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Entry
EC 3.4.19.11                Enzyme                                 

Name
gamma-D-glutamyl-meso-diaminopimelate peptidase;
endopeptidase I;
gamma-D-glutamyldiaminopimelate endopeptidase;
gamma-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase;
gamma-glutamyl-L-meso-diaminopimelyl endopeptidase;
gamma-D-glutamyl-meso-diaminopimelate endopeptidase;
gamma-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase;
gamma-D-glutamyl-meso-diaminopimelic endopeptidase;
gamma-D-glutamyl-meso-D-aminopimelic endopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of gamma-D-glutamyl bonds to the L-terminus (position 7) of meso-diaminopimelic acid (meso-A2pm) in 7-(L-Ala-gamma-D-Glu)-meso-A2pm and 7-(L-Ala-gamma-D-Glu)-7-(D-Ala)-meso-A2pm. It is required that the D-terminal amino and carboxy groups of meso-A2pm are unsubstituted
Comment
A 45-kDa metallopeptidase from Bacillus sphaericus, the substrates being components of the bacterial spore wall. A member of peptidase family M14 (carboxypeptidase A family). Endopeptidase II has similar activity, but differs in cellular location, molecular mass and catalytic mechanism [3]
History
EC 3.4.19.11 created 1996
Orthology
K01308  g-D-glutamyl-meso-diaminopimelate peptidase
Genes
BSU: BSU24830(yqgT)
BSR: I33_2565
BSL: A7A1_3558
BSH: BSU6051_24830(yqgT)
BSY: I653_11935
BSUT: BSUB_02660(yqgT)
BSUL: BSUA_02660(yqgT)
BSUS: Q433_13590
BSS: BSUW23_12300(yqgT)
BST: GYO_2747
BSO: BSNT_08925(yqgT)
BSQ: B657_24830(yqgT)
BSX: C663_2367(yqgT)
BLI: BL01578(yqgT)
BLD: BLi02657(yqgT)
BLH: BaLi_c27390(yqgT)
BAY: RBAM_023160(yqgT)
BAQ: BACAU_2329(yqgT)
BYA: BANAU_2468(yqgT)
BAMP: B938_11970
BAML: BAM5036_2238(yqgT)
BAMA: RBAU_2451(yqgT)
BAMN: BASU_2241(yqgT)
BAMB: BAPNAU_1267(yqgT)
BAMT: AJ82_13115
BAMY: V529_25900(yqgT)
BAO: BAMF_2385(yqgT)
BAZ: BAMTA208_12765(yqgT)
BQL: LL3_02681(yqgT)
BXH: BAXH7_02605(yqgT)
BQY: MUS_2780(yqgT)
BAMI: KSO_007800
BAMC: U471_23960
BAMF: U722_12600
BHA: BH1603
BPU: BPUM_2213
BPUM: BW16_11990
BPUS: UP12_11240
BMQ: BMQ_4500
BMD: BMD_4486
BMEG: BG04_1492
BJS: MY9_2507
BACW: QR42_11185
BACP: SB24_17140
BACB: OY17_14855
BACY: QF06_10610
BALM: BsLM_2441
BEO: BEH_19785
BGY: BGLY_2933
OIH: OB1731
GKA: GK2441
GTN: GTNG_2380
GGH: GHH_c25180(yqgT)
AFL: Aflv_0897(yqgT)
AAMY: GFC30_2636
AXL: AXY_07970
LSP: Bsph_4703
HHD: HBHAL_2017(yqgT)
BSE: Bsel_0990
PPY: PPE_01674
PPM: PPSC2_08820(yqgT)
PPO: PPM_1677(yqgT)
PPOL: X809_09070
PPOY: RE92_03480
PMW: B2K_09460
ASOC: CB4_01294
CTC: CTC_00595
CBO: CBO1374
CBA: CLB_1398
CBH: CLC_1409
CBY: CLM_1547
CBL: CLK_0816
CBB: CLD_3164
CBI: CLJ_B1489
CBF: CLI_1470
CBM: CBF_1446
CKL: CKL_0988
CKR: CKR_0892
CPAS: Clopa_0912
CTYK: CTK_C06910
CTH: Cthe_2387
HSC: HVS_15630
CCE: Ccel_3421
CSD: Clst_1455
RUM: CK1_07060
BFI: CIY_33400
RIX: RO1_39600
RIM: ROI_27900
ROB: CK5_27750
CSO: CLS_14600
HSD: SD1D_1068
STH: STH1567
SGY: Sgly_0915
EHL: EHLA_3133
BPRM: CL3_29340
 » show all
Taxonomy
Reference
1  [PMID:849747]
  Authors
Arminjon F, Guinand M, Vacheron MJ, Michel G.
  Title
Specificity profiles of the membrane-bound gamma-D-glutamyl-(L)meso-diaminopimelateendopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602.
  Journal
Eur J Biochem 73:557-65 (1977)
DOI:10.1111/j.1432-1033.1977.tb11351.x
Reference
2  [PMID:3922755]
  Authors
Garnier M, Vacheron MJ, Guinand M, Michel G.
  Title
Purification and partial characterization of the extracellular gamma-D-glutamyl-(L)meso-diaminopimelate endopeptidase I, from Bacillus sphaericus NCTC 9602.
  Journal
Eur J Biochem 148:539-43 (1985)
DOI:10.1111/j.1432-1033.1985.tb08873.x
  Sequence
Reference
3  [PMID:8503890]
  Authors
Hourdou ML, Guinand M, Vacheron MJ, Michel G, Denoroy L, Duez C, Englebert S, Joris B, Weber G, Ghuysen JM.
  Title
Characterization of the sporulation-related gamma-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein.
  Journal
Biochem J 292 ( Pt 2):563-70 (1993)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.19.11
IUBMB Enzyme Nomenclature: 3.4.19.11
ExPASy - ENZYME nomenclature database: 3.4.19.11
BRENDA, the Enzyme Database: 3.4.19.11
CAS: 62572-28-5

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