KEGG   ENZYME: 3.4.17.17
Entry
EC 3.4.17.17                Enzyme                                 

Name
tubulinyl-Tyr carboxypeptidase;
carboxypeptidase-tubulin;
soluble carboxypeptidase;
tubulin-tyrosine carboxypeptidase;
tubulin carboxypeptidase;
tubulinyltyrosine carboxypeptidase;
tyrosinotubulin carboxypeptidase;
tyrosyltubulin carboxypeptidase;
TTCPase;
brain I carboxypeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Cleavage of the -Glu!Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr
Comment
Active at neutral pH, from brain
History
EC 3.4.17.17 created 1992
Orthology
K23355  tubulinyl-Tyr carboxypeptidase
Genes
HSA: 22846(VASH1) 79805(VASH2)
PTR: 467514(VASH1) 469677(VASH2)
PPS: 100967415(VASH2) 100989180(VASH1)
GGO: 101137077(VASH1) 101141201(VASH2)
PON: 100435809(VASH1) 100441602(VASH2)
NLE: 100595129(VASH1) 100605439(VASH2)
MCC: 703906(VASH1) 709924(VASH2)
MCF: 102123580(VASH1) 102131153(VASH2)
CSAB: 103229375(VASH1) 103230115(VASH2)
RRO: 104669834(VASH2) 104677605(VASH1)
RBB: 108515237(VASH2) 108534944(VASH1)
CJC: 100397672(VASH1) 100406551(VASH2)
SBQ: 101053333(VASH2) 101053704(VASH1)
MMU: 226841(Vash2) 238328(Vash1)
MCAL: 110300912(Vash2) 110307194(Vash1)
MPAH: 110321665(Vash2) 110324401(Vash1)
RNO: 498309(Vash2) 503052(Vash1)
MUN: 110556980(Vash2) 110558251(Vash1)
CGE: 100757885(Vash1) 100765067(Vash2)
NGI: 103727059(Vash2) 103739714(Vash1)
HGL: 101704998 101710727(Vash1) 101715471(Vash2)
CCAN: 109695988(Vash1) 109700716(Vash2)
OCU: 100358035(VASH1) 100358188(VASH2)
TUP: 102488072(VASH2) 102503007(VASH1)
CFA: 490799(VASH1) 608015(VASH2)
VVP: 112918294(VASH1) 112921775(VASH2)
AML: 100476792(VASH1) 100481580(VASH2)
UMR: 103670849(VASH1) 103672459(VASH2)
UAH: 113262685(VASH2) 113270306(VASH1)
ORO: 101362315(VASH1) 101374275(VASH2)
FCA: 101098109(VASH2) 101100138(VASH1)
PTG: 102953942(VASH2) 102959175(VASH1)
PPAD: 109253876(VASH1) 109254617(VASH2)
AJU: 106966761(VASH2) 106974406(VASH1)
BTA: 615419(VASH1)
BOM: 102284846(VASH2) 102288157(VASH1)
BIU: 109564417(VASH1) 109570322(VASH2)
BBUB: 102391518(VASH1) 102397822(VASH2)
CHX: 102180692(VASH2) 102191708(VASH1)
OAS: 101112736(VASH1) 101113869(VASH2)
SSC: 100511141(VASH1) 100525601(VASH2)
CFR: 102515682(VASH1)
CDK: 105086073(VASH1) 105099299(VASH2)
BACU: 103004715(VASH1) 103017810(VASH2)
LVE: 103069068(VASH2) 103088023(VASH1)
OOR: 101269423(VASH1) 101274279(VASH2)
DLE: 111176225(VASH1) 111184690(VASH2)
PCAD: 102980169(VASH1) 102982224(VASH2)
ECB: 100051887(VASH1) 100053514(VASH2)
EPZ: 103561589(VASH1) 103561619(VASH2)
EAI: 106827156(VASH2) 106830943(VASH1)
MYB: 102239187(VASH2) 102257662(VASH1)
MYD: 102768958(VASH2) 102769000(VASH1)
MNA: 107542882(VASH1) 107546275(VASH2)
HAI: 109379155(VASH2) 109381579(VASH1)
DRO: 112296644(VASH2) 112311519(VASH1)
PALE: 102883203(VASH2) 102894367(VASH1)
RAY: 107516678(VASH1) 107521631(VASH2)
MJV: 108390749(VASH1) 108391309(VASH2)
LAV: 100659573(VASH2) 100677064(VASH1)
MDO: 100022684(VASH1) 100022988(VASH2)
SHR: 100929104(VASH1) 100929151(VASH2)
PCW: 110208298(VASH1) 110222685(VASH2)
OAA: 100075991(VASH2) 100076763(VASH1)
GGA: 421364(VASH2) 423369(VASH1)
MGP: 100539286(VASH2) 100545015(VASH1)
CJO: 107311069(VASH2) 107315105(VASH1)
NMEL: 110395692(VASH2) 110401731(VASH1)
APLA: 101794922(VASH1) 101804871(VASH2)
ACYG: 106031583(VASH2) 106038819(VASH1)
TGU: 100221915(VASH1) 100225767(VASH2)
LSR: 110477241(VASH1) 110479945(VASH2)
SCAN: 103821515(VASH2) 103826513(VASH1)
GFR: 102040188(VASH2) 102045384(VASH1)
FAB: 101805861(VASH1) 101817071(VASH2)
PHI: 102100897(VASH1) 102102256(VASH2)
