Entry
Name
glutamate carboxypeptidase;
carboxypeptidase G;
carboxypeptidase G1;
carboxypeptidase G2;
glutamyl carboxypeptidase;
N-pteroyl-L-glutamate hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups
Comment
A zinc enzyme produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp. Its ability to hydrolyse pteroyl-L-glutamate (folic acid) has led to its use as a folate-depleting, antitumour agent. Type example of peptidase family M20
History
EC 3.4.17.11 created 1992
Orthology
K01295 glutamate carboxypeptidase
Genes
PSHI : SAMEA2665130_2422(cpg2)
PHEI : NCTC12003_01198(cpg2)
PFQ : QQ39_05445 QQ39_12875
PRAG : EKN56_12295 EKN56_16790
LRI : NCTC12151_01066(cpg2_1) NCTC12151_01103(cpg2_2) NCTC12151_01603(cpg2_3)
ALIG : NCTC10568_02329(cpg2)
PPR : PBPRA2427(PSPTO257) PBPRA2583(DR2493) PBPRB0711
PGB : H744_1c0163 H744_2c1371
PDS : CAY62_08090 CAY62_09390
PAEB : NCGM1900_3629(cpg2)
PST : PSPTO_2120 PSPTO_2570 PSPTO_3233
PSB : Psyr_1915 Psyr_2261 Psyr_3078
PSYR : N018_08910 N018_10485 N018_11150
PSAV : PSA3335_17465 PSA3335_19340
PAMG : BKM19_011955 BKM19_014145 BKM19_018005 BKM19_027080
PAVL : BKM03_12900 BKM03_16530 BKM03_18810
PVD : CFBP1590__1979(cpg2) CFBP1590__2375 CFBP1590__3152 CFBP1590__3961
PCAB : JGS08_11570 JGS08_15240 JGS08_17235
PCOF : POR16_08680 POR16_10660 POR16_13760
PTRE : I9H09_11305 I9H09_14330 I9H09_16070
PSYI : MME58_09775 MME58_11850 MME58_15705
PAST : N015_11655 N015_12665 N015_17385
PFE : PSF113_1983 PSF113_3505
PLUL : FOB45_03845 FOB45_06340
PBA : PSEBR_a2190 PSEBR_a3733
PBC : CD58_03910 CD58_10520
PSK : U771_13390 U771_27315
PFZ : AV641_11660 AV641_19755
PGG : FX982_03231 FX982_04282
PVK : EPZ47_19085 EPZ47_21705
PBZ : GN234_14280 GN234_28295
PSHH : HU773_013445 HU773_017640
PZA : HU749_012590 HU749_019785
AEI : AOY20_03865 AOY20_03870
PTU : PTUN_a1212 PTUN_b0431
ALT : ambt_03270 ambt_12250
ASP : AOR13_2253 AOR13_661
ASQ : AVL57_09950 AVL57_15275
AAW : AVL56_09095 AVL56_14270
ALE : AV939_08965 AV939_14140
ALZ : AV940_08745 AV940_13880
LLG : 44548918_01291(cpg2)
LJR : NCTC11533_01644(cpg2)
LCJ : NCTC11976_02333(cpg2_1) NCTC11976_03028(cpg2_2)
LWA : SAMEA4504053_1641(cpg2)
LSS : NCTC12082_00830(cpg2_1) NCTC12082_02275(cpg2_2)
LADL : NCTC12735_01935(cpg2)
LCAD : PXX05_06595 PXX05_06825
GAI : IMCC3135_10410(cpg2)
HTT : HZS52_01160 HZS52_23990
HPRO : LMS44_02660 LMS44_04190
HAA : A5892_03025 A5892_07560 A5892_18325
ENW : MJO57_04420 MJO57_23855
EEI : NX720_04995 NX720_05805
AEM : CK911_10130 CK911_12180
AEL : NCTC12917_01343(cpg2)
AJD : I6H43_03565 I6H43_16015
CDIZ : CEDIAZO_02420(cpg2)
RSM : CMR15_10307(cgp2) CMR15_mp10239
RSY : RSUY_00620(cpg2_1) RSUY_36030(cpg2_2)
RPJ : N234_10835 N234_26340 N234_26600
RIN : ACS15_3475 ACS15_4659
