KEGG ENZYME: 3.4.17.2

ENZYME: 3.4.17.2

Entry

EC 3.4.17.2                 Enzyme

Name

carboxypeptidase B;
protaminase;
pancreatic carboxypeptidase B;
tissue carboxypeptidase B;
peptidyl-L-lysine [L-arginine]hydrolase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases

Reaction(IUBMB)

Preferential release of a C-terminal lysine or arginine amino acid

Comment

A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).

History

EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2

Orthology

K01291

carboxypeptidase B

Genes

HSA:	1360(CPB1)

PTR:	460763(CPB1)

PPS:	100992024(CPB1)

GGO:	101129511(CPB1)

PON:	100434248(CPB1)

NLE:	100606718(CPB1)

HMH:	116481117(CPB1)

MCC:	712639(CPB1)

MCF:	102133877(CPB1)

MTHB:

126947489

MNI:	105470042(CPB1)

CSAB:

103241512(CPB1)

CATY:

105587503(CPB1)

PANU:

101002891(CPB1)

TGE:	112619758(CPB1)

MLEU:

105534118(CPB1)

RRO:	104671554(CPB1)

RBB:	108518296(CPB1)

TFN:	117084056(CPB1)

PTEH:

111544724(CPB1)

CANG:

105523880(CPB1)

CJC:	100406051(CPB1)

SBQ:	101037025(CPB1)

CIMI:

108300863(CPB1)

CSYR:

103275577(CPB1)

MMUR:

105881239(CPB1)

LCAT:

123630152(CPB1)

PCOQ:

105809142(CPB1)

OGA:	100955228(CPB1)

MMU:	76703(Cpb1)

MCAL:

110291636(Cpb1)

MPAH:

110320577(Cpb1)

RNO:	24271(Cpb1)

MCOC:

116094749(Cpb1)

ANU:	117707479(Cpb1)

MUN:	110563021(Cpb1)

CGE:	100751091(Cpb1)

MAUA:

101834834(Cpb1)

PROB:

127223381(Cpb1)

PLEU:

114686243(Cpb1)

MORG:

121452995(Cpb1)

MFOT:

126490664

AAMP:

119826800(Cpb1)

NGI:	103745993(Cpb1)

HGL:	101715608(Cpb1)

CPOC:

100716012(Cpb1)

CCAN:

109682822(Cpb1)

DORD:

105996002(Cpb1)

DSP:	122095228(Cpb1)

NCAR:

124993158

OCU:

100358803

OPI:	101533613(CPB1)

TUP:	102469136(CPB1)

GVR:

103597450

CFA:	403512(CPB1)

CLUD:

112661126(CPB1)

VVP:	112932756(CPB1)

VLG:	121479046(CPB1)

AML:	100471468(CPB1)

UMR:	103678088(CPB1)

UAH:	113254039(CPB1)

UAR:	123802734(CPB1)

ELK:

111147955

LLV:

125098503

MPUF:

101692613(CPB1)

NVS:	122910443(CPB1)

ORO:	101376449(CPB1)

EJU:	114209076(CPB1)

ZCA:	113916955(CPB1)

MLX:	117999403(CPB1)

NSU:	110576787(CPB1)

LWW:	102733422(CPB1)

FCA:	101082684(CPB1)

PYU:	121033804(CPB1)

PBG:	122491878(CPB1)

LRUF:

124527000

PTG:	102968194(CPB1)

PPAD:

109260704(CPB1)

PUC:

125921959

AJU:	106975221(CPB1)

HHV:	120237633(CPB1)

BTA:	510039(CPB1)

BOM:	102265167(CPB1)

BIU:	109564536(CPB1)

BBUB:

102406620(CPB1)

BBIS:

105001754(CPB1)

CHX:	102184477(CPB1)

OAS:	101123433(CPB1)

ODA:	120858396(CPB1)

CCAD:

122445076(CPB1)

SSC:	397341(CPB1)

CFR:	102508460(CPB1)

CBAI:

105081274(CPB1)

CDK:	105089516(CPB1)

VPC:	102531278(CPB1)

BACU:

103002331(CPB1)

LVE:	103090379(CPB1)

OOR:	101269328(CPB1)

DLE:	111179171(CPB1)

PCAD:

102974801(CPB1)

PSIU:

116753196(CPB1)

ECB:	100058959(CPB1)

EPZ:	103558753(CPB1)

EAI:	106829437(CPB1)

MYB:	102244805(CPB1)

MYD:	102772230(CPB1)

MMYO:

118677112(CPB1)

MLF:	102419077(CPB1)

MNA:	107544050(CPB1)

PKL:	118722863(CPB1)

HAI:	109375861(CPB1)

DRO:	112300986(CPB1)

SHON:

118997900(CPB1)

AJM:	119055977(CPB1)

PDIC:

114490912(CPB1)

