KEGG   ENZYME: 3.4.17.3
Entry
EC 3.4.17.3                 Enzyme                                 
Name
lysine carboxypeptidase;
carboxypeptidase N;
arginine carboxypeptidase;
kininase I;
anaphylatoxin inactivator;
plasma carboxypeptidase B;
creatine kinase conversion factor;
bradykinase;
kininase Ia;
hippuryllysine hydrolase;
bradykinin-decomposing enzyme;
protaminase;
CPase N;
creatinine kinase convertase;
peptidyl-L-lysine(-L-arginine) hydrolase;
CPN
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Release of a C-terminal basic amino acid, preferentially lysine
Comment
A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.3 created 1972 as EC 3.4.12.7, transferred 1978 to EC 3.4.17.3, modified 1989
Orthology
K01292  carboxypeptidase N catalytic subunit
Genes
HSA1369(CPN1)
PTR107966811(CPN1)
PPS100994885(CPN1)
GGO101136315(CPN1)
PON100448102(CPN1)
NLE100595544(CPN1)
MCC709434(CPN1)
MCF102146119(CPN1)
CSAB103216380
CATY105581828(CPN1)
PANU100997838(CPN1)
TGE112631730(CPN1)
RRO104656557(CPN1)
RBB108535064(CPN1)
TFN117068618(CPN1)
PTEH111538692(CPN1)
CJC100412406(CPN1)
SBQ101050699(CPN1)
CSYR103263188(CPN1)
MMUR105873449(CPN1)
LCAT123650141(CPN1)
OGA100950512(CPN1)
MMU93721(Cpn1)
MCAL110285505(Cpn1)
MPAH110330628(Cpn1)
RNO365466(Cpn1)
MCOC116103884(Cpn1)
MUN110552974(Cpn1)
CGE100752048(Cpn1)
MAUA101837904(Cpn1)
PLEU114706457(Cpn1)
MORG121454343(Cpn1)
AAMP119809079(Cpn1)
NGI103731905
HGL101718051(Cpn1)
CPOC100725809(Cpn1)
CCAN109681489(Cpn1)
DORD105986679(Cpn1)
DSP122115859(Cpn1)
NCAR124985110
OCU100344758(CPN1)
TUP102499941(CPN1)
CFA477795(CPN1)
CLUD112672187(CPN1)
VVP112914786(CPN1)
VLG121484114(CPN1)
AML100467677(CPN1)
UMR103676448(CPN1)
UAH113251825(CPN1)
UAR123795859(CPN1)
ELK111145084
LLV125085202
MPUF101681991(CPN1)
ORO101363324(CPN1)
EJU114205443(CPN1)
ZCA113923926(CPN1)
MLX118024860(CPN1)
FCA101090390(CPN1)
PYU121037103(CPN1)
PBG122493131(CPN1)
PTG102973010(CPN1)
PPAD109272764(CPN1)
AJU106966861(CPN1)
HHV120243179(CPN1)
BTA536753(CPN1)
BOM102283003(CPN1)
BBUB102398093(CPN1)
CHX102180453(CPN1)
OAS101120287(CPN1)
ODA120873526(CPN1)
CCAD122446057(CPN1)
SSC100157984(CPN1)
CFR102505284(CPN1)
CBAI105081749(CPN1)
CDK105084312(CPN1)
VPC102535178(CPN1)
BACU103018234(CPN1)
LVE103083659(CPN1)
OOR101280134(CPN1)
DLE111172400(CPN1)
PCAD102983536(CPN1)
PSIU116741651(CPN1)
ECB100070412(CPN1)
EPZ103542363(CPN1)
EAI106846702(CPN1)
MYB102262371(CPN1)
MYD102761933(CPN1)
MMYO118669863(CPN1)
MLF102424554(CPN1)
MNA107542522(CPN1)
PKL118719387(CPN1)
HAI109379588(CPN1)
DRO112300350(CPN1)
SHON118999526(CPN1)
AJM119064550(CPN1)
PDIC114497546(CPN1)
PHAS123828910(CPN1)
MMF118632434(CPN1)
RFQ117035766(CPN1)
PALE102894046(CPN1)
PGIG120609211(CPN1)
PVP105304666(CPN1)
RAY107499779(CPN1)
MJV108409592(CPN1)
TOD119233594(CPN1)
SARA101538658(CPN1)
LAV100664930(CPN1)
TMU101340515
DNM101432402(CPN1)
MDO100020383(CPN1)
GAS123238256(CPN1)
SHR100924516(CPN1)
PCW110215500(CPN1)
OAA100087406(CPN1)
GGA769143(CPN1)
PCOC116231739(CPN1)
MGP100545641(CPN1)
CJO107316068(CPN1)
NMEL110399891(CPN1)
APLA101803617(CPN1)
ACYG106033451(CPN1)
AFUL116491494(CPN1)
TGU100231475(CPN1)
LSR110473605(CPN1)
SCAN103813898(CPN1)
PMOA120502201(CPN1)
OTC121341719(CPN1)
PRUF121350359(CPN1)
GFR102043170(CPN1)
FAB101818188(CPN1)
PHI102110254(CPN1)
PMAJ107206689(CPN1)
CCAE111930929(CPN1)
CCW104697908(CPN1)
CBRC103624529(CPN1)
ETL114071122(CPN1)
ZAB102065024(CPN1)
ACHL103808932(CPN1)
FPG101919893(CPN1)
FCH102053681(CPN1)
CLV102095577(CPN1)
EGZ104129072(CPN1)
NNI104012843(CPN1)
PLET104620630(CPN1)
PCRI104024885(CPN1)
