KEGG   ENZYME: 3.4.16.6
Entry
EC 3.4.16.6                 Enzyme                                 
Name
carboxypeptidase D;
cereal serine carboxypeptidase II;
Saccharomyces cerevisiae KEX1 gene product;
carboxypeptidase Kex1;
gene KEX1 serine carboxypeptidase;
KEX1 carboxypeptidase;
KEX1 proteinase;
KEX1DELTAp;
CPDW-II;
serine carboxypeptidase (misleading);
Phaseolus proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine-type carboxypeptidases
Reaction(IUBMB)
Preferential release of a C-terminal arginine or lysine residue
Comment
A carboxypeptidase with optimum pH 4.5-6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). In peptidase family S10 (carboxypeptidase C family).
History
EC 3.4.16.6 created 1972 as EC 3.4.12.1, transferred 1978 to EC 3.4.16.1, part transferred 1993 to EC 3.4.16.6 (EC 3.4.16.3 created 1972 as EC 3.4.12.12, transferred 1978 to EC 3.4.16.3, transferred 1992 to EC 3.4.16.1), (EC 3.4.21.13 created 1972, transferred 1978 to EC 3.4.16.1), modified 2011
Orthology
K01288  carboxypeptidase D
Genes
SCE: YGL203C(KEX1)
SEUB: DI49_1775
SPAO: SPAR_G00560
AGO: AGOS_AFR549W
ERC: Ecym_1217
KLA: KLLA0_F09999g
KMX: KLMA_20260(KEX1)
LTH: KLTH0G01980g
VPO: Kpol_1041p46
ZRO: ZYRO0C06006g
CGR: CAGL0G01232g
NCS: NCAS_0E00660(NCAS0E00660)
NDI: NDAI_0I02850(NDAI0I02850)
TPF: TPHA_0A05770(TPHA0A05770)
TBL: TBLA_0I03220(TBLA0I03220)
TGB: HG536_0D05120
TDL: TDEL_0D05800(TDEL0D05800)
KAF: KAFR_0D01410(KAFR0D01410)
KNG: KNAG_0B00650(KNAG0B00650)
ZMK: HG535_0B02420
PPA: PAS_chr2-1_0174
DHA: DEHA2F22352g
PIC: PICST_78088(KEX1)
PGU: PGUG_00385
SPAA: SPAPADRAFT_73535
LEL: LELG_05440
CAL: CAALFM_C700940WA(CaO19.7020)
CTP: CTRG_04891
COT: CORT_0G01740 CORT_0H00280
CDU: CD36_70870
CTEN: CANTEDRAFT_119566
YLI: YALI0B05170g
CLU: CLUG_04442
CLUS: A9F13_04g00627
CAUR: CJI96_0001812
SLB: AWJ20_993(KEX1)
PKZ: C5L36_0A07080
BNN: FOA43_002128
BBRX: BRETT_003872
OPA: HPODL_04558
NCR: NCU04316 NCU06720
NTE: NEUTE1DRAFT56417(NEUTE1DRAFT_56417) NEUTE1DRAFT57101(NEUTE1DRAFT_57101)
SMP: SMAC_05571 SMAC_06613
PAN: PODANSg8857 PODANSg8931
TTT: THITE_121141 THITE_2108975
MTM: MYCTH_2302321 MYCTH_2302738 MYCTH_97448
CTHR: CTHT_0061740 CTHT_0063260
MGR: MGG_00775
PPEI: PpBr36_03117 PpBr36_08359
TMN: UCRPA7_1896 UCRPA7_4147 UCRPA7_7378
SSCK: SPSK_01057 SPSK_08740
FGR: FGSG_04546 FGSG_05797 FGSG_10145
FPU: FPSE_02639 FPSE_03226 FPSE_11231
FVR: FVEG_02869 FVEG_04402 FVEG_11127
FOX: FOXG_05262 FOXG_07474 FOXG_13694
