KEGG   ENZYME: 3.4.17.20
Entry
EC 3.4.17.20                Enzyme                                 
Name
carboxypeptidase U;
arginine carboxypeptidase;
carboxypeptidase R;
plasma carboxypeptidase B (misleading, since the term carboxypeptidase B is used for other enzymes);
thrombin-activatable fibrinolysis inhibitor
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Release of C-terminal Arg and Lys from a polypeptide
Comment
Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U, with activity similar to that of the more stable lysine carboxypeptidase, except that no preference is shown for Lys over Arg. A zinc enzyme, in peptidase family M14 (carboxypeptidase A family)
History
EC 3.4.17.20 created 1997
Orthology
K01300  carboxypeptidase B2
Genes
HSA1361(CPB2)
PTR452582(CPB2)
PPS100993828(CPB2)
GGO101153798(CPB2)
PON100452501(CPB2)
NLE100582393(CPB2)
MCC703317(CPB2)
MCF102132600(CPB2)
MTHB126940373
CSAB103214382(CPB2)
CATY105587782(CPB2)
PANU101009284(CPB2)
TGE112610806(CPB2)
RRO104658149(CPB2)
RBB108528946(CPB2)
TFN117063285(CPB2)
PTEH111522998(CPB2)
CJC100411115(CPB2)
SBQ101041667(CPB2)
CSYR103264476(CPB2)
MMUR105881162(CPB2)
LCAT123649276(CPB2)
MMU56373(Cpb2)
MCAL110309374(Cpb2)
MPAH110325644(Cpb2)
RNO113936(Cpb2)
MCOC116084081(Cpb2)
MUN110547470(Cpb2)
CGE100754304(Cpb2)
MAUA101832358(Cpb2)
PLEU114699220(Cpb2)
MORG121461115(Cpb2)
AAMP119800387(Cpb2)
NGI103726752(Cpb2)
HGL101712343(Cpb2)
CPOC100736054(Cpb2)
CCAN109698557(Cpb2)
DORD105981839(Cpb2)
DSP122112732(Cpb2)
NCAR124984469
OCU100341346
OPI101536220(CPB2)
TUP102473098(CPB2)
GVR103591895(CPB2)
CFA608910(CPB2)
CLUD112678877(CPB2)
VVP112933941(CPB2)
VLG121476871(CPB2)
AML100482734(CPB2)
UMR103677685(CPB2)
UAH113251347(CPB2)
UAR123791831(CPB2)
ELK111147094
LLV125096446
MPUF101693960(CPB2)
ORO101370239(CPB2)
EJU114212061(CPB2)
ZCA113920041(CPB2)
MLX118009180(CPB2)
NSU110587683(CPB2)
LWW102726651(CPB2)
FCA101082116(CPB2)
PYU121012974(CPB2)
PBG122482654(CPB2)
LRUF124511153
PTG102952076(CPB2)
PPAD109265929(CPB2)
AJU106972009(CPB2)
HHV120246731(CPB2)
BTA508222(CPB2)
BOM102285531(CPB2)
BIU109566696(CPB2)
BBUB102390937(CPB2)
BBIS104999147(CPB2)
CHX102181135(CPB2)
OAS101112329(CPB2)
ODA120883212(CPB2)
CCAD122447320(CPB2)
SSC100155038(CPB2)
CFR102509764(CPB2)
CBAI105066131(CPB2)
CDK105089749(CPB2)
VPC102530988(CPB2)
BACU103010017(CPB2)
LVE103075780(CPB2)
OOR101269719(CPB2)
DLE111175334(CPB2)
PCAD102985818(CPB2)
PSIU116742987(CPB2)
ECB100058534(CPB2)
EPZ103548935(CPB2)
EAI106829669(CPB2)
MYB102250791(CPB2)
MYD102755974(CPB2)
MMYO118651919(CPB2)
MLF102429248(CPB2)
MNA107542259(CPB2)
PKL118730773(CPB2)
HAI109391288(CPB2)
DRO112310676(CPB2)
SHON118994837(CPB2)
AJM119037366(CPB2)