ACUN113481538(CPN1)
TALA104357431(CPN1)
PADL103916348(CPN1)
ACHC115348470(CPN1)
HALD104322467(CPN1)
CCRI104161967(CPN1)
CSTI104561412
EHS104516536(CPN1)
CMAC104473885(CPN1)
MUI104546281(CPN1)
FGA104076696(CPN1)
GSTE104263987(CPN1)
LDI104340587(CPN1)
MNB103777043(CPN1)
OHA104338201(CPN1)
AAM106494714(CPN1)
AROW112964190(CPN1)
NPD112957193(CPN1)
DNE112989784(CPN1)
ASN102373779(CPN1)
AMJ102567467(CPN1)
PSS102453241(CPN1)
CMY102944605(CPN1)
CPIC101948942(CPN1)
TST117880168(CPN1)
CABI116817684(CPN1)
MRV120369441(CPN1)
ACS100563397(cpn1)
PVT110084028(CPN1)
SUND121925729(CPN1)
PBI103054238(CPN1)
PMUR107287742(CPN1)
TSR106537857(CPN1)
PGUT117678571(CPN1)
VKO123026486(CPN1)
PMUA114597618(CPN1)
ZVI118094020(CPN1)
GJA107121131(CPN1)
STOW125438023(CPN1)
XLA108696975(cpn1.L) 398791(cpn1.S)
XTR550020(cpn1)
NPR108789679(CPN1)
RTEM120946767(CPN1)
BBUF121003335(CPN1)
BGAR122941567(CPN1)
DRE337172(cpn1)
SRX107722209 107755523
SANH107684044 107702463
SGH107566747 107581572(cpn1)
CCAR109094710 109100080(cpn1)
CAUA113069504 113073777 113111602
PPRM120474619(cpn1)
MAMB125255437(cpn1)
IPU108274305(cpn1)
PHYP113527392(cpn1)
SMEO124389254(cpn1)
TFD113639001(cpn1)
AMEX103037340(cpn1)
EEE113587528(cpn1)
TRU101063492(cpn1)
LCO104927896(cpn1)
NCC104953335(cpn1)
CGOB115024261(cpn1)
ELY117247647(cpn1)
EFO125880433(cpn1)
PLEP121959210(cpn1)
SLUC116061352(cpn1)
ECRA117936820(cpn1)
ESP116670730(cpn1)
PFLV114548707(cpn1)
GAT120818892(cpn1)
PPUG119213106(cpn1)
MSAM119916412(cpn1)
CUD121528292(cpn1)
ALAT119009416(cpn1)
MZE101471524(cpn1)
ONL100709588(cpn1)
OAU116329798(cpn1)
OLA101156125(cpn1)
OML112154450(cpn1)
XMA102227125(cpn1)
XCO114151892(cpn1)
XHE116726731(cpn1)
PRET103481278(cpn1)
PFOR103153384(cpn1)
PLAI106948317(cpn1)
PMEI106907600(cpn1)
GAF122823006(cpn1)
CVG107094718(cpn1)
CTUL119792205
GMU124875638(cpn1)
NFU107387875(cpn1)
KMR108248818(cpn1)
ALIM106536196(cpn1)
NWH119423498 119429703
AOCE111567296(cpn1)
MCEP125022728(cpn1)
CSEM103381454(cpn1)
POV109627019(cpn1)
SSEN122759021(cpn1)
HHIP117752373(cpn1)
HSP118100721(cpn1)
LCF108898746(cpn1)
SDU111220291(cpn1)
SLAL111657127(cpn1)
XGL120794083(cpn1)
HCQ109523878(cpn1)
BPEC110154274(cpn1)
MALB109963082(cpn1)
BSPL114846334(cpn1)
SASA100196707(cpn1)
OTW121840653(cpn1)
OMY110491814(cpn1)
OGO124020313(cpn1)
ONE115106756(cpn1)
SALP111977708
SNH120046428(cpn1)
CCLU121572070(cpn1)
ELS105026237(cpn1)
SFM108940406(cpn1)
PKI111836044(cpn1)
AANG118221373(cpn1)
LOC102688364(cpn1)
PSPA121322021 121325968
ARUT117415124 117417952
LCM102367336(CPN1)
RTP109924839(cpn1)
BFO118414428 118419334
BBEL109466903 109478523 109484003
FOC113216854
EAF111712708
VDE111248153
VJA111272575
SMMSmp_142190
 » show all
Reference
1  [PMID:7341915]
  Authors
Plummer TH Jr, Erdos EG.
  Title
Human plasma carboxypeptidase N.
  Journal
Methods Enzymol 80 Pt C:442-9 (1981)
DOI:10.1016/s0076-6879(81)80038-9
Reference
2  [PMID:6750606]
  Authors
Levin Y, Skidgel RA, Erdos EG.
  Title
Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i).
  Journal
Proc Natl Acad Sci U S A 79:4618-22 (1982)
DOI:10.1073/pnas.79.15.4618
Reference
3  [PMID:3074547]
  Authors
Skidgel RA.
  Title
Basic carboxypeptidases: regulators of peptide hormone activity.
  Journal
Trends Pharmacol Sci 9:299-304 (1988)
DOI:10.1016/0165-6147(88)90015-6
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.3
IUBMB Enzyme Nomenclature: 3.4.17.3
ExPASy - ENZYME nomenclature database: 3.4.17.3
BRENDA, the Enzyme Database: 3.4.17.3
CAS: 9013-89-2

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