KEGG   ENZYME: 3.4.17.17Help
Entry
EC 3.4.17.17                Enzyme                                 

Name
tubulinyl-Tyr carboxypeptidase;
carboxypeptidase-tubulin;
soluble carboxypeptidase;
tubulin-tyrosine carboxypeptidase;
tubulin carboxypeptidase;
tubulinyltyrosine carboxypeptidase;
tyrosinotubulin carboxypeptidase;
tyrosyltubulin carboxypeptidase;
TTCPase;
brain I carboxypeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of the -Glu!Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr
Comment
Active at neutral pH, from brain
History
EC 3.4.17.17 created 1992
Reference
1  [PMID:7452228]
  Authors
Argarana CE, Barra HS, Caputto R.
  Title
Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification.
  Journal
J Neurochem 34:114-8 (1980)
DOI:10.1111/j.1471-4159.1980.tb04628.x
Reference
2  [PMID:6114100]
  Authors
Kumar N, Flavin M.
  Title
Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin.
  Journal
J Biol Chem 256:7678-86 (1981)
Reference
3  [PMID:6862022]
  Authors
Arce CA, Barra HS.
  Title
Association of tubulinyl-tyrosine carboxypeptidase with microtubules.
  Journal
FEBS Lett 157:75-8 (1983)
DOI:10.1016/0014-5793(83)81119-3
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.17
IUBMB Enzyme Nomenclature: 3.4.17.17
ExPASy - ENZYME nomenclature database: 3.4.17.17
BRENDA, the Enzyme Database: 3.4.17.17
CAS: 73050-23-4

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