KEGG ENZYME: 3.4.17.2

ENZYME: 3.4.17.2

Entry

EC 3.4.17.2                 Enzyme

Name

carboxypeptidase B;
protaminase;
pancreatic carboxypeptidase B;
tissue carboxypeptidase B;
peptidyl-L-lysine [L-arginine]hydrolase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases

Reaction(IUBMB)

Preferential release of a C-terminal lysine or arginine amino acid

Comment

A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).

History

EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2

Orthology

K01291

carboxypeptidase B

Genes

HSA:	1360(CPB1)

PTR:	460763(CPB1)

PPS:	100992024(CPB1)

GGO:	101129511(CPB1)

PON:	100434248(CPB1)

PPYG:

129033542(CPB1)

NLE:	100606718(CPB1)

HMH:	116481117(CPB1)

SSYN:

129466135(CPB1)

MCC:	712639(CPB1)

MCF:	102133877(CPB1)

MTHB:

126947489

MNI:	105470042(CPB1)

CSAB:

103241512(CPB1)

CATY:

105587503(CPB1)

PANU:

101002891(CPB1)

TGE:	112619758(CPB1)

MLEU:

105534118(CPB1)

RRO:	104671554(CPB1)

RBB:	108518296(CPB1)

TFN:	117084056(CPB1)

PTEH:

111544724(CPB1)

CANG:

105523880(CPB1)

CJC:	100406051(CPB1)

SBQ:	101037025(CPB1)

CIMI:

108300863(CPB1)

ANAN:

105706606(CPB1)

CSYR:

103275577(CPB1)

MMUR:

105881239(CPB1)

LCAT:

123630152(CPB1)

PCOQ:

105809142(CPB1)

OGA:	100955228(CPB1)

MMU:	76703(Cpb1)

MCAL:

110291636(Cpb1)

MPAH:

110320577(Cpb1)

RNO:	24271(Cpb1)

MCOC:

116094749(Cpb1)

ANU:	117707479(Cpb1)

ASYL:

127683475(Cpb1)

MUN:	110563021(Cpb1)

CGE:	100751091(Cpb1)

MAUA:

101834834(Cpb1)

PROB:

127223381(Cpb1)

PLEU:

114686243(Cpb1)

MORG:

121452995(Cpb1)

MFOT:

126490664

AAMP:

119826800(Cpb1)

NGI:	103745993(Cpb1)

HGL:	101715608(Cpb1)

CPOC:

100716012(Cpb1)

CCAN:

109682822(Cpb1)

DORD:

105996002(Cpb1)

DSP:	122095228(Cpb1)

DMER:

138804482 138837652

PLOP:

125342453(Cpb1)

NCAR:

124993158

MMMA:

107143326(Cpb1)

ITI:	101964389(Cpb1)

OCU:

100358803

OPI:	101533613(CPB1)

TUP:	102469136(CPB1)

GVR:

103597450

CFA:	403512(CPB1)

CLUD:

112661126(CPB1)

VVP:	112932756(CPB1)

VLG:	121479046(CPB1)

NPO:	129507211(CPB1)

AML:	100471468(CPB1)

UMR:	103678088(CPB1)

UAH:	113254039(CPB1)

UAR:	123802734(CPB1)

ELK:

111147955

LLV:

125098503

MPUF:

101692613(CPB1)

MNP:	132010155(CPB1)

MLK:	131825903(CPB1)

NVS:	122910443(CPB1)

ORO:	101376449(CPB1)

EJU:	114209076(CPB1)

ZCA:	113916955(CPB1)

MLX:	117999403(CPB1)

NSU:	110576787(CPB1)

LWW:	102733422(CPB1)

FCA:	101082684(CPB1)

PYU:	121033804(CPB1)

PCOO:

112849673(CPB1)

PBG:	122491878(CPB1)

PVIV:

125175745(CPB1)

LRUF:

124527000

LGF:	123611428(CPB1)

AJU:

106975221

PTG:	102968194(CPB1)

