KEGG   ENZYME: 3.4.17.24
Entry
EC 3.4.17.24                Enzyme                                 

Name
tubulin-glutamate carboxypeptidase;
cytosolic carboxypeptidase 1;
cytosolic carboxypeptidase 5;
CCP1;
CCP5;
Agtpbp1 (gene name);
AGBL5 (gene name)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
History
EC 3.4.17.24 created 2020
Orthology
K23435  cytosolic carboxypeptidase protein 1
K23436  cytosolic carboxypeptidase protein 4
K23438  cytosolic carboxypeptidase protein 5
K23439  cytosolic carboxypeptidase protein 6
Genes
HSA: 123624(AGBL1) 23287(AGTPBP1) 60509(AGBL5) 84871(AGBL4)
PTR: 456843(AGBL4) 459092(AGBL5) 464558(AGTPBP1) 467750(AGBL1)
PPS: 100967527(AGBL4) 100984168(AGBL5) 100992666(AGBL1) 100995580(AGTPBP1)
GGO: 101129763(AGBL1) 101131625(AGBL5) 101141317(AGTPBP1) 101147269(AGBL4)
PON: 100435341(AGBL4) 100442193(AGTPBP1) 100447882(AGBL5) 100457638(AGBL1)
NLE: 100580221(AGBL4) 100584395(AGBL1) 100598919(AGBL5) 100606230(AGTPBP1)
MCC: 697940(AGBL5) 699665(AGBL1) 709949(AGTPBP1)
MCF: 101867253(AGBL5) 102121173(AGBL1) 102135599(AGTPBP1) 107126370(AGBL4)
CSAB: 103219676(AGTPBP1) 103220617(AGBL5) 103224854(AGBL4) 103231124(AGBL1)
RRO: 104668510(AGBL5) 104669579 104673902(AGTPBP1) 104673973(AGBL4)
RBB: 108520519(AGTPBP1) 108522470(AGBL1) 108526687(AGBL4) 108532697(AGBL5)
CJC: 100385282(AGBL5) 100387973(AGBL1) 100393071(AGBL4) 100413848(AGTPBP1)
SBQ: 101028014(AGBL1) 101037784(AGBL5) 101050152(AGBL4) 101054034(AGTPBP1)
MMU: 231093(Agbl5) 244071(Agbl1) 67269(Agtpbp1) 78933(Agbl4)
MCAL: 110293190(Agbl4) 110293900(Agbl5) 110298802(Agbl1) 110307624(Agtpbp1)
MPAH: 110317945(Agbl1) 110322833(Agbl4) 110324258(Agbl5) 110333756(Agtpbp1)
RNO: 100911395 290986(Agtpbp1) 308724(Agbl1) 362710(Agbl5)
MUN: 110542733(Agbl4) 110547698(Agbl5) 110554882(Agtpbp1) 110563861(Agbl1)
CGE: 100750752(Agbl1) 100759283(Agbl4) 100762486(Agbl5) 100772683(Agtpbp1)
NGI: 103733566(Agbl4) 103735672(Agbl5) 103738764(Agtpbp1) 103749471(Agbl1)
HGL: 101704503(Agbl5) 101710436(Agbl4) 101722036(Agtpbp1) 101725425(Agbl1)
CCAN: 109679852(Agbl5) 109685042(Agtpbp1) 109685302(Agbl1) 109701007(Agbl4)
OCU: 100352303(AGBL1) 100352650(AGBL5) 100353437(AGBL4) 103352412(AGTPBP1)
TUP: 102485269(AGBL5) 102485661(AGBL1) 102489333(BEND5) 102501867(AGTPBP1)
CFA: 475695(AGBL5) 479034(AGBL1) 484146(AGTPBP1) 610123(AGBL4)
VVP: 112908541(AGBL5) 112908674(AGTPBP1) 112921932(AGBL1)
AML: 100467720(AGBL5) 100471800(AGBL4) 100474364(AGTPBP1) 100479250(AGBL1)
UMR: 103660055(AGBL1) 103667635(AGTPBP1) 103670884(AGBL4) 103671659(AGBL5)
UAH: 113254695(AGBL4) 113263567(AGBL1) 113269801(AGTPBP1) 113270950(AGBL5)
ORO: 101364418(AGTPBP1) 101373894(AGBL1) 101374004(AGBL4) 101385156(AGBL5)
FCA: 101081287(AGBL5) 101087359(AGTPBP1) 101092766(AGBL1)
PTG: 102949822(AGTPBP1) 102950142(AGBL4) 102963120(AGBL5) 102968543(AGBL1)
PPAD: 109251700(AGTPBP1) 109267037(AGBL5) 109273402(AGBL1)
AJU: 106967843(AGBL5) 106978570(AGTPBP1) 106982639(AGBL1)
BTA: 100300175(AGBL1) 534958(AGTPBP1) 538585(AGBL5) 615787(AGBL4)
