KEGG   ENZYME: 3.4.17.17
Entry
EC 3.4.17.17                Enzyme                                 
Name
tubulinyl-Tyr carboxypeptidase;
carboxypeptidase-tubulin;
soluble carboxypeptidase;
tubulin-tyrosine carboxypeptidase;
tubulin carboxypeptidase;
tubulinyltyrosine carboxypeptidase;
tyrosinotubulin carboxypeptidase;
tyrosyltubulin carboxypeptidase;
TTCPase;
brain I carboxypeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Cleavage of the -Glu!Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr
Comment
Active at neutral pH, from brain
History
EC 3.4.17.17 created 1992
Orthology
K23355  tubulinyl-Tyr carboxypeptidase
Genes
HSA22846(VASH1) 79805(VASH2)
PTR467514(VASH1) 469677(VASH2)
PPS100967415(VASH2) 100989180(VASH1)
GGO101137077(VASH1) 101141201(VASH2)
PON100435809(VASH1) 100441602(VASH2)
NLE100595129(VASH1) 100605439(VASH2)
MCC703906(VASH1) 709924(VASH2)
MCF102123580(VASH1) 102131153(VASH2)
CSAB103229375(VASH1) 103230115(VASH2)
CATY105577030(VASH2) 105590884(VASH1)
PANU101001897(VASH1) 101012622(VASH2)
TGE112605119(VASH2) 112628599(VASH1)
RRO104669834(VASH2) 104677605(VASH1)
RBB108515237(VASH2) 108534944(VASH1)
TFN117069292(VASH1) 117074013(VASH2)
PTEH111521305(VASH1) 111537136(VASH2)
CJC100397672(VASH1) 100406551(VASH2)
SBQ101053333(VASH2) 101053704(VASH1)
CSYR103256377(VASH1) 103257407(VASH2)
MMUR105859048(VASH1) 105880530(VASH2)
OGA100957612(VASH1) 100963892(VASH2)
MMU226841(Vash2) 238328(Vash1)
MCAL110300912(Vash2) 110307194(Vash1)
MPAH110321665(Vash2) 110324401(Vash1)
RNO498309(Vash2) 503052(Vash1)
MCOC116068751(Vash2) 116079648(Vash1)
MUN110556980(Vash2) 110558251(Vash1)
CGE100757885(Vash1) 100765067(Vash2)
PLEU114697857(Vash1) 114698228(Vash2)
NGI103727059(Vash2) 103739714(Vash1)
HGL101704998 101710727(Vash1) 101715471(Vash2)
CPOC100714784(Vash2) 100716274(Vash1)
CCAN109695988(Vash1) 109700716(Vash2)
DORD105984943(Vash2) 105986471(Vash1)
DSP122109359(Vash2) 122118646(Vash1)
OCU100358035(VASH1) 100358188(VASH2)
OPI101520481(VASH2) 101524400(VASH1)
TUP102488072(VASH2) 102503007(VASH1)
CFA490799(VASH1) 608015(VASH2)
VVP112918294(VASH1) 112921775(VASH2)
VLG121491987(VASH2) 121492869(VASH1)
AML100476792(VASH1) 100481580(VASH2)
UMR103670849(VASH1) 103672459(VASH2)
UAH113262685(VASH2) 113270306(VASH1)
UAR123785844(VASH2) 123798954(VASH1)
ELK111148629 111150671
LLV125085779 125105000
MPUF101675441(VASH1) 101688867(VASH2)
ORO101362315(VASH1) 101374275(VASH2)
EJU114204397(VASH1) 114225957(VASH2)
ZCA113909777(VASH1) 113932411(VASH2)
MLX118002397(VASH1) 118014322(VASH2)
FCA101098109(VASH2) 101100138(VASH1)
PYU121011772(VASH2) 121032087(VASH1)
PBG122469364(VASH1) 122476187(VASH2)
PTG102953942(VASH2) 102959175(VASH1)
PPAD109253876(VASH1) 109254617(VASH2)
AJU106966761(VASH2) 106974406(VASH1)
HHV120230491(VASH2) 120231986(VASH1)
BTA615419(VASH1)
BOM102284846(VASH2) 102288157(VASH1)
BIU109564417(VASH1) 109570322(VASH2)
BBUB102391518(VASH1) 102397822(VASH2)
