KEGG   ENZYME: 3.4.17.12
Entry
EC 3.4.17.12                Enzyme                                 
Name
carboxypeptidase M;
CPM
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Cleavage of C-terminal arginine or lysine residues from polypeptides
Comment
A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family)
History
EC 3.4.17.12 created 1992
Orthology
K01296  carboxypeptidase M
Genes
HSA1368(CPM)
PTR452067(CPM)
PPS100969689(CPM)
GGO101130328(CPM)
PON100171502(CPM)
NLE100602479(CPM)
HMH116478989(CPM)
MCC718315(CPM)
MCF102138123(CPM)
MTHB126931706
MNI105473402(CPM)
CSAB103238691(CPM)
CATY105580996(CPM)
PANU101018002(CPM)
TGE112634275(CPM)
MLEU105537116(CPM)
RRO104658666(CPM)
RBB108532256(CPM)
TFN117089768(CPM)
PTEH111528611(CPM)
CANG105502660(CPM)
CJC100410597(CPM)
SBQ101040778(CPM)
CIMI108315987(CPM)
CSYR103269050(CPM)
MMUR105884628(CPM)
LCAT123639533(CPM)
PCOQ105808419(CPM)
OGA100959155(CPM)
MMU70574(Cpm)
MCAL110304045(Cpm)
MPAH110326791(Cpm)
RNO314855(Cpm)
MCOC116076314(Cpm)
ANU117696799(Cpm)
MUN110562244(Cpm)
CGE100770407(Cpm)
MAUA101832744(Cpm)
PROB127215728(Cpm)
PLEU114693315(Cpm)
MORG121458191(Cpm)
MFOT126515658
AAMP119803443(Cpm)
NGI103745080(Cpm)
HGL101724468(Cpm)
CPOC100732968(Cpm)
CCAN109693329(Cpm)
DORD105986885(Cpm)
DSP122124079(Cpm)
PLOP125361421(Cpm)
NCAR124983196
MMMA107140072(Cpm)
OCU100349485 108176913
OPI101519258(CPM)
TUP102474632(CPM)
GVR103601366(CPM)
CFA100685525(CPM)
CLUD112677879(CPM)
VVP112922195(CPM)
VLG121491248(CPM)
NPO129511630(CPM)
AML100481997(CPM)
UMR103656872(CPM)
UAH113256293(CPM)
UAR123787143(CPM)
ELK111142131
LLV125107552
MPUF101689497(CPM)
MNP132019433(CPM)
MLK131839137(CPM)
NVS122891706(CPM)
ORO101386105(CPM)
EJU114214944(CPM)
ZCA113921845(CPM)
MLX118008588(CPM)
NSU110570610(CPM)
LWW102730370(CPM)
FCA101097407(CPM)
PYU121040768(CPM)
PCOO112863821(CPM)
PBG122474008(CPM)
LRUF124501297
PTG102967223(CPM)
PPAD109270485(CPM)
PUC125919326
AJU106966349
HHV120240804(CPM)
BTA513281(CPM)
BOM102287201(CPM)
BIU109559246(CPM)
BBUB102402297(CPM)
BBIS104989768(CPM)
CHX102172872(CPM)
OAS101104474(CPM)
BTAX128047456(CPM)
ODA120857721(CPM)
CCAD122427263(CPM)
MBEZ129535572(CPM)
SSC100628221(CPM)
CFR102522173(CPM)
CBAI105081335(CPM)
CDK105101084(CPM)
VPC102538081(CPM)
BACU103017503(CPM)
LVE103081156(CPM)
OOR101286496(CPM)
DLE111173760(CPM)
PCAD102992832(CPM)
PSIU116761019(CPM)
NASI112393947(CPM)
ECB100059473(CPM)
EPZ103558164(CPM)
EAI106843580(CPM)
MYB102256624(CPM)
MYD102770875(CPM)
MMYO118650129(CPM)
MLF102420573(CPM)
MNA107526849(CPM)
PKL118729243(CPM)
EFUS103292524(CPM)
HAI109381649(CPM)
DRO112318964(CPM)
SHON118989365(CPM)
AJM119052718(CPM)
PDIC114514175(CPM)
PHAS123812982(CPM)
MMF118624621(CPM)
RFQ117029273(CPM)
PPAM129075870(CPM)
PALE102884706(CPM)
PGIG120605044(CPM)
PVP105301351(CPM)
RAY107509040 107512675(CPM)
MJV108394492(CPM)
TOD119247527(CPM)
SARA101546949(CPM)
