Entry
Name
carboxypeptidase B;
protaminase;
pancreatic carboxypeptidase B;
tissue carboxypeptidase B;
peptidyl-L-lysine [L-arginine]hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential release of a C-terminal lysine or arginine amino acid
Comment
A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2
Orthology
Genes
DMER : 138804482 138837652
CTIG : 120313105 120314649
XLA : 108716366 495368(cpb1.S) 733324
RTEM : 120936609 120936610 120936612
ACAT : 141139605 141139606 141139607
BBUF : 121000001 121000002(CPB1)
BGAR : 122934978 122935842
CCAR : 109051049(cpb1) 109051051
CAUA : 113042243 113065920
CGIB : 127946118 128013036
MASI : 127431856 127434253
TRN : 134310438(cpb1) 134310439
CHAR : 105889252 105889322 105889323
SPIL : 134065934(cpb1) 134065999
PLEP : 121960595(cpb1) 121963515
SLAL : 111656271 111664977
PSPA : 121322869 121326681(cpb1)
ARUT : 117423574(cpb1) 117423575
RTP : 109915629 109915630 109915631(cpb1)
CPLA : 122556172(cpb1) 122556361
LERI : 129703333 129703334 129703790
HAKA : 140725715 140725717 140725718 140725719
PMRN : 116956800 116956807
SCLV : 120345672 120346029 120346135 120346136
LPIC : 129265974 129280865 129281537 129281547
AJJ : 139964435 139964770 139964935 139979559
AFIL : 140137236 140167321 140168490
DMO : Dmoj_GI12855 Dmoj_GI12859 Dmoj_GI20107 Dmoj_GI20119
DAZ : 108611601 108614325 108614328
DMK : 116935390 123466444 123472379
AFRA : 136031790 136031912 136031928
HAZT : 108669645 108672726 108673501
PPOI : 119102555 119102857
LLON : 135498709 135498713
ATEN : 116299718 116307328 116307329
» show all
Taxonomy
Reference
1
Authors
Folk JE.
Title
Carboxypeptidase B (porcine pancreas).
Journal
Methods Enzymol 19:504-508 (1970)
Reference
Authors
Brodrick JW, Geokas MC, Largman C.
Title
Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.
Journal
Reference
Authors
Butterworth J, Duncan JJ.
Title
Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.
Journal
Reference
Authors
Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD.
Title
Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.2
ExPASy - ENZYME nomenclature database: 3.4.17.2