BOM: 102267692(AGBL5) 102269694(AGTPBP1) 102283480(AGBL1) 106700796(AGBL4)
BIU: 109556881(AGBL4) 109563218(AGTPBP1) 109566301(AGBL5) 109575497
BBUB: 102391803(AGBL5) 102392503(AGBL4) 102405329(AGTPBP1) 102414193(AGBL1)
CHX: 102181597(AGTPBP1) 102185284(AGBL5) 102185399(AGBL1) 106501960 106501971
SSC: 100518857(AGTPBP1) 100523841(AGBL5) 100524296(AGBL1) 100737108(AGBL4)
CFR: 102506549(AGTPBP1) 102507055(AGBL1) 102510642(AGBL5) 102522878(AGBL4)
CDK: 105084707(AGTPBP1) 105085471(AGBL1) 105092943(AGBL4) 105098525(AGBL5)
BACU: 102998879(AGTPBP1) 103005463(AGBL4) 103009183(AGBL5) 103011912(AGBL1)
LVE: 103072986(AGBL4) 103073894(AGBL1) 103082044(AGTPBP1) 103091091(AGBL5)
OOR: 101269945(AGBL5) 101270994(AGBL1) 101276850(AGBL4) 101288448(AGTPBP1)
DLE: 111166798(AGTPBP1) 111169336(AGBL1) 111174969(AGBL5) 111175792(AGBL4)
PCAD: 102974211(AGBL4) 102977787(AGBL1) 102990531(AGBL5) 102996111(AGTPBP1)
ECB: 100055532(AGBL5) 100061665(AGTPBP1) 100063327(AGBL4) 100070057(AGBL1)
EPZ: 103540450(AGTPBP1) 103546447(AGBL5) 103558371(AGBL1) 103565708(AGBL4)
EAI: 106822036(AGTPBP1) 106832012(AGBL1) 106833857 106833896(AGBL4) 106837023(AGBL5)
MYB: 102252036(AGBL1) 102259621(AGBL5) 102261301(BEND5) 102263005(AGTPBP1)
MYD: 102763395(AGBL4) 102772229(AGBL1) 102772501(AGBL5) 102775228(AGTPBP1)
MNA: 107534272(AGBL5) 107534457(AGBL1) 107539425(AGBL4) 107544951(AGTPBP1)
HAI: 109372376(AGTPBP1) 109381802(AGBL5) 109390266(AGBL4)
DRO: 112297772(AGBL5) 112304325(AGTPBP1) 112306058(AGBL1) 112314560(AGBL4)
PALE: 102879682(AGBL4) 102880556(AGBL1) 102893096(AGTPBP1) 102893326(AGBL5)
RAY: 107502158(AGBL5) 107502785(AGTPBP1) 107514023(AGBL4) 107514187(AGBL1)
MJV: 108391206(AGBL5) 108394227 108395144(AGTPBP1) 108399114(AGBL1)
LAV: 100653652(AGBL5) 100654111(AGTPBP1) 100666754(AGBL1) 100670614(AGBL4)
MDO: 100017490(AGBL1) 100025865(AGBL5) 100619019(AGTPBP1) 100619105(AGBL4)
SHR: 100913599(AGBL5) 100927064(AGTPBP1) 100928716
PCW: 110192328(AGBL1) 110194588(AGTPBP1) 110206491(AGBL5) 110209326(AGBL4)
OAA: 100075393(AGBL1) 100078812(AGBL5) 100090362(AGTPBP1)
GGA: 427460(AGTPBP1) 427507(AGBL1) 770678(AGBL5)
CJO: 107306249(AGTPBP1) 107312306(AGBL5) 107318857(AGBL1)
NMEL: 110389323(AGTPBP1) 110396886(AGBL5) 110403848(AGBL1)
APLA: 101790953(AGBL5) 101793469(AGBL1) 101796396(BEND5) 101804998(AGTPBP1)
ACYG: 106033024(AGBL4) 106036461(AGBL1) 106045374(AGTPBP1)
TGU: 100219998(AGTPBP1) 100224531(AGBL1) 115494671(AGBL5)
LSR: 110470588(AGBL1) 110472595(AGTPBP1) 110478519(AGBL5)
SCAN: 103815191 103816212(AGBL1) 103822952(AGTPBP1) 103825094(AGBL5)
GFR: 102033946 102035278(AGBL1) 102040093(AGTPBP1) 102041456(AGBL4) 102041539(AGBL5)
FAB: 101806246(AGBL4) 101807546(AGBL5) 101816991(AGTPBP1) 101820233(AGBL1)
PHI: 102100354(AGTPBP1) 102103060(AGBL1) 102106464(AGBL5) 102112919(AGBL4)
PMAJ: 107198687(AGBL5) 107209101(AGBL1) 107216241(AGTPBP1)
CCAE: 111927318(AGBL5) 111934033(AGBL1) 111940795(AGTPBP1)
CCW: 104684084(AGBL1) 104692004(AGTPBP1) 104695527(AGBL4)
