| Entry |
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| Name |
carboxypeptidase B;
protaminase;
pancreatic carboxypeptidase B;
tissue carboxypeptidase B;
peptidyl-L-lysine [L-arginine]hydrolase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
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| Reaction(IUBMB) |
Preferential release of a C-terminal lysine or arginine amino acid
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| Comment |
A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).
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| History |
EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2
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| Orthology |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Folk, J.E. |
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| Title |
Carboxypeptidase B (porcine pancreas). |
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| Journal |
Methods Enzymol 19:504-508 (1970) |
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| Reference |
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| Authors |
Brodrick JW, Geokas MC, Largman C. |
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| Title |
Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion. |
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| Journal |
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| Reference |
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| Authors |
Butterworth J, Duncan JJ. |
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| Title |
Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis. |
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| Journal |
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| Reference |
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| Authors |
Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD. |
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| Title |
Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin? |
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| Journal |
Life Sci 31:1793-6 (1982) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.17.2 |
| ExPASy - ENZYME nomenclature database: | 3.4.17.2 |
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