PMAJ: 107202182(VASH2) 107205885(VASH1)
CCAE: 111926188(VASH2) 111929953(VASH1)
CCW: 104685349(VASH1) 104685638(VASH2)
ETL: 114057408(VASH1) 114060879(VASH2)
FPG: 101913398(VASH1) 101922895(VASH2)
FCH: 102053232(VASH1) 102054695(VASH2)
CLV: 102083541(VASH1) 102087216(VASH2)
EGZ: 104132843(VASH2) 104133274(VASH1)
NNI: 104019667(VASH2) 104021041(VASH1)
ACUN: 113477728(VASH2) 113480719(VASH1)
PADL: 103913053(VASH1) 103922106(VASH2)
AAM: 106483059(VASH1) 106490468(VASH2)
ASN: 102382822(VASH2) 102384320(VASH1)
AMJ: 102562332(VASH2) 102570972(VASH1)
PSS: 102458381(VASH2) 102458749(VASH1)
CMY: 102929711(VASH2) 102931804(VASH1)
CPIC: 101942942(VASH1) 101951120(VASH2)
ACS: 100557275(vash2) 100567889(vash1)
PVT: 110079099(VASH1) 110079500(VASH2)
PBI: 103051877(VASH2) 103058643(VASH1)
PMUR: 107285967(VASH1) 107287439(VASH2)
TSR: 106546123(VASH2) 106547279(VASH1)
PMUA: 114591680(VASH1) 114594681(VASH2)
GJA: 107116468(VASH1) 107124211(VASH2)
XLA: 108698679(vash1.L) 108716453(vash2.L) 108717714(vash2.S)
XTR: 100216209(vash1) 100492435(vash2)
NPR: 108784063(VASH2)
DRE: 100001748(vash1) 562668(vash2)
SRX: 107716557(vash2) 107724254(vash1) 107727667
SGH: 107553414 107554792(vash1) 107558951(vash2)
IPU: 108270374(vash1)
PHYP: 113538818(vash1)
AMEX: 103022300(vash1) 103025056(vash2)
TRU: 101064900(vash1) 101077349(vash2)
LCO: 104921343(vash1) 104930471(vash2)
NCC: 104956258 104963639(vash1)
MZE: 101474640(vash2) 101477043(vash1) 101477508
ONL: 100698228(vash1) 100698854
OLA: 101157344(vash2) 101166671(vash1)
XMA: 102217438 102218433(vash1)
XCO: 114134356(vash1) 114158670
PRET: 103457201(vash2) 103458493(vash1)
CVG: 107097096(vash1) 107103601(vash2)
NFU: 107377876(vash2) 107392415(vash1)
KMR: 108236802(vash1) 108242567(vash2)
ALIM: 106533514(vash1) 106534480
AOCE: 111566948(vash2) 111577226(vash1)
CSEM: 103376691(vash1) 103381297(vash2)
POV: 109627782(vash1) 109643877(vash2)
LCF: 108887472(vash2) 108892496(vash1)
SDU: 111225753(vash1) 111231679(vash2)
HCQ: 109516724(vash2) 109526109(vash1)
BPEC: 110155678(vash1)
MALB: 109952815(vash2) 109967957(vash1)
SASA: 106571425(vash2) 106589786 106607828 106611058(vash1)
ELS: 105015699(vash1) 105017746(vash2)
SFM: 108928535(vash2) 108930705(vash1)
PKI: 111852466(vash1) 111858825(vash2)
LCM: 102358272(VASH1) 102365011(VASH2)
CMK: 103186161(vash2) 103191173(vash1)
RTP: 109912565(vash2) 109920428(vash1)
CIN: 100183377
SPU: 577818
APLC: 110978374
SKO: 102806929
FCD: 110844105
PCAN: 112569882
CRG: 105332125
MYI: 110446260
OBI: 106868585
LAK: 106166560
SHX: MS3_00013
EGL: EGR_04106
EPA: 110233351
ADF: 107344394
AMIL: 114967722
PDAM: 113667153
SPIS: 111330425
DGT: 114526374
HMG: 100198054
SPAR: SPRG_02341
 » show all
Reference
1  [PMID:7452228]
  Authors
Argarana CE, Barra HS, Caputto R.
  Title
Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification.
  Journal
J Neurochem 34:114-8 (1980)
DOI:10.1111/j.1471-4159.1980.tb04628.x
Reference
2  [PMID:6114100]
  Authors
Kumar N, Flavin M.
  Title
Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin.
  Journal
J Biol Chem 256:7678-86 (1981)
Reference
3  [PMID:6862022]
  Authors
Arce CA, Barra HS.
  Title
Association of tubulinyl-tyrosine carboxypeptidase with microtubules.
  Journal
FEBS Lett 157:75-8 (1983)
DOI:10.1016/0014-5793(83)81119-3
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.17
IUBMB Enzyme Nomenclature: 3.4.17.17
ExPASy - ENZYME nomenclature database: 3.4.17.17
BRENDA, the Enzyme Database: 3.4.17.17
CAS: 73050-23-4

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