KEGG ENZYME: 3.4.17.12

ENZYME: 3.4.17.12

Entry

EC 3.4.17.12                Enzyme

Name

carboxypeptidase M;
CPM

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases

Reaction(IUBMB)

Cleavage of C-terminal arginine or lysine residues from polypeptides

Comment

A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family)

History

EC 3.4.17.12 created 1992

Orthology

K01296

carboxypeptidase M

Genes

HSA:

1368(CPM)

PTR:	452067(CPM)

PPS:	100969689(CPM)

GGO:	101130328(CPM)

PON:	100171502(CPM)

PPYG:

129009952(CPM)

NLE:	100602479(CPM)

HMH:	116478989(CPM)

SSYN:

129461022(CPM)

MCC:	718315(CPM)

MCF:	102138123(CPM)

MTHB:

126931706

MNI:	105473402(CPM)

CSAB:

103238691(CPM)

CATY:

105580996(CPM)

PANU:

101018002(CPM)

TGE:	112634275(CPM)

MLEU:

105537116(CPM)

RRO:	104658666(CPM)

RBB:	108532256(CPM)

TFN:	117089768(CPM)

PTEH:

111528611(CPM)

CANG:

105502660(CPM)

CJC:	100410597(CPM)

SBQ:	101040778(CPM)

CIMI:

108315987(CPM)

ANAN:

105709494(CPM)

CSYR:

103269050(CPM)

MMUR:

105884628(CPM)

LCAT:

123639533(CPM)

PCOQ:

105808419(CPM)

OGA:	100959155(CPM)

MMU:	70574(Cpm)

MCAL:

110304045(Cpm)

MPAH:

110326791(Cpm)

RNO:	314855(Cpm)

MCOC:

116076314(Cpm)

ANU:	117696799(Cpm)

ASYL:

127671272(Cpm)

MUN:	110562244(Cpm)

CGE:	100770407(Cpm)

MAUA:

101832744(Cpm)

PROB:

127215728(Cpm)

PLEU:

114693315(Cpm)

MORG:

121458191(Cpm)

MFOT:

126515658

AAMP:

119803443(Cpm)

NGI:	103745080(Cpm)

HGL:	101724468(Cpm)

CPOC:

100732968(Cpm)

CCAN:

109693329(Cpm)

DORD:

105986885(Cpm)

DSP:	122124079(Cpm)

PLOP:

125361421(Cpm)

NCAR:

124983196

MMMA:

107140072(Cpm)

ITI:	101958492(Cpm)

OCU:	100349485 108176913

OPI:	101519258(CPM)

TUP:	102474632(CPM)

GVR:	103601366(CPM)

CFA:	100685525(CPM)

CLUD:

112677879(CPM)

VVP:	112922195(CPM)

VLG:	121491248(CPM)

NPO:	129511630(CPM)

AML:	100481997(CPM)

UMR:	103656872(CPM)

UAH:	113256293(CPM)

UAR:	123787143(CPM)

ELK:

111142131

LLV:

125107552

MPUF:

101689497(CPM)

MNP:	132019433(CPM)

MLK:	131839137(CPM)

NVS:	122891706(CPM)

ORO:	101386105(CPM)

EJU:	114214944(CPM)

ZCA:	113921845(CPM)

MLX:	118008588(CPM)

NSU:	110570610(CPM)

LWW:	102730370(CPM)

FCA:	101097407(CPM)

PYU:	121040768(CPM)

PCOO:

112863821(CPM)

PBG:	122474008(CPM)

PVIV:

125170534(CPM)

LRUF:

124501297

LGF:	123591365(CPM)

AJU:

106966349

PTG:	102967223(CPM)

PPAD:

109270485(CPM)

PUC:

125919326

PLEZ:

122224814(CPM)

HHV:	120240804(CPM)

BTA:	513281(CPM)

BOM:	102287201(CPM)

BIU:	109559246(CPM)

BBUB:

102402297(CPM)

BBIS:

104989768(CPM)

CHX:	102172872(CPM)