PDIC114508873(CPB2)
PHAS123818757(CPB2)
MMF118622819(CPB2)
RFQ117021276(CPB2)
PALE102878653(CPB2)
PGIG120583898(CPB2)
PVP105298906(CPB2)
RAY107505990(CPB2)
MJV108407588(CPB2)
TOD119258511(CPB2)
SARA101550576(CPB2)
LAV100662006 100662575
TMU101350804 101351060
ETF101639359(CPB2)
DNM101429335(CPB2)
MDO100016398(CPB2)
GAS123240070(CPB2)
SHR100928968(CPB2)
PCW110197346(CPB2)
OAA100083738(CPB2)
GGA418851(CPB2)
PCOC116244214(CPB2)
MGP100545409(CPB2)
CJO107308136(CPB2)
NMEL110387568(CPB2)
APLA101791007(CPB2)
ACYG106035057(CPB2)
AFUL116500497(CPB2)
TGU100229153(CPB2)
LSR110469572(CPB2)
SCAN103827416(CPB2)
PMOA120505867(CPB2)
OTC121337305(CPB2)
PRUF121353298(CPB2)
GFR102041508(CPB2)
FAB101808771(CPB2)
PHI102107395(CPB2)
PMAJ107199992(CPB2)
CCAE111937540(CPB2)
CCW104689980(CPB2)
CBRC103615151(CPB2)
ETL114059887(CPB2)
ZAB102063880(CPB2)
ACHL103799533(CPB2)
FPG101919154(CPB2)
FCH102052809(CPB2)
CLV102085489(CPB2)
EGZ104131617(CPB2)
NNI104010961(CPB2)
PLET104614601(CPB2)
PCRI104035897(CPB2)
PCAO104039840
ACUN113481749(CPB2)
TALA104360053(CPB2)
PADL103915914(CPB2)
AFOR103903665(CPB2)
ACHC115350569(CPB2)
HALD104316719(CPB2)
HLE104841642(CPB2)
AGEN126045121
GCL127024593
CCRI104164172(CPB2)
CSTI104560652
CMAC104484836(CPB2)
MUI104537650(CPB2)
FGA104084406(CPB2)
GSTE104251360(CPB2)
LDI104346210(CPB2)
OHA104336972(CPB2)
NNT104407710(CPB2)
DPUB104306715(CPB2)
PGUU104459815(CPB2)
ACAR104524048
CPEA104391544(CPB2)
AVIT104269179(CPB2)
CVF104282841(CPB2)
CUCA104056527(CPB2)
TEO104377233
BRHI104501866(CPB2)
AAM106489197(CPB2)
AROW112969186(CPB2)
NPD112950354(CPB2)
TGT104580888(CPB2)
DNE112988199(CPB2)
SCAM104148969(CPB2)
ASN102376487(CPB2)
AMJ102562517(CPB2)
CPOO109306508(CPB2)
GGN109303407(CPB2)
PSS102448472(CPB2)
CMY102946625(CPB2)
CPIC101933938(CPB2)
TST117870958(CPB2)
CABI116830941(CPB2)
MRV120370365(CPB2)
ACS100567959(cpb2)
PVT110076120(CPB2)
SUND121919080(CPB2)
PBI103051972(CPB2)
PMUR107289863(CPB2)
CTIG120318879(CPB2)
PGUT117674319(CPB2)
VKO123030303(CPB2)
PMUA114593624(CPB2)
ZVI118082531(CPB2)
GJA107110254(CPB2)
STOW125439804(CPB2)
XLA108708528(cpb2.L) 108709798(cpb2.S)
XTR595005(cpb2)
NPR108794281(CPB2)
RTEM120929623(CPB2)
BBUF120995927(CPB2)
BGAR122933206(CPB2)
DRE100000935(cpb2)
SRX107707839(cpb2)
SANH107654270(cpb2)
SGH107588824(cpb2)
CCAR109067316(cpb2)
CAUA113044382(cpb2)
PPRM120479668(cpb2)
MAMB125272331(cpb2)
IPU108258492(cpb2)
PHYP113537361(cpb2)
SMEO124377841(cpb2)
TFD113648661(cpb2)
AMEX103039184(cpb2)
EEE113585022(cpb2)
TRU101063870(cpb2)
TNGGSTEN00027145G001
LCO104937555(cpb2)
NCC104941379
CGOB115016827
ELY117249807 117249816
EFO125884922(cpb2)
PLEP121950552 121962801 121962880
SLUC116044783(cpb2)
ECRA117939427(cpb2)
ESP116673913(cpb2)