PPAD:

109260704(CPB1)

PUC:

125921959

PLEZ:

122229702(CPB1)

HHV:	120237633(CPB1)

BTA:	510039(CPB1)

BOM:	102265167(CPB1)

BIU:	109564536(CPB1)

BBUB:

102406620(CPB1)

BBIS:

105001754(CPB1)

CHX:	102184477(CPB1)

OAS:	101123433(CPB1)

BTAX:

128053929(CPB1)

CSUM:

138079651(CPB1)

ODA:	120858396(CPB1)

CCAD:

122445076(CPB1)

MREE:

136173293(CPB1)

OVR:	110149290(CPB1)

MBEZ:

129551204(CPB1)

SSC:	397341(CPB1)

CFR:	102508460(CPB1)

CBAI:

105081274(CPB1)

CDK:	105089516(CPB1)

VPC:	102531278(CPB1)

BACU:

103002331(CPB1)

BMUS:

118894504(CPB1)

LVE:	103090379(CPB1)

OOR:	101269328(CPB1)

LALB:

132520387(CPB1)

GMF:	115862120(CPB1)

DDP:	132424298(CPB1)

DLE:	111179171(CPB1)

PCAD:

102974801(CPB1)

PSIU:

116753196(CPB1)

PPHC:

136122943(CPB1)

NASI:

112415903(CPB1)

ECB:	100058959(CPB1)

EPZ:	103558753(CPB1)

EAI:	106829437(CPB1)

MYB:	102244805(CPB1)

MYD:	102772230(CPB1)

MMYO:

118677112(CPB1)

MLF:	102419077(CPB1)

MDT:	132230561(CPB1)

MYUM:

139003729(CPB1)

PKL:	118722863(CPB1)

EFUS:

103302019(CPB1)

MNA:	107544050(CPB1)

DRO:	112300986(CPB1)

SHON:

118997900(CPB1)

AJM:	119055977(CPB1)

PDIC:

114490912(CPB1)

PHAS:

123827086(CPB1)

MMF:	118617487(CPB1)

PPAM:

129080002(CPB1)

HAI:	109375861(CPB1)

RFQ:	117037814(CPB1)

PALE:

102895857(CPB1)

PGIG:

120593794(CPB1)

PVP:	105294947(CPB1)

RAY:	107513417(CPB1)

MJV:	108388604(CPB1)

TOD:	119256908(CPB1)

SARA:

101537528(CPB1)

SFUM:

130030699(CPB1)

SETR:

126025543(CPB1)

LAV:	100658791(CPB1)

TMU:

101345894

ETF:	101647120(CPB1)

DNM:	101439280(CPB1)

MDO:	100012656(CPB1)

GAS:	123241970(CPB1)

SHR:	100927003(CPB1)

AFZ:

127552966

PCW:	110204795(CPB1)

TVP:	118848088(CPB1)

PBRV:

138174406(CPB1)

MLAO:

141491634(CPB1)

OAA:	100091762(CPB1)

TACU:

119929711

GGA:	424888(CPB1)

PCOC:

116230871(CPB1)

MGP:	100544821(CPB1)

CJO:	107318162(CPB1)

TPAI:

128082573(CPB1)

LMUT:

125697882(CPB1)

NMEL:

110398295(CPB1)

APLA:

101797837(CPB1)

ACYG:

106036191(CPB1)

CATA:

118247025(CPB1)

AFUL:

116492661(CPB1)

TGU:	100222062(CPB1)

LSR:	110473919(CPB1)

SCAN:

103815405(CPB1)

PMOA:

120508574(CPB1)

OTC:	121341125(CPB1)

PRUF:

121357960(CPB1)

ATRC:

139594951(CPB1)

GFR:	102034134(CPB1)

FAB:	101812580(CPB1)

OMA:	130256967(CPB1)

PHI:

102112631

PMAJ:

107209058(CPB1)

CCAE:

111933485(CPB1)

CCW:	104693471(CPB1)

CBRC:

103624820(CPB1)

ACOE:

138114593

ETL:

114057377

ZAB:	102069952(CPB1)

ZLE:	135451593(CPB1)

ACHL:

103803235

SVG:

106862580

MMEA:

130580395(CPB1)

HRT:	120757127(CPB1)

SATI:

136365687(CPB1)

CCIC:

134047704(CPB1)

FPG:	101914576(CPB1)

FCH:	102052617(CPB1)

CCRI:

104161255(CPB1)

NNT:

104399301

SHAB:

115611596(CPB1)

ACUN:

113483340(CPB1)

TALA:

104359305(CPB1)

ACHC:

115346850(CPB1)

HLE:	104832261(CPB1)

AGEN:

126039406

HHAR:

128148976(CPB1)

GCL:

127020207

CSTI:

104550543

LDI:	104352696(CPB1)

MNB:

103780797

DPUB:

104309518(CPB1)

PPUS:

135180450(CPB1)

AVIT:

104267024

BRHI:

104501769

EGZ:	104127123(CPB1)

NNI:	104015688(CPB1)

PCRI:

104026830

PADL:

103913837

AFOR:

103901440

FGA:	104082615(CPB1)

GSTE:

104255369

CBOY:

140654340(CPB1)

CLV:	102083429(CPB1)

CNIC:

135991533(CPB1)

MUI:	104533360(CPB1)

PGUU:

104461861(CPB1)

PLET:

104613878

EHS:	104514127(CPB1)

CMAC:

104476157(CPB1)

CUCA:

104063419(CPB1)

TEO:

104369950

BREG:

104639578

OHA:	104338758(CPB1)

ACAR:

104528415(CPB1)

CPEA:

104392327(CPB1)

CVF:	104284991(CPB1)

RTD:	128911212(CPB1)

CRID:

134517817(CPB1)

AAM:	106485858(CPB1)

AROW:

112962156(CPB1)

NPD:	112947448(CPB1)

TGT:	104576161(CPB1)

DNE:	112981681(CPB1)

SCAM:

104153215(CPB1)

ASN:

102371682

AMJ:	102570215(CPB1)

CPOO:

109308307(CPB1)

GGN:	109288135(CPB1)

PSS:

102455777

CMY:

102929825

CCAY:

125642091

DCC:

119861919

CPIC:

101953934

TST:

117882840

CABI:

116839938

MRV:

120371996

ACS:	100562609(cpb1)

ASAO:

132770614

PVT:

110073048

SUND:

121927004(CPB1)

PBI:

103064521

PMUR:

107284837(CPB1)

CTIG:

120313105 120314649

TSR:

106538569

PGUT:

117678308

PCAE:

139318774

APRI:

131200671

PTEX:

113436882

NSS:

113410288

VKO:	123024761(CPB1)

PMUA:

114597863

PRAF:

128414641

ZVI:

118093640

HCG:

128351233

GJA:	107124660(CPB1)

STOW:

125437975

EMC:

129332120

XLA:	108716366 495368(cpb1.S) 733324

XTR:	496994(cpb1)

NPR:	108797312 108797314

RTEM:

120936609 120936610 120936612

ACAT:

141139605 141139606 141139607

BBUF:

121000001 121000002(CPB1)

BGAR:

122934978 122935842

DTC:

141095185

PWL:

138265570

MUO:	115478674(CPB1)

GSH:	117366353(CPB1)

DRE:	322412(cpb1)

SRX:	107739144(cpb1)

SANH:

107687549

SGH:	107588040(cpb1)

CCAR:

109051049(cpb1) 109051051

CAUA:

113042243 113065920

CGIB:

127946118 128013036

PTET:

122330098(cpb1)

LROH:

127155602(cpb1)

GRF:	141300765(cpb1)

OMC:	131533538(cpb1)

PPRM:

120475800(cpb1)

RKG:	130084461(cpb1)

MAMB:

125258029(cpb1)

CIDE:

127505714

CERY:

137014144(cpb1)

MASI:

