KEGG   ENZYME: 3.4.17.10
Entry
EC 3.4.17.10                Enzyme                                 
Name
carboxypeptidase E;
carboxypeptidase H;
enkephalin convertase;
cobalt-stimulated chromaffin granule carboxypeptidase;
insulin granule-associated carboxypeptidase;
enkephalin convertase;
membrane-bound carboxypeptidase;
carboxypeptidase E;
enkephalin-precursor endopeptidase;
enkephalin precursor carboxypeptidase;
peptidyl-L-lysine(-L-arginine) hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Release of C-terminal arginine or lysine residues from polypeptides
Comment
A zinc enzyme, activated by Co2+. Inhibited by 1,10-phenanthroline and other chelating agents. pH optimum 5.6. Located in storage granules of secretory cells, and active in processing of protein hormones and bioactive peptides. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.10 created 1986, modified 2000
Orthology
K01294  carboxypeptidase E
Genes
HSA1363(CPE)
PTR461592(CPE)
PPS100983801(CPE)
GGO101136106(CPE)
PON100458397(CPE)
NLE100603608(CPE)
MCC708881(CPE)
MCF101926881(CPE)
MTHB126955356
CSAB103236491(CPE)
CATY105597842(CPE)
PANU101015352(CPE)
TGE112624226(CPE)
RRO104663436(CPE)
RBB108521930(CPE)
TFN117086096(CPE)
PTEH111553644(CPE)
CJC100397838(CPE)
SBQ101051920(CPE)
CSYR103260653(CPE)
MMUR105874675(CPE) 109729436
LCAT123638712(CPE)
OGA100946887(CPE)
MMU12876(Cpe)
MCAL110299922(Cpe)
MPAH110336388(Cpe)
RNO25669(Cpe)
MCOC116069370(Cpe)
MUN110549041(Cpe)
CGE100757401(Cpe)
MAUA101837704(Cpe)
PLEU114701081(Cpe)
MORG121462808(Cpe)
MFOT126499468
AAMP119812432(Cpe)
NGI103727151(Cpe)
HGL101719011(Cpe)
CPOC100721385(Cpe)
CCAN109687903(Cpe)
DORD105991112(Cpe)
DSP122125653(Cpe)
NCAR124983676
OCU100343425 100343872 108175425(CPE) 108176236
OPI101534889(CPE)
TUP102501876(CPE)
CFA475492(CPE)
CLUD112654380(CPE)
VVP112926935(CPE)
VLG121481598(CPE)
AML100475157(CPE)
UMR103658128(CPE)
UAH113255825(CPE)
UAR123793170(CPE)
ELK111154849
LLV125093066
MPUF101678770(CPE)
ORO101385133(CPE)
EJU114210192(CPE)
ZCA113925330(CPE)
MLX118022179(CPE)
NSU110588466(CPE)
FCA101080963(CPE)
PYU121027536(CPE)
PBG122474825(CPE)
LRUF124520887
PTG102969754(CPE)
PPAD109262444(CPE)
AJU106967484(CPE)
HHV120243708(CPE)
BTA280753(CPE)
BOM102278899(CPE)
BIU109571486(CPE)
BBUB102396253(CPE)
CHX102191726(CPE)
OAS443028(CPE)
ODA120871433(CPE)
CCAD122451234(CPE)
SSC100037304(CPE)
CFR102519597(CPE)
CBAI105079738(CPE)
CDK105089282(CPE)
VPC102528459(CPE)
BACU103006962(CPE)
LVE103090381(CPE)
OOR101288868(CPE)
DLE111168080(CPE)
PCAD102974139(CPE)
PSIU116754566(CPE)
ECB100061513(CPE)
EPZ103568033(CPE)
EAI106837735(CPE)
MYB102263369(CPE)
MYD102762285(CPE)
MMYO118658780(CPE)
MLF102429035(CPE)
MNA107525575(CPE)
PKL118711121(CPE)
HAI109386961(CPE)
DRO112312334(CPE)
SHON118995374(CPE)
AJM119045727(CPE)
PDIC114503104(CPE)
PHAS123814186(CPE)
MMF118615627(CPE)
RFQ117038266(CPE)
PALE102881821(CPE)
PGIG120613477(CPE)
PVP105294494(CPE)
RAY107515593(CPE)
MJV108387541(CPE)
TOD119257954(CPE)
SARA101554844(CPE)
