KEGG   ENZYME: 3.4.17.1
Entry
EC 3.4.17.1                 Enzyme                                 
Name
carboxypeptidase A;
carboxypolypeptidase;
pancreatic carboxypeptidase A;
tissue carboxypeptidase A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro
Comment
A zinc enzyme formed from procarboxypeptidase A. Isolated from cattle, pig and dogfish pancreas, and other sources including mast cells [3] and skeletal muscle [4]. Type example of peptidase family M14.
History
EC 3.4.17.1 created 1961 as EC 3.4.2.1, transferred 1972 to EC 3.4.12.2, transferred 1978 to EC 3.4.17.1
Orthology
K08779  carboxypeptidase A1
K08780  carboxypeptidase A3
K08781  carboxypeptidase A5
K08782  carboxypeptidase A6
Genes
HSA1357(CPA1) 1359(CPA3) 57094(CPA6) 93979(CPA5)
PTR100614351(CPA1) 471081(CPA3) 472786(CPA6) 742366(CPA5)
PPS100981388(CPA1) 100982515(CPA5) 100982967(CPA6) 100992364(CPA3)
GGO101129862(CPA3) 101139091(CPA6) 101153254(CPA5) 101154468(CPA1)
PON100431233(CPA3) 100451977(CPA6) 100459398(CPA5) 100460151(CPA1)
NLE100591248(CPA6) 100604190(CPA5) 100605530(CPA1) 100606371(CPA3)
MCC702974(CPA5) 703095(CPA1) 705117(CPA6) 712564(CPA3)
MCF101865458(CPA5) 102122589(CPA6) 102133770(CPA1) 102134275(CPA3)
CSAB103226893(CPA1) 103226894(CPA5) 103236928(CPA6) 103241514(CPA3)
CATY105585239(CPA6) 105587507(CPA3) 105598580(CPA5) 105598582(CPA1)
PANU101002543(CPA3) 101005395(CPA6) 101006610(CPA5) 101007275(CPA1)
TGE112618870(CPA3) 112620186(CPA1) 112620817(CPA5) 112630310(CPA6)
RRO104668815(CPA6) 104671555(CPA3) 104674463(CPA5) 104674464(CPA1)
RBB108518295(CPA3) 108531565(CPA5) 108531568(CPA1) 108544895(CPA6)
TFN117073656(CPA5) 117073658(CPA1) 117079035(CPA6) 117084055(CPA3)
PTEH111539828(CPA5) 111539858(CPA1) 111544727(CPA3) 111549273(CPA6)
CJC100389601(CPA6) 100391972(CPA1) 100393077(CPA5) 100405681(CPA3)
SBQ101037345(CPA3) 101037789(CPA6) 101040071(CPA5) 101040402(CPA1)
CSYR103255340(CPA6) 103258983(CPA1) 103258994(CPA5) 103275576(CPA3)
MMUR105857512(CPA6) 105881240(CPA3) 105884872(CPA5) 105884873(CPA1)
OGA100955544(CPA3) 100962964(CPA1) 100966497(CPA6) 105888345(CPA5)
MMU109697(Cpa1) 12873(Cpa3) 329093(Cpa6) 74649(Cpa5)
MCAL110290954(Cpa3) 110292762(Cpa6) 110296173(Cpa5) 110296742(Cpa1)
MPAH110316552(Cpa5) 110316651(Cpa1) 110320453(Cpa3) 110338756(Cpa6)
RNO24269(Cpa1) 312913(Cpa6) 408212(Cpa5) 54242(Cpa3)
MCOC116088166(Cpa6) 116094747(Cpa3) 116098044(Cpa1) 116098681(Cpa5)
MUN110550987(Cpa1) 110550995(Cpa5) 110552853(Cpa6) 110563018(Cpa3)
CGE100751382(Cpa3) 100757381(Cpa5) 100757667(Cpa1) 100761681(Cpa6)
PLEU114686244(Cpa3) 114690103(Cpa6) 114691064(Cpa5) 114691065(Cpa1)
NGI103744535(Cpa5) 103744537(Cpa1) 103745992(Cpa3) 103751382(Cpa6)
HGL101699386(Cpa1) 101699746(Cpa5) 101708498(Cpa6) 101715950(Cpa3)
CPOC100715728(Cpa3) 100716045(Cpa6) 100735765(Cpa5) 100736043(Cpa1)
