KEGG ENZYME: 3.4.17.22

ENZYME: 3.4.17.22

Entry

EC 3.4.17.22                Enzyme

Name

metallocarboxypeptidase D;
carboxypeptidase D (cattle, human, mouse, rat);
gp180 (duck)

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases

Reaction(IUBMB)

Releases C-terminal Arg and Lys from polypeptides

Comment

Activated by Co2+; inhibited by [(2-guanidinoethyl)sulfanyl]butanedioate. Large molecule (180 kDa) because of presence of three copies of metallopeptidase domain. The product of the silver gene (Drosophila) is similar. A zinc metallopeptidase in peptidase family M14 (carboxypeptidase A family)

History

EC 3.4.17.22 created 1997

Orthology

K07752

carboxypeptidase D

Genes

HSA:

1362(CPD)

PTR:	454557(CPD)

PPS:	100977539(CPD)

GGO:	101128462(CPD)

PON:	100436717(CPD)

NLE:	100597052(CPD)

HMH:	116474564(CPD)

MCC:	712407(CPD)

MCF:	102135486(CPD)

MTHB:

126938976

MNI:	105476838(CPD)

CSAB:

103242665(CPD)

CATY:

105591562(CPD)

PANU:

101016026(CPD)

TGE:	112609145(CPD)

MLEU:

105547020(CPD)

RRO:	104665980(CPD)

RBB:	108517294(CPD)

TFN:	117067645(CPD)

PTEH:

111520767(CPD)

CANG:

105510869

CJC:	100394725(CPD)

SBQ:	101034539(CPD)

CIMI:

108313607(CPD)

CSYR:

103258388(CPD)

MMUR:

105857947(CPD)

LCAT:

123620235(CPD)

PCOQ:

105820758(CPD)

OGA:	100941711(CPD)

MMU:	12874(Cpd)

MCAL:

110304688(Cpd)

MPAH:

110331499(Cpd)

RNO:	25306(Cpd)

MCOC:

116079227(Cpd)

ANU:	117710211(Cpd)

MUN:	110559449(Cpd)

CGE:	100757331(Cpd)

MAUA:

101825460(Cpd)

PROB:

127218882(Cpd)

PLEU:

114691458(Cpd)

MORG:

121456201(Cpd)

MFOT:

126492453

AAMP:

119812396(Cpd)

NGI:	103730489(Cpd)

HGL:	101707145(Cpd)

CPOC:

100716995(Cpd)

CCAN:

109695996(Cpd)

DORD:

105985666(Cpd)

DSP:	122120384(Cpd)

NCAR:

124979971

OCU:

100339843

OPI:	101524900(CPD)

TUP:	102482407(CPD)

GVR:	103597134(CPD)

CFA:	480636(CPD)

CLUD:

112677611(CPD)

VVP:	112933188(CPD)

VLG:	121473071(CPD)

AML:	100476363(CPD)

UMR:	103667395(CPD)

UAH:	113269090(CPD)

UAR:	123776845(CPD)

ELK:

111151441

LLV:

125087174

MPUF:

101691841(CPD)

NVS:	122906372(CPD)

ORO:	101378469(CPD)

EJU:	114213800(CPD)

ZCA:	113939480(CPD)

MLX:	118025245(CPD)

NSU:	110593312(CPD)

LWW:	102730240(CPD)

FCA:	101081771(CPD)

PYU:	121017273(CPD)

PBG:	122486068(CPD)

LRUF:

124512996

PTG:	102964772(CPD)

PPAD:

109255186(CPD)

PUC:

125927519

AJU:	106968721(CPD)

HHV:	120246157(CPD)

BTA:	532189(CPD)

BOM:	102274420(CPD)

BIU:	109573746(CPD)

BBUB:

102405741(CPD)

BBIS:

105004143(CPD)

CHX:	102173329(CPD)

OAS:	101122802(CPD)

ODA:	120866240(CPD)

CCAD:

122448007(CPD)

SSC:	100517495(CPD)

CFR:	102509584(CPD)

