KEGG   ENZYME: 3.4.17.23
Entry
EC 3.4.17.23                Enzyme                                 
Name
angiotensin-converting enzyme 2;
ACE-2;
ACE2;
hACE2;
angiotensin converting enzyme 2;
angiotensin converting enzyme-2;
Tmem27
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine [RN:R09535]
Reaction(KEGG)
R09535
Substrate
angiotensin II [CPD:C02135];
H2O [CPD:C00001]
Product
angiotensin-(1--7);
L-phenylalanine [CPD:C00079]
Comment
A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2.
History
EC 3.4.17.23 created 2009
Orthology
K09708  angiotensin-converting enzyme 2
Genes
HSA59272(ACE2)
PTR465511(ACE2)
PPS100970340(ACE2)
GGO101142534(ACE2)
PON100171441(ACE2)
PPYG129024770(ACE2)
NLE100602708(ACE2)
HMH116811532(ACE2)
SSYN129476374(ACE2)
MCC712790(ACE2)
MCF102130864(ACE2)
MTHB126946901
MNI105478157(ACE2)
CSAB103231639(ACE2)
CATY105574684(ACE2)
PANU101008749(ACE2)
TGE112615413(ACE2)
MLEU105550583(ACE2)
RRO104664530(ACE2)
RBB108539696(ACE2)
TFN117077264(ACE2)
PTEH111531712(ACE2)
CANG105510462
CJC100408882(ACE2)
SBQ101045190(ACE2)
CIMI108291904(ACE2)
ANAN105705080(ACE2)
CSYR103267011(ACE2)
MMUR105882317(ACE2)
LCAT123628560(ACE2)
PCOQ105805773(ACE2)
OGA100951881(ACE2)
MMU70008(Ace2)
MCAL110286854(Ace2)
MPAH110313851(Ace2)
RNO302668(Ace2)
MCOC116090418(Ace2)
ANU117695200(Ace2)
MUN110542541(Ace2)
CGE100772552(Ace2)
MAUA101823817(Ace2)
PROB127218185(Ace2)
PLEU114705723(Ace2)
MORG121439480(Ace2)
MFOT126512736
AAMP119804711(Ace2)
NGI103740288(Ace2)
HGL101697829(Ace2)
CPOC100302675(Ace2)
DORD105997641(Ace2)
DSP122108549(Ace2)
PLOP125344172(Ace2)
NCAR124971823
MMMA107144246(Ace2)
OCU100327258(ACE2)
OPI101526767(ACE2)
TUP102484728(ACE2)
GVR103607293
CFA480847(ACE2)
CLUD112653200(ACE2)
VVP112910549(ACE2)
VLG121483384(ACE2)
NPO129518830(ACE2)
AML100465802(ACE2)
UMR103668146(ACE2)
UAH113240702(ACE2)
UAR123797272(ACE2)
ELK111157129
LLV125091709
MPUF101673097(ACE2)
MNP132006914(ACE2)
MLK131821656(ACE2)
NVS122897655(ACE2)
ORO101373514(ACE2)
EJU114218071(ACE2)
ZCA113931501(ACE2)
MLX118004949(ACE2)
NSU110572485(ACE2)
LWW102726269
FCA554349(ACE2)
PYU121025614(ACE2)
PCOO112871621(ACE2)
PBG122476826(ACE2)
PVIV125157818(ACE2)
LRUF124509367
PTG102965716(ACE2)
PPAD109248320(ACE2)
PUC125931501
AJU106974224
HHV120232915(ACE2)
BTA509235(ACE2)
BOM102274886(ACE2)
BIU109555348(ACE2)
BBUB102409199(ACE2)
BBIS104984774(ACE2)
CHX102184608(ACE2)
OAS101103622(ACE2)
BTAX128070268(ACE2)
ODA120882560(ACE2)
CCAD122434819(ACE2)
MBEZ129564307(ACE2)
SSC100144303(ACE2)
CFR102523304(ACE2)
CBAI105079297(ACE2)
CDK105100402(ACE2)
VPC102526063(ACE2)
BACU103009000(ACE2)
BMUS118888930(ACE2)
LVE103086585(ACE2)
OOR101283738(ACE2)
DLE111168887(ACE2)
PCAD102996907(ACE2)
PSIU116747656(ACE2)
NASI112399149(ACE2)
ECB100055952(ACE2)
EPZ103568003(ACE2)
EAI106841569(ACE2)
MYB102259026(ACE2)
MYD102763166(ACE2)
MMYO118654484(ACE2)
MLF102419076(ACE2)
PKL118719785(ACE2)
EFUS103298184(ACE2)
MNA107529512(ACE2)
DRO112313373(ACE2)
SHON118987251(ACE2)
AJM119058376(ACE2)
PDIC114504693(ACE2)
PHAS123829997(ACE2)
MMF118636490(ACE2)
PPAM129076971(ACE2)
HAI109395939(ACE2)
RFQ117022979(ACE2)
PALE102888407(ACE2)
PGIG120611083(ACE2)
PVP105294000(ACE2)