ETL: 114055935(AGTPBP1) 114058032(AGBL1)
FPG: 101910996(AGBL4) 101913785(AGTPBP1) 101917029(AGBL5) 101917771(AGBL1)
FCH: 102050219(AGBL1) 102053070(AGTPBP1) 102057277(AGBL5)
CLV: 102089515 102091444(AGTPBP1) 102094300(AGBL1) 102096556(AGBL5)
EGZ: 104122859(AGBL1) 104123498(AGBL4) 104133023(AGBL5) 104135555(AGTPBP1)
NNI: 104009146(AGBL5) 104009366(AGBL4) 104011750(AGTPBP1) 104017235(AGBL1)
ACUN: 113483991(AGBL1) 113490073(AGTPBP1) 113490969(AGBL5)
PADL: 103912454(AGBL4) 103920398(AGTPBP1) 103922979(AGBL5) 103926371(AGBL1)
ASN: 102372082(AGBL5) 102375387(AGBL1) 102375582(AGBL4) 102385577(AGTPBP1)
AMJ: 102567716(AGTPBP1) 106737155(AGBL1) 106739689 109284448
PSS: 102450499(AGBL4) 102454920 102461124(AGBL5) 102463518(AGTPBP1)
CMY: 102936906(AGTPBP1) 102939217(AGBL5) 102939366(AGBL4) 102943192(AGBL1)
CPIC: 101936265(AGBL1) 101942395(AGBL5) 101948424(AGTPBP1)
ACS: 100559096(agbl5) 100563132(agtpbp1) 103279750
PVT: 110072942(AGBL1) 110085557(AGTPBP1) 110086970(AGBL5)
PBI: 103056704(AGBL5) 103063646(AGTPBP1) 103064303 103067702(AGBL1)
PMUR: 107284150(AGBL1) 107284474(AGBL4) 107286459(AGBL5) 107289721(AGTPBP1)
TSR: 106550079(AGBL5) 106552266(AGBL4) 106556810(AGTPBP1)
PMUA: 114584494(AGBL1) 114594996(AGBL5) 114599023(BEND5) 114606533(AGTPBP1)
GJA: 107109456(AGBL4) 107109522(AGBL1) 107113807(AGBL5) 107117203(AGTPBP1)
XLA: 108700246 108706989(agtpbp1.S) 108711466(agbl1.L) 108712837(agbl1.S) 446690(agbl5.L) 446993(agtpbp1.L)
XTR: 100135097(agtpbp1) 100145249(agbl5) 100485158(agbl1) 100495721(agbl4)
NPR: 108784279 108786947(AGBL1) 108800640(AGTPBP1) 108803751(AGBL5)
DRE: 100536841(agbl1) 445479(agbl5) 550450(agbl4) 554164(agtpbp1)
IPU: 108265333(agtpbp1) 108265765(agbl4) 108269067(agbl1) 108279859(agbl5)
PHYP: 113526967(agbl4) 113532241(agbl5) 113533342(agtpbp1) 113546615(agbl1)
AMEX: 103026357(agbl4) 103030228(agbl5) 103039550(agtpbp1) 111195774
EEE: 113572046(agbl4) 113575797(agbl5) 113578774(agtpbp1) 113579058 113590409
TRU: 101063000(agbl5) 101065928(agbl4) 101077586(agtpbp1)
LCO: 104920264(agtpbp1) 104930014(agbl5) 104930477(agbl4)
NCC: 104947153(agbl5) 104961591(agtpbp1)
ONL: 100692438(agtpbp1) 100702700(agbl5) 102081727
OLA: 101155157(agbl5) 101160643(agbl4) 101172500(agtpbp1)
XMA: 102225116(agbl5) 102230662(agbl4) 102236038(agtpbp1)
XCO: 114150947(agbl4) 114154356(agtpbp1) 114159021(agbl5)
PRET: 103457830(agbl5) 103470216(agtpbp1)
CVG: 107084453(agtpbp1) 107087952(agbl4) 107097721(agbl5)
NFU: 107378146(agbl5) 107393107(agbl4) 107394031(agtpbp1)
KMR: 108230725(agbl4) 108231879(agbl5) 108234562(agtpbp1)
ALIM: 106521582(agbl4) 106526221(agtpbp1) 106534634(agbl5)
AOCE: 111566278 111569377(agbl1) 111576460(agtpbp1) 111587914(agbl5)
CSEM: 103379876 103380698(agbl5) 103397560(agbl4) 103398167(agtpbp1)
POV: 109625419(agbl4) 109632576(agbl5) 109639821(agtpbp1) 109640594
LCF: 108878275(agtpbp1) 108881379(agbl4) 108884586 108898072(agbl5)
SDU: 111216348(agbl5) 111216379(agbl4) 111230800(agtpbp1) 111234819
