Entry |
|
Name |
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
|
Reaction(IUBMB) |
Cleavage of C-terminal arginine or lysine residues from polypeptides
|
Comment |
A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family)
|
History |
EC 3.4.17.12 created 1992
|
Orthology |
|
Genes |
RAY: | 107509040 107512675(CPM) |
XLA: | 108711091(cpm.L) 108713154(cpm.S) |
SANH: | 107666948 107669712 |
CCAR: | 109065747 109086964 109103579 |
CAUA: | 113048227 113061649 |
CGIB: | 127956866 127972912 |
MASI: | 127435415 127436819 |
LCF: | 108885735 108895863(cpm) |
STRU: | 115182046 115182933 |
PKI: | 111844282 111851094(cpm) 111851214 |
PSPA: | 121317975 121320079 |
ARUT: | 117396714 117414918 117419352 |
CMK: | 103184619 103185307(cpm) |
DSI: | Dsimw501_GD24843(Dsim_GD24843) |
AALB: | 109421998 109424095 |
ACER: | 107993798 107999567 |
AGIF: | 122857402 122857406 |
CSET: | 123312784 123312785 123316880 |
PPYR: | 116168537 116177988 |
CFEL: | 113371376 113380821 113381179 |
CLEC: | 106669957 106672221 |
HHAL: | 106678144 106683340 |
SGRE: | 126341697 126344231 |
DPX: | DAPPUDRAFT_39340 DAPPUDRAFT_53984 |
DMK: | 116919902 116929845 116936652 123475797 |
DPZ: | 124311077 124327147 124343203 |
EAF: | 111699046 111705218 111707342 |
ISC: | IscW_ISCW001311 IscW_ISCW004264 IscW_ISCW019087 |
DPTE: | 113794945 113795238 |
PTEP: | 107446375 107448812 |
GAE: | 121366701 121367662 121367665 |
MMER: | 123528645 123534002 |
DPOL: | 127831765 127853752 127873876 |
» show all
|
Reference |
|
Authors |
Skidgel RA. |
Title |
Basic carboxypeptidases: regulators of peptide hormone activity. |
Journal |
|
Reference |
|
Authors |
Deddish PA, Skidgel RA, Erdos EG. |
Title |
Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase). |
Journal |
|
Reference |
|
Authors |
Skidgel RA, Davis RM, Tan F. |
Title |
Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones. |
Journal |
J Biol Chem 264:2236-41 (1989) |
Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.17.12 |
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