OAS:	101104474(CPM)

BTAX:

128047456(CPM)

CSUM:

138078473(CPM)

ODA:	120857721(CPM)

CCAD:

122427263(CPM)

MREE:

136167227(CPM)

OVR:	110134340(CPM)

MBEZ:

129535572(CPM)

SSC:	100628221(CPM)

CFR:	102522173(CPM)

CBAI:

105081335(CPM)

CDK:	105101084(CPM)

VPC:	102538081(CPM)

BACU:

103017503(CPM)

BMUS:

118901991(CPM)

LVE:	103081156(CPM)

OOR:	101286496(CPM)

LALB:

132529134(CPM)

DLE:	111173760(CPM)

PCAD:

102992832(CPM)

PSIU:

116761019(CPM)

PPHC:

136130940(CPM)

NASI:

112393947(CPM)

ECB:	100059473(CPM)

EPZ:	103558164(CPM)

EAI:	106843580(CPM)

MYB:	102256624(CPM)

MYD:	102770875(CPM)

MMYO:

118650129(CPM)

MLF:	102420573(CPM)

MDT:	132227908(CPM)

MYUM:

139006926(CPM)

PKL:	118729243(CPM)

EFUS:

103292524(CPM)

MNA:	107526849(CPM)

DRO:	112318964(CPM)

SHON:

118989365(CPM)

AJM:	119052718(CPM)

PDIC:

114514175(CPM)

PHAS:

123812982(CPM)

MMF:	118624621(CPM)

PPAM:

129075870(CPM)

HAI:	109381649(CPM)

RFQ:	117029273(CPM)

PALE:

102884706(CPM)

PGIG:

120605044(CPM)

PVP:	105301351(CPM)

RAY:	107512675(CPM)

MJV:	108394492(CPM)

TOD:	119247527(CPM)

SARA:

101546949(CPM)

SFUM:

130038964(CPM)

SETR:

126021880(CPM)

LAV:	100665759(CPM)

TMU:

101349661

ETF:	101658120(CPM)

DNM:	101417155(CPM)

MDO:	100021372(CPM)

GAS:	123248978(CPM)

SHR:	100921178(CPM)

AFZ:

127564479

PCW:	110211047(CPM)

TVP:	118850283(CPM)

PBRV:

138155888(CPM)

OAA:	100080749(CPM)

TACU:

119936584(CPM)

GGA:	417843(CPM)

PCOC:

116226593(CPM)

MGP:	100543962(CPM)

CJO:	107310518(CPM)

TPAI:

128073881(CPM)

LMUT:

125688067(CPM)

NMEL:

110392788(CPM)

APLA:

101789743(CPM)

ACYG:

106045412(CPM)

CATA:

118246863(CPM)

AFUL:

116494980(CPM)

TGU:	100225708(CPM)

LSR:	110477994(CPM)

SCAN:

103813678(CPM)

PMOA:

120499768(CPM)

OTC:	121339479(CPM)

PRUF:

121352550(CPM)

ATRC:

139588294(CPM)

GFR:	102037874(CPM)

FAB:	101813399(CPM)

OMA:	130248664(CPM)

PHI:	102101701(CPM)

PMAJ:

107204719(CPM)

CCAE:

111937509(CPM)

CCW:	104698374(CPM)

CBRC:

103614884(CPM)

ACOE:

138100952(CPM)

ETL:	114062166(CPM)

ZAB:	102062686(CPM)

ZLE:	135442282(CPM)

ACHL:

103799311(CPM)

SVG:	106855282(CPM)

MMEA:

130580185(CPM)

HRT:	120751368(CPM)

SATI:

136361329(CPM)

CCIC:

134043102(CPM)

FPG:	101923955(CPM)

FCH:	102048341(CPM)

CCRI:

104168814(CPM)

NNT:	104410548(CPM)

SHAB:

115605368(CPM)

ACUN:

113491126(CPM)

TALA:

104366267(CPM)

ACHC:

115336120(CPM)

HALD:

104318062(CPM)