RPU : CDC45_15800 CDC45_18980
REH : H16_B1105(h16_B1105)
CNC : CNE_2c10660(cpg1) CNE_2c19870(cpg2)
CUH : BJN34_22155 BJN34_27210
CTI : RALTA_B0928(cgp2) RALTA_B1901
CBW : RR42_m0075 RR42_s1258 RR42_s1393 RR42_s1394
CCUP : BKK81_02795 BKK81_27210 BKK81_31560
CUP : BKK80_02140 BKK80_24790 BKK80_29110
CUU : BKK79_10130 BKK79_30485 BKK79_35065
CCAM : M5D45_00200 M5D45_25470
CCAX : KZ686_11375 KZ686_21240
PLG : NCTC10937_03115(cpg2_1) NCTC10937_04404(cpg2_2)
BHZ : ACR54_02309(cpg2_1) ACR54_04317(cpg2_2)
BTRM : SAMEA390648700925(cpg2)
BBRO : BAU06_12270 BAU06_23570
BFZ : BAU07_14215 BAU07_23765
BPDZ : BBN53_01495 BBN53_10275
BOH : AKI39_11490 AKI39_21665 AKI39_22550
BGM : CAL15_01990 CAL15_21865
AXY : AXYL_00387 AXYL_03401
AXO : NH44784_017821 NH44784_044851
AXN : AX27061_0423 AX27061_2655
AXX : ERS451415_00418(cpg2_1) ERS451415_02638(cpg2_2)
ADT : APT56_02245 APT56_15105
AIS : BUW96_06980 BUW96_27720
ACHR : C2U31_06920 C2U31_21165
ACHB : DVB37_01835 DVB37_12600
ADY : HLG70_05905 HLG70_19800 HLG70_26120
ACHO : H4P35_01895 H4P35_12340
AMUI : PE062_09025 PE062_25900
PACR : FXN63_08005 FXN63_20875
ACK : C380_03495 C380_12455
ACIO : EAG14_09630 EAG14_18415
AMON : H9L24_04170 H9L24_12365
AANT : HUK68_11035 HUK68_21110
DEL : DelCs14_0062 DelCs14_0954 DelCs14_5141
DTS : BI380_17825 BI380_22035 BI380_26860
DHK : BO996_02695 BO996_06975 BO996_26370
DLA : I6G47_17680 I6G47_21985 I6G47_27420
VAP : Vapar_1543 Vapar_1560 Vapar_4731
VPE : Varpa_1683 Varpa_1715 Varpa_4614 Varpa_5372
VPD : VAPA_1c16380 VAPA_1c48900 VAPA_1c49950
VBO : CKY39_09565 CKY39_09755 CKY39_24400 CKY39_29385
VAM : C4F17_10640 C4F17_10725 C4F17_22405 C4F17_29840
CTES : O987_00200 O987_01140
CODO : LAD35_10395 LAD35_11655 LAD35_19940
LIH : L63ED372_00416(cpg2)
CPRA : CPter91_0559 CPter91_1351 CPter91_2716 CPter91_3594
MUM : FCL38_23925 FCL38_25800
DUG : HH213_04945 HH213_14430
SUTT : SUTMEG_09670 SUTMEG_19470
SUTK : FG381_00530 FG381_05785
SWS : I6J16_00630 I6J16_06010
XYK : GT347_22000 GT347_26595
BBAY : A4V04_08300 A4V04_12300
URU : DSM104443_02352(cpg2_1) DSM104443_02563(cpg2_2) DSM104443_03168(cpg2_3)
UPL : DSM104440_02294(cpg2)
BEBA : BWI17_14165 BWI17_15455
OPS : A8A54_16305 A8A54_18440
BJA : bll0789(bll0789) bll3749(bll3749) blr5597(blr5597) blr7006(blr7006)
BJU : BJ6T_07930 BJ6T_15280 BJ6T_24010 BJ6T_41460 BJ6T_61330
BJP : RN69_03900 RN69_07550 RN69_11730 RN69_20140 RN69_29700
BRA : BRADO0047 BRADO2922 BRADO6431
BBT : BBta_0052 BBta_1203 BBta_5255
BRS : S23_00390 S23_12990 S23_26530
AOL : S58_00520 S58_46920 S58_65500
BRC : BCCGELA001_00190 BCCGELA001_05080 BCCGELA001_23815 BCCGELA001_31390
BRAD : BF49_0040 BF49_1296 BF49_4500 BF49_6054 BF49_7362
BIC : LMTR13_00815 LMTR13_16055