CCAN109682823(Cpa3) 109699192(Cpa5) 109699196(Cpa1) 109699271(Cpa6)
DORD105995978(Cpa3) 105999452(Cpa6) 106001313(Cpa5) 106001321(Cpa1)
DSP122095216(Cpa3) 122095815(Cpa6) 122121850(Cpa5) 122121851(Cpa1)
OCU100345666(CPA6) 100349745(CPA5) 100351403(CPA1) 100355711(CPA3)
OPI101520604(CPA5) 101532640(CPA1) 101532868(CPA6) 101533146(CPA3)
TUP102468722(CPA3) 102486586(CPA6) 102490256(CPA5) 102492627(CPA1)
CFA475192(CPA1) 482257(CPA5) 485707(CPA3) 486983(CPA6)
VVP112928931(CPA5) 112929000(CPA1) 112929989(CPA6) 112932789(CPA3)
VLG121474796(CPA1) 121474890(CPA5) 121478884(CPA3) 121498743(CPA6)
AML100471713(CPA3) 100478795(CPA5) 109488326
UMR103676661(CPA5) 103676701(CPA1) 103678079(CPA3) 103681273(CPA6)
UAH113253074(CPA6) 113254040(CPA3) 113264216(CPA5) 113264226(CPA1)
UAR123788954 123788955(CPA5) 123794528 123800481(CPA6) 123802730(CPA3)
ELK111151528 111151863 111152035 111155383
MPUF101671653(CPA6) 101680516 101692911(CPA3)
ORO101370218(CPA6) 101375838(CPA1) 101376160(CPA3) 101376313(CPA5)
EJU114208957(CPA3) 114211673(CPA1) 114211736(CPA5) 114215967(CPA6)
ZCA113911394(CPA5) 113911858(CPA1) 113916954(CPA3) 113936753(CPA6)
MLX118004928(CPA3) 118014898(CPA6) 118020564(CPA5) 118021086(CPA1)
FCA101082429(CPA3) 101089089(CPA5) 101089929(CPA1) 101093080(CPA6)
PYU121028334(CPA1) 121028335(CPA5) 121033806(CPA3) 121038151(CPA6)
PBG122488739(CPA5) 122488740(CPA1) 122491877(CPA3) 122495465(CPA6)
PTG102965372(CPA1) 102966038(CPA5) 102967903(CPA3) 102972645(CPA6)
PPAD109260711(CPA3) 109268987(CPA5) 109268992 109269315(CPA6)
AJU106971274(CPA6) 106973907(CPA5) 106973908(CPA1) 106975220(CPA3)
HHV120237632(CPA3) 120238688(CPA5) 120238989(CPA1) 120241685(CPA6)
BTA100337371(CPA6) 286762(CPA1) 511416(CPA5) 528454(CPA3)
BOM102265447(CPA3) 102266646 102270897(CPA5) 102271372(CPA1)
BIU109557628 109557630(CPA1) 109559413(CPA3)
BBUB102406290(CPA3) 102406832(CPA1) 102407150(CPA5) 102410083(CPA6)
CHX102173692(CPA3) 102174320(CPA6) 102182943(CPA5) 102183207(CPA1)
OAS101102739(CPA6) 101116902 101117326 101123173(CPA3)
ODA120858402(CPA3) 120877350 120877545 120878646(CPA6)
CCAD122438641(CPA5) 122438643(CPA1) 122445075(CPA3) 122451094(CPA6)
SSC100158041(CPA6) 100513961(CPA5) 100628044(CPA3) 397476(CPA1)
CFR102508209(CPA3) 102510282(CPA6) 102522976 102523392(CPA1)
CBAI105063079(CPA1) 105063080(CPA5) 105081269(CPA3) 105081443(CPA6)
CDK105085386(CPA5) 105085388(CPA1) 105089508(CPA3) 105096937(CPA6)
BACU103000037(CPA3) 103007986(CPA6) 103017082(CPA5) 103017517(CPA1)
LVE103068506(CPA5) 103068782(CPA1) 103070002(CPA3) 103084923(CPA6)
OOR101272605(CPA1) 101272861(CPA5) 101287149(CPA6) 101290405(CPA3)
DLE111178409(CPA5) 111179172(CPA3) 111182775 111185609(CPA6)
PCAD102974225(CPA3) 102983091(CPA6) 102993675(CPA5) 102993960(CPA1)