CHX102180692(VASH2) 102191708(VASH1)
OAS101112736(VASH1) 101113869(VASH2)
ODA120852679(VASH1) 120880057(VASH2)
CCAD122443891(VASH1) 122451899(VASH2)
SSC100511141(VASH1) 100525601(VASH2)
CFR102515682(VASH1)
CBAI105063390(VASH1) 105064536(VASH2)
CDK105086073(VASH1) 105099299(VASH2)
VPC102532890(VASH2) 102536983(VASH1)
BACU103004715(VASH1) 103017810(VASH2)
LVE103069068(VASH2) 103088023(VASH1)
OOR101269423(VASH1) 101274279(VASH2)
DLE111176225(VASH1) 111184690(VASH2)
PCAD102980169(VASH1) 102982224(VASH2)
PSIU116740213(VASH2) 116749531(VASH1)
ECB100051887(VASH1) 100053514(VASH2)
EPZ103561589(VASH1) 103561619(VASH2)
EAI106827156(VASH2) 106830943(VASH1)
MYB102239187(VASH2) 102257662(VASH1)
MYD102768958(VASH2) 102769000(VASH1)
MMYO118658423(VASH1) 118672920(VASH2)
MLF102417187(VASH2) 102427234 102442330(VASH1)
MNA107542882(VASH1) 107546275(VASH2)
PKL118715044(VASH1) 118721727(VASH2)
HAI109379155(VASH2) 109381579(VASH1)
DRO112296644(VASH2) 112311519(VASH1)
SHON118976665(VASH1) 119004235(VASH2)
AJM119049270(VASH1) 119063141(VASH2)
PDIC114492419(VASH1) 114511909(VASH2)
PHAS123808173(VASH1) 123818345(VASH2)
MMF118637739(VASH2) 118640088(VASH1)
RFQ117015018(VASH2) 117023477(VASH1)
PALE102883203(VASH2) 102894367(VASH1)
PGIG120617528(VASH2) 120619533(VASH1)
PVP105290084(VASH1) 105295023(VASH2)
RAY107516678(VASH1) 107521631(VASH2)
MJV108390749(VASH1) 108391309(VASH2)
TOD119234566(VASH2) 119239343(VASH1)
SARA101546807(VASH1) 101547073(VASH2)
LAV100659573(VASH2) 100677064(VASH1)
TMU101351804 101359344
DNM101411426(VASH2) 101418992(VASH1)
MDO100022684(VASH1) 100022988(VASH2)
GAS123235866(VASH1) 123245202(VASH2)
SHR100929104(VASH1) 100929151(VASH2)
PCW110208298(VASH1) 110222685(VASH2)
OAA100075991(VASH2) 100076763(VASH1)
GGA421364(VASH2) 423369(VASH1)
PCOC116228968(VASH1) 116230485(VASH2)
MGP100539286(VASH2) 100545015(VASH1)
CJO107311069(VASH2) 107315105(VASH1)
NMEL110395692(VASH2) 110401731(VASH1)
APLA101794922(VASH1) 101804871(VASH2)
ACYG106031583(VASH2) 106038819(VASH1)
AFUL116487606(VASH2) 116489428(VASH1)
TGU100221915(VASH1) 100225767(VASH2)
LSR110477241(VASH1) 110479945(VASH2)
SCAN103821515(VASH2) 103826513(VASH1)
PMOA120496863(VASH2) 120500257(VASH1)
OTC121331726(VASH1) 121340645(VASH2)
PRUF121355960(VASH1) 121358592(VASH2)
GFR102040188(VASH2) 102045384(VASH1)
FAB101805861(VASH1) 101817071(VASH2)
PHI102100897(VASH1) 102102256(VASH2)
PMAJ107202182(VASH2) 107205885(VASH1)
CCAE111926188(VASH2) 111929953(VASH1)
CCW104685349(VASH1) 104685638(VASH2)
ETL114057408(VASH1) 114060879(VASH2)
ZAB102065505(VASH1) 102070224(VASH2)
FPG101913398(VASH1) 101922895(VASH2)
FCH102053232(VASH1) 102054695(VASH2)
CLV102083541(VASH1) 102087216(VASH2)
EGZ104132843(VASH2) 104133274(VASH1)
NNI104019667(VASH2) 104021041(VASH1)
ACUN113477728(VASH2) 113480719(VASH1)
TALA104356422(VASH1) 104362411(VASH2)
PADL103913053(VASH1) 103922106(VASH2)
ACHC115348577(VASH1) 115349943(VASH2)