CBAI:

105071627(CPD)

CDK:	105088145(CPD)

VPC:	102526219(CPD)

BACU:

103018688(CPD)

LVE:	103070181(CPD)

OOR:	101288119(CPD)

DLE:	111186020(CPD)

PCAD:

102996164(CPD)

PSIU:

116744987(CPD)

ECB:	100072234(CPD)

EPZ:	103555366(CPD)

EAI:	106822001(CPD)

MYB:	102248065(CPD)

MYD:	102770691(CPD)

MMYO:

118671874(CPD)

MLF:	102441134(CPD)

MNA:	107528806(CPD)

PKL:	118702572(CPD)

HAI:	109386883(CPD)

DRO:	112308708(CPD)

SHON:

119003732(CPD)

AJM:	119061988(CPD)

PDIC:

114503948(CPD)

PHAS:

123816717(CPD)

MMF:	118635075(CPD)

RFQ:	117013109(CPD)

PALE:

102882023(CPD)

PGIG:

120621008(CPD)

PVP:	105291883(CPD)

RAY:	107507748(CPD)

MJV:	108404052(CPD)

TOD:	119232899(CPD)

SARA:

101543287(CPD)

LAV:	100656143(CPD)

TMU:

101345198

ETF:	101645738(CPD)

DNM:	101447175(CPD)

MDO:	100015882(CPD)

GAS:	123246807(CPD)

SHR:	100923705(CPD)

AFZ:

127558870

PCW:	110192185(CPD)

OAA:	100078830(CPD)

GGA:	417590(CPD)

PCOC:

116228028(CPD)

MGP:	100545345(CPD)

CJO:	107322671(CPD)

NMEL:

110407962(CPD)

APLA:

101802114(CPD)

ACYG:

106045786(CPD)

AFUL:

116497243(CPD)

TGU:	100219416(CPD) 116809159

LSR:	110467714(CPD)

SCAN:

103820140(CPD)

PMOA:

120507687(CPD)

OTC:	121345743(CPD)

PRUF:

121361624(CPD)

GFR:	102042306(CPD)

FAB:	101810441(CPD)

PHI:	102109483(CPD)

PMAJ:

107212948(CPD)

CCAE:

111937954(CPD)

CCW:	104691182(CPD)

CBRC:

103613357(CPD)

ETL:	114061228(CPD)

ZAB:	102068901(CPD)

ACHL:

103799743(CPD)

SVG:	106853366(CPD)

FPG:	101913850(CPD)

FCH:	102048834(CPD)

CLV:	102093976(CPD)

EGZ:	104121866(CPD)

NNI:	104012208(CPD)

PLET:

104618008(CPD)

PCRI:

104035640(CPD)

PCAO:

104045542(CPD)

ACUN:

113487075(CPD)

TALA:

104362808(CPD)

PADL:

103920816(CPD)

AFOR:

103898116(CPD)

ACHC:

115347176(CPD)

HALD:

104320315(CPD)

HLE:	104835606(CPD)

AGEN:

126039387

GCL:

127024257

CSTI:

104552602(CPD)

EHS:	104513023(CPD)

CMAC:

104479925(CPD)

MUI:	104542044(CPD)

FGA:	104079447(CPD)

GSTE:

104256931(CPD)

LDI:	104346364(CPD)

MNB:	103776437(CPD)

OHA:	104327170(CPD)

NNT:	104399864(CPD)

SHAB:

115601913(CPD)

DPUB:

104302784(CPD)

PGUU:

104471453(CPD)

ACAR:

104522975(CPD)

CPEA:

104384828(CPD)

AVIT:

104272035(CPD)

CVF:	104282144(CPD)

CUCA:

104057180(CPD)

TEO:	104370009(CPD)

BRHI:

104500311(CPD)

AAM:

106493764

AROW:

112960690(CPD)

NPD:	112945375(CPD)

TGT:	104576798(CPD)

DNE:	112983953(CPD)

SCAM:

104142849(CPD)

ASN:	102370437(CPD)

