KEGG   ENZYME: 3.4.17.2
Entry
EC 3.4.17.2                 Enzyme                                 
Name
carboxypeptidase B;
protaminase;
pancreatic carboxypeptidase B;
tissue carboxypeptidase B;
peptidyl-L-lysine [L-arginine]hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Preferential release of a C-terminal lysine or arginine amino acid
Comment
A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2
Orthology
K01291  carboxypeptidase B
Genes
HSA1360(CPB1)
PTR460763(CPB1)
PPS100992024(CPB1)
GGO101129511(CPB1)
PON100434248(CPB1)
NLE100606718(CPB1)
MCC712639(CPB1)
MCF102133877(CPB1)
CSAB103241512(CPB1)
CATY105587503(CPB1)
PANU101002891(CPB1)
TGE112619758(CPB1)
RRO104671554(CPB1)
RBB108518296(CPB1)
TFN117084056(CPB1)
PTEH111544724(CPB1)
CJC100406051(CPB1)
SBQ101037025(CPB1)
CSYR103275577(CPB1)
MMUR105881239(CPB1)
OGA100955228(CPB1)
MMU76703(Cpb1)
MCAL110291636(Cpb1)
MPAH110320577(Cpb1)
RNO24271(Cpb1)
MCOC116094749(Cpb1)
MUN110563021(Cpb1)
CGE100751091(Cpb1)
PLEU114686243(Cpb1)
NGI103745993(Cpb1)
HGL101715608(Cpb1)
CPOC100716012(Cpb1)
CCAN109682822(Cpb1)
DORD105996002(Cpb1)
DSP122095228(Cpb1)
OCU100358803(CPB1)
OPI101533613(CPB1)
TUP102469136(CPB1)
CFA403512(CPB1)
VVP112932756(CPB1)
VLG121479046(CPB1)
AML100471468(CPB1)
UMR103678088(CPB1)
UAH113254039(CPB1)
UAR123802734(CPB1)
ELK111147955
LLV125098503
MPUF101692613(CPB1)
ORO101376449(CPB1)
EJU114209076(CPB1)
ZCA113916955(CPB1)
MLX117999403(CPB1)
FCA101082684(CPB1)
PYU121033804(CPB1)
PBG122491878(CPB1)
PTG102968194(CPB1)
PPAD109260704(CPB1)
AJU106975221(CPB1)
HHV120237633(CPB1)
BTA510039(CPB1)
BOM102265167(CPB1)
BIU109564536(CPB1)
BBUB102406620(CPB1)
CHX102184477(CPB1)
OAS101123433(CPB1)
ODA120858396(CPB1)
CCAD122445076(CPB1)
SSC397341(CPB1)
CFR102508460(CPB1)
CBAI105081274(CPB1)
CDK105089516(CPB1)
VPC102531278(CPB1)
BACU103002331(CPB1)
LVE103090379(CPB1)
OOR101269328(CPB1)
DLE111179171(CPB1)
PCAD102974801(CPB1)
PSIU116753196(CPB1)
ECB100058959(CPB1)
EPZ103558753(CPB1)
EAI106829437(CPB1)
MYB102244805(CPB1)
MYD102772230(CPB1)
MMYO118677112(CPB1)
MLF102419077(CPB1)
MNA107544050(CPB1)
PKL118722863(CPB1)
HAI109375861(CPB1)
DRO112300986(CPB1)
SHON118997900(CPB1)
AJM119055977(CPB1)
PDIC114490912(CPB1)
PHAS123827086(CPB1)
MMF118617487(CPB1)
RFQ117037814(CPB1)
PALE102895857(CPB1)
PGIG120593794(CPB1)
PVP105294947(CPB1)
RAY107513417(CPB1)
MJV108388604(CPB1)
TOD119256908(CPB1)
SARA101537528(CPB1)
LAV100658791(CPB1)
TMU101345894
DNM101439280(CPB1)
MDO100012656(CPB1)
GAS123241970(CPB1)
SHR100927003(CPB1)
PCW110204795(CPB1)
OAA100091762(CPB1)
GGA424888(CPB1)
PCOC116230871(CPB1)
MGP100544821(CPB1)
CJO107318162(CPB1)
NMEL110398295(CPB1)
APLA101797837
ACYG106036191
AFUL116492661(CPB1)
TGU100222062(CPB1)
LSR110473919(CPB1)
SCAN103815405(CPB1)
PMOA120508574(CPB1)
OTC121341125(CPB1)
PRUF121357960(CPB1)
GFR102034134(CPB1)
FAB101812580(CPB1)
PHI102112631(CPB1)
PMAJ107209058
CCAE111933485(CPB1)
CCW104693471(CPB1)
ETL114057377
ZAB102069952(CPB1)
FPG101914576(CPB1)
FCH102052617(CPB1)
CLV102083429(CPB1)
EGZ104127123(CPB1)
NNI104015688(CPB1)
ACUN113483340(CPB1)
TALA104359305(CPB1)
PADL103913837
ACHC115346850(CPB1)
AAM106485858(CPB1)
AROW112962156(CPB1)
NPD112947448(CPB1)
DNE112981681(CPB1)
ASN102371682
AMJ102570215(CPB1)
CPOO109308307(CPB1)
GGN109288135(CPB1)
PSS102455777
CMY102929825
CPIC101953934
TST117882840
CABI116839938
MRV120371996
ACS100562609(cpb1)
PVT110073048
SUND121927004(CPB1)
PBI103064521
PMUR107284837(CPB1)
TSR106538569
PGUT117678308