RAY107497263(ACE2)
MJV108390919(ACE2)
TOD119246786(ACE2)
SARA101538370(ACE2)
SETR125998723(ACE2)
LAV100663153(ACE2)
TMU101343545
ETF101656395(ACE2)
DNM101429092(ACE2)
MDO100031783(ACE2)
GAS123241705(ACE2)
SHR100917420(ACE2)
AFZ127553615
PCW110222490(ACE2)
TVP118837758(ACE2)
OAA100085223(ACE2)
GGA418623(ACE2)
PCOC116230727(ACE2)
MGP100541186(ACE2)
CJO107325566(ACE2)
TPAI128076552(ACE2)
LMUT125687963(ACE2)
NMEL110392736(ACE2)
APLA101792697(ACE2)
ACYG106037784(ACE2)
CATA118245768(ACE2)
AFUL116498237(ACE2)
TGU100232752(ACE2)
LSR110471619(ACE2)
SCAN103815821(ACE2)
PMOA120504620(ACE2)
OTC121342248(ACE2)
PRUF121356213(ACE2)
GFR102037445(ACE2)
FAB101814772(ACE2)
OMA130252717(ACE2)
PHI102108306(ACE2)
PMAJ107206020(ACE2)
CCAE111922841(ACE2)
CCW104686166(ACE2)
CBRC103611746(ACE2)
ETL114066567(ACE2)
ZAB102067801(ACE2)
ZLE135445434(ACE2)
ACHL103810970(ACE2)
SVG106852915(ACE2)
MMEA130578770(ACE2)
HRT120748819(ACE2)
FPG101911905(ACE2)
FCH102045810(ACE2)
CLV102095592(ACE2)
EGZ104127303(ACE2)
NNI104022575(ACE2)
PCRI104029332(ACE2)
PLET104624367(ACE2)
EHS104502443(ACE2)
PCAO104049988(ACE2)
ACUN113480767(ACE2)
TALA104364304(ACE2)
PADL103918227(ACE2)
AFOR103896937(ACE2)
ACHC115334679(ACE2)
HALD104310355(ACE2)
HLE104840548(ACE2)
AGEN126052875
GCL127026027
CCRI104165694(ACE2)
CSTI104561893(ACE2)
CMAC104481125(ACE2)
MUI104537500(ACE2)
BREG104636426
FGA104075932(ACE2)
GSTE104261683(ACE2)
LDI104350299(ACE2)
MNB103771950(ACE2)
OHA104334989(ACE2)
NNT104405453(ACE2)
SHAB115604077(ACE2)
PGUU104470941(ACE2)
ACAR104527265(ACE2)
CPEA104385382(ACE2)
AVIT104273417(ACE2)
CVF104289986(ACE2)
RTD128915154(ACE2)
CUCA104063399(ACE2)
TEO104374083(ACE2)
BRHI104495535(ACE2)
AAM106490772(ACE2)
AROW112976192(ACE2)
NPD112943996(ACE2)
TGT104572141(ACE2)
DNE112995661(ACE2)
SCAM104140442(ACE2)
ASN102388701(ACE2)
AMJ102570994(ACE2)
CPOO109306030(ACE2)
GGN109303314(ACE2)
PSS102452742(ACE2)
CMY102938941(ACE2)
CCAY125641506(ACE2)
DCC119843507(ACE2)
CPIC101950848(ACE2)
TST117869503(ACE2)
CABI116821846(ACE2)
MRV120375732(ACE2)
ACS100565298(ace2)
ASAO132771692(ACE2)
PVT110075460(ACE2)
SUND121925094(ACE2)
PBI103068164(ACE2)
PMUR107290068(ACE2)
CTIG120306512(ACE2)
TSR106541239 106553039(ACE2)
PGUT117675857(ACE2)
APRI131199951(ACE2)
PTEX113445202(ACE2)
NSS113416856(ACE2)
VKO123033092(ACE2)
PRAF128413188(ACE2)
ZVI118085306(ACE2)
HCG128351280(ACE2)
GJA107115822(ACE2)
STOW125431331(ACE2)
EMC129325501(ACE2)
XLA100037182(ace2.S) 108707435(ace2.L)
XTR100486137(ace2)
NPR108792313(ACE2)
RTEM120927763(ACE2)
BBUF120994623(ACE2)
BGAR122927935 122930372(ACE2)
MUO115469546(ACE2)
GSH117363038(ACE2)
DRE492331(ace2)
SRX107737258 107751135
SANH107691301(ace2) 107695051
SGH107555905 107569674
CCAR109101192 109101497
CAUA113055292 113111073(ace2)
CGIB127968584 128022223
PTET122354480(ace2)
LROH127172960(ace2)
OMC131549029(ace2)
PPRM120480577(ace2)
RKG130085545(ace2)
MAMB125256625(ace2)
CIDE127522319
MASI127426183 127428003
TROS130571431(ace2)
TDW130410350(ace2)
MANU129427964(ace2)
IPU108259124
IFU128603044(ace2)
PHYP113547458(ace2)
SMEO124380062(ace2)
TFD113657143(ace2)
TVC132838731(ace2)
TRN134304225(ace2)
AMEX103030208(ace2)
CMAO118800932(ace2)
EEE113578258(ace2)
