EC                 Enzyme                                 

cathepsin X;
cathepsin B2;
cysteine-type carboxypeptidase;
cathepsin IV;
cathepsin Z;
acid carboxypeptidase;
lysosomal carboxypeptidase B
Acting on peptide bonds (peptidases);
Cysteine-type carboxypeptidases
Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity
Cathepsin X is a lysosomal cysteine peptidase of family C1 (papain family). The pH optimum is dependent on the substrate and is 5.0 for the carboxypeptidase activity. Unstable above pH 7.0. Compound E-64, leupeptin and antipain are inhibitors, but not cystatin C. Cathepsin X is ubiquitously distributed in mammalian tissues. The propeptide is extremely short (38 amino acid residues) and the proenzyme is catalytically active. Human gene locus: 20q13.
EC created 1981, modified 2000
K08568  cathepsin X
HSA: 1522(CTSZ)
PTR: 736240(CTSZ)
PPS: 100978982(CTSZ)
GGO: 101135556(CTSZ)
PON: 100445547(CTSZ)
NLE: 100605843(CTSZ)
MCC: 694157(CTSZ)
MCF: 102118566(CTSZ)
CSAB: 103243445(CTSZ)
CATY: 105585314(CTSZ)
PANU: 101006441(CTSZ)
RRO: 104663800(CTSZ)
RBB: 108541622(CTSZ)
TFN: 117069005(CTSZ)
PTEH: 111555632(CTSZ)
CJC: 100409242(CTSZ)
SBQ: 101044087(CTSZ)
MMUR: 105874515(CTSZ)
MMU: 64138(Ctsz)
MCAL: 110310623(Ctsz)
MPAH: 110318622(Ctsz)
RNO: 252929(Ctsz)
MCOC: 116091501(Ctsz)
MUN: 110556816(Ctsz)
CGE: 100689392(Ctsz)
PLEU: 114682019(Ctsz)
NGI: 103741460(Ctsz)
HGL: 101720244(Ctsz)
CCAN: 109692783(Ctsz)
OCU: 100101623(CTSZ)
OPI: 101526318(CTSZ)
TUP: 102500911(CTSZ)
CFA: 611983(CTSZ)
VVP: 112932215(CTSZ)
VLG: 121478076(CTSZ)
AML: 100473166(CTSZ)
UMR: 103670963(CTSZ)
UAH: 113258770(CTSZ)
ORO: 101365974(CTSZ)
ELK: 111141946
MPUF: 101685427(CTSZ)
EJU: 114197916(CTSZ)
MLX: 118024013(CTSZ)
FCA: 101087983(CTSZ)
PYU: 121019952(CTSZ)
PBG: 122467216(CTSZ)
PTG: 102956771(CTSZ)
PPAD: 109253464(CTSZ)
AJU: 106969919(CTSZ)
HHV: 120234857(CTSZ)
BTA: 404187(CTSZ)
BOM: 102265582(CTSZ)
BIU: 109567290(CTSZ)
BBUB: 102412544(CTSZ)
CHX: 102175417(CTSZ)
OAS: 101101911(CTSZ)
ODA: 120869382(CTSZ)
CCAD: 122448259(CTSZ)
SSC: 100141405(CTSZ)
CFR: 102515641(CTSZ)
CBAI: 105071799(CTSZ)
CDK: 105095690(CTSZ)
BACU: 103013660(CTSZ)
LVE: 103085943(CTSZ)
OOR: 101287339(CTSZ)
DLE: 111186744(CTSZ)
PCAD: 102993000(CTSZ)
ECB: 100056600(CTSZ)
EPZ: 103565404(CTSZ)
EAI: 106825078(CTSZ)
MYB: 102242643(CTSZ)
MYD: 102770003(CTSZ)
MMYO: 118662996(CTSZ)
MNA: 107529626(CTSZ)
HAI: 109380091(CTSZ)
DRO: 112304016(CTSZ)
SHON: 118996544(CTSZ)
AJM: 119055312(CTSZ)
MMF: 118618330(CTSZ)
PALE: 102884357(CTSZ)
PGIG: 120603887(CTSZ)
RAY: 107500086(CTSZ)
MJV: 108406175(CTSZ)
TOD: 119237005(CTSZ)
LAV: 100655776(CTSZ)
TMU: 101347887
MDO: 100027054(CTSZ)
SHR: 100927306(CTSZ)
PCW: 110205154(CTSZ)
OAA: 100080444(CTSZ)
GGA: 419311(CTSZ)
PCOC: 116227940(CTSZ)
MGP: 100550055(CTSZ)
CJO: 107323052(CTSZ)
NMEL: 110408306(CTSZ)
APLA: 101804246(CTSZ)
ACYG: 106040695(CTSZ)
TGU: 100225523(CTSZ)
LSR: 110483614(CTSZ)
SCAN: 103818879(CTSZ)
PMOA: 120507088(CTSZ)
OTC: 121342977(CTSZ)
PRUF: 121359538(CTSZ)
GFR: 102041571(CTSZ)
FAB: 101818266(CTSZ)