VKO123024761(CPB1)
PMUA114597863
ZVI118093640
GJA107124660(CPB1)
XLA108716366 495368(cpb1.S) 733324
XTR496994(cpb1)
NPR108797312 108797314
RTEM120936609 120936610 120936612
BBUF121000001 121000002(CPB1)
BGAR122934978 122935842
DRE322412(cpb1)
SRX107739144(cpb1)
SANH107687549
SGH107588040(cpb1)
CCAR109051049(cpb1) 109051051
CAUA113042243 113065920
IPU108272506(cpb1)
PHYP113545433
SMEO124383839(cpb1)
AMEX103027518(cpb1)
EEE113584770
TRU101065526
TNGGSTEN00023935G001
LCO104937211(cpb1)
NCC104965401
CGOB115025725(cpb1)
ELY117264410(cpb1)
PLEP121960595(cpb1) 121963515
SLUC116053755(cpb1)
ECRA117937952(cpb1)
PFLV114549602(cpb1)
GAT120811322(cpb1)
PPUG119198921(cpb1)
MSAM119910408(cpb1)
CUD121527280(cpb1)
MZE101480644(cpb1)
ONL100702694(cpb1)
OAU116314465(cpb1)
OLA101169819(cpb1)
OML112151102(cpb1)
XMA102232269(cpb1)
XCO114136502(cpb1)
XHE116711775(cpb1)
PRET103456548(cpb1)
PFOR103140421
PLAI106950253
PMEI106931585
GAF122824569(cpb1)
CVG107096477(cpb1)
CTUL119788913(cpb1)
GMU124857753(cpb1)
NFU107382805(cpb1)
KMR108230520(cpb1)
ALIM106513362(cpb1)
NWH119426552(cpb1)
AOCE111579237(cpb1)
CSEM103377267(cpb1)
POV109629670(cpb1)
SSEN122785014(cpb1)
HHIP117753689(cpb1)
LCF108881689(cpb1)
SDU111237915(cpb1)
SLAL111656271 111664977
XGL120789829(cpb1)
HCQ109519484
BPEC110170041(cpb1)
MALB109961496(cpb1)
SASA100196225(cbpb1)
OTW112227610(cpb1)
OMY110490876(cpb1)
OGO124039440(cpb1)
SALP112074819
SNH120038059(cpb1)
ELS105026596
SFM108927668
PKI111840702
AANG118226628(cpb1)
LOC102696207(cpb1)
PSPA121322869 121326681(cpb1)
ARUT117423574(cpb1) 117423575
LCM102347915(CPB1)
CMK103184479
RTP109915629 109915630 109915631
CIN100179788 100181959
SCLV120345672 120346029 120346135 120346136
DER6544308
DPODpse_GA21165
DPE6597184
DMN108165536
DWI6639599
DMODmoj_GI12855 Dmoj_GI12859 Dmoj_GI20107 Dmoj_GI20119
DAZ108611601 108614325 108614328
DNV108650121 108652278
MDE101895246
LCQ111684849
ACOZ120949967
CQUCpipJ_CPIJ010806
AME551327
ALAB122710957
BIM100746741
BTER100649475
BPYO122575243
CCAL108626036
OBB114871244
MGEN117226134
MDL103569002
TCA657015
OTU111416215
HAW110373533 110373545
TNL113499978
BTAB109035442
DMK116935390 123466444 123472379
PJA122262451
PTRU123516176
HAZT108669645 108672726 108673501
DFR124492514 124499926
BGT106071075
GAE121389552
HRF124116362
HRJ124274751 124286202
CRG105322408 105345633 117683583
PMAX117338266
OSN115226688
NVE5519024
ATEN116299718 116307328 116307329
 » show all
Reference
1
  Authors
Folk, J.E.
  Title
Carboxypeptidase B (porcine pancreas).
  Journal
Methods Enzymol 19:504-508 (1970)
Reference
2  [PMID:1009123]
  Authors
Brodrick JW, Geokas MC, Largman C.
  Title
Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.
  Journal
Biochim Biophys Acta 452:468-81 (1976)
DOI:10.1016/0005-2744(76)90197-2
Reference
3  [PMID:40714]
  Authors
Butterworth J, Duncan JJ.
  Title
Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.
  Journal
Clin Chim Acta 97:39-43 (1979)
DOI:10.1016/0009-8981(79)90023-8
Reference
4  [PMID:6130442]
  Authors
Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD.
  Title
Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?
  Journal
Life Sci 31:1793-6 (1982)
DOI:10.1016/0024-3205(82)90212-0
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.2
IUBMB Enzyme Nomenclature: 3.4.17.2
ExPASy - ENZYME nomenclature database: 3.4.17.2
BRENDA, the Enzyme Database: 3.4.17.2
CAS: 9025-24-5

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