LAV100665759(CPM)
TMU101349661
ETF101658120(CPM)
DNM101417155(CPM)
MDO100021372(CPM)
GAS123248978(CPM)
SHR100921178(CPM)
AFZ127564479
PCW110211047(CPM)
OAA100080749(CPM)
GGA417843(CPM)
PCOC116226593(CPM)
MGP100543962(CPM)
CJO107310518(CPM)
TPAI128073881(CPM)
LMUT125688067(CPM)
NMEL110392788(CPM)
APLA101789743(CPM)
ACYG106045412(CPM)
CATA118246863(CPM)
AFUL116494980(CPM)
TGU100225708(CPM)
LSR110477994(CPM)
SCAN103813678(CPM)
PMOA120499768(CPM)
OTC121339479(CPM)
PRUF121352550(CPM)
GFR102037874(CPM)
FAB101813399(CPM)
OMA130248664(CPM)
PHI102101701(CPM)
PMAJ107204719(CPM)
CCAE111937509(CPM)
CCW104698374(CPM)
CBRC103614884(CPM)
ETL114062166(CPM)
ZAB102062686(CPM)
ACHL103799311(CPM)
SVG106855282(CPM)
MMEA130580185(CPM)
HRT120751368(CPM)
FPG101923955(CPM)
FCH102048341(CPM)
CLV102085565(CPM)
EGZ104132947(CPM)
NNI104011003(CPM)
PCRI104032000(CPM)
PLET104625311(CPM)
EHS104515221(CPM)
PCAO104047942(CPM)
ACUN113491126(CPM)
TALA104366267(CPM)
PADL103920039(CPM)
AFOR103893924(CPM)
ACHC115336120(CPM)
HALD104318062(CPM)
HLE104828225(CPM)
AGEN126034596
GCL127020593
CCRI104168814(CPM)
CSTI104558168(CPM)
CMAC104483892(CPM)
MUI104538984(CPM)
BREG104632747(CPM)
FGA104074509(CPM)
GSTE104264417(CPM)
LDI104344818(CPM)
MNB103769979(CPM)
OHA104326765(CPM)
NNT104410548(CPM)
SHAB115605368(CPM)
DPUB104305551(CPM)
PGUU104471926(CPM)
ACAR104531860(CPM)
CPEA104388813(CPM)
AVIT104274688(CPM)
CVF104288919(CPM)
RTD128907965(CPM)
CUCA104061313(CPM)
TEO104380289(CPM)
BRHI104493673(CPM)
AAM106488152(CPM)
AROW112970417(CPM)
NPD112958840(CPM)
TGT104574438(CPM)
DNE112983355(CPM)
SCAM104142043(CPM)
ASN102385520(CPM)
AMJ102562411(CPM)
CPOO109315514(CPM)
GGN109295716(CPM)
PSS102463630(CPM)
CMY102930730(CPM)
CCAY125630220(CPM)
DCC119845912(CPM)
CPIC101936032(CPM)
TST117877725(CPM)
CABI116834440(CPM)
MRV120395545(CPM)
ACS100556918(cpm)
ASAO132776174(CPM)
PVT110075131(CPM)
SUND121930776(CPM)
PBI103063247(CPM)
PMUR107284409(CPM)
CTIG120308445(CPM)
TSR106538065(CPM)
PGUT117655616(CPM)
APRI131201823(CPM)
PTEX113435767(CPM)
NSS113412264(CPM)
VKO123033308(CPM)
PMUA114605044(CPM)
PRAF128422096(CPM)
ZVI118090968(CPM)
HCG128327320(CPM)
GJA107105717(CPM)
STOW125434260(CPM)
EMC129336010(CPM)
XLA108711091(cpm.L) 108713154(cpm.S)
XTR496721(cpm)
NPR108804545(CPM)
RTEM120931988(CPM)
BBUF120980570(CPM)
BGAR122925810(CPM)
MUO115478175(CPM)
GSH117364356(CPM)
DRE550253(cpm)
SRX107710685 107728505
SANH107666948 107669712
SGH107590974(cpm)
CCAR109065747 109086964 109103579
CAUA113048227 113061649
CGIB127956866 127972912
PTET122342722(cpm)
LROH127163924(cpm)
OMC131539476(cpm)
PPRM120476854(cpm)
RKG130082682(cpm)
MAMB125246446(cpm)
CIDE127511042
MASI127435415 127436819
TROS130547665(cpm)
TDW130421133(cpm)
MANU129432326(cpm)
IPU108279953
IFU128623402(cpm)
PHYP113532257(cpm)
SMEO124401660(cpm)
TFD113655870(cpm)
TVC132859283(cpm)
AMEX103028806(cpm)
CMAO118812329(cpm)
EEE113569671(cpm)
