KEGG   ENZYME: 3.4.16.5
Entry
EC 3.4.16.5                 Enzyme                                 

Name
carboxypeptidase C;
carboxypeptidase Y;
serine carboxypeptidase I;
cathepsin A;
lysosomal protective protein;
deamidase;
lysosomal carboxypeptidase A;
phaseolin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine-type carboxypeptidases
Reaction(IUBMB)
Release of a C-terminal amino acid with broad specificity
Comment
A carboxypeptidase with optimum pH 4.5-6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). Widely distributed in eukaryotes. Type example of peptidase family S10.
History
EC 3.4.16.5 created 1972 as EC 3.4.12.1, transferred 1978 to EC 3.4.16.1, part transferred 1993 to EC 3.4.16.5 (EC 3.4.16.3 created 1972 as EC 3.4.12.12, transferred 1978 to EC 3.4.16.3, transferred 1992 to EC 3.4.16.1), (EC 3.4.21.13 created 1972, transferred 1978 to EC 3.4.16.1)
Orthology
K13289  cathepsin A (carboxypeptidase C)
Genes
HSA: 5476(CTSA)
PTR: 458290(CTSA)
PPS: 100969338(CTSA)
GGO: 101150972(CTSA)
PON: 100173381(CTSA)
NLE: 100584301(CTSA)
MCC: 708592(CTSA)
MCF: 101866185(CTSA)
CSAB: 103245139(CTSA)
CATY: 105588500(CTSA)
PANU: 101004937(CTSA)
RRO: 104678820(CTSA)
RBB: 108533329(CTSA)
TFN: 117068853(CTSA)
PTEH: 111530028(CTSA)
CJC: 100413773(CTSA)
SBQ: 101033824(CTSA)
MMUR: 105859252(CTSA)
MMU: 19025(Ctsa)
MCAL: 110310814(Ctsa)
MPAH: 110317842(Ctsa)
RNO: 296370(Ctsa)
MCOC: 116091373(Ctsa)
MUN: 110549351(Ctsa)
CGE: 100772055(Ctsa)
PLEU: 114692628(Ctsa)
NGI: 103737935(Ctsa)
HGL: 101720484(Ctsa)
CCAN: 109689272(Ctsa)
OCU: 100339600(CTSA)
TUP: 102485953(CTSA) 102488508
CFA: 611146(CTSA)
VVP: 112931900(CTSA)
VLG: 121478141(CTSA)
AML: 100474665(CTSA)
UMR: 103669857(CTSA)
UAH: 113258664(CTSA)
ORO: 101379146(CTSA)
ELK: 111141795
MPUF: 101678325(CTSA)
EJU: 114223138(CTSA)
MLX: 118011546(CTSA)
FCA: 101085538 111559765(CTSA)
PTG: 102958713(CTSA)
PPAD: 109272351(CTSA)
AJU: 106969007(CTSA)
HHV: 120243285(CTSA)
BTA: 518169(CTSA)
BOM: 102280027(CTSA)
BIU: 109567503(CTSA)
BBUB: 102412556(CTSA)
CHX: 102182324(CTSA)
OAS: 101113615(CTSA)
ODA: 120869514(CTSA)
SSC: 100156798(CTSA)
CFR: 102508708(CTSA)
CBAI: 105071889(CTSA)
CDK: 105087842(CTSA)
BACU: 103017862(CTSA)
LVE: 103087262(CTSA)
OOR: 101276848(CTSA)
DLE: 111170150(CTSA)
PCAD: 102975673(CTSA)
ECB: 100071127(CTSA)
EPZ: 103551923(CTSA)
EAI: 106843038(CTSA)
MYB: 102259776(CTSA)
MYD: 102766118(CTSA)
MMYO: 118662756(CTSA)
MNA: 107530900(CTSA)
HAI: 109379946(CTSA)
DRO: 112304018(CTSA)
SHON: 118985543(CTSA)
AJM: 119063319(CTSA)
MMF: 118618615(CTSA)
PALE: 102888117(CTSA)
PGIG: 120603734(CTSA)