PSIU116742505(CPA6) 116753315(CPA3) 116759397(CPA1) 116759488(CPA5)
ECB100050818(CPA3) 100057174(CPA1) 100063218(CPA6) 100071982(CPA5)
EPZ103546320(CPA5) 103546346(CPA1) 103558754(CPA3) 103559068(CPA6)
EAI106829400(CPA6) 106829464(CPA3) 106839554(CPA5) 106839555(CPA1)
MYB102244500(CPA3) 102253809(CPA5) 102254107(CPA1) 102261578(CPA6)
MYD102771945(CPA3) 102774311(CPA1) 102774597(CPA5) 102775107(CPA6)
MMYO118665740(CPA1) 118665741(CPA5) 118670921(CPA6) 118676305(CPA3)
MLF102418649(CPA1) 102418967(CPA5) 102419383(CPA3) 102442148(CPA6)
MNA107532168(CPA6) 107537325(CPA1) 107537392(CPA5) 107543971(CPA3)
PKL118712853(CPA5) 118718343(CPA6) 118719711(CPA1)
HAI109375860(CPA3) 109384611(CPA1) 109384613(CPA5)
DRO112299888(CPA1) 112299893(CPA5) 112300968(CPA3) 112315517(CPA6)
SHON118989149(CPA5) 118989237(CPA1) 118995583(CPA6) 118997939(CPA3)
AJM119051980(CPA6) 119055979(CPA3) 119064268(CPA1) 119064275(CPA5)
PDIC114490926(CPA3) 114507774(CPA5) 114507889(CPA1) 114514750(CPA6)
PHAS123827155(CPA3) 123829772(CPA5) 123829822(CPA1) 123833310(CPA6)
MMF118617282(CPA3) 118620005(CPA5) 118620031(CPA1) 118631748(CPA6)
RFQ117018181(CPA1) 117018184(CPA5) 117033938(CPA6) 117036872(CPA3)
PALE102887668(CPA1) 102889901(CPA5) 102891573(CPA6) 102896116(CPA3)
PGIG120585469(CPA6) 120593772(CPA3) 120600976(CPA5) 120600980(CPA1)
PVP105290204(CPA5) 105290206(CPA1) 105294989(CPA3) 105295086(CPA6)
RAY107512780(CPA5) 107512818(CPA1) 107513402(CPA3) 107514826(CPA6)
MJV108383744(CPA1) 108383746(CPA5) 108387497(CPA6) 108388612(CPA3)
TOD119246901(CPA5) 119249734(CPA6) 119250608(CPA1) 119256907(CPA3)
SARA101537988(CPA1) 101538421(CPA6) 101543629(CPA3) 101557877(CPA5)
LAV100675118(CPA3) 100675175(CPA5) 100676313(CPA6)
TMU101341979 101345637 101351516 101351783
DNM101439715(CPA3) 101440457(CPA6) 101447267
MDO100017752(CPA3) 100020573(CPA5) 100028936(CPA6) 100618537(CPA1)
GAS123231677(CPA6) 123241971(CPA3) 123248954 123256182
SHR100913477(CPA6) 100916834 100917098 100928548(CPA3)
PCW110203333(CPA3) 110219021(CPA6) 110219171 110219194
OAA100079424 100079460 100080502(CPA6)
GGA395276(CPA1) 416683(CPA5) 420171(CPA6)
PCOC116236241(CPA6) 116236427 116236453
MGP104910030 104910066 104910360(CPA6)
CJO107310229(CPA6) 107310992 107311154
NMEL110392202 110392203 110394594(CPA6)
APLA101789381 101804024(CPA6) 101805302 113843433
ACYG106030668(CPA6) 106038694 106038764
AFUL116485648(CPA6) 116499113 116501433
TGU100222078(CPA6) 100224866
LSR110478876 110478877 110484799(CPA6)
SCAN103812743(CPA6) 103822464 103822502
PMOA120499291(CPA6) 120502569 120502572
OTC121334167 121334192 121340158(CPA6)
PRUF121351930(CPA6) 121355033 121355036
GFR102040894(CPA6) 102044084 102044252
FAB101811637(CPA6) 101814266 101814452
PHI102104077(CPA6) 102108966 102109153(CPA1)
PMAJ107204466 107204467 107214970(CPA6)