LAV100673979(CPE)
TMU101342305
DNM101444929(CPE)
MDO100021886(CPE)
GAS123251233(CPE)
SHR111721570(CPE)
PCW110200932(CPE)
OAA100078274(CPE)
GGA422424(CPE)
PCOC116243178(CPE)
MGP100551301(CPE)
CJO107313017(CPE)
NMEL110398417(CPE)
APLA101791161(CPE)
ACYG106032323(CPE)
AFUL116488878(CPE)
TGU100221584(CPE)
LSR110484767(CPE)
SCAN103826220(CPE)
PMOA120497955(CPE)
OTC121348465(CPE)
PRUF121360232(CPE)
GFR102034548(CPE)
FAB101815330(CPE)
PHI102111561(CPE)
PMAJ107203328(CPE)
CCAE111927887(CPE)
CCW104690531(CPE)
CBRC103620013(CPE)
ETL114057538(CPE)
ZAB102069103(CPE)
ACHL103809154(CPE)
FPG101918946(CPE)
FCH102052005(CPE)
CLV102087027(CPE)
EGZ104124050(CPE)
NNI104021257(CPE)
PLET104626704(CPE)
PCRI104038496(CPE)
ACUN113479706(CPE)
TALA104368407(CPE)
PADL103916249(CPE)
AFOR103893300(CPE)
ACHC115346193(CPE)
HALD104322196(CPE)
CCRI104162802
EHS104515669(CPE)
CMAC104480875(CPE)
MUI104537389(CPE)
GSTE104260520(CPE)
LDI104354164(CPE)
MNB103782555
OHA104331660(CPE)
NNT104404419(CPE)
DPUB104303885(CPE)
PGUU104470152(CPE)
AVIT104268450(CPE)
CVF104294196(CPE)
AAM106484070(CPE)
AROW112965910(CPE)
NPD112949287(CPE)
TGT104573404(CPE)
DNE112997086(CPE)
SCAM104145583(CPE)
ASN102374554(CPE)
AMJ102570894(CPE)
CPOO109309600(CPE)
GGN109300374(CPE)
PSS102449554(CPE)
CMY102930293(CPE)
CPIC101943255(CPE)
TST117878114(CPE)
CABI116827603(CPE)
MRV120406062(CPE)
ACS100552346(cpe)
PVT110083481(CPE)
SUND121930497(CPE)
PBI103058963(CPE)
PMUR107290874(CPE)
CTIG120309828(CPE)
TSR106550762(CPE)
PGUT117662129(CPE)
VKO123023786(CPE)
PMUA114604300(CPE)
ZVI118083969(CPE)
GJA107110627(CPE)
STOW125439835(CPE)
XLA100158368(cpe.L) 100158417(cpe.S)
XTR100127580(cpe)
NPR108788888(CPE)
RTEM120920642(CPE)
BBUF120990090(CPE)
BGAR122940227(CPE)
DRE407979(cpe)
SRX107745061 107750458
SANH107655967(cpe) 107702282
SGH107548348 107591555
CCAR109046543(cpe) 109046548
CAUA113044229 113106919
PPRM120493796(cpe)
MAMB125272611(cpe)
IPU108260799(cpe)
PHYP113544333(cpe)
SMEO124381331(cpe)
TFD113660783(cpe)
AMEX111195201(cpe)
EEE113591222(cpe)
TRU101070693(cpe)
TNGGSTEN00007231G001
LCO104933865(cpe)
NCC104962900(cpe)
CGOB115015126(cpe)
ELY117255829(cpe)
EFO125886266(cpe)
PLEP121942156(cpe)
SLUC116034347(cpe)
ECRA117960642(cpe)
ESP116704374(cpe)
PFLV114566924(cpe)
GAT120825000(cpe)
PPUG119217592(cpe)
MSAM119898811(cpe)
CUD121507993(cpe)
ALAT119027826(cpe)
MZE101480085(cpe)
ONL100534407(cpe)
OAU116334014(cpe)
OLA101160712(cpe)
OML112137512(cpe)
XMA102232385(cpe)
XCO114144234(cpe)
XHE116719994(cpe)
PRET103460607(cpe)
PFOR103136388(cpe)
PLAI106964573(cpe)
PMEI106908328(cpe)
GAF122830419(cpe)
CVG107090485(cpe)
CTUL119774385(cpe)
GMU124868423(cpe)
NFU107374118(cpe)
KMR108231654(cpe)
ALIM106525845(cpe)
NWH119422561(cpe)
AOCE111580244(cpe)
MCEP125003516(cpe)
CSEM103384084(cpe)
POV109638274(cpe)
SSEN122771477(cpe)
HHIP117764932(cpe)
HSP118121169(cpe)
LCF108893107 108902176
SDU111216731(cpe)
SLAL111657367(cpe)
XGL120800168(cpe)
HCQ109511155(cpe)
BPEC110167556(cpe)
MALB109972120(cpe)
BSPL114859327(cpe)