NHE: NECHADRAFT_63845 NECHADRAFT_64790 NECHADRAFT_69476
FFC: NCS54_00705800 NCS54_00878700 NCS54_01191900
TRE: TRIREDRAFT_66183 TRIREDRAFT_74517
TRR: M419DRAFT_10901 M419DRAFT_25801
MAW: MAC_01104 MAC_02763 MAC_03529 MAC_03847 MAC_04682 MAC_08114
MAJ: MAA_02240 MAA_02969 MAA_04542 MAA_05628 MAA_09950 MAA_10322
CMT: CCM_01903 CCM_02046 CCM_05627
PLJ: VFPFJ_04784 VFPFJ_08558 VFPFJ_08594 VFPFJ_10515
PTKZ: JDV02_002791 JDV02_006775(KEX1) JDV02_006803 JDV02_009608 JDV02_010231
VAL: VDBG_00507 VDBG_09155
VDA: VDAG_00116 VDAG_07306
CFJ: CFIO01_02002 CFIO01_03220 CFIO01_03657 CFIO01_04609 CFIO01_09693
CLUP: CLUP02_10893 CLUP02_14164 CLUP02_14260
CHIG: CH63R_03255 CH63R_06204 CH63R_08873 CH63R_13962
SAPO: SAPIO_CDS2668 SAPIO_CDS5731
ELA: UCREL1_8291 UCREL1_8304 UCREL1_8756
PFY: PFICI_01738 PFICI_03315 PFICI_06116 PFICI_12307 PFICI_13115 PFICI_13795
SSL: SS1G_05449 SS1G_09475 SS1G_10553 SS1G_13633
BFU: BCIN_03g02030 BCIN_04g01480 BCIN_06g00630 BCIN_06g02510 BCIN_09g02350
MBE: MBM_05049 MBM_07942 MBM_09227
PSCO: LY89DRAFT_691164 LY89DRAFT_696238 LY89DRAFT_719400 LY89DRAFT_727454 LY89DRAFT_778734 LY89DRAFT_785996 LY89DRAFT_786346
GLZ: GLAREA_01023 GLAREA_09722 GLAREA_10188 GLAREA_11916
ANI: AN1384.2 AN2555.2
AFM: AFUA_1G08940 AFUA_2G03510 AFUA_6G00310
ACT: ACLA_026530 ACLA_091010 ACLA_099380
NFI: NFIA_016700 NFIA_035860 NFIA_047470
AOR: AO090005001632 AO090010000534 AO090020000351 AO090120000232
ANG: ANI_1_1212124(An14g02150) ANI_1_1592074(An08g00430) ANI_1_568044(An05g02170) ANI_1_664024(An02g04690) ANI_1_998064(An07g08030)
AFV: AFLA_004461 AFLA_009455 AFLA_010311 AFLA_014021
ALUC: AKAW2_11467S AKAW2_21223S AKAW2_30937S(KEX1) AKAW2_40904S AKAW2_81357S
ACHE: ACHE_30988S(KEX1)
APUU: APUU_50318A(KEX1) APUU_81007S
PCS: Pc16g01980 Pc18g04660 Pc20g10240 Pc22g21120
PDP: PDIP_02600 PDIP_41670 PDIP_71590
TMF: EYB26_000573 EYB26_003276 EYB26_009308
TRG: TRUGW13939_04044 TRUGW13939_04059 TRUGW13939_10242
CIM: CIMG_02284 CIMG_07181
CPW: CPC735_035110 CPC735_039410
URE: UREG_01452 UREG_05722 UREG_06786
PBL: PAAG_00330 PAAG_06137
PBN: PADG_02348 PADG_07980
ABE: ARB_01587 ARB_02032 ARB_03758 ARB_06414
TVE: TRV_01049 TRV_03565 TRV_05861 TRV_07747
AJE: HCAG_01993
BGH: BDBG_00152 BDBG_03944
PNO: SNOG_05144 SNOG_14756 SNOG_14891
PTE: PTT_00914 PTT_08433 PTT_18732
BZE: COCCADRAFT_42167 COCCADRAFT_4776 COCCADRAFT_97830
BSC: COCSADRAFT_138953 COCSADRAFT_178202 COCSADRAFT_99447
BOR: COCMIDRAFT_1823 COCMIDRAFT_27768 COCMIDRAFT_40804
AALT: CC77DRAFT_1032844 CC77DRAFT_1064811 CC77DRAFT_930297