127431856 127434253

TROS:

130547376(agtr1b)

TDW:	130413257(cpb1)

MANU:

129426229(cpb1)

PDAB:

135785333(cpb1)

IPU:

108272506

IFU:	128614947(cpb1)

PHYP:

113545433

SMEO:

124383839(cpb1)

TFD:	113651177(cpb1)

TVC:	132845537(cpb1)

CGAR:

128519986(cpb1)

NGRA:

132886164(cpb1)

TRN:	134310438(cpb1) 134310439

AMEX:

103027518(cpb1)

CMAO:

118815849(cpb1)

EEE:

113584770

CHAR:

105889252 105889322 105889323

SPIL:

134065934(cpb1) 134065999

TRU:

101065526

TFS:	130514082(cpb1)

TNG:	GSTEN00023935G001

LCO:	104937211(cpb1)

NCC:

104965401

TBEN:

117497523(cpb1)

CGOB:

115025725(cpb1)

PGEO:

117465833(cpb1)

GACU:

117549902(cpb1)

EMAC:

134858002(cpb1)

ELY:	117264410(cpb1)

EFO:	125881667(cpb1)

PLEP:

121960595(cpb1) 121963515

SLUC:

116053755(cpb1)

ECRA:

117937952(cpb1)

ESP:	116672341(cpb1)

PFLV:

114549602(cpb1)

GAT:	120811322(cpb1)

PPUG:

119198921(cpb1)

AFB:	129110442(cpb1)

CLUM:

117749608(cpb1)

PSWI:

130205910(cpb1)

CANA:

137788699(cpb1)

CVE:	137871846(cpb1)

MSAM:

119910408(cpb1)

SCHU:

122866662(cpb1)

CUD:	121527280(cpb1)

SPUL:

138595772(cpb1)

LMIX:

132994238(cpb1)

ALAT:

119008623(cpb1)

ASTR:

137587673(cpb1)

MZE:	101480644(cpb1)

ONL:	100702694(cpb1)

OAU:	116314465(cpb1)

OLA:	101169819(cpb1)

OML:	112151102(cpb1)

CSAI:

133422907(cpb1)

XMA:	102232269(cpb1)

XCO:	114136502(cpb1)

XHE:	116711775(cpb1)

PRET:

103456548(cpb1)

PFOR:

103140421

PLAI:

106950253

PMEI:

106931585

GAF:	122824569(cpb1)

PPRL:

129364940(cpb1)

CVG:	107096477(cpb1)

CTUL:

119788913(cpb1)

GMU:	124857753(cpb1)

NFU:	107382805(cpb1)

KMR:	108230520(cpb1)

ALIM:

106513362(cpb1)

NWH:	119426552(cpb1)

AOCE:

111579237(cpb1)

EJA:	138204313(cpb1)

BFRE:

138623819(cpb1)

MCEP:

124995724(cpb1)

CSEM:

103377267(cpb1)

POV:	109629670(cpb1)

SSEN:

122785014(cpb1)

SSOE:

131468679(cpb1)

HHIP:

117753689(cpb1)

HSP:	118098741(cpb1)

PPLT:

128426134(cpb1)

SMAU:

118291297(cpb1)

LCF:

108881689

SDU:	111237915(cpb1)

SLAL:

111656271 111664977

XGL:	120789829(cpb1)

HCQ:

109519484

SSCV:

125985920(cpb1)

SBIA:

133492994(cpb1)

PEE:	133396346(cpb1)

PTAO:

133470542(cpb1)

BPEC:

110170041(cpb1)

ENY:	140364652(cpb1)

MALB:

109961496(cpb1)

BSPL:

114854746(cpb1)

SJO:	128382619(cpb1)

SSCO:

134002221(cpb1)

GMH:

115537552

SASA:

100196225(cbpb1)

OTW:	112227610(cpb1)

OMY:	110490876(cpb1)

OGO:	124039440(cpb1)

OKI:

109883246

OKE:	118380037(cpb1)