HLE:	104828225(CPM)

AGEN:

126034596

HHAR:

128135336(CPM)

GCL:

127020593

CSTI:

104558168(CPM)

LDI:	104344818(CPM)

MNB:	103769979(CPM)

DPUB:

104305551(CPM)

PPUS:

135187289(CPM)

AVIT:

104274688(CPM)

BRHI:

104493673(CPM)

EGZ:	104132947(CPM)

NNI:	104011003(CPM)

PCRI:

104032000(CPM)

PCAO:

104047942(CPM)

PADL:

103920039(CPM)

AFOR:

103893924(CPM)

FGA:	104074509(CPM)

GSTE:

104264417(CPM)

CBOY:

140658948(CPM)

CLV:	102085565(CPM)

CNIC:

135998791(CPM)

MUI:	104538984(CPM)

PGUU:

104471926(CPM)

PLET:

104625311(CPM)

EHS:	104515221(CPM)

CMAC:

104483892(CPM)

CUCA:

104061313(CPM)

TEO:	104380289(CPM)

BREG:

104632747(CPM)

OHA:	104326765(CPM)

ACAR:

104531860(CPM)

CPEA:

104388813(CPM)

CVF:	104288919(CPM)

RTD:	128907965(CPM)

CRID:

134510105(CPM)

AAM:	106488152(CPM)

AROW:

112970417(CPM)

NPD:	112958840(CPM)

TGT:	104574438(CPM)

DNE:	112983355(CPM)

SCAM:

104142043(CPM)

ASN:	102385520(CPM)

AMJ:	102562411(CPM)

CPOO:

109315514(CPM)

GGN:	109295716(CPM)

PSS:	102463630(CPM)

CMY:	102930730(CPM)

CCAY:

125630220(CPM)

DCC:	119845912(CPM)

CPIC:

101936032(CPM)

TST:	117877725(CPM)

CABI:

116834440(CPM)

MRV:	120395545(CPM)

ACS:	100556918(cpm)

ASAO:

132776174(CPM)

PVT:	110075131(CPM)

SUND:

121930776(CPM)

PBI:	103063247(CPM)

PMUR:

107284409(CPM)

CTIG:

120308445(CPM)

TSR:	106538065(CPM)

PGUT:

117655616(CPM)

PCAE:

139319552(CPM)

APRI:

131201823(CPM)

PTEX:

113435767(CPM)

NSS:	113412264(CPM)

VKO:	123033308(CPM)

PMUA:

114605044(CPM)

PRAF:

128422096(CPM)

ZVI:	118090968(CPM)

HCG:	128327320(CPM)

GJA:	107105717(CPM)

STOW:

125434260(CPM)

EMC:	129336010(CPM)

XLA:	108711091(cpm.L) 108713154(cpm.S)

XTR:	496721(cpm)

NPR:	108804545(CPM)

RTEM:

120931988(CPM)

ACAT:

141132074(CPM)

BBUF:

120980570(CPM)

BGAR:

122925810(CPM)

DTC:	141059205(CPM)

PWL:	138288048(CPM) 138302240

MUO:	115478175(CPM)

GSH:	117364356(CPM)

DRE:	550253(cpm)

SRX:	107710685 107728505

SANH:

107666948 107669712

SGH:	107590974(cpm)

CCAR:

109065747 109086964

CAUA:

113048227 113061649

CGIB:

127956866 127972912

PTET:

122342722(cpm)

LROH:

127163924(cpm)

GRF:	141333768(cpm)

OMC:	131539476(cpm)

PPRM:

120476854(cpm)

RKG:	130082682(cpm)

MAMB:

125246446(cpm)

CIDE:

127511042

CERY:

137024562(cpm)

MASI:

127435415 127436819

TROS:

130547665(cpm)

TDW:	130421133(cpm)

MANU:

129432326(cpm)

PDAB:

135760646(cpm)

IPU:

108279953

IFU:	128623402(cpm)

PHYP:

113532257(cpm)

SMEO:

124401660(cpm)

TFD:	113655870(cpm)