ZTR: MYCGRDRAFT_106874 MYCGRDRAFT_109759 MYCGRDRAFT_42709 MYCGRDRAFT_75070(PEP-S10.1) MYCGRDRAFT_77233
PFJ: MYCFIDRAFT_162667 MYCFIDRAFT_37055 MYCFIDRAFT_58150 MYCFIDRAFT_60084 MYCFIDRAFT_63696
FFU: CLAFUR5_05611 CLAFUR5_08887 CLAFUR5_09819 CLAFUR5_12123 CLAFUR5_13481
BCOM: BAUCODRAFT_115526 BAUCODRAFT_87777
NPA: UCRNP2_1073 UCRNP2_3893 UCRNP2_5314
TML: GSTUM_00004029001 GSTUM_00010123001
SPO: SPAC1296.03c(sxa2) SPBC16G5.09
SOM: SOMG_01644(sxa2) SOMG_03911(kex1)
CNE: CNC05760 CND00600 CND01720 CNE00660
CNB: CNBC1420 CNBD4620 CNBD5670 CNBE0600
CNG: CNAG_00919 CNAG_01040 CNAG_02494 CNAG_02966
CGI: CGB_C8330W CGB_E0630W CGB_J2010C
TMS: TREMEDRAFT_41638
TASA: A1Q1_01088 A1Q1_05245 A1Q1_06751
PPL: POSPLDRAFT_88585
TVS: TRAVEDRAFT_126828 TRAVEDRAFT_133452 TRAVEDRAFT_148659 TRAVEDRAFT_155002 TRAVEDRAFT_159926 TRAVEDRAFT_162948 TRAVEDRAFT_29080 TRAVEDRAFT_45058 TRAVEDRAFT_52610 TRAVEDRAFT_63629 TRAVEDRAFT_70376 TRAVEDRAFT_74788
DSQ: DICSQDRAFT_108110 DICSQDRAFT_110240 DICSQDRAFT_169358 DICSQDRAFT_181585 DICSQDRAFT_65706 DICSQDRAFT_99992
PCO: PHACADRAFT_177131 PHACADRAFT_249107 PHACADRAFT_250924 PHACADRAFT_264079
SHS: STEHIDRAFT_147812 STEHIDRAFT_158272 STEHIDRAFT_169312 STEHIDRAFT_169473 STEHIDRAFT_49038 STEHIDRAFT_84379
HIR: HETIRDRAFT_123766 HETIRDRAFT_146116 HETIRDRAFT_147022 HETIRDRAFT_437612 HETIRDRAFT_57243
PSQ: PUNSTDRAFT_105464 PUNSTDRAFT_128382 PUNSTDRAFT_133360 PUNSTDRAFT_136362 PUNSTDRAFT_142825 PUNSTDRAFT_147019 PUNSTDRAFT_77958
ADL: AURDEDRAFT_115302 AURDEDRAFT_155239 AURDEDRAFT_162243 AURDEDRAFT_165386 AURDEDRAFT_165396 AURDEDRAFT_167524 AURDEDRAFT_168262 AURDEDRAFT_169176 AURDEDRAFT_170625 AURDEDRAFT_180086 AURDEDRAFT_184323 AURDEDRAFT_184759 AURDEDRAFT_50652 AURDEDRAFT_87806
FME: FOMMEDRAFT_100431 FOMMEDRAFT_115456 FOMMEDRAFT_116589 FOMMEDRAFT_135071 FOMMEDRAFT_87242 FOMMEDRAFT_90430
GTR: GLOTRDRAFT_113875 GLOTRDRAFT_114370 GLOTRDRAFT_121369 GLOTRDRAFT_122955 GLOTRDRAFT_30246 GLOTRDRAFT_42128 GLOTRDRAFT_44561 GLOTRDRAFT_58449
RSX: RhiXN_03770 RhiXN_08512
LBC: LACBIDRAFT_253991 LACBIDRAFT_292054
CCI: CC1G_00916 CC1G_01392
ABP: AGABI1DRAFT37296(AGABI1DRAFT_37296) AGABI1DRAFT45474(AGABI1DRAFT_45474) AGABI1DRAFT70057(AGABI1DRAFT_70057) AGABI1DRAFT84490(AGABI1DRAFT_84490)
ABV: AGABI2DRAFT195700(AGABI2DRAFT_195700) AGABI2DRAFT205752(AGABI2DRAFT_205752) AGABI2DRAFT68978(AGABI2DRAFT_68978) AGABI2DRAFT79914(AGABI2DRAFT_79914)
PCUB: JR316_0004428 JR316_0005301
MPR: MPER_06442