OMM:	135530547 135530548

OCLA:

139366651

SALP:

112074819

SNH:	120038059(cpb1)

CCLU:

121556330(cpb1)

ELS:

105026596

OEP:	134034608(cpb1)

SFM:

108927668

PKI:

111840702

AANG:

118226628(cpb1)

AROT:

135253250(cpb1)

CCOG:

133126577(cpb1)

LOC:	102696207(cpb1)

PSPA:

121322869 121326681(cpb1)

ARUT:

117423574(cpb1) 117423575

PSEX:

120533734(cpb1)

LCM:	102347915(CPB1)

CMK:

103184479

RTP:	109915629 109915630 109915631(cpb1)

CPLA:

122556172(cpb1) 122556361

HOC:	132821423 132821771

LERI:

129703333 129703334 129703790

HAKA:

140725715 140725717 140725718 140725719

PMRN:

116956800 116956807

CIN:	100179788 100181959

SCLV:

120345672 120346029 120346135 120346136

LPIC:

129265974 129280865 129281537 129281547

AJJ:	139964435 139964770 139964935 139979559

AFIL:

140137236 140167321 140168490

PFLL:

139150167

DER:

6544308

DPO:

4813564

DPE:

6597184

DMN:

108165536

DWI:

6639599

DMO:	Dmoj_GI12855 Dmoj_GI12859 Dmoj_GI20107 Dmoj_GI20119

DAZ:	108611601 108614325 108614328

DNV:	108650121 108652278

MDE:

101895246

LCQ:

111684849

ACOZ:

120949967

AMER:

121592755

CQU:	CpipJ_CPIJ010806

AME:

551327

ALAB:

122710957

ADR:

102675322

AFLR:

100867865

BIM:

100746741

BHUN:

126873203

BTER:

100649475

BPYO:

122575243

CCAL:

108626036

OBB:

114871244

MGEN:

117226134

MDL:

103569002

DSM:

124405396

NFB:

124175635

HAW:	110373533 110373545

TNL:

113499978

BTAB:

109035442

PAME:

138692093

BROR:

134542725

DMK:	116935390 123466444 123472379

AFRA:

136031790 136031912 136031928

PTRU:

123516176

ESN:

126985762

MRJ:

136830333

PORN:

139759763

HAZT:

108669645 108672726 108673501

PPOI:

119102555 119102857

DFR:	124492514 124499926

PVUL:

126815856

GAE:

121389552

HRF:

124116362

HRJ:	124274751 124286202

HASI:

137297636

CRG:	105345633 117683583

CANU:

128164092

OED:	125653503 125664371

PMAX:

117338266

AIRR:

138316617

DPOL:

127855630

MAEA:

128242638

OSN:

115226688

LJP:

135475668

LLON:

135498709 135498713

NVE:

5519024

ATEN:

116299718 116307328 116307329

» show all

Reference

Authors

Folk JE.

Title

Carboxypeptidase B (porcine pancreas).

Journal

Methods Enzymol 19:504-508 (1970)

Reference

2 [PMID:1009123]

Authors

Brodrick JW, Geokas MC, Largman C.

Title

Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.

Journal

Biochim Biophys Acta 452:468-81 (1976)
DOI:10.1016/0005-2744(76)90197-2

Reference

3 [PMID:40714]

Authors

Butterworth J, Duncan JJ.

Title

Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.

Journal

Clin Chim Acta 97:39-43 (1979)
DOI:10.1016/0009-8981(79)90023-8

Reference

4 [PMID:6130442]

Authors

Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD.

Title

Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?

Journal

Life Sci 31:1793-6 (1982)
DOI:10.1016/0024-3205(82)90212-0

Other DBs

ExplorEnz - The Enzyme Database:

3.4.17.2

IUBMB Enzyme Nomenclature:

3.4.17.2

ExPASy - ENZYME nomenclature database:

3.4.17.2

BRENDA, the Enzyme Database:

3.4.17.2

CAS:

9025-24-5

DBGET integrated database retrieval system