KEGG   ENZYME: 3.4.17.10
Entry
EC 3.4.17.10                Enzyme                                 

Name
carboxypeptidase E;
carboxypeptidase H;
enkephalin convertase;
cobalt-stimulated chromaffin granule carboxypeptidase;
insulin granule-associated carboxypeptidase;
enkephalin convertase;
membrane-bound carboxypeptidase;
carboxypeptidase E;
enkephalin-precursor endopeptidase;
enkephalin precursor carboxypeptidase;
peptidyl-L-lysine(-L-arginine) hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Release of C-terminal arginine or lysine residues from polypeptides
Comment
A zinc enzyme, activated by Co2+. Inhibited by 1,10-phenanthroline and other chelating agents. pH optimum 5.6. Located in storage granules of secretory cells, and active in processing of protein hormones and bioactive peptides. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.10 created 1986, modified 2000
Orthology
K01294  carboxypeptidase E
Genes
HSA: 1363(CPE)
PTR: 461592(CPE)
PPS: 100983801(CPE)
GGO: 101136106(CPE)
PON: 100458397(CPE)
NLE: 100603608(CPE)
MCC: 708881(CPE)
MCF: 101926881(CPE)
CSAB: 103236491(CPE)
CATY: 105597842(CPE)
PANU: 101015352(CPE)
RRO: 104663436(CPE)
RBB: 108521930(CPE)
TFN: 117086096(CPE)
CJC: 100397838(CPE)
SBQ: 101051920(CPE)
MMUR: 105874675(CPE) 109729436
MMU: 12876(Cpe)
MCAL: 110299922(Cpe)
MPAH: 110336388(Cpe)
RNO: 25669(Cpe)
MCOC: 116069370(Cpe)
MUN: 110549041(Cpe)
CGE: 100757401(Cpe)
PLEU: 114701081(Cpe)
NGI: 103727151(Cpe)
HGL: 101719011(Cpe)
CCAN: 109687903(Cpe)
TUP: 102501876(CPE)
CFA: 475492(CPE)
VVP: 112926935(CPE)
VLG: 121481598(CPE)
AML: 100475157(CPE)
UMR: 103658128(CPE)
UAH: 113255825(CPE)
ORO: 101385133(CPE)
ELK: 111154849
MPUF: 101678770(CPE)
EJU: 114210192(CPE)
MLX: 118022179(CPE)
FCA: 101080963(CPE)
PTG: 102969754(CPE)
PPAD: 109262444(CPE)
AJU: 106967484(CPE)
HHV: 120243708(CPE)
BTA: 280753(CPE)
BOM: 102278899(CPE)
BIU: 109571486(CPE)
BBUB: 102396253(CPE)
CHX: 102191726(CPE)
OAS: 443028(CPE)
ODA: 120871433(CPE)
SSC: 100037304(CPE)
CFR: 102519597(CPE)
CDK: 105089282(CPE)
BACU: 103006962(CPE)
LVE: 103090381(CPE)
OOR: 101288868(CPE)
DLE: 111168080(CPE)
PCAD: 102974139(CPE)
ECB: 100061513(CPE)
EPZ: 103568033(CPE)
EAI: 106837735(CPE)
MYB: 102263369(CPE)
MYD: 102762285(CPE)
MMYO: 118658780(CPE)
MNA: 107525575(CPE)
HAI: 109386961(CPE)
DRO: 112312334(CPE)
SHON: 118995374(CPE)
AJM: 119045727(CPE)
MMF: 118615627(CPE)
PALE: 102881821(CPE)
RAY: 107515593(CPE)
MJV: 108387541(CPE)
LAV: 100673979(CPE)
TMU: 101342305
MDO: 100021886(CPE)
SHR: 111721570(CPE)
PCW: 110200932(CPE)
OAA: 100078274(CPE)
GGA: 422424(CPE)
PCOC: 116243178(CPE)
MGP: 100551301(CPE)
CJO: 107313017(CPE)
NMEL: 110398417(CPE)
APLA: 101791161(CPE)
ACYG: 106032323(CPE)
TGU: 100221584(CPE)
LSR: 110484767(CPE)
SCAN: 103826220(CPE)
PMOA: 120497955(CPE)
GFR: 102034548(CPE)
FAB: 101815330(CPE)
PHI: 102111561(CPE)
PMAJ: 107203328(CPE)
CCAE: 111927887(CPE)
CCW: 104690531(CPE)
ETL: 114057538(CPE)
FPG: 101918946(CPE)
FCH: 102052005(CPE)
CLV: 102087027(CPE)
EGZ: 104124050(CPE)
NNI: 104021257(CPE)
ACUN: 113479706(CPE)
PADL: 103916249(CPE)
AAM: 106484070(CPE)
ASN: 102374554(CPE)
AMJ: 102570894(CPE)
CPOO: 109309600(CPE)
GGN: 109300374(CPE)
PSS: 102449554(CPE)
CMY: 102930293(CPE)
CPIC: 101943255(CPE)
TST: 117878114(CPE)