SASA106592377 106592880 106594914
STRU115183510(cpe)
OTW121844277(cpe)
OMY110510809 118936622
OGO124020868(cpe)
CCLU121563415 123487058
ELS105007587(cpe)
SFM108924563(cpe)
PKI111837357(cpe)
AANG118228457(cpe)
LOC102686261(cpe) 102695460
PSPA121295375(cpe) 121322832
ARUT117408479 117420719(cpe)
LCM102345755 102363651(CPE)
CMK103177339(cpe)
RTP109915800(cpe)
BFO118405757 118411334 118414102 118422385
BBEL109466686 109479053 109480702 109485318
CIN100184198
SCLV120347184
SPU115919038 590436 757239
APLC110976275 110986515
SKO100368040
RZE108358568
TCA661126
DPA109538435
SOY115882691
ATD109593965
CSET123319356
AGB108917877
LDC111505098
NVL108563898
APLN108741549
PPYR116165092
OTU111421511
BMOR101740426
BMAN114250849
MSEX115441111
DPLKGM_200937
BANY112045970
NIQ126768773
PMAC106712963 106714818
PPOT106105530
PXU106125479
HAW110378989
HZE124630178
TNL113502436
SLIU111349548
OFU114362897
PXY105382852 105388226
CFEL113366348 113376800
API100159898 115033052
DNX107171599
AGS114128358
RMD113556847
DCI103511299 103521155
CLEC106669270
HHAL106686022
NLU111062089
PHUPhum_PHUM596800
FOC113217969
TPAL117653319
ZNE110838058
CSEC111868526
FCD110856293
DPXDAPPUDRAFT_40462
DMK116925273
PVM113808692
PJA122246247
PCHN125041360
HAME121873826
PCLA123745847
PTRU123505756
HAZT108673835
EAF111705493 111711764 111716728
PPOI119104600
DSV119436558
RSAN119400022
RMP119161543
TUT107369460
DPTE113790810
DFR124496680
CSCU111624417
PTEP107447793
SDM118184077
CELCELE_F01D4.4(egl-21)
CBRCBG_08337(Cbr-egl-21)
BMYBM_BM3120(Bma-egl-21)
LOALOAG_14773 LOAG_15234
NAINECAME_11860
TSPTsp_07700 Tsp_12941
HROHELRODRAFT_112638
LGILOTGIDRAFT_52083
PCAN112557565
BGT106062212
GAE121378413
HRF124121096
HRJ124262979 124266140
CRG105329096
MYI110448592
PMAX117332941
MMER123564605
OBI106873361
OSN115223914
LAK106176829
OVIT265_14439
ACANACA1_163930
 » show all
Reference
1  [PMID:10206965]
  Authors
Qian Y, Varlamov O, Fricker LD.
  Title
Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway.
  Journal
J Biol Chem 274:11582-6 (1999)
DOI:10.1074/jbc.274.17.11582
Reference
2
  Authors
Fricker, L.D.
  Title
Carboxypeptidase E/H.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 1341-1344.
Reference
3
  Authors
Fricker, L.D.
  Title
Methods for studying carboxypeptidase E.
  Journal
Methods Neurosci 23:237-250 (1995)
Reference
4  [PMID:2334405]
  Authors
Manser E, Fernandez D, Loo L, Goh PY, Monfries C, Hall C, Lim L.
  Title
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.
  Journal
Biochem J 267:517-25 (1990)
DOI:10.1042/bj2670517
  Sequence
[hsa:1363] [rno:25669]
Reference
5  [PMID:2897826]
  Authors
Fricker LD.
  Title
Carboxypeptidase E.
  Journal
Annu Rev Physiol 50:309-21 (1988)
DOI:10.1146/annurev.ph.50.030188.001521
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.10
IUBMB Enzyme Nomenclature: 3.4.17.10
ExPASy - ENZYME nomenclature database: 3.4.17.10
BRENDA, the Enzyme Database: 3.4.17.10
CAS: 81876-95-1

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