BRO : BRAD285_2666 BRAD285_7623
BRK : CWS35_05370 CWS35_11680 CWS35_28530 CWS35_29980
BOT : CIT37_10300 CIT37_20060 CIT37_26345 CIT37_35175
BRQ : CIT40_20005 CIT40_26380 CIT40_31465
BGQ : X265_00200 X265_08070 X265_15660 X265_24575
BGZ : XH91_00220 XH91_07440 XH91_13420 XH91_21785
BSYM : CIT39_19340 CIT39_25370 CIT39_30520
BBET : F8237_14645 F8237_21325 F8237_28300
BARH : WN72_00225 WN72_07790 WN72_10710 WN72_20115 WN72_31155 WN72_43840
BVZ : BRAD3257_0039 BRAD3257_0947(cpg) BRAD3257_3510 BRAD3257_5284(cpg) BRAD3257_7928
BEL : BE61_09540 BE61_18590 BE61_44230 BE61_77620
BDG : LPJ38_03555 LPJ38_09380 LPJ38_12620 LPJ38_30180
BSEP : HAP48_0006020 HAP48_0009905 HAP48_0016305 HAP48_0033950 HAP48_0045525
BQB : J4P68_0004690 J4P68_0014520 J4P68_0020145 J4P68_0035230
BSEI : KMZ68_00180 KMZ68_17250
BBAN : J4G43_000250 J4G43_007155 J4G43_010290 J4G43_020570 J4G43_033565
BCAN : BcanWSM471_00420 BcanWSM471_16220 BcanWSM471_24755 BcanWSM471_30615
RBK : E0H22_04645 E0H22_17535
VGO : GJW-30_1_00280(cpg2_1) GJW-30_1_00281(cpg2_2) GJW-30_1_00785(cpg2_3) GJW-30_1_02687(cpg2_4) GJW-30_1_03869(cpg2_5)
TRB : HB776_12955 HB776_21860
BOP : AXW83_03090 AXW83_22860 AXW83_25200
BOS : BSY19_1366 BSY19_3033 BSY19_3957
BVV : BHK69_10140 BHK69_21970 BHK69_28420
BOI : BLM15_04580 BLM15_15820
BOF : FQV39_04210 FQV39_13090 FQV39_15480
MRD : Mrad2831_0896 Mrad2831_2417
MAQU : Maq22A_c01095(argE) Maq22A_c22390(argE)
MPHY : MCBMB27_00491 MCBMB27_02036
METX : A3862_18665 A3862_26095
MMES : MMSR116_26770 MMSR116_27070
MTEA : DK419_19940 DK419_28105
MIND : mvi_15610 mvi_39130
MIV : C4E04_12085 C4E04_14680 C4E04_17970
CHEL : AL346_14000 AL346_19595
CDQ : BOQ54_06660 BOQ54_10300
RHZ : RHPLAN_28730 RHPLAN_70280
CMET : K6K41_00175 K6K41_07525
SIW : GH266_02350 GH266_20755
PHR : C6569_01760 C6569_03735 C6569_05110 C6569_07245
PSTG : E8M01_19580 E8M01_22100 E8M01_33525
ACUT : MRB58_07255 MRB58_22885 MRB58_24255
PHB : HYN04_06440 HYN04_10715
BVY : NCTC9239_01104(cpg2)
TSV : DSM104635_02383(cpg2)
SPSE : SULPSESMR1_00342(cpg2)
AHT : ANTHELSMS3_04769(cpg2)
PPRU : FDP22_00415 FDP22_19060
NRE : BES08_02400 BES08_10015 BES08_23385
NOV : TQ38_014145 TQ38_018465 TQ38_020950 TQ38_023865
NOT : C7W88_04905 C7W88_16220
NOR : FA702_09100 FA702_10645
NGF : FRF71_00775 FRF71_05730
NOG : GKE62_03225 GKE62_11745 GKE62_14850
SPHK : SKP52_15225 SKP52_17920
SPHP : LH20_08755 LH20_16380
SMAG : AN936_04375 AN936_16325
SMAZ : LH19_16615 LH19_18805
STER : AOA14_02620 AOA14_04180
SGI : SGRAN_2745(cpg2) SGRAN_3458
SPHQ : BWQ93_00215 BWQ93_13075
SPHO : C3E99_05140 C3E99_12095
SPHX : E5675_02945 E5675_06320
SPHU : SPPYR_0180 SPPYR_0850 SPPYR_1233
SPHD : HY78_01510 HY78_24045
RDI : CMV14_12365 CMV14_15610