CCAE111923177 111923178 111924668(CPA6)
CCW104692921(CPA6) 104695957 104695958
ETL114067775(CPA6) 114070973 114070974
ZAB102060846(CPA6) 102067885 102068365
FPG101915285(CPA6) 101922598(CPA1) 101922771
FCH102054064(CPA6) 102059678 102059843
CLV102093364(CPA6) 102098115 102098295
EGZ104122389(CPA6) 104123450 104123452
NNI104009675(CPA6) 104010476 104010512
ACUN113477305(CPA6) 113491262
TALA104357525 104358183 104365677(CPA6)
PADL103922804 103922819 103926240(CPA6)
ACHC115340350(CPA6) 115342075 115342076
AAM106484584(CPA6) 106489368 106489371
AROW112971510(CPA6) 112978049 112978111
NPD112944211(CPA6) 112951611 112951620
DNE112992166 112992176 112992268(CPA6)
ASN102370184 102370973(CPA6) 102377914 102378155 102378392
AMJ102563103(CPA1) 102563344 102569985(CPA3) 102577051(CPA6) 106737473
CPOO109316018 109319399(CPA6)
GGN109288134 109292274 109292318 109304941(CPA6)
PSS102453847(CPA6) 102456017 102460506 102460747
CMY102929605 102937934(CPA6) 102942351 102942795
CPIC101930758 101942494 101947906(CPA6) 101950052
TST117871655(CPA6) 117873520 117874110 117883374
CABI116825157 116825158 116839223(CPA6) 116839947
MRV120371995 120373410 120395443 120398486(CPA6)
ACS100555460 100562415 100564029 100564420 100566934(cpa6)
PVT110073047 110073052 110089384(CPA6) 110089538 110089540
SUND121926102 121927003 121927590(CPA6) 121931303 121931315
PBI103050484 103051327(CPA6) 103063807 103064043
PMUR107284827 107284829 107296621(CPA6) 107300115
TSR106537620(CPA1) 106540503(CPA6) 106556019
PGUT117657263 117672869(CPA6) 117678305 117678306
VKO123020441(CPA6) 123024763 123024778 123033052
PMUA114596745 114598143 114600534(CPA6) 114605791
ZVI118090189(CPA6) 118091153 118093695 118093997
GJA107108459(CPA6) 107124661 107124663 107126151 107126158
XLA100126651 108717078 379614(cpa1.S) 379903(cpa6.L) 495367(cpa1.L)
XTR100144967(cpa6) 100494117(cpa3) 105947369 497006(cpa1)
NPR108785191(CPA6) 108795107 108795160 108797313
RTEM120931675 120931676 120931677 120936608 120941099(CPA6)
BBUF120984751 120984768 120986038 121001227(CPA6)
BGAR122925373 122925374 122925375 122935819 122939324(CPA6)
DRE100002342(cpa6) 246092(cpa5) 325886(cpa1)
SRX107707418 107741013 107753533 107753534 107758292
SANH107665736 107665737 107679580 107686690 107695399
SGH107561863 107561864 107585008(cpa6) 107595150
CCAR109048988(cpa6) 109050678 109050683 109057643
CAUA113042257 113043225 113043227 113043258 113043259 113066032 113066750 113066751 113066753
IPU100529045(cbpa1) 108256134(cpa6) 108269091
PHYP113541251(cpa6) 113546600 113546609
SMEO124385618 124386147 124403843(cpa6)
AMEX103029000 103029424 103046592(cpa6) 111195717
EEE113584988 113590690(cpa6)
TRU100137506(cpa1) 101065753(cpa6) 101068207
TNGGSTEN00019168G001 GSTEN00029814G001
LCO104921508(cpa6) 104930740
NCC104940976 104958691(cpa6)