RAY: 107514542(CTSA)
MJV: 108392907(CTSA)
TOD: 119236020(CTSA)
LAV: 100665041(CTSA) 100676352
MDO: 100022069(CTSA) 100024941
SHR: 100915300 100933780(CTSA)
PCW: 110192388 110193676(CTSA)
OAA: 100076065
GGA: 428163(CTSA)
PCOC: 116225646(CTSA)
MGP: 100547907(CTSA)
CJO: 107323140(CTSA)
NMEL: 110408332(CTSA)
APLA: 101801880(CTSA)
ACYG: 106047180(CTSA)
TGU: 100220062(CTSA)
LSR: 110479786(CTSA)
SCAN: 103818651(CTSA)
PMOA: 120497809(CTSA)
GFR: 102038566(CTSA)
FAB: 101812393(CTSA)
PHI: 102113628(CTSA)
PMAJ: 107213227(CTSA)
CCAE: 111938164(CTSA)
CCW: 104687726(CTSA)
ETL: 114063057(CTSA)
FPG: 101912460(CTSA)
FCH: 102045880(CTSA)
CLV: 102087924(CTSA)
EGZ: 104127960(CTSA)
NNI: 104018334(CTSA)
PADL: 103916205(CTSA)
AAM: 106497597(CTSA)
ASN: 102368270 102373938(CTSA)
AMJ: 102564952(CTSA) 102572879
CPOO: 109310441 109313296(CTSA)
GGN: 109289682 109292477(CTSA)
PSS: 102460692(CTSA)
CMY: 102942772(CTSA)
CPIC: 101938768(CTSA)
TST: 117885711(CTSA)
ACS: 100559820 100561404(ctsa)
PVT: 110086236(CTSA)
PBI: 103049522(CTSA) 112541987
PMUR: 107298445(CTSA)
PGUT: 117669608(CTSA) 117670332
PMUA: 114599892(CTSA) 114601854
ZVI: 118086888 118089308(CTSA)
GJA: 107111356(CTSA)
XLA: 494810(ctsa.L)
XTR: 734066(ctsa)
NPR: 108793373(CTSA)
DRE: 321818(ctsa) 792966(si:ch211-122f10.4)
CCAR: 109052126(ctsa)
IPU: 108271760(ctsa)
PHYP: 113532065(ctsa)
AMEX: 103027152 103035030(ctsa)
EEE: 113569846 113571584(ctsa)
TRU: 101066746(ctsa) 101077421
LCO: 104927289 104933133(ctsa)
NCC: 104945215
CGOB: 115024929(ctsa)
ELY: 117254112(si:ch211-122f10.4) 117256367(ctsa)
PLEP: 121940545 121957060(si:ch211-122f10.4)
SLUC: 116060544(si:ch211-122f10.4) 116062611(ctsa)
ECRA: 117941192 117943103(si:ch211-122f10.4)
PFLV: 114554751(ctsa) 114565953
GAT: 120833441(si:ch211-122f10.4) 120834957(ctsa)
MSAM: 119886135(ctsa) 119890104 119890996(si:ch211-122f10.4)
CUD: 121506762(si:ch211-122f10.4) 121507447(ctsa)
ONL: 100700252(ctsa) 100706635
OAU: 116312697(ctsa) 116334576(si:ch211-122f10.4)
OLA: 101168356 101173697(ctsa)
OML: 112145598 112145599 112160554(si:ch211-122f10.4)
XMA: 102229123 102234395(ctsa)
XCO: 114135284(ctsa) 114142723
PRET: 103460358(ctsa) 103462555
CTUL: 119788650(ctsa) 119798977(si:ch211-122f10.4)
KMR: 108250713(ctsa) 108251491(si:ch211-122f10.4)
ALIM: 106531749(ctsa) 106532157
AOCE: 111571413(ctsa) 111587671
CSEM: 103378882 103386821(ctsa)
POV: 109636834 109647685(ctsa)
LCF: 108877788 108890718(ctsa)
SDU: 111217614 111219402(ctsa)
SLAL: 111646244 111656535(ctsa)
XGL: 120783358(ctsa) 120804373(si:ch211-122f10.4)
HCQ: 109522647(ctsa) 109525936
BPEC: 110175414(ctsa)