AAM106483059(VASH1) 106490468(VASH2)
AROW112961719(VASH1) 112969210(VASH2)
NPD112955016(VASH1) 112955122(VASH2)
DNE112989454(VASH2) 112995413(VASH1)
ASN102382822(VASH2) 102384320(VASH1)
AMJ102562332(VASH2) 102570972(VASH1)
CPOO109319718(VASH2) 109321336(VASH1)
GGN109296841(VASH2) 109298597(VASH1)
PSS102458381(VASH2) 102458749(VASH1)
CMY102929711(VASH2) 102931804(VASH1)
CPIC101942942(VASH1) 101951120(VASH2)
TST117874453(VASH2) 117876362(VASH1)
CABI116818289(VASH2) 116837487(VASH1)
MRV120400992(VASH2) 120403730(VASH1)
ACS100557275(vash2) 100567889(vash1)
PVT110079099(VASH1) 110079500(VASH2)
SUND121916115 121919855(VASH2)
PBI103051877(VASH2) 103058643(VASH1)
PMUR107285967(VASH1) 107287439(VASH2)
TSR106546123(VASH2) 106547279(VASH1)
PGUT117665851(VASH1) 117671697(VASH2)
VKO123026370(VASH1) 123032320(VASH2)
PMUA114591680(VASH1) 114594681(VASH2)
ZVI118081692(VASH1) 118083165(VASH2)
GJA107116468(VASH1) 107124211(VASH2)
XLA108698679(vash1.L) 108716453(vash2.L) 108717714(vash2.S)
XTR100216209(vash1) 100492435(vash2)
NPR108784063(VASH2)
RTEM120920697(VASH1) 120937912(VASH2)
BBUF120981655(VASH1) 120999499(VASH2)
BGAR122922818(VASH1) 122935667(VASH2)
DRE100001748(vash1) 562668(vash2)
SRX107716557(vash2) 107724254(vash1) 107727667
SANH107675075 107676263 107702244(vash1)
SGH107553414 107554792(vash1) 107558951(vash2)
CCAR109053756 109058896 109107370(vash1)
CAUA113051046 113078712 113116931(vash1) 113120741
IPU108270374(vash1)
PHYP113538818(vash1)
SMEO124390262(vash1)
AMEX103022300(vash1) 103025056(vash2)
EEE113569538 113580656 113585379(vash2)
TRU101064900(vash1) 101077349(vash2)
TNGGSTEN00018504G001 GSTEN00032342G001
LCO104921343(vash1) 104930471(vash2)
NCC104956258 104963639(vash1)
CGOB115003617(vash2) 115027416(vash1)
ELY117266756(vash1) 117270748(vash2)
PLEP121953825(vash1) 121955986(vash2)
SLUC116035583(vash1) 116056172(vash2)
ECRA117935456(vash1) 117961018(vash2)
PFLV114546994(vash1) 114573405(vash2)
GAT120808304(vash2) 120833063(vash1)
PPUG119194722(vash2) 119228023(vash1)
MSAM119908715(vash2) 119909798(vash1)
CUD121521566(vash2) 121526425(vash1)
MZE101474640(vash2) 101477043(vash1) 101477508
ONL100698228(vash1) 100698854
OAU116322311(vash1) 116329504(vash2)
OLA101157344(vash2) 101166671(vash1)
OML112140973(vash2) 112162948(vash1)
XMA102217438 102218433(vash1)
XCO114134356(vash1) 114158670
XHE116709227(vash1) 116734317(vash2)
PRET103457201(vash2) 103458493(vash1)
PFOR103136153(vash1) 103146761
PLAI106948383 106957619(vash1)
PMEI106903744(vash1) 106929580
GAF122825420(vash2) 122846598(vash1)
CVG107097096(vash1) 107103601(vash2)
CTUL119787579(vash1) 119789416(vash2)
GMU124855539(vash1) 124881913(vash2)
NFU107377876(vash2) 107392415(vash1)
KMR108236802(vash1) 108242567(vash2)
ALIM106533514(vash1) 106534480
NWH119418393(vash2) 119427897(vash1)
AOCE111566948(vash2) 111577226(vash1)
CSEM103376691(vash1) 103381297(vash2)
POV109627782(vash1) 109643877(vash2)
SSEN122783056(vash1) 122784013(vash2)
