Entry
Name
acylaminoacyl-peptidase;
acylamino-acid-releasing enzyme;
N-acylpeptide hydrolase;
N-formylmethionine (fMet) aminopeptidase;
alpha-N-acylpeptide hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide
Comment
Active at neutral pH. Several variants of this enzyme exist; the human erythrocyte enzyme is relatively specific for removal of N-acetylalanine from peptides. Displays dipeptidyl-peptidase activity on glycyl-peptides, perhaps as a result of mis-recognition of the glycyl residue as an uncharged N-acyl group. Inhibited by diisopropyl fluorophosphate. In peptidase family S9 (prolyl oligopeptidase family).
History
EC 3.4.19.1 created 1978 as EC 3.4.14.3, transferred 1981 to EC 3.4.19.1
Orthology
K01303 acylaminoacyl-peptidase
Genes
GGA : 415926(APEH) 770794(AAREL)
PCOC : 116241103 116241105
CJO : 107319598 107319599(APEH)
NMEL : 110405049(APEH) 110405050
ACYG : 106048758 106048772
AFUL : 116492926 116493144(APEH)
PMOA : 120495691(APEH) 120514120
PRUF : 121352763 121352923
GFR : 102042072(APEH) 102042238
FAB : 101810254 101815864(APEH)
CBRC : 103614353(APEH) 103614354
FPG : 101919631(APEH) 101919804
FCH : 102059371(APEH) 102059543
TALA : 116959110 116959532
ACHC : 115353782 115353783(APEH)
HLE : 104828136(APEH) 104828137
AGEN : 126049748 126049749
LDI : 104348928(APEH) 104351682
SHAB : 115614320 115614688
DPUB : 104306650 104306674
AROW : 112960594 112960600
SCAM : 104147870(APEH) 104147872
ACS : 100567769(apeh) 103277916
SUND : 121920358 121921307(APEH)
PBI : 103058104(APEH) 103063154
CTIG : 120315024 120315025(APEH)
PGUT : 117679059 117679069
ZVI : 118080574 118080575(APEH)
GJA : 107109058(APEH) 107109059
STOW : 125429078 125430022
DRE : 100333019(apeh) 678599(zgc:136971)
SANH : 107669673 107698444(apeh)
CCAR : 109083451(apeh) 109095384 109110148
CAUA : 113078400 113107799(apeh) 113107954
CGIB : 127963345(zgc:136971) 128019178
PPRM : 120481299 120483563(zgc:136971)
MAMB : 125279882(zgc:136971) 125280535(apeh)
CIDE : 127517488 127517721
MASI : 127415069(zgc:136971) 127424693 127424731
IPU : 108265705(apeh) 108265926(zgc:136971)
PHYP : 113533362(apeh) 113533537
SMEO : 124400033(apeh) 124400352(zgc:136971)
TFD : 113655831(zgc:136971) 113656077
AMEX : 103027063 103034957(apeh)
EEE : 113578880(apeh) 113589455
TNG : GSTEN00008970G001 GSTEN00027959G001
CGOB : 115010464 115010876
ELY : 117258664(zgc:136971) 117258822(apeh)
EFO : 125891116(zgc:136971) 125892462(apeh)
PLEP : 121946728(apeh) 121947576(zgc:136971)
SLUC : 116040829(zgc:136971) 116061967(apeh)
ECRA : 117947448(apeh) 117948106(zgc:136971)
PFLV : 114558796 114559445
GAT : 120829723(zgc:136971) 120829838(apeh)
PPUG : 119199468 119222130(zgc:136971) 119223415
MSAM : 119905439(apeh) 119905713(zgc:136971)
CUD : 121516962(apeh) 121518003(zgc:136971)
ALAT : 119022257(apeh) 119022628(zgc:136971)
OAU : 116324687(zgc:136971) 116330781(apeh)
OML : 112158935(apeh) 112159656(zgc:136971)
PRET : 103467450 103473525(apeh)
PFOR : 103129855 103155924(apeh)
PLAI : 106956352(apeh) 106959473
PMEI : 106930119 106930477(apeh)
GAF : 122824328(apeh) 122831686(zgc:136971)
CVG : 107094859 107098949(apeh)
CTUL : 119784344(apeh) 119789254(zgc:136971)
GMU : 124873754(zgc:136971) 124875143(apeh)
NFU : 107373674 107390611(apeh)
KMR : 108233030(zgc:136971) 108235266(apeh)