SPHM : G432_01265 G432_01865
SSAN : NX02_15345 NX02_27790
SKR : BRX40_16430 BRX40_19610
SPLM : BXU08_05250 BXU08_11635
SPKC : KC8_02720 KC8_03470
SPHC : CVN68_04795 CVN68_19990
SLUT : H9L13_04745 H9L13_05105
SLAN : GV829_04735 GV829_09745
SSED : H9L14_03635 H9L14_11320
SPAP : H3Z74_09745 H3Z74_11640
SPII : G7077_02590 G7077_09120
SARI : H5J25_06640 H5J25_09910
SCHY : GVO57_06640 GVO57_12400
SSUA : FPZ54_01530 FPZ54_07955
SBIN : SBA_ch1_18290 SBA_ch1_25340
SAER : NEF64_02615 NEF64_10505
SQO : NMP03_05890 NMP03_09490
SCAB : LZK98_07910 LZK98_10075
SPHR : BSY17_2906 BSY17_381
SHYD : CJD35_00970 CJD35_12695
SYA : A6768_09220 A6768_10465
SPYG : YGS_C1P1033 YGS_C1P1467
SPPH : KFK14_06385 KFK14_08385
SPHG : AZE99_04975 AZE99_11340
SFLA : SPHFLASMR4Y_01345(cpg2)
BLAS : BSY18_1885 BSY18_3547
BFW : B5J99_00270 B5J99_08530
PALG : HFP57_02590 HFP57_08900
SPHS : ETR14_05780 ETR14_20140 ETR14_22825
POQ : KZX46_07730 KZX46_14155
PMEA : KTC28_03430 KTC28_12320
AEP : AMC99_00857 AMC99_01352
ALH : G6N82_00210 G6N82_13285
ERY : CP97_08030 CP97_11460
EGN : BMF35_a0016 BMF35_a1705
EFV : CHH26_05395 CHH26_07375
QCI : NCF85_07095 NCF85_09560
ERR : DVR09_10720 DVR09_12740
EMV : HQR01_02560 HQR01_10400
RGI : RGI145_06160 RGI145_11940 RGI145_13005
ROS : CTJ15_05380 CTJ15_11245 CTJ15_23370
RMUC : FOB66_07965 FOB66_13805 FOB66_14655
RMT : IAI58_06355 IAI58_09165 IAI58_14125 IAI58_20635
RCV : PFY06_03500 PFY06_04500 PFY06_12145
SRF : LHU95_00955 LHU95_15705 LHU95_17505
SHUM : STHU_06870 STHU_35860
SVC : STVA_28770 STVA_33050 STVA_45570
STEL : STAQ_06470 STAQ_24230 STAQ_35680
SKT : IGS68_07990 IGS68_08690
SMUC : JL100_018690 JL100_019605
SROE : JL101_017425 JL101_018345
ELIO : KO353_05045 KO353_05210 KO353_08310
NACI : NUH88_03960 NUH88_08360 NUH88_15500
DFI : AXF13_05625 AXF13_05640
DFL : DFE_1411(cpg) DFE_2472(cpg)
DWD : DSCW_28110 DSCW_37830
BFD : NCTC4823_00797(cpg2)
BLE : BleG1_1011 BleG1_3859
ASED : IRT44_08035 IRT44_17950
MEKU : HUW50_14545 HUW50_24490
BBE : BBR47_06280 BBR47_37200
BFM : BP422_13960 BP422_28755
BAGR : BA6348_12500 BA6348_25440
BCHS : JNE38_03495 JNE38_13685 JNE38_18845
BPAB : PSE45_03590 PSE45_17155
ACYC : JI721_05165 JI721_16795
SPOP : SporoP37_11065 SporoP37_12200
SURE : SporoP32a_05075 SporoP32a_11030
CDRK : B9W14_06240 B9W14_09575
PFAA : MM59RIKEN_03830 MM59RIKEN_17120 MM59RIKEN_19320 MM59RIKEN_30450
ACOL : K5I23_03670 K5I23_08490
ETM : CE91St48_04990 CE91St48_12090 CE91St48_37220
BPRS : CK3_07920 CK3_07950 CK3_35190
DHO : Dia5BBH33_04580 Dia5BBH33_12600 Dia5BBH33_12610
AFN : Acfer_0206 Acfer_0764 Acfer_1866
AIN : Acin_0270 Acin_1152 Acin_2162 Acin_2282
PFAC : PFJ30894_00553(cpg2_1) PFJ30894_00554(cpg2_2) PFJ30894_02282(cpg2_3)
NFR : ERS450000_01671(cpg2)
