KEGG ENZYME: 3.4.17.12

ENZYME: 3.4.17.12

Entry

EC 3.4.17.12 Enzyme

Name

carboxypeptidase M;
CPM

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases

Reaction(IUBMB)

Cleavage of C-terminal arginine or lysine residues from polypeptides

Comment

A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family)

History

EC 3.4.17.12 created 1992

Orthology

K01296

carboxypeptidase M

Genes

HSA:

1368(CPM)

PTR:	452067(CPM)

PPS:	100969689(CPM)

GGO:	101130328(CPM)

PON:	100171502(CPM)

NLE:	100602479(CPM)

MCC:	718315(CPM)

MCF:	102138123(CPM)

CSAB:

103238691(CPM)

RRO:	104658666(CPM)

RBB:	108532256(CPM)

CJC:	100410597(CPM)

SBQ:	101040778(CPM)

MMU:	70574(Cpm)

MCAL:

110304045(Cpm)

MPAH:

110326791(Cpm)

RNO:	314855(Cpm)

MUN:	110562244(Cpm)

CGE:	100770407(Cpm)

NGI:	103745080(Cpm)

HGL:	101724468(Cpm)

CCAN:

109693329(Cpm)

OCU:	100349485(CPM) 108176913

TUP:	102474632(CPM)

CFA:	100685525(CPM)

VVP:	112922195(CPM)

AML:	100481997(CPM)

UMR:	103656872(CPM)

UAH:	113256293(CPM)

ORO:	101386105(CPM)

ELK:

111142131

FCA:	101097407(CPM)

PTG:	102967223(CPM)

PPAD:

109270485(CPM)

AJU:	106966349(CPM)

BTA:	513281(CPM)

BOM:	102287201(CPM)

BIU:	109559246(CPM)

BBUB:

102402297(CPM)

CHX:	102172872(CPM)

OAS:	101104474(CPM)

SSC:	100628221(CPM)

CFR:	102522173(CPM)

CDK:	105101084(CPM)

BACU:

103017503(CPM)

LVE:	103081156(CPM)

OOR:	101286496(CPM)

DLE:	111173760(CPM)

PCAD:

102992832(CPM)

ECB:	100059473(CPM)

EPZ:	103558164(CPM)

EAI:	106843580(CPM)

MYB:	102256624(CPM)

MYD:	102770875(CPM)

MNA:	107526849(CPM)

HAI:	109381649(CPM)

DRO:	112318964(CPM)

PALE:

102884706(CPM)

RAY:	107509040 107512675(CPM)

MJV:	108394492(CPM)

LAV:	100665759(CPM)

TMU:

101349661

MDO:	100021372(CPM)

SHR:	100921178(CPM)

PCW:	110211047(CPM)

OAA:	100080749(CPM)

GGA:	417843(CPM)

MGP:	100543962(CPM)

CJO:	107310518(CPM)

NMEL:

110392788(CPM)

APLA:

101789743(CPM)

ACYG:

106045412(CPM)

TGU:	100225708(CPM)

LSR:	110477994(CPM)

SCAN:

103813678(CPM)

GFR:	102037874(CPM)

FAB:	101813399(CPM)

PHI:	102101701(CPM)

PMAJ:

107204719(CPM)

CCAE:

111937509(CPM)

CCW:	104698374(CPM)

ETL:	114062166(CPM)

FPG:	101923955(CPM)

FCH:	102048341(CPM)

CLV:	102085565(CPM)

EGZ:	104132947(CPM)

NNI:	104011003(CPM)

ACUN:

113491126(CPM)

PADL:

103920039(CPM)

AAM:	106488152(CPM)

ASN:	102385520(CPM)

AMJ:	102562411(CPM)

PSS:	102463630(CPM)

CMY:	102930730(CPM)

CPIC:

101936032(CPM)

ACS:	100556918(cpm)

PVT:	110075131(CPM)

PBI:	103063247(CPM)

PMUR:

107284409(CPM)

TSR:	106538065(CPM)

PMUA:

114605044(CPM)

GJA:	107105717(CPM)

XLA:	108711091(cpm.L) 108713154(cpm.S)

XTR:	496721(cpm)

NPR:	108804545(CPM)

DRE:	550253(cpm)

SRX:	107710685 107728505

SANH:

107666948 107669712

SGH:	107590974(cpm)

CCAR:

109065747 109086964 109103579

IPU:	108279953(cpm)

PHYP:

113532257(cpm)

AMEX:

103028806(cpm)

EEE:	113569671(cpm)

TRU:	101065920(cpm)

TNG:	GSTEN00034650G001

LCO:	104931508(cpm)

MZE:	101469424(cpm)

ONL:	100694650(cpm)

OLA:	101169896(cpm)

XMA:	102218156(cpm)

XCO:	114161096(cpm)

PRET:

103459312(cpm)

CVG:	107090615(cpm)

NFU:	107386863(cpm)

KMR:

108228768

ALIM:

106532836(cpm)

AOCE:

111586661(cpm)

CSEM:

103382529(cpm)

POV:	109646163(cpm)

LCF:	108885735 108895863

SDU:	111224538(cpm)

SLAL:

111665929(cpm)

HCQ:	109532598(cpm)

BPEC:

110161911(cpm)

MALB:

109952968(cpm)

SALP:

112079471

ELS:	105017802(cpm)

SFM:	108936551(cpm)

PKI:	111844282 111851094(cpm) 111851214

LCM:	102355516(CPM)

CMK:	103184619 103185307(cpm)

RTP:	109928784 109934683

BFO:	BRAFLDRAFT_78420

SPU:	105438690 580514

APLC:

110977803

SKO:	100375345 100375539

DER:

6550015

DSE:

6617981

DSI:	Dsimw501_GD24843(Dsim_GD24843)

DYA:	Dyak_GE17613

DAN:

6505309

DSR:

110181608

DPO:	Dpse_GA18350

DPE:

6600041

DMN:

108164720

DWI:

6649059

DGR:	Dgri_GH12395

DMO:	Dmoj_GI14727

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP000756

AAG:

5574253

AALB:

109421998 109424095

CQU:	CpipJ_CPIJ019890

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_207768

PMAC:

PRAP:

HAW:

TNL:

API:	100163058 100163764

DNX:	107168618 107169553

AGS:	114119923 114126292

RMD:	113554587 113555251

BTAB:

109039932

CLEC:

106669957 106672221

PHU:	Phum_PHUM098090

ZNE:	110828034 110831202

FCD:

110863174

DPX:	DAPPUDRAFT_53984

ISC:	IscW_ISCW001311 IscW_ISCW004264 IscW_ISCW019087

TUT:

DPTE:

PTEP:

PCAN:

MYI:

OBI:

EGL:

Reference

1 [PMID:3074547]

Authors

Skidgel RA.

Title

Basic carboxypeptidases: regulators of peptide hormone activity.

Journal

Trends Pharmacol Sci 9:299-304 (1988)
DOI:10.1016/0165-6147(88)90015-6

Reference

2 [PMID:2775217]

Authors

Deddish PA, Skidgel RA, Erdos EG.

Title

Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase).

Journal

Biochem J 261:289-91 (1989)
DOI:10.1042/bj2610289

Reference

3 [PMID:2914904]

Authors

Skidgel RA, Davis RM, Tan F.

Title

Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones.

Journal

J Biol Chem 264:2236-41 (1989)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.17.12

IUBMB Enzyme Nomenclature:

3.4.17.12

ExPASy - ENZYME nomenclature database:

3.4.17.12

BRENDA, the Enzyme Database:

3.4.17.12

CAS:	120038-28-0

DBGET integrated database retrieval system