HHIP117756088(vash1) 117758387(vash2)
LCF108887472(vash2) 108892496(vash1)
SDU111225753(vash1) 111231679(vash2)
SLAL111647847 111649403 111663223(vash1)
XGL120789114(vash2) 120794998(vash1)
HCQ109516724(vash2) 109526109(vash1)
BPEC110155678(vash1)
MALB109952815(vash2) 109967957(vash1)
SASA106571425(vash2) 106589786 106607828 106611058(vash1)
OTW112218086 112250195(vash2) 112257142(vash1) 112261794
OMY110497929 110505534 110522251 110529635(vash2)
OGO123990779(vash2) 123995111 124002233 124045263(vash1)
ONE115107777(vash2) 115138495(vash1) 115139389 115146235
SALP111954431 111963260(vash1) 111968742 112068144
SNH120019746 120023683(vash1) 120024367(vash2) 120059876
ELS105015699(vash1) 105017746(vash2)
SFM108928535(vash2) 108930705(vash1)
PKI111852466(vash1) 111858825(vash2)
AANG118207727(vash1) 118230877(vash2)
LOC102689361(vash2) 102692686(vash1)
PSPA121315292 121317095 121323964 121329878
ARUT117402263 117411019 117420033 117422511
LCM102358272(VASH1) 102365011(VASH2)
CMK103186161(vash2) 103191173(vash1)
RTP109912565(vash2) 109920428(vash1)
BFO118416109
BBEL109484081
CIN100183377
SCLV120335562
SPU577818
APLC110978374
SKO102806929
FCD110844105
EAF111710880
HROHELRODRAFT_133665
LGILOTGIDRAFT_133279
PCAN112569882
BGT106055460
GAE121371981
HRF124122789
HRJ124289856
CRG105332125
MYI110446260
PMAX117324462
MMER123531285
OBI106868585
OSN115217533
LAK106166560
SMMSmp_133170
SHXMS3_0013722
OVIT265_13521
EGLEGR_04106
NVE5497109 5511937
EPA110233351
ATEN116297062
ADF107344394
AMIL114967722
PDAM113667153
SPIS111330425
DGT114526374
XEN124457902
HMG100198054
TADTRIADDRAFT_18894 TRIADDRAFT_20295 TRIADDRAFT_34465
AQU100634964 100635742
SMOSELMODRAFT_4128 SELMODRAFT_4129
PPP112273664 112279716 112282088 112289781
MISMICPUN_100853
MPPMICPUCDRAFT_60539
MBRMONBRDRAFT_29390
SREPTSG_07536
PIFPITG_03851
PSOJPHYSODRAFT_473639
SPARSPRG_02341
EHXEMIHUDRAFT_101049
GTTGUITHDRAFT_80379
TBRTb11.03.0040
TBGTbgDal_XI1140
TCR506925.520
LMALMJF_27_0460
LIFLINJ_27_0470
LDOLDBPK_270470
LMILMXM_27_0460
LBZLBRM_27_0550
LPANLPMP_270450
 » show all
Reference
1  [PMID:7452228]
  Authors
Argarana CE, Barra HS, Caputto R.
  Title
Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification.
  Journal
J Neurochem 34:114-8 (1980)
DOI:10.1111/j.1471-4159.1980.tb04628.x
Reference
2  [PMID:6114100]
  Authors
Kumar N, Flavin M.
  Title
Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin.
  Journal
J Biol Chem 256:7678-86 (1981)
Reference
3  [PMID:6862022]
  Authors
Arce CA, Barra HS.
  Title
Association of tubulinyl-tyrosine carboxypeptidase with microtubules.
  Journal
FEBS Lett 157:75-8 (1983)
DOI:10.1016/0014-5793(83)81119-3
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.17
IUBMB Enzyme Nomenclature: 3.4.17.17
ExPASy - ENZYME nomenclature database: 3.4.17.17
BRENDA, the Enzyme Database: 3.4.17.17
CAS: 73050-23-4

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