PHI: 102103433(CTSZ)
PMAJ: 107213248(CTSZ)
CCAE: 111938177(CTSZ)
CCW: 104687808(CTSZ)
ETL: 114056210(CTSZ)
FPG: 101921980(CTSZ)
FCH: 102059599(CTSZ)
CLV: 102084569(CTSZ)
EGZ: 104130672(CTSZ)
NNI: 104009598(CTSZ)
ACUN: 113487623(CTSZ)
PADL: 103919374(CTSZ)
AAM: 106492788(CTSZ)
AROW: 112972591(CTSZ)
NPD: 112949780(CTSZ)
DNE: 112986165(CTSZ)
ASN: 102384346(CTSZ)
AMJ: 102561646(CTSZ)
CPOO: 109318706(CTSZ)
GGN: 109292636(CTSZ)
PSS: 102447291(CTSZ)
CMY: 102934401(CTSZ)
CPIC: 101938312(CTSZ)
TST: 117885662(CTSZ)
CABI: 116826100(CTSZ)
PVT: 110084725 110084731(CTSZ)
PBI: 103065322(CTSZ) 103065568
GJA: 107111924(CTSZ) 107111931
XLA: 432187(ctsz.L) 494800(ctsz.S)
XTR: 100127597(ctsz)
NPR: 108802340(CTSZ)
DRE: 100333521 450022(ctsz)
IPU: 108272968(ctsz) 108280169
PHYP: 113533381 113545887(ctsz)
EEE: 113577871(ctsz)
TRU: 101077965(ctsz)
NCC: 104948760 104954748(ctsz)
CGOB: 115008545(ctsz) 115022593
SLUC: 116045840 116066470(ctsz)
ECRA: 117942891(ctsz)
PFLV: 114553806(ctsz) 114565417
GAT: 120816042 120835333(ctsz)
PPUG: 119208848 119230125(ctsz)
MSAM: 119885934(ctsz) 119901806
ONL: 100696456 100708870(ctsz)
OAU: 116313367 116329886(ctsz)
OLA: 101156316(ctsz) 101171361
OML: 112144898(ctsz) 112152409
AOCE: 111579743(ctsz)
SASA: 106565426(CATZ) 106569716 106583261(CATZ)
OMY: 100136231(cathy) 110510807 110528245(ctsz)
ELS: 105016941(ctsz) 105030515
SFM: 108928420(ctsz) 108930071
PKI: 111835251(ctsz)
LOC: 102686170(ctsz)
PSPA: 121307803 121319452(ctsz)
LCM: 102354050(CTSZ)
CMK: 103171603(ctsz)
BFO: 118417697
BBEL: 109483239
SKO: 102804623
CEL: CELE_F32B5.8(cpz-1) CELE_M04G12.2(cpz-2)
CBR: CBG04105(Cbr-cpz-1) CBG06727(Cbr-cpz-2)
BMY: BM_BM3754(Bma-cpz-1)
TSP: Tsp_10493
PCAN: 112576650
CRG: 105327153
MYI: 110453406
PMAX: 117337774
OBI: 106881834
OSN: 115212941
LAK: 106156390
ATEN: 116298646
ADF: 107348434
AMIL: 114964139
PDAM: 113681648
SPIS: 111329960
DGT: 114516372
PPP: 112282901
DFA: DFA_10566 DFA_10571(ctsZ)
SMIN: v1.2.007800.t1(symbB.v1.2.007800.t1)
 » show all
1  [PMID:10504234]
Nagler DK, Zhang R, Tam W, Sulea T, Purisima EO, Menard R
Human cathepsin X: A cysteine protease with unique carboxypeptidase activity.
Biochemistry 38:12648-54 (1999)
2  [PMID:9738465]
Nagler DK, Menard R
Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions.
FEBS Lett 434:135-9 (1998)
3  [PMID:9642240]
Santamaria I, Velasco G, Pendas AM, Fueyo A, Lopez-Otin C.
Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location.
J Biol Chem 273:16816-23 (1998)
4  [PMID:577]
McDonald JK, Ellis S.
On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1.
Life Sci 17:1269-76 (1975)
5  [PMID:1122298]
Otto K, Riesenkonig H.
Improved purification of cathepsin B1 and cathepsin B2.
Biochim Biophys Acta 379:462-75 (1975)
6  [PMID:4429705]
Ninjoor V, Taylor SL, Tappel AL.
Purification and characterization of rat liver lysosomal cathepsin B2.
Biochim Biophys Acta 370:308-21 (1974)
Other DBs
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CAS: 37217-21-3

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