ALIM : 106513079(apeh) 106523903 106523914
NWH : 119417593(apeh) 119417693(zgc:136971)
AOCE : 111570009 111574391
MCEP : 124997898(zgc:136971) 125022208(apeh)
CSEM : 103384671 103384986(apeh)
SSEN : 122776629(zgc:136971) 122777359(apeh)
HHIP : 117764187(zgc:136971) 117764815(apeh)
HSP : 118111009(apeh) 118111426(zgc:136971)
LCF : 108877888 108891729(zgc:136971)
XGL : 120804035(apeh) 120804543(zgc:136971)
SSCV : 125988408(zgc:136971) 125988895
BPEC : 110164337 110164529
MALB : 109968751 109970409
BSPL : 114858466(apeh) 114858578(zgc:136971)
SASA : 106566520(apeh) 106572275
STRU : 115166227 115166228 115166229 115166230 115168544(apeh) 115186142 115186143
OTW : 112215840(zgc:136971) 112222360(apeh)
OMY : 110492560(apeh) 110532073(zgc:136971)
OGO : 124031769(zgc:136971) 124045572(apeh)
ONE : 115101982(apeh) 115131960
SALP : 111966270 112075521(apeh)
SNH : 120059455(zgc:136971) 120061445(apeh)
CCLU : 121538145(zgc:136971) 121546083(apeh)
AANG : 118207176(zgc:136971) 118208215
PSPA : 121328622 121329185(apeh)
ARUT : 117411788 117411912 117962413 117964009
PSEX : 120540431(zgc:136971)
LCM : 102351784(APEH) 102352874
SCLV : 120341819 120342226 120342227
BCOO : 119068143 119080617
TPRE : 106653231 106654148
PPYR : 116175611 116175757
API : 100167555 100168218 100169146 100573475
HHAL : 106685860 106685861
CBR : CBG_11649(Cbr-dpf-5)
NVE : 116609737 116609738 5512276
AMIL : 114947681 114947682 114947683
CSAT : 104723745 104732186 109124643
BRP : 103833453 103868336 103872033
BNA : 106349067 106360606 106401462 106406252 106415233
BOE : 106300842 106312247 106331151
RSZ : 108818380 108820831 108822763
MINC : 123210019 123219984
PVU : PHAVU_007G279900g PHAVU_007G280000g
APRC : 113870811 113872585
MTR : 11420124 11429366 25482911
PSAT : 127097767 127097769
LJA : Lj0g3v0015409.1(Lj0g3v0015409.1)
AHF : 112719931 112727726 112747534 112793110
LANG : 109325642 109352404
PMUM : 103323948 103323950
PAVI : 110763562 110763564
PDUL : 117623090 117623114
PALZ : 118056683 118056707
NSY : 104223836 104223837 104224252
NTO : 104096282 104096283 104121104
SSPL : 121774181 121776064 121776171 121777697
ECAD : 122604689 122604718
CQI : 110686144 110718543 110722172 110739376
MING : 122061651 122091191
TSS : 122638728 122638735 122642666
DOSA : Os10t0415800-01(Os10g0415800)
TDC : 119285881 119319613 119322638 119348890
TAES : 123061550 123131769 123135638 123138938 123143221 123182530
LPER : 127309064 127344932
SITA : 101784436 101785236
PVIR : 120651052 120688237 120693407
PHAI : 112874717 112875312
SCM : SCHCO_02590080(SCHCODRAFT_02590080) SCHCO_02639825(SCHCODRAFT_02639825)
APE : APE_1547.1 APE_1832 APE_2290.1
» show all
Taxonomy
Reference
Authors
Tsunasawa S, Narita K, Ogata K.
Title
Purification and properties of acylamino acid-releasing enzyme from rat liver.
Journal
J Biochem (Tokyo) 77:89-102 (1975)
Reference
Authors
Unger T, Nagelschmidt M, Struck H.
Title
N-Acetylaminoacyl-p-nitranilidase from human placenta. Purification and some properties.
Journal
Reference
Authors
Kobayashi K, Smith JA.
Title
Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction.
Journal
J Biol Chem 262:11435-45 (1987)
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.19.1
ExPASy - ENZYME nomenclature database: 3.4.19.1