SLAL: 111647738(agbl1) 111648828 111651875 111660977(agtpbp1) 111672500(agbl5)
HCQ: 109513058(agbl1) 109513238(agbl5) 109514215(agtpbp1) 109532003(agbl4)
BPEC: 110153490(agtpbp1) 110160058(agbl4) 110169491 110173927(agbl5)
MALB: 109961528(agtpbp1) 109962165(agbl5) 109967452(agbl4)
ELS: 105008985(agbl5) 105011755(agbl4) 105014456(agtpbp1) 105018600(agbl1)
SFM: 108919067(agbl4) 108926553 108929344(agbl5) 108938646(agtpbp1) 108941199
PKI: 111839261(agtpbp1) 111845017 111845721 111848973(agbl4) 111851559(agbl5)
LCM: 102348649(AGBL1) 102349582(AGTPBP1) 102351389(AGBL4) 102357494(AGBL5)
CMK: 103183136(agbl5) 103185259(agbl4) 103188166(agtpbp1) 103189904
RTP: 109912776 109913190(agbl5) 109928951 109932582(agtpbp1)
DME: Dmel_CG31019(CG31019)
DER: 6555034
DSE: 6612891
DSI: Dsimw501_GD21534(Dsim_GD21534)
DAN: 6505565
DSR: 110186619
DPE: 6595329
DMN: 108155703
DWI: 6651399
DAZ: 108620630
DNV: 108660024
DHE: 111597392
DVI: 6631280
MDE: 101897289
LCQ: 111679490
AALB: 109418093
DPTE: 113796633
CEL: CELE_EEED8.6(ccpp-6) CELE_F56H1.5(ccpp-1)
BMY: Bm1_11405
HMG: 100215815
PCB: PCHAS_020810(PC000329.04.0)
SMIN: v1.2.006491.t1(symbB.v1.2.006491.t1) v1.2.029805.t2(symbB.v1.2.029805.t2)
SPAR: SPRG_01956
TCR: 504013.70
ILO: IL1416
MARM: YQ22_16550
WIN: WPG_3049
 » show all
Reference
1  [PMID:21074048]
  Authors
Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND, Lacroix B, Bosch Grau M, Bec N, Larroque C, Desagher S, Holzer M, Andrieux A, Moutin MJ, Janke C
  Title
A family of protein-deglutamylating enzymes associated with neurodegeneration.
  Journal
Cell 143:564-78 (2010)
DOI:10.1016/j.cell.2010.10.014
  Sequence
Reference
2  [PMID:20519502]
  Authors
Kimura Y, Kurabe N, Ikegami K, Tsutsumi K, Konishi Y, Kaplan OI, Kunitomo H, Iino Y, Blacque OE, Setou M
  Title
Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).
  Journal
J Biol Chem 285:22936-41 (2010)
DOI:10.1074/jbc.C110.128280
  Sequence
[cel:CELE_EEED8.6] [mmu:231093]
Reference
3  [PMID:22170066]
  Authors
Berezniuk I, Vu HT, Lyons PJ, Sironi JJ, Xiao H, Burd B, Setou M, Angeletti RH, Ikegami K, Fricker LD
  Title
Cytosolic carboxypeptidase 1 is involved in processing alpha- and beta-tubulin.
  Journal
J Biol Chem 287:6503-17 (2012)
DOI:10.1074/jbc.M111.309138
Reference
4  [PMID:24022482]
  Authors
Berezniuk I, Lyons PJ, Sironi JJ, Xiao H, Setou M, Angeletti RH, Ikegami K, Fricker LD
  Title
Cytosolic carboxypeptidase 5 removes alpha- and gamma-linked glutamates from tubulin.
  Journal
J Biol Chem 288:30445-53 (2013)
DOI:10.1074/jbc.M113.497917
Reference
5  [PMID:24743595]
  Authors
Pathak N, Austin-Tse CA, Liu Y, Vasilyev A, Drummond IA
  Title
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
  Journal
Mol Biol Cell 25:1836-44 (2014)
DOI:10.1091/mbc.E13-01-0033
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.24
IUBMB Enzyme Nomenclature: 3.4.17.24
ExPASy - ENZYME nomenclature database: 3.4.17.24
BRENDA, the Enzyme Database: 3.4.17.24

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