MRR: Moror_1518 Moror_16893 Moror_17267 Moror_2050 Moror_2051
MORE: E1B28_002557 E1B28_004799 E1B28_010066
SCM: SCHCO_02622192(SCHCODRAFT_02622192) SCHCO_02631590(SCHCODRAFT_02631590) SCHCO_02645761(SCHCODRAFT_02645761) SCHCO_02730054(SCHCODRAFT_02730054)
CPUT: CONPUDRAFT_126951 CONPUDRAFT_130798 CONPUDRAFT_152664
SLA: SERLADRAFT_367312 SERLADRAFT_446295 SERLADRAFT_473031
WSE: WALSEDRAFT_28238
WIC: J056_001540
UMA: UMAG_01888 UMAG_03465
PFP: PFL1_02152 PFL1_06670
SGRA: EX895_003974 EX895_006439
MGL: MGL_0815 MGL_2498
MRT: MRET_0003 MRET_4176
MSYM: MSY001_0294 MSY001_2158 MSY001_2239
PGR: PGTG_01128 PGTG_10662 PGTG_14112 PGTG_14427 PGTG_14432 PGTG_18559 PGTG_21811
PTRC: PtA15_18A354 PtA15_5A906 PtA15_6A496 PtA15_6A524 PtA15_8A30 PtA15_8A34
MLR: MELLADRAFT_116360 MELLADRAFT_117480 MELLADRAFT_123594 MELLADRAFT_123595
DDI: DDB_G0280105
DFA: DFA_04033
PTI: PHATRDRAFT_1391
FCY: FRACYDRAFT_210750
TPS: THAPSDRAFT_261024 THAPSDRAFT_41521
AAF: AURANDRAFT_2660
PIF: PITG_02213
PSOJ: PHYSODRAFT_553288
SPAR: SPRG_00614
NGR: NAEGRDRAFT_74700
 » show all
Reference
1
  Authors
Breddam, K.
  Title
Serine carboxypeptidases. A review.
  Journal
Carlsberg Res Commun 51:83-128 (1986)
Reference
2
  Authors
Breddam, K., Sorensen, S.B. and Svendsen, I.
  Title
Primary structure and enzymatic properties of carboxypeptidase II from wheat bran.
  Journal
Carlsberg Res Commun 52:297-311 (1987)
Reference
3  [PMID:3301004]
  Authors
Dmochowska A, Dignard D, Henning D, Thomas DY, Bussey H.
  Title
Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and alpha-factor precursor processing.
  Journal
Cell 50:573-84 (1987)
DOI:10.1016/0092-8674(87)90030-4
  Sequence
[sce:YGL203C]
Reference
4  [PMID:1390755]
  Authors
Liao DI, Breddam K, Sweet RM, Bullock T, Remington SJ.
  Title
Refined atomic model of wheat serine carboxypeptidase II at 2.2-A resolution.
  Journal
Biochemistry 31:9796-812 (1992)
DOI:10.1021/bi00155a037
Other DBs
ExplorEnz - The Enzyme Database: 3.4.16.6
IUBMB Enzyme Nomenclature: 3.4.16.6
ExPASy - ENZYME nomenclature database: 3.4.16.6
BRENDA, the Enzyme Database: 3.4.16.6
CAS: 153967-26-1

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Gene (993)   
   KEGG ORTHOLOGY (1)   
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Protein sequence (302)   
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3D Structure (3)   
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Protein domain (5)   
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