PHAS:

123827086(CPB1)

MMF:	118617487(CPB1)

RFQ:	117037814(CPB1)

PALE:

102895857(CPB1)

PGIG:

120593794(CPB1)

PVP:	105294947(CPB1)

RAY:	107513417(CPB1)

MJV:	108388604(CPB1)

TOD:	119256908(CPB1)

SARA:

101537528(CPB1)

LAV:	100658791(CPB1)

TMU:

101345894

ETF:	101647120(CPB1)

DNM:	101439280(CPB1)

MDO:	100012656(CPB1)

GAS:	123241970(CPB1)

SHR:	100927003(CPB1)

AFZ:

127552966

PCW:	110204795(CPB1)

OAA:	100091762(CPB1)

GGA:	424888(CPB1)

PCOC:

116230871(CPB1)

MGP:	100544821(CPB1)

CJO:	107318162(CPB1)

NMEL:

110398295(CPB1)

APLA:

101797837

ACYG:

106036191

AFUL:

116492661(CPB1)

TGU:	100222062(CPB1)

LSR:	110473919(CPB1)

SCAN:

103815405(CPB1)

PMOA:

120508574(CPB1)

OTC:	121341125(CPB1)

PRUF:

121357960(CPB1)

GFR:	102034134(CPB1)

FAB:	101812580(CPB1)

PHI:

102112631

PMAJ:

107209058(CPB1)

CCAE:

111933485(CPB1)

CCW:	104693471(CPB1)

CBRC:

103624820(CPB1)

ETL:

114057377

ZAB:	102069952(CPB1)

ACHL:

103803235

SVG:

106862580

FPG:	101914576(CPB1)

FCH:	102052617(CPB1)

CLV:	102083429(CPB1)

EGZ:	104127123(CPB1)

NNI:	104015688(CPB1)

PLET:

104613878

PCRI:

104026830

ACUN:

113483340(CPB1)

TALA:

104359305(CPB1)

PADL:

103913837

AFOR:

103901440

ACHC:

115346850(CPB1)

HLE:	104832261(CPB1)

AGEN:

126039406

GCL:

127020207

CCRI:

104161255(CPB1)

CSTI:

104550543

EHS:	104514127(CPB1)

CMAC:

104476157(CPB1)

MUI:	104533360(CPB1)

FGA:	104082615(CPB1)

GSTE:

104255369

LDI:	104352696(CPB1)

MNB:

103780797

OHA:	104338758(CPB1)

NNT:

104399301

SHAB:

115611596(CPB1)

DPUB:

104309518(CPB1)

PGUU:

104461861(CPB1)

ACAR:

104528415(CPB1)

CPEA:

104392327(CPB1)

AVIT:

104267024

CVF:	104284991(CPB1)

CUCA:

104063419(CPB1)

TEO:

104369950

BRHI:

104501769

AAM:	106485858(CPB1)

AROW:

112962156(CPB1)

NPD:	112947448(CPB1)

TGT:	104576161(CPB1)

DNE:	112981681(CPB1)

SCAM:

104153215(CPB1)

ASN:

102371682

AMJ:	102570215(CPB1)

CPOO:

109308307(CPB1)

GGN:	109288135(CPB1)

PSS:

102455777

CMY:

102929825

CPIC:

101953934

TST:

117882840

CABI:

116839938

MRV:

120371996

ACS:	100562609(cpb1)

PVT:

110073048

SUND:

121927004(CPB1)

PBI:

103064521

PMUR:

107284837(CPB1)

CTIG:

120313105 120314649

TSR:

106538569

PGUT:

117678308

VKO:	123024761(CPB1)

PMUA:

114597863

ZVI:

118093640

GJA:	107124660(CPB1)

STOW:

125437975

XLA:	108716366 495368(cpb1.S) 733324

XTR:	496994(cpb1)

NPR:	108797312 108797314

RTEM:

120936609 120936610 120936612

BBUF:

121000001 121000002(CPB1)

BGAR:

122934978 122935842

DRE:	322412(cpb1)

SRX:	107739144(cpb1)

SANH:

107687549

SGH:	107588040(cpb1)

CCAR:

109051049(cpb1) 109051051

CAUA:

113042243 113065920

CGIB:

127946118 128013036

PPRM:

120475800(cpb1)

MAMB:

125258029(cpb1)

CIDE:

127505714

MASI:

127431856 127434253

IPU:	108272506(cpb1)

PHYP:

113545433

SMEO:

124383839(cpb1)

TFD:	113651177(cpb1)

AMEX:

103027518(cpb1)

EEE:

113584770

TRU:

101065526

TNG:	GSTEN00023935G001

LCO:	104937211(cpb1)

NCC:

104965401

CGOB:

115025725(cpb1)

ELY:	117264410(cpb1)

EFO:	125881667(cpb1)

PLEP:

121960595(cpb1) 121963515

SLUC:

116053755(cpb1)

ECRA:

117937952(cpb1)

ESP:	116672341(cpb1)

PFLV:

114549602(cpb1)

GAT:	120811322(cpb1)

PPUG:

119198921(cpb1)

MSAM:

119910408(cpb1)

CUD:	121527280(cpb1)

ALAT:

119008623(cpb1)

MZE:	101480644(cpb1)

ONL:	100702694(cpb1)

OAU:	116314465(cpb1)

OLA:	101169819(cpb1)

OML:	112151102(cpb1)

XMA:	102232269(cpb1)

XCO:	114136502(cpb1)

XHE:	116711775(cpb1)

PRET:

103456548(cpb1)

PFOR:

103140421

PLAI:

106950253

PMEI:

106931585

GAF:	122824569(cpb1)

CVG:	107096477(cpb1)

CTUL:

119788913(cpb1)

GMU:	124857753(cpb1)

NFU:	107382805(cpb1)

KMR:	108230520(cpb1)

ALIM:

106513362(cpb1)

NWH:	119426552(cpb1)

AOCE:

111579237(cpb1)

MCEP:

124995724(cpb1)

CSEM:

103377267(cpb1)

POV:	109629670(cpb1)

SSEN:

122785014(cpb1)

HHIP:

117753689(cpb1)

HSP:	118098741(cpb1)

LCF:

108881689

SDU:	111237915(cpb1)

SLAL:

111656271 111664977

XGL:	120789829(cpb1)

HCQ:

109519484

SSCV:

125985920

BPEC:

110170041(cpb1)

MALB:

109961496(cpb1)

BSPL:

114854746(cpb1)

SASA:

100196225(cbpb1)

OTW:	112227610(cpb1)

OMY:	110490876(cpb1)

OGO:	124039440(cpb1)

SALP:

112074819

SNH:	120038059(cpb1)

CCLU:

121556330(cpb1)

ELS:

105026596

SFM:

108927668

PKI:

111840702

AANG:

118226628(cpb1)

LOC:	102696207(cpb1)

PSPA:

121322869 121326681(cpb1)

ARUT:

117423574(cpb1) 117423575

PSEX:

120533734(cpb1)

LCM:	102347915(CPB1)

CMK:

103184479

RTP:	109915629 109915630 109915631

CIN:	100179788 100181959

SCLV:

120345672 120346029 120346135 120346136

DER:

6544308

DPO:

4813564

DPE:

6597184

DMN:

108165536

DWI:

6639599

DMO:	Dmoj_GI12855 Dmoj_GI12859 Dmoj_GI20107 Dmoj_GI20119

DAZ:	108611601 108614325 108614328

DNV:	108650121 108652278

MDE:

101895246

LCQ:

111684849

ACOZ:

120949967

CQU:	CpipJ_CPIJ010806

AME:

551327

ALAB:

122710957

BIM:

100746741

BTER:

100649475

BPYO:

122575243

CCAL:

108626036

OBB:

114871244

MGEN:

117226134

MDL:

103569002

TCA:

657015

OTU:

111416215

HAW:	110373533 110373545

TNL:

113499978

BTAB:

109035442

DMK:	116935390 123466444 123472379

PJA:

122262451

PTRU:

123516176

HAZT:

108669645 108672726 108673501

PPOI:

119102555 119102857

DFR:	124492514 124499926

BGT:

106071075

GAE:

121389552

HRF:

124116362

HRJ:	124274751 124286202

CRG:	105322408 105345633 117683583

PMAX:

117338266

DPOL:

127855630

OSN:

115226688

NVE:

5519024

ATEN:

116299718 116307328 116307329

» show all

Reference

Authors

Folk, J.E.

Title

Carboxypeptidase B (porcine pancreas).

Journal

Methods Enzymol 19:504-508 (1970)

Reference

2 [PMID:1009123]

Authors

Brodrick JW, Geokas MC, Largman C.

Title

Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.

Journal

Biochim Biophys Acta 452:468-81 (1976)
DOI:10.1016/0005-2744(76)90197-2

Reference

3 [PMID:40714]

Authors

Butterworth J, Duncan JJ.

Title

Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.

Journal

Clin Chim Acta 97:39-43 (1979)
DOI:10.1016/0009-8981(79)90023-8

Reference

4 [PMID:6130442]

Authors

Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD.

Title

Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?

Journal

Life Sci 31:1793-6 (1982)
DOI:10.1016/0024-3205(82)90212-0

Other DBs

ExplorEnz - The Enzyme Database:

3.4.17.2

IUBMB Enzyme Nomenclature:

3.4.17.2

ExPASy - ENZYME nomenclature database:

3.4.17.2

BRENDA, the Enzyme Database:

3.4.17.2

CAS:

9025-24-5

DBGET integrated database retrieval system