MALB: 109964585 109966949(ctsa)
OMY: 110506581(si:ch211-122f10.4) 110528562(ctsa)
ELS: 105016109 105016705(ctsa)
SFM: 108936511(ctsa) 108937935
PKI: 111835880(ctsa) 111846630
AANG: 118211793(ctsa) 118226845(si:ch211-122f10.4)
PSPA: 121298046(ctsa) 121320200 121325949(si:ch211-122f10.4)
ARUT: 117399404 117425024(si:ch211-122f10.4) 117425942 117431553
LCM: 102354641(CTSA) 102367606
CMK: 103191463(ctsa)
RTP: 109929856 109938362(ctsa)
APLC: 110988405
SKO: 100370840
HAME: 121873139
TUT: 107366517
DPTE: 113799250
CSCU: 111633317
PTEP: 107456912
SDM: 118195456
CEL: CELE_F13D12.6(ctsa-1.2) CELE_F41C3.5(ctsa-1.1) CELE_Y16B4A.2(Y16B4A.2) CELE_Y40D12A.2(ctsa-4.2)
BMY: BM_BM3985(Bm3985)
PCAN: 112568668
BGT: 106055601
GAE: 121388303
MYI: 110453620
PMAX: 117338455
OBI: 106874211
LAK: 106171672
NCOL: 116245239
SCE: YBR139W(ATG42) YMR297W(PRC1)
NCS: NCAS_0F02120(NCAS0F02120) NCAS_0I02290(NCAS0I02290)
NDI: NDAI_0A06870(NDAI0A06870) NDAI_0C03670(NDAI0C03670)
TPF: TPHA_0A05520(TPHA0A05520)
TBL: TBLA_0C06920(TBLA0C06920)
TDL: TDEL_0G00500(TDEL0G00500)
KAF: KAFR_0I02520(KAFR0I02520)
SLB: AWJ20_4686(PRC1)
BNN: FOA43_003909(CPY1)
BBRX: BRETT_000630(CPY1)
NCR: NCU00477
NTE: NEUTE1DRAFT82484(NEUTE1DRAFT_82484)
MGR: MGG_05663
SSCK: SPSK_07330
MAW: MAC_06140
MAJ: MAA_05766
CMT: CCM_05858
BFU: BCIN_10g04320(Bccp4)
MBE: MBM_01234
ANI: AN5442.2
ANG: ANI_1_1208074(An08g08750) ANI_1_238044(An05g01870)
SPO: SPAC19G12.10c(cpy1)
TASA: A1Q1_00190
LBC: LACBIDRAFT_189535(LbPR_S3) LACBIDRAFT_295014(LbPR_S2)
 » show all
Reference
1
  Authors
Breddam, K.
  Title
Serine carboxypeptidases. A review.
  Journal
Carlsberg Res Commun 51:83-128 (1986)
Reference
2  [PMID:3028649]
  Authors
Valls LA, Hunter CP, Rothman JH, Stevens TH
  Title
Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide.
  Journal
Cell 48:887-97 (1987)
DOI:10.1016/0092-8674(87)90085-7
  Sequence
[sce:YMR297W]
Reference
3  [PMID:1737744]
  Authors
Jackman HL, Morris PW, Deddish PA, Skidgel RA, Erdos EG.
  Title
Inactivation of endothelin I by deamidase (lysosomal protective protein).
  Journal
J Biol Chem 267:2872-5 (1992)
Reference
4  [PMID:1487525]
  Authors
Miller JJ, Changaris DG, Levy RS.
  Title
Purification, subunit structure and inhibitor profile of cathepsin A.
  Journal
J Chromatogr 627:153-62 (1992)
DOI:10.1016/0021-9673(92)87195-e
Other DBs
ExplorEnz - The Enzyme Database: 3.4.16.5
IUBMB Enzyme Nomenclature: 3.4.16.5
ExPASy - ENZYME nomenclature database: 3.4.16.5
BRENDA, the Enzyme Database: 3.4.16.5
CAS: 9046-67-7

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