CHAR105892307(cpm)
TRU101065920(cpm)
TFS130519071(cpm)
TNGGSTEN00034650G001
LCO104931508(cpm)
TBEN117485188(cpm)
CGOB115006014
PGEO117441017(cpm)
GACU117559822(cpm)
ELY117249497(cpm)
EFO125882631(cpm)
SLUC116047906(cpm)
ECRA117938846(cpm)
ESP116673132(cpm)
PFLV114550286(cpm)
PPUG119210906(cpm)
AFB129112469(cpm)
CLUM117726362(cpm)
MSAM119896125(cpm)
SCHU122871232(cpm)
CUD121505674(cpm)
ALAT119032365(cpm)
MZE101469424(cpm)
ONL100694650(cpm)
OAU116312820(cpm)
OLA101169896(cpm)
OML112157427(cpm)
XMA102218156(cpm)
XCO114161096(cpm)
XHE116736968(cpm)
PRET103459312(cpm)
PFOR103155873
PLAI106939951(cpm)
PMEI106925010
GAF122826414(cpm)
CVG107090615(cpm)
CTUL119790611(cpm)
GMU124883123(cpm)
NFU107386863(cpm)
KMR108228768(cpm)
ALIM106532836(cpm)
NWH119428444
AOCE111586661(cpm)
MCEP125000408(cpm)
CSEM103382529(cpm)
POV109646163(cpm)
SSEN122767290(cpm)
HHIP117757033(cpm)
HSP118101940(cpm)
LCF108885735 108895863(cpm)
SDU111224538(cpm)
SLAL111665929(cpm)
XGL120797152(cpm)
HCQ109532598(cpm)
SSCV125985799
SBIA133493761(cpm)
PEE133397441(cpm)
PTAO133471796(cpm)
BPEC110161911(cpm)
MALB109952968(cpm)
BSPL114862526(cpm)
SJO128353124(cpm)
STRU115182046 115182933
OTW112240098(cpm)
OMY110517153 118942834
OGO124018752 124018753
OKI116360552 116372993
OKE127927714(cpm)
SALP112079471
SNH120050144(cpm)
CCLU121555439(cpm)
ELS105017802(cpm)
SFM108936551(cpm)
PKI111844282 111851094(cpm) 111851214
AANG118219042(cpm)
LOC102692210(cpm)
PSPA121317975 121320079
ARUT117396714 117414918 117419352
PSEX120539582(cpm)
LCM102355516(CPM)
CMK103184619 103185307(cpm)
RTP109928784 109934683
CPLA122559327 122564612
HOC132824844 132825758
LERI129706416 129711950(cpm)
PMRN116947440(CPM)
LRJ133351600
BFO118425712
BBEL109464542
SPU105438690 580514
LPIC129282994
APLC110977803
SKO100375345 100375539
DMEDmel_CG4678(CG4678)
DER6550015
DSE6617981
DSIDsimw501_GD24843(Dsim_GD24843)
DYADyak_GE17613
DAN6505309
DSR110181608
DPO4815902
DPE6600041
DMN108164720
DWI6649059
DGR6564522
DMODmoj_GI14727
DAZ108618780
DNV108656677
DHE111605327
DVI6631846
CCAT101456149
BOD106615696
BDR105227459
RZE108367453
TDA119666743 119671710
MDE101888089
SCAC106091030
LCQ111690937
LSQ119608024
GFS119644631
ECOE129948361
HIS119657599
AGA1272346
ACOZ120958697
AARA120905640
AMER121591387
ASTE118517482
AFUN125762114
AMOU128306559
AALI118460217
AAG5574253
AALB109421998 109424095
CQUCpipJ_CPIJ019890
CPII120415622
CNS116341664
BCOO119067301
AME726554
ACER107993798 107999567
ALAB122719234
ADR102670868
AFLR100865158
BIM100749411
BBIF117210447
BVK117237893
BVAN117158093
BTER100650514
BAFF126918937
BPYO122577619
BPAS132908318
FVI122533895
CCAL108622736
OBB114880420
MGEN117222870
NMEA116432339
CGIG122402996
SOC105199420
MPHA105830622
AEC105154001
ACEP105622717
PBAR105424849
VEM105562695
HST105187308
DQU106750198
CFO105247831
FEX115245009
LHU105672794
PGC109852697
OBO105275236
LHT122500823
LBD127285834