CGOB115009565(cpa1) 115025585(cpa6)
ELY117261758(cpa5) 117264495(cpa6)
PLEP121950605(cpa5) 121960886(cpa6)
SLUC116036232(cpa5) 116037871(cpa6)
ECRA117938173(cpa6) 117948932(cpa5) 117948934
PFLV114549348(cpa6) 114559689 114559690
GAT120808983(cpa5) 120811864(cpa6)
PPUG119196453 119198274(cpa6)
MSAM119894083 119894084(cpa5) 119909424(cpa6)
CUD121515132 121515165 121515702 121527415(cpa6)
MZE101466641 101466908 101469809(cpa6)
ONL100704779(cpa6) 100708633 100708903
OAU116317505 116317513 116319758(cpa6)
OLA101163471 101163721 101171451(cpa6)
OML112139168 112139176 112151343(cpa6)
XMA102218995 102227745 102235124(cpa6)
XCO114137240(cpa6) 114142466 114142727 114143113
XHE116712388(cpa6) 116716504 116729811
PRET103456656(cpa6) 103465629 103465673
PFOR103139765(cpa6) 103150616 103150617 103150618
PLAI106944643(cpa6) 106964494 106964498 106964500
PMEI106909314(cpa6) 106917183 106917184 106917185
GAF122824321(cpa6) 122836046 122836087(cpa5)
CVG107083209 107083212 107103758(cpa6)
CTUL119777989(cpa6) 119780416(cpa5) 119780425
NFU107373665 107373669(cpa1) 107382901(cpa6)
KMR108230423(cpa6) 108248203(cpa5)
ALIM106513464(cpa6) 106518851(cpa1)
NWH119416049(cpa5) 119426274(cpa6)
AOCE111572477(cpa6) 111572782 111572797 111572798
CSEM103377116(cpa6) 103379591(cpa1)
POV109624458(cpa1) 109629585(cpa6)
SSEN122770587(cpa6) 122776268(cpa5)
HHIP117754139(cpa6) 117762950(cpa5)
LCF108881799(cpa6) 108894026(cpa1)
SDU111220928(cpa6) 111222466(cpa1)
SLAL111655568(cpa1) 111662872(cpa6)
XGL120789997(cpa6) 120793017
HCQ109513694(cpa6) 109530868(cpa1)
BPEC110155108(cpa1) 110160851(cpa6)
MALB109956416(cpa1) 109960137(cpa6)
SASA100195857(cbpa1) 106561558 106573018 106579545 106590408(cpa6) 106598577
OTW112218857(cpa5) 112218859 112233602 112234030(cpa6) 112253490
OMY100305236(cbpa1) 110490931 110499523(cpa5) 110499537 110535317(cpa6)
OGO123991333 123993108 124033557 124033578 124039139
ONE115104923(cpa6) 115109666 115130146 115133965 115133967
SALP111953053 111973119 112069038(cpa1)
SNH120027716 120043586 120043588 120050615 120053524 120053526
ELS105018296 105018297 105019581(cpa6)
SFM108918689 108918705 108935422(cpa6)
PKI111834784(cpa6) 111836010(cpa1)
AANG118219219 118224663(cpa6)
LOC102685329 102685663 102685946 102690075(cpa6)
PSPA121314342(cpa6) 121319880 121320260
ARUT117394977(cpa6) 117415967 117416000 117420108
LCM102353603(CPA1) 102358269(CPA6)
CMK103174486(cpa6) 103176959
RTP109915918 109917249 109922326
SCLV120339097 120339102 120342892 120343452
SPU100893878 115918269 115918837 574780 580915 582373 585090
APLC110979624 110982245
DER6541771
DSIDsimw501_GD22482(Dsim_GD22482)
DSR110182699
DPODpse_GA15002 Dpse_GA16855 Dpse_GA22915
DPE6588908 6600361
DMN108162233 108164704 108165577
DWI6641539
DMODmoj_GI12970 Dmoj_GI16517
DAZ108610671 108613555