CABI: 116827603(CPE)
ACS: 100552346(cpe)
PVT: 110083481(CPE)
PBI: 103058963(CPE)
PMUR: 107290874(CPE)
TSR: 106550762(CPE)
PGUT: 117662129(CPE)
PMUA: 114604300(CPE)
ZVI: 118083969(CPE)
GJA: 107110627(CPE)
XLA: 100158368(cpe.L) 100158417(cpe.S)
XTR: 100127580(cpe)
NPR: 108788888(CPE)
DRE: 407979(cpe)
SANH: 107655967(cpe) 107702282
CCAR: 109046543(cpe) 109046548
IPU: 108260799(cpe)
PHYP: 113544333(cpe)
AMEX: 111195201(cpe)
EEE: 113591222(cpe)
TRU: 101070693(cpe)
LCO: 104933865(cpe)
NCC: 104962900(cpe)
ELY: 117255829(cpe)
PLEP: 121942156(cpe)
SLUC: 116034347(cpe)
GAT: 120825000(cpe)
MSAM: 119898811(cpe)
CUD: 121507993(cpe)
MZE: 101480085(cpe)
ONL: 100534407(cpe)
OAU: 116334014(cpe)
OLA: 101160712(cpe)
OML: 112137512(cpe)
XMA: 102232385(cpe)
XCO: 114144234(cpe)
XHE: 116719994(cpe)
PRET: 103460607(cpe)
CVG: 107090485(cpe)
NFU: 107374118(cpe)
KMR: 108231654(cpe)
ALIM: 106525845(cpe)
AOCE: 111580244(cpe)
CSEM: 103384084(cpe)
POV: 109638274(cpe)
SDU: 111216731(cpe)
SLAL: 111657367(cpe)
XGL: 120800168(cpe)
HCQ: 109511155(cpe)
BPEC: 110167556(cpe)
MALB: 109972120(cpe)
ELS: 105007587(cpe)
SFM: 108924563(cpe)
PKI: 111837357(cpe)
LOC: 102686261(cpe) 102695460
PSPA: 121295375(cpe) 121322832
ARUT: 117408479 117420719(cpe)
LCM: 102345755 102363651(CPE)
CMK: 103177339(cpe)
RTP: 109915800(cpe)
CIN: 100184198
SCLV: 120347184
SKO: 100368040
TCA: 661126
DPA: 109538435
ATD: 109593965
AGB: 108917877
NVL: 108563898
APLN: 108741549
PPYR: 116165092
OTU: 111421511
BMOR: 101740426
BMAN: 114250849
MSEX: 115441111
BANY: 112045970
PPOT: 106105530
PXU: 106125479
PRAP: 110998514
HAW: 110378989
TNL: 113502436
DNX: 107171599
AGS: 114128358
RMD: 113556847
CLEC: 106669270
NLU: 111062089
ZNE: 110838058
CSEC: 111868526
FCD: 110856293
PVM: 113808692
HAME: 121873826
DSV: 119436558
RSAN: 119400022
RMP: 119161543
TUT: 107369460
DPTE: 113790810
CSCU: 111624417
PTEP: 107447793
SDM: 118184077
CEL: CELE_F01D4.4(egl-21)
CBR: CBG08337(Cbr-egl-21)
BMY: BM_BM3120(Bma-egl-21)
PCAN: 112557565
BGT: 106062212
GAE: 121378413
CRG: 105329096
MYI: 110448592
PMAX: 117332941
OBI: 106873361
LAK: 106176829
 » show all
Reference
1  [PMID:10206965]
  Authors
Qian Y, Varlamov O, Fricker LD.
  Title
Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway.
  Journal
J Biol Chem 274:11582-6 (1999)
DOI:10.1074/jbc.274.17.11582
Reference
2
  Authors
Fricker, L.D.
  Title
Carboxypeptidase E/H.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 1341-1344.
Reference
3
  Authors
Fricker, L.D.
  Title
Methods for studying carboxypeptidase E.
  Journal
Methods Neurosci 23:237-250 (1995)
Reference
4  [PMID:2334405]
  Authors
Manser E, Fernandez D, Loo L, Goh PY, Monfries C, Hall C, Lim L.
  Title
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.
  Journal
Biochem J 267:517-25 (1990)
DOI:10.1042/bj2670517
  Sequence
[hsa:1363] [rno:25669]
Reference
5  [PMID:2897826]
  Authors
Fricker LD.
  Title
Carboxypeptidase E.
  Journal
Annu Rev Physiol 50:309-21 (1988)
DOI:10.1146/annurev.ph.50.030188.001521
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.10
IUBMB Enzyme Nomenclature: 3.4.17.10
ExPASy - ENZYME nomenclature database: 3.4.17.10
BRENDA, the Enzyme Database: 3.4.17.10
CAS: 81876-95-1

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