MDL103572139
CGLO123265191
FAS105270050
DAM107043863
AGIF122857402 122857406
CINS118074500
VCAN122414935
CCIN107273411
DSM124408073
NPT124216052
NFB124180593
NLO107224166
NVG124302076
TCA103314076
DPA109538330
SOY115879907 115888420
AGRG126745238
ATD109603743
CSET123312784 123312785 123316880
AGB108903476
LDC111502302 111510285
NVL108563697
APLN108740741
PPYR116168537 116177988
BMOR101744869
BMAN114249892
MSEX115445183
DPLKGM_207768
BANY112046213
MJU123872640
NIQ126773883
VCD124533994
MCIX123656256
PMAC106717926
PPOT106108528
PXU106115889
PRAP110995092
PBX123709942
PNAP125049087
ZCE119830712
CCRC123695948
LSIN126975966
HAW110372804
HZE124637307
TNL113498506
SLIU111348027
OFU114360961
PGW126371868
CFEL113371376 113380821 113381179
CCRN123294062
API100163058 100163764
DNX107168618 107169553
AGS114119923 114126292
RMD113554587 113555251
ACOO126838379 126838396
DVT126901175 126902235
BTAB109039932
CLEC106669957 106672221
HHAL106678144 106683340
NLU111044577 111064421
HVI124367620 124367621 124367995 124372383 124374427
MQU128982858 128983213
PHUPhum_PHUM098090
FOC113217736
TPAL117644293
ZNE110828034 110831202
CSEC111873444
SGRE126341697 126344231
IEL124158639 124158961
FCD110863174
DPXDAPPUDRAFT_39340 DAPPUDRAFT_53984
DMK116919902 116929845 116936652 123475797
DPZ124311077 124327147 124343203
PJA122256433
PCHN125038708
PMOO119598115
HAME121870988
PCLA123759720
CQD128695704
PTRU123510544
ESN127000193
HAZT108665321
EAF111699046 111705218 111707342
LSM121117865 121126808
TCF131877530 131888023 131889556
DSV119441449
RSAN119382704
RMP119176760
TUT107360791
DPTE113794945 113795238
DFR124490784 124500326
CSCU111634767
PTEP107446375 107448812
UDV129232493 129234230
LPOL106464156 106467857
PMEO129581013
PCAN112562506
GAE121366701 121367662 121367665
HRF124137854
HRJ124283825
CVN111134694 111138443
OED125677944
MYI110464022
PMAX117333121
MCAF127712274
MMER123528645 123534002
RPHI132719871 132741949
DPOL127831765 127853752 127873876
OBI106873734
OSN115222654
EGLEGR_02374
HSY130613446 130613842
 » show all
Reference
1  [PMID:3074547]
  Authors
Skidgel RA.
  Title
Basic carboxypeptidases: regulators of peptide hormone activity.
  Journal
Trends Pharmacol Sci 9:299-304 (1988)
DOI:10.1016/0165-6147(88)90015-6
Reference
2  [PMID:2775217]
  Authors
Deddish PA, Skidgel RA, Erdos EG.
  Title
Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase).
  Journal
Biochem J 261:289-91 (1989)
DOI:10.1042/bj2610289
Reference
3  [PMID:2914904]
  Authors
Skidgel RA, Davis RM, Tan F.
  Title
Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones.
  Journal
J Biol Chem 264:2236-41 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.12
IUBMB Enzyme Nomenclature: 3.4.17.12
ExPASy - ENZYME nomenclature database: 3.4.17.12
BRENDA, the Enzyme Database: 3.4.17.12
CAS: 120038-28-0

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