TVC:	132859283(cpm)

CGAR:

128534028(cpm)

NGRA:

132869700(cpm)

TRN:

134325141

AMEX:

103028806(cpm)

CMAO:

118812329(cpm)

EEE:	113569671(cpm)

CHAR:

105892307(cpm)

SPIL:

134071256(cpm)

TRU:	101065920(cpm)

TFS:	130519071(cpm)

TNG:	GSTEN00034650G001

LCO:	104931508(cpm)

TBEN:

117485188(cpm)

CGOB:

115006014

PGEO:

117441017(cpm)

GACU:

117559822(cpm)

EMAC:

134879094(cpm)

ELY:	117249497(cpm)

EFO:	125882631(cpm)

SLUC:

116047906(cpm)

ECRA:

117938846(cpm)

ESP:	116673132(cpm)

PFLV:

114550286(cpm)

PPUG:

119210906(cpm)

AFB:	129112469(cpm)

CLUM:

117726362(cpm)

PSWI:

130200868(cpm)

CANA:

137791556(cpm)

CVE:	137866580(cpm)

MSAM:

119896125(cpm)

SCHU:

122871232(cpm)

CUD:	121505674(cpm)

SPUL:

138599806(cpm)

LMIX:

132956337(cpm)

ALAT:

119032365(cpm)

ASTR:

137589318(cpm)

MZE:	101469424(cpm)

ONL:	100694650(cpm)

OAU:	116312820(cpm)

OLA:	101169896(cpm)

OML:	112157427(cpm)

CSAI:

133424067(cpm)

XMA:	102218156(cpm)

XCO:	114161096(cpm)

XHE:	116736968(cpm)

PRET:

103459312(cpm)

PFOR:

103155873

PLAI:

106939951(cpm)

PMEI:

106925010

GAF:	122826414(cpm)

PPRL:

129352873(cpm)

CVG:	107090615(cpm)

CTUL:

119790611(cpm)

GMU:	124883123(cpm)

NFU:	107386863(cpm)

KMR:	108228768(cpm)

ALIM:

106532836(cpm)

NWH:

119428444

AOCE:

111586661(cpm)

EJA:	138213307(cpm)

BFRE:

138633152(cpm)

MCEP:

125000408(cpm)

CSEM:

103382529(cpm)

POV:	109646163(cpm)

SSEN:

122767290(cpm)

SSOE:

131456891(cpm)

HHIP:

117757033(cpm)

HSP:	118101940(cpm)

PPLT:

128429216(cpm)

SMAU:

118287371(cpm)

LCF:	108885735 108895863(cpm)

SDU:	111224538(cpm)

SLAL:

111665929(cpm)

XGL:	120797152(cpm)

HCQ:	109532598(cpm)

SSCV:

125985799(cpm)

SBIA:

133493761(cpm)

PEE:	133397441(cpm)

PTAO:

133471796(cpm)

BPEC:

110161911(cpm)

ENY:	140367388(cpm)

MALB:

109952968(cpm)

BSPL:

114862526(cpm)

SJO:	128353124(cpm)

SSCO:

134004746(cpm)

GMH:	115542460(cpm)

STRU:

115182046 115182933

OTW:	112240098(cpm)

OMY:	110517153 118942834

OGO:	124018752 124018753

OKI:	116360552 116372993

OKE:	127927714(cpm)

OMM:	135515556 135515566 135529152

OCLA:

139379616 139392879 139392881

SALP:

112079471

SNH:	120050144(cpm)

CCLU:

121555439(cpm)

ELS:	105017802(cpm)

OEP:	134037579(cpm)

SFM:	108936551(cpm)

PKI:	111844282 111851094(cpm) 111851214

AANG:

118219042(cpm)

AROT:

135245496(cpm)

CCOG:

133119122(cpm)

LOC:	102692210(cpm)

PSPA:

121317975 121320079

ARUT:

117396714 117414918 117419352

PSEX:

120539582(cpm)

LCM:	102355516(CPM)

CMK:	103184619 103185307(cpm)

