7

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