DNV108649789 108650139
DHE111594723 111596233 111601087
DVI6635619
MDE101901386
LCQ111682466
AGAAgaP_AGAP001026 AgaP_AGAP006207 AgaP_AGAP008070 AgaP_AGAP009593(CBPA1_ANOGA)
ACOZ120948630 120950284 120956760 120959847 120960062
AARA120893703 120904328 120904329
AAG5572631
AALB109408645 109408648 109622197 109622199 115269806 115270435
CQUCpipJ_CPIJ010801 CpipJ_CPIJ010804 CpipJ_CPIJ010805
CPII120414177 120416861 120428198 120428547
AME551524
CCAL108632844
OBB114878079
ACEP105624211
PBAR105423967
LHU105667677
PGC109858005
OBO105278203
PCF106785794
NVI100113905 100124174
CSOL105362431 105368087
TCA107398413
BMAN114243901
DPLKGM_204784 KGM_207527
ZCE119831915
HAW110373523
OFU114362868
AGS114126387
CLEC106667093
HHAL106687671
NLU111043555
PHUPhum_PHUM564730
FOC113202904 113202905 113208503
FCD110851001 110862267
DPXDAPPUDRAFT_130340 DAPPUDRAFT_304390 DAPPUDRAFT_304918 DAPPUDRAFT_93775
DMK116922708 116925405 116925412 116927444 116927454 116927939 116928904 116936010 123467327 123467328 123467331 123467602 123470645 123472377 123474613 123474682 123475332 123475393 123475394 123475395 123475396
PVM113805827 113812351 113825742 113825764
PJA122242843 122259615 122263378
HAME121858694 121861029
PTRU123510896 123514704
HAZT108668906 108668907 108673893
EAF111698974 111703044 111706706 111708349
DSV119464488
RSAN119378625
RMP119176733
TUT107359313
DPTE113793445
DFR124492383 124492384
SDM118179331
TSPTsp_08243
PCAN112558251
GAE121388609
HRF124148261 124148262
HRJ124252758 124269187 124272425 124272436 124286232 124291302
MMER123543132
EGLEGR_11281
EPA110245250
XEN124434223
AQU100638497
ACANACA1_057490 ACA1_290560
EHXEMIHUDRAFT_115016 EMIHUDRAFT_217682 EMIHUDRAFT_242119
 » show all
Reference
1
  Authors
Petra, P.H.
  Title
Bovine procarboxypeptidase and carboxypeptidase A.
  Journal
Methods Enzymol 19:460-503 (1970)
Reference
2  [PMID:5140186]
  Authors
Reeck GR, Walsh KA, Neurath H.
  Title
Isolation and characterization of carboxypeptidases A and B from activated pancreatic juice.
  Journal
Biochemistry 10:4690-8 (1971)
DOI:10.1021/bi00801a015
Reference
3  [PMID:7371832]
  Authors
Everitt MT, Neurath H.
  Title
Rat peritoneal mast cell carboxypeptidase: localization, purification, and enzymatic properties.
  Journal
FEBS Lett 110:292-6 (1980)
DOI:10.1016/0014-5793(80)80095-0
Reference
4  [PMID:7018567]
  Authors
Bodwell JE, Meyer WL.
  Title
Purification and characterization of carboxypeptidase A from rat skeletal muscle.
  Journal
Biochemistry 20:2767-77 (1981)
DOI:10.1021/bi00513a010
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.1
IUBMB Enzyme Nomenclature: 3.4.17.1
ExPASy - ENZYME nomenclature database: 3.4.17.1
BRENDA, the Enzyme Database: 3.4.17.1
CAS: 11075-17-5

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