RTP:	109928784 109934683

CPLA:

122559327 122564612

HOC:	132824844 132825758

LERI:

129706416 129711950(cpm)

HAKA:

140731212 140734959

PMRN:

116947440(CPM)

LRJ:

133351600

BFO:

118425712

BBEL:

109464542

SPU:	105438690 580514

LPIC:

129282994

AJJ:	139964440 139964441

APLC:

110977803

ARUN:

117291889 117304580

AAMU:

139939925 139952395

AFIL:

140154819

SKO:	100375345 100375539

PFLL:

139143737 139143738 139143739

DME:	Dmel_CG4678(CG4678)

DER:

6550015

DSE:

6617981

DSI:	Dsimw501_GD24843(Dsim_GD24843)

DYA:	Dyak_GE17613

DAN:

6505309

DSR:

110181608

DPO:

4815902

DPE:

6600041

DMN:

108164720

DWI:

6649059

DGR:

6564522

DMO:	Dmoj_GI14727

DAZ:

108618780

DNV:

108656677

DHE:

111605327

DVI:

6631846

CCAT:

101456149

BOD:

106615696

BDR:

105227459

RZE:

108367453

AOQ:

129237711

ALUD:

128857393

TDA:	119666743 119671710

MDE:

101888089

SCAC:

106091030

LCQ:

111690937

LSQ:

119608024

CVJ:

135957080

GFS:

119644631

ECOE:

129948361

CLON:

129618697

HIS:

119657599

AGA:

1272346

ACOZ:

120958697

AARA:

120905640

AMER:

121591387

ASTE:

118517482

AMAP:

126559273

AFUN:

125762114

AMOU:

128306559

AMRS:

128714533

AALI:

118460217

ACOS:

131268950

AAG:

5574253

AALB:

109421998 109424095

ASUA:

134206149 134207156

CQU:	CpipJ_CPIJ019890

CPII:

120415622

CBRI:

134834105

CNS:

116341664

BCOO:

119067301

PPAP:

129806919

AME:

726554

ACER:

107993798 107999567

ALAB:

122719234

ADR:

102670868

AFLR:

100865158

BIM:

100749411

BBIF:

117210447

BVK:

117237893

BVAN:

117158093

BHUN:

126868958

BTER:

100650514

BAFF:

126918937

BPYO:

122577619

BPAS:

132908318

FVI:

122533895

CCAL:

108622736

OBB:

114880420

OLG:

117600160

MGEN:

117222870

NMEA:

116432339

CGIG:

122402996

SOC:

105199420

MPHA:

105830622

AEC:

105154001

ACEP:

105622717

PBAR:

105424849

VEM:

105562695

COBS:

139107341

TLN:

139816049

HST:

105187308

DQU:

106750198

CFO:

105247831

FEX:

115245009

PMEC:

138936000

LHU:

105672794

PGC:

109852697

OBO:

105275236

LHT:

122500823

LBD:

127285834

MDL:

103572139

CGLO:

123265191

FAS:

105270050

DAM:

107043863

AGIF:

122857402 122857406

CINS:

118074500

VCAN:

122414935

CCIN:

107273411

DSM:

124408073

NPT:

124216052

NFB:

124180593

NLO:

107224166

NVG:

124302076

AROA:

105686052

TCA:

103314076

TMOL:

138137818

DPA:

109538330

ESIM:

136419169

EFOR:

136338728

SOY:	115879907 115888420

AGRG:

126745238

ATD:

109603743

CSET:

123312784 123312785 123316880

HAXR:

123683478

AGB:

108903476

LDC:	111502302 111510285

DVV:	114325229 114325232 126884788

NVL:

108563697

APLN:

108740741

PPYR:

116168537 116177988

BMOR:

101744869

BMAN:

114249892

MSEX:

115445183

DPL:	KGM_207768

BANY:

112046213

MJU:

123872640

NIQ:

126773883

VCD:

124533994

MCIX:

123656256

PMAC:

106717926

PPOT:

106108528

PXU:

106115889

BPHI:

137933606

PRAP:

110995092

PBX:

123709942

PNAP:

125049087

ZCE:

119830712

CCRC:

123695948

LSIN:

126975966

AAGE:

121733448

HAW:

110372804

HZE:

124637307

TNL:

113498506

SLIU:

111348027

OFU:

114360961

ONU:

135075207

ATRA:

106137748

GMW:

113520544

PXY:

119692970

PGW:

126371868

LGLY:

125230680

CSTB:

134746147

CFUM:

141437347

CFEL:

113371376 113380821 113381179

CCRN:

123294062

API:	100163058 100163764

DNX:	107168618 107169553

AGS:	114119923 114126292

RMD:	113554587 113555251

ACOO:

126838379 126838396

DVT:	126901175 126902235

BTAB:

109039932

CLEC:

106669957 106672221

HHAL:

106678144 106683340

NLU:	111044577 111064421

HVI:	124367620 124367621 124367995 124372383 124374427

MQU:	128982858 128983213

PHU:	Phum_PHUM098090

FOC:

113217736

TPAL:

117644293

ZNE:	110828034 110831202

CSEC:

111873444

PAME:

138691244 138714857

SGRE:

126341697 126344231

BROR:

134533011 134535087 134540467

IEL:	124158639 124158961

HAMR:

139686686 139691490 139692789

FCD:

110863174

DPX:	DAPPUDRAFT_39340 DAPPUDRAFT_53984

DMK:	116919902 116929845 116936652 123475797

DPZ:	124311077 124327147 124343203

AFRA:

136032051 136037125 136038644

PVM:

113829800

PJA:

122256433

PCHN:

125038708

PMOO:

119598115

HAME:

121870988

PCLA:

123759720

CQD:

128695704

PTRU:

123510544

ESN:

127000193

MNZ:

135202272

MRJ:

136847222

PORN:

139750261

HAZT:

108665321

EAF:	111699046 111705218 111707342

LSM:	121117865 121126808

TCF:	131877530 131888023 131889556

DSV:

119441449

RSAN:

119382704

RMP:

119176760

GOE:

100904639

TUT:

107360791

DPTE:

113794945 113795238

DFR:	124490784 124500326

CSCU:

111634767 111637135

CVS:	136988037 136990454

PTEP:

107446375 107448812

ABRU:

129965638 129965782

UDV:	129232493 129234230

LPOL:

106464156 106467857

PMEO:

129581013

PCAN:

112562506

LSAX:

138975195

GAE:	121366701 121367662 121367665

HRF:

124137854

HRJ:

124283825

HASI:

137255363

CRG:	105343166 109620566

CVN:	111134694 111138443

OED:

125677944

MYI:

110464022

PMAX:

117333121

AIRR:

138331151

MCAF:

127712274

MMER:

123528645 123534002

RPHI:

132719871 132741949

DPOL:

127831765 127853752 127873876

MAEA:

128207267 128221074

OBI:

106873734

OSN:

115222654

EGL:

EGR_02374

LLON:

135483127

HSY:	130613446 130613842

» show all

Reference

1 [PMID:3074547]

Authors

Skidgel RA.

Title

Basic carboxypeptidases: regulators of peptide hormone activity.

Journal

Trends Pharmacol Sci 9:299-304 (1988)
DOI:10.1016/0165-6147(88)90015-6

Reference

2 [PMID:2775217]

Authors

Deddish PA, Skidgel RA, Erdos EG.

Title

Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase).

Journal

Biochem J 261:289-91 (1989)
DOI:10.1042/bj2610289

Reference

3 [PMID:2914904]

Authors

Skidgel RA, Davis RM, Tan F.

Title

Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones.

Journal

J Biol Chem 264:2236-41 (1989)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.17.12

IUBMB Enzyme Nomenclature:

3.4.17.12

ExPASy - ENZYME nomenclature database:

3.4.17.12

BRENDA, the Enzyme Database:

3.4.17.12

CAS:	120038-28-0

DBGET integrated database retrieval system