AMJ:	102566010(CPD)

CPOO:

109317227(CPD)

GGN:	109293358(CPD)

PSS:	102462593(CPD)

CMY:	102937712(CPD)

CPIC:

101930837(CPD)

TST:	117867384(CPD)

CABI:

116829764(CPD)

MRV:	120387219(CPD)

PVT:	110084275(CPD)

SUND:

121917004(CPD)

PBI:	103063983(CPD)

PMUR:

107298419(CPD)

CTIG:

120318842(CPD)

TSR:	106545879(CPD)

PGUT:

117658188(CPD)

VKO:	123023347(CPD)

PMUA:

114585585(CPD)

ZVI:	118097044(CPD)

GJA:	107119558(CPD)

STOW:

125445579(CPD)

XLA:	108707943(cpd.L) 108708851(cpd.S)

XTR:	100135269(cpd)

NPR:	108800486(CPD)

RTEM:

120927723(CPD)

BBUF:

120994660(CPD)

BGAR:

122930408(CPD)

DRE:	563008(cpda)

SRX:	107713140 107731961 107743672 107744773

SANH:

107664935 107675205 107690421

SGH:	107581996 107585576 107587220 107592607

CCAR:

109045857 109060340 109083236 109103251(cpd)

CAUA:

113038153 113058476 113070073 113115031

CGIB:

127972479 128029201

PPRM:

120478643(cpda) 120482486(cpdb)

MAMB:

125248367(cpda) 125252188(cpdb)

CIDE:

127496061

MASI:

127421877 127430249

IPU:	108277877(cpda) 108279099(cpdb)

PHYP:

113532697(cpd) 113541382

SMEO:

124394716(cpda)

TFD:	113643628(cpda)

AMEX:

103034353(cpd) 103045613

EEE:	113569722(cpd) 113582238

TRU:	101064552(cpd)

TNG:	GSTEN00010092G001

LCO:	104922855(cpd)

NCC:	104943195(cpd)

CGOB:

115017497(cpd)

ELY:	117259637(cpda)

EFO:	125888240(cpda)

PLEP:

121942848(cpda)

SLUC:

116048296(cpda)

ECRA:

117939204(cpda)

ESP:	116670937(cpd)

PFLV:

114551262(cpd)

GAT:	120824433(cpda)

PPUG:

119193993(cpda)

MSAM:

119883582(cpda)

CUD:	121518178(cpda)

ALAT:

119033382(cpda)

MZE:	101482580(cpd)

ONL:	100698903(cpd)

OAU:	116325713(cpda)

OLA:	101173725(cpd)

OML:	112149456(cpda)

XMA:	102218419(cpd)

XCO:	114133445(cpd)

XHE:	116708196(cpd)

PRET:

103474532(cpd)

PFOR:

103145582(cpd)

PLAI:

106948051(cpd)

PMEI:

106927795(cpd)

GAF:	122832174(cpda)

CVG:	107095025(cpd)

CTUL:

119782805(cpda)

GMU:	124883995(cpda)

NFU:	107380397(cpd)

KMR:	108246050(cpda)

ALIM:

106534193(cpd)

NWH:	119410604(cpda)

AOCE:

111585159(cpd)

MCEP:

125013322(cpda)

CSEM:

103378079(cpd)

POV:	109630253(cpd)

SSEN:

122773710(cpda)

HHIP:

117773396(cpda)

HSP:	118105974(cpda)

LCF:	108890362(cpda)

SDU:	111224052(cpd)

SLAL:

111668121(cpd)

XGL:	120791636(cpda)

HCQ:	109525484(cpd)

SSCV:

125972809

BPEC:

110174241(cpd)

MALB:

109960216(cpd)

BSPL:

114867508(cpda)

SASA:

106581036 106612847

STRU:

115163343 115206273

OTW:	112246916 112267012

OMY:	110503857 110507689

OGO:	123992800 124005178

ONE:	115116537 115141767

SALP:

111959355 111982774

SNH:	120018231 120029108

CCLU:

121566527 121567898

ELS:	105007417(cpd)

SFM:	108932207(cpd)

PKI:	111860566(cpd)

AANG:

118210097(cpda)

LOC:	102692446(cpd)

PSPA:

121308674(cpda)

ARUT:

117429629 117430554

PSEX:

120531472(cpda)

LCM:	102351860(CPD)

CMK:

103183365

RTP:	109918746(cpd)

BFO:	118413667 118426111 118427510

BBEL:

109463160 109463612 109463635

CIN:

100180843

SCLV:

120331015 120341665

SPU:

593440

APLC:

110980715

SKO:	100367428 100372562

DME:	Dmel_CG4122(svr)

DER:

6555783

DSE:

6615869

DSI:	Dsimw501_GD16509(Dsim_GD16509)

DYA:	Dyak_GE16618

DAN:

6504608

DSR:

110183075

DPO:

6901408

DPE:

6598149

DMN:

108159252

DWI:

6644767

DGR:

6565846

DMO:	Dmoj_GI15159

DAZ:

108618259

DNV:

108656323

DHE:

111593082

DVI:

6636081

CCAT:

101462369

BOD:

106625782

RZE:

108377769

MDE:

101900836

SCAC:

106093712

LCQ:

111676751

LSQ:

119609294

HIS:

119655560

AGA:	AgaP_AGAP002414

ACOZ:

120948991

AARA:

120894160

ASTE:

118506890

AAG:

23687919

AALB:

109422660 115260168

CQU:	CpipJ_CPIJ009464 CpipJ_CPIJ009465

CPII:

120414381

CNS:

116348711

BCOO:

119084248

AME:

724816

ACER:

107993797

ALAB:

122719329

BIM:

100749957

BBIF:

117213585

BVK:

117234262

BVAN:

117163196

BTER:

100651403

BPYO:

122568609

CCAL:

108630368

OBB:

114874739

MGEN:

117221903

NMEA:

116430378

CGIG:

122399407

SOC:

105199087

MPHA:

105833089

AEC:

105152604

ACEP:

105617236

PBAR:

105433737

VEM:

105564077

HST:

105184921

DQU:

106747187

CFO:

105251427

FEX:

115244802

LHU:

105668319

PGC:

109863141

OBO:

105280420

PCF:

106783784

PFUC:

122520066

VPS:

122631503

NVI:

100122498

CSOL:

105365417

TPRE:

106653140

MDL:

103571699

CGLO:

123271762

FAS:

105273111

DAM:

107039422

AGIF:

122854974

CCIN:

107266632

TCA:

655207

DPA:

109540038

SOY:

115876489

ATD:

109602651

CSET:

123320609

AGB:

108910193

LDC:

111505211

NVL:

108563176

APLN:

108735792

PPYR:

116162581

OTU:

111420598

BMOR:

101735927

MSEX:

115455674

DPL:	KGM_206855

BANY:

112045921

NIQ:

126775417

PMAC:

106712962

PPOT:

106106028

PXU:

106117845

PRAP:

110997051

PBX:

123712916

PNAP:

125056147

ZCE:

119833882

CCRC:

123700061

HAW:

110382679

HZE:

124639344

TNL:

113502763

SLIU:

111360061

OFU:	114352896 114360848

PXY:	105384432 105391574 105394772

CFEL:

113369781

API:

100161290

DNX:

107164754

AGS:

114119778

RMD:

113550382

BTAB:

109033499 109034391

DCI:

103513394

CLEC:

106664715

HHAL:

106681823 106691197

NLU:

111050394

PHU:	Phum_PHUM392810

FOC:

113207213

TPAL:

117642553

ZNE:

110826868

CSEC:

111870064

FCD:

110850729

DPX:	DAPPUDRAFT_250728

DMK:

116927841

DPZ:

124325965

PVM:	113813967 113827202

PJA:

122260287

PCHN:

125029297

HAME:

121879405

PCLA:

123763619

PTRU:

123516951

HAZT:

108678957

EAF:	111698819 111709190 111716650

LSM:

121124750

PPOI:

119111851

ISC:	IscW_ISCW007964

DSV:

119446686

RSAN:

119389501 119389506

VDE:

111253535

VJA:	111266374 111273015

TUT:

107369162

DPTE:

113799761

DFR:

124499813

CSCU:

111622109

SDM:

118184900

CEL:	CELE_F59A3.1(cpd-1)

CBR:

CBG_12487

BMY:	BM_BM11935(Bma-cpd-1)

LOA:	LOAG_08391

TSP:

Tsp_00258

LGI:	LOTGIDRAFT_226642

PCAN:

112561933

BGT:

106059226

GAE:

121368157

HRF:

124119271

HRJ:

124259925

CRG:	105333147 105343166

MYI:

110446872

PMAX:

117332640

MMER:

123533958

DPOL:

127865161

OBI:

106880679

OSN:

115224523

LAK:

106176567

SMM:	Smp_159890

SHX:	MS3_00010665

OVI:	T265_14579

NVE:	5502924 5513076 5513584 5518577 5519098 5519099

EPA:	110236473 110240551 110243944 110247075

ATEN:

116289641 116296036

ADF:	107334139 107334491 107353995

AMIL:

114948211 114957509 114957926 114976312

PDAM:

113666372 113681020 113684813 113685986

SPIS:

111324602 111327875 111336557 111342677

DGT:	114520353 114525020 114526262

XEN:	124433673 124435258

HMG:	100208105 100208464 100213926

TAD:	TRIADDRAFT_28479 TRIADDRAFT_32385 TRIADDRAFT_36680

AQU:

100636145

GMX:	100775772 100779927

GSJ:	114371992 114403285

PVU:	PHAVU_007G083600g

VRA:

106772299

VAR:

108326385

VUN:

114192081

CCAJ:

109805851

APRC:

113872012

MTR:

25485045

CAM:

101510794

PSAT:

127092517

LJA:	Lj5g3v1914090.1(Lj5g3v1914090.1)

ADU:

107467853

AIP:

107617945

AHF:	112712476 112775617

LANG:

109335576 109346745

PPER:

18767851

PMUM:

103336220

PAVI:

110760284

MNT:

21384369

CILL:

122296472

VVI:

100249088

SOT:

102582791

CANN:

107856023

NTA:

107809795

NSY:

104240271

NTO:

104087394

NAU:

109236874

OEU:

111393795

MBR:	MONBRDRAFT_27454

SRE:	PTSG_06583

DDI:	DDB_G0288963

DFA:

DFA_04675

ACAN:

ACA1_140780

NGR:	NAEGRDRAFT_79374

LACI:

CW733_02530

WIN:

WPG_1411

LUT:	Lupro_08720

AQA:	D1815_13320

MESQ:

C7H62_0045

CACI:

CLOAM1811

» show all

Reference

1 [PMID:9525948]

Authors

Eng FJ, Novikova EG, Kuroki K, Ganem D, Fricker LD

Title

gp180, a protein that binds duck hepatitis B virus particles, has metallocarboxypeptidase D-like enzymatic activity.

Journal

J Biol Chem 273:8382-8 (1998)
DOI:10.1074/jbc.273.14.8382

Sequence

[apla:101802114]

Reference

2 [PMID:7559630]

Authors

Song L, Fricker LD.

Title

Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary.

Journal

J Biol Chem 270:25007-13 (1995)
DOI:10.1074/jbc.270.42.25007

Reference

3 [PMID:8910535]

Authors

Song L, Fricker LD.

Title

Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D.

Journal

J Biol Chem 271:28884-9 (1996)
DOI:10.1074/jbc.271.46.28884

Other DBs

ExplorEnz - The Enzyme Database:

3.4.17.22

IUBMB Enzyme Nomenclature:

3.4.17.22

ExPASy - ENZYME nomenclature database:

3.4.17.22

BRENDA, the Enzyme Database:

3.4.17.22

CAS:	153967-26-1

DBGET integrated database retrieval system