NAH : F5544_15610 F5544_25045
REY : O5Y_04470 O5Y_23670 O5Y_24880
REB : XU06_04710 XU06_24085
RQI : C1M55_04940 C1M55_25240
RHOD : AOT96_04995 AOT96_15345
SVL : Strvi_4051 Strvi_6258
SRC : M271_01565 M271_05115
SVT : SVTN_32325 SVTN_37360
SLC : SL103_15565 SL103_16710 SL103_18405
SGM : GCM10017557_01360 GCM10017557_01660 GCM10017557_82200
STRO : STRMOE7_02840 STRMOE7_04155
SRIM : CP984_00375 CP984_39345
SPLA : CP981_30490 CP981_33665
SNIG : HEK616_48790 HEK616_77450
KAU : B6264_01640 B6264_03130
KIT : CFP65_0970 CFP65_6161
KIS : HUT16_10305 HUT16_29385
LVI : G7068_04920 G7068_05450
RSA : RSal33209_1303 RSal33209_1316
AUL : DCC27_003940 DCC27_003945
SERW : FY030_06530 FY030_06755 FY030_12995
BLY : A2T55_05070 A2T55_16710
BLIN : BLSMQ_0957 BLSMQ_3633
BRI : FDF13_01165 FDF13_04705
BLUT : EW640_09620 EW640_13490
BCAU : I6G59_02665 I6G59_07815
NEX : NE857_04960 NE857_18470
NGN : LCN96_28910 LCN96_41785
AOI : AORI_3072 AORI_4238 AORI_5359
AJA : AJAP_12105 AJAP_17715
AMQ : AMETH_3899 AMETH_4293 AMETH_4593
AMYC : CU254_26115 CU254_33445
AMYB : BKN51_14190 BKN51_19020
AMYY : YIM_20525(cpg1) YIM_20655(cpg2)
AORI : SD37_20045 SD37_21685
AACD : LWP59_21585 LWP59_35750
APRT : MUY14_17230 MUY14_18465
AROO : NQK81_00810 NQK81_40450 NQK81_44865
PHH : AFB00_25520 AFB00_28035
SESP : BN6_27900 BN6_67390
KPHY : AOZ06_22010 AOZ06_37570
ASE : ACPL_2329 ACPL_3781(cpg2)
ACTS : ACWT_2204 ACWT_3653
CATI : CS0771_43040 CS0771_53300
DFU : Dfulv_15525 Dfulv_36655
CCAZ : COUCH_16915 COUCH_24910
RRD : RradSPS_1837 RradSPS_2501
EUZ : DVS28_a2139 DVS28_a3178
CAP : CLDAP_12640 CLDAP_18510
PBF : CFX0092_A1855 CFX0092_A2213
KBS : EPA93_31460 EPA93_35015
PMET : G4Y79_11265 G4Y79_21005
STI : Sthe_0483 Sthe_1638 Sthe_2872
OBG : Verru16b_00221(cpg2)
UAM : UABAM_02587 UABAM_04118
GRW : FTO74_16880 FTO74_19025
TSA : AciPR4_0242 AciPR4_4014
ADIN : H7849_16910 H7849_19420
FVA : FV113G1_17740 FV113G1_26090 FV113G1_29120
FUL : C4N20_08285 C4N20_08315 C4N20_10630 C4N20_13365
GRL : LPB144_05650 LPB144_08910
FBC : FB2170_00445 FB2170_02200
SYI : SB49_08175 SB49_08315
AALG : AREALGSMS7_03977(cpg2)
» show all
Taxonomy
Reference
Authors
Goldman P, Levy CC.
Title
Carboxypeptidase G: purification and properties.
Journal
Reference
Authors
McCullough JL, Chabner BA, Bertino JR.
Title
Purification and properties of carboxypeptidase G 1 .
Journal
J Biol Chem 246:7207-13 (1971)
Reference
Authors
Albrecht AM, Boldizsar E, Hutchison DJ.
Title
Carboxypeptidase displaying differential velocity in hydrolysis of methotrexate, 5-methyltetrahydrofolic acid, and leucovorin.
Journal
Reference
Authors
Sherwood RF, Melton RG, Alwan SM, Hughes P
Title
Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.17.11