PFLV114551165(cpb2)
GAT120821258(cpb2)
PPUG119222101(cpb2)
MSAM119902776(cpb2)
CUD121506353 121506369(cpb2) 121506377 121506387 121506399
ALAT119015053(cpb2)
MZE101484595 112430744
ONL100699903
OAU116319211(cpb2)
OLA101175299(cpb2)
OML112160012(cpb2)
XMA102234292(cpb2)
XCO114138216(cpb2)
XHE116715788
PRET103475539(cpo)
PFOR103147128
PLAI106950966
PMEI106905192(cpb2)
GAF122827454(cpb2)
CVG107093726(cpb2)
CTUL119784424(cpb2)
GMU124861754(cpb2)
NFU107381108(cpb2)
KMR108246710(cpb2)
ALIM106529640(cpb2)
NWH119429107(cpb2)
AOCE111580792(cpb2)
MCEP125000609(cpb2)
CSEM103389881(cpb2)
POV109643485
SSEN122765173(cpb2)
HHIP117777455(cpb2)
HSP118103143(cpb2)
LCF108872994
SDU111238723(cpb2)
SLAL111644417(cpb2)
XGL120797961(cpb2)
HCQ109520860(cpb2)
BPEC110168983(cpb2)
BSPL114870192(cpb2)
SASA106574315(cpb2) 106575090(cpo)
STRU115179320 115195939
OTW112266587(cpb2)
OMY110495951(cpb2)
OGO124008022 124010502(cpb2)
ONE115129625 115144654
SALP111953182 111953547(cpb2)
SNH120051231(cpb2)
CCLU121554179
ELS105023706(cpo)
PKI111860687
AANG118222270(cpb2)
LOC102697256(cpb2)
PSPA121320685 121327503
ARUT117405533 117406811
PSEX120523699(cpb2)
LCM102355283(CPB2)
CMK103177537(cpb2)
RTP109917215
AAG5572629
FEX115240213
CSET123316844
PPYR116173585
PXU106118984
NLU111047712
PCLA123749699
VDE111243188
VJA111259794 111266533
HROHELRODRAFT_185234
EPA110245430
SPIS111335355
PIFPITG_00756
 » show all
Reference
1  [PMID:1939207]
  Authors
Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D.
  Title
Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma.
  Journal
J Biol Chem 266:21833-8 (1991)
  Sequence
[hsa:1361]
Reference
2  [PMID:8130654]
  Authors
Shinohara T, Sakurada C, Suzuki T, Takeuchi O, Campbell W, Ikeda S, Okada N, Okada H.
  Title
Pro-carboxypeptidase R cleaves bradykinin following activation.
  Journal
Int Arch Allergy Immunol 103:400-4 (1994)
DOI:10.1159/000236661
Reference
3  [PMID:8195249]
  Authors
Wang W, Hendriks DF, Scharpe SS.
  Title
Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen.
  Journal
J Biol Chem 269:15937-44 (1994)
Reference
4  [PMID:7727441]
  Authors
Tan AK, Eaton DL.
  Title
Activation and characterization of procarboxypeptidase B from human plasma.
  Journal
Biochemistry 34:5811-6 (1995)
DOI:10.1021/bi00017a012
Reference
5  [PMID:8916945]
  Authors
Broze GJ Jr, Higuchi DA.
  Title
Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma.
  Journal
Blood 88:3815-23 (1996)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.20
IUBMB Enzyme Nomenclature: 3.4.17.20
ExPASy - ENZYME nomenclature database: 3.4.17.20
BRENDA, the Enzyme Database: 3.4.17.20
CAS: 156621-18-0

DBGET integrated database retrieval system