CHAR105893318(ace2) 105893961
TRU101066589(ace2)
TFS130517506(ace2)
TNGGSTEN00018041G001
LCO104919764(ace2)
NCC104963551(ace2)
TBEN117471608(ace2)
CGOB115005777(ace2)
PGEO117465461(ace2)
GACU117549374(ace2)
EMAC134863466(ace2)
ELY117263329(ace2)
EFO125878828(ace2)
PLEP121945388(ace2)
SLUC116054689(ace2)
ECRA117947475(ace2)
ESP116669656(ace2)
PFLV114560278(ace2)
GAT120808741(ace2)
PPUG119225508(ace2)
AFB129106465(ace2)
CLUM117727424(ace2)
PSWI130192921(ace2)
MSAM119890262(ace2)
SCHU122874501(ace2)
CUD121521168(ace2)
ALAT119018333(ace2)
MZE101480744(ace2)
ONL100699386(ace2)
OAU116311736(ace2)
OML112160389(ace2)
CSAI133460181(ace2)
XMA102218691(ace2)
XCO114143639(ace2)
XHE116719116(ace2)
PRET103462028(ace2)
PFOR103143561(ace2)
PLAI106952008(ace2)
PMEI106914635(ace2)
GAF122820294(ace2)
PPRL129369427(ace2)
CVG107082518(ace2)
CTUL119782330(ace2)
GMU124867441(ace2)
NFU107381688(ace2)
KMR108250149(ace2)
ALIM106536269(ace2)
NWH119429166(ace2)
AOCE111567340(ace2)
MCEP125005739(ace2)
CSEM103378664(ace2)
POV109624773(ace2)
SSEN122771881(ace2)
HHIP117759282(ace2)
HSP118113077(ace2)
PPLT128434631(ace2)
SMAU118302191(ace2)
LCF108887946
SDU111224725(ace2)
SLAL111651666(ace2)
XGL120794742(ace2)
HCQ109526010(ace2)
SSCV125966797
SBIA133497730(ace2)
PEE133399314(ace2)
PTAO133467595(ace2)
BPEC110161222(ace2)
MALB109965722(ace2)
BSPL114851880(ace2)
SJO128360392(ace2)
SASA106595857 106609069(ace2)
STRU115188686 115188791
OTW112239661(ace2)
OMY110496986 110500299
OGO124028887
OKI109879259 109887010
OKE118382156(ace2)
SALP112076415(ace2)
SNH120042338 120042431(ace2)
CCLU121562841(ace2)
ELS105019921(ace2)
SFM108920456(ace2)
PKI111850234(ace2)
AANG118213842(ace2)
LOC102690232(ace2)
PSPA121320626(ace2) 121328027
ARUT117406081 117407347(ace2)
PSEX120523603(ace2)
LCM102362771(ACE2)
CMK103177482(ace2)
HOC132820893(ace2)
LERI129702785(ace2)
PMRN116957162(ACE2)
BBEL109476928
LPIC129274227 129275092
AJC117106339
SKO100375272 100375575 102806594
OBB114878034
CGIG122405136
SOC105205666
MPHA105827808
HST105186217
DQU106744847
LHU105672116
OBO105281396
DPXDAPPUDRAFT_65345
DMK116922098 116928362
DPZ124312323 124328503 124328504 124340502
HAME121875276
CQD128692655
MNZ135200806
TCF131883002
 » show all
Reference
1  [PMID:11815627]
  Authors
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P
  Title
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related  carboxypeptidase.
  Journal
J Biol Chem 277:14838-43 (2002)
DOI:10.1074/jbc.M200581200
  Sequence
[hsa:59272]
Reference
2  [PMID:17897633]
  Authors
Lambert DW, Hooper NM, Turner AJ
  Title
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.
  Journal
Biochem Pharmacol 75:781-6 (2008)
DOI:10.1016/j.bcp.2007.08.012
Reference
3  [PMID:14754895]
  Authors
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW
  Title
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
  Journal
J Biol Chem 279:17996-8007 (2004)
DOI:10.1074/jbc.M311191200
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.23
IUBMB Enzyme Nomenclature: 3.4.17.23
ExPASy - ENZYME nomenclature database: 3.4.17.23
BRENDA, the Enzyme Database: 3.4.17.23

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