KEGG   ENZYME: 3.4.19.15
Entry
EC 3.4.19.15                Enzyme                                 
Name
desampylase;
SAMP-protein conjugate cleaving protease;
HvJAMM1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
Sysname
N6-[small archaeal modifier protein]-[protein]-L-lysine hydrolase
Reaction(IUBMB)
an N6-[small archaeal modifier protein]-[protein]-L-lysine + H2O = a [protein]-L-lysine + a small archaeal modifier protein
Substrate
N6-[small archaeal modifier protein]-[protein]-L-lysine;
H2O [CPD:C00001]
Product
[protein]-L-lysine [CPD:C02188];
small archaeal modifier protein
Comment
The enzyme, characterized from the archaeon Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolysing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein. The enzyme contains Zn2+. cf. EC 3.4.19.12, ubiquitinyl hydrolase 1. In peptidase family M67.
History
EC 3.4.19.15 created 2015 as EC 3.4.24.88, transferred 2016 to EC 3.4.19.15
Orthology
K20110  desampylase
Genes
NOVTQ38_006285
NOTC7W88_02335
NORFA702_05950
NGFFRF71_08915
NOGGKE62_12120
SPHDHY78_27620
RDICMV14_11305
SPANAWL63_17655
SKRBRX40_11505
SPLMBXU08_01815
SPLKAV944_13690
SPHCCVN68_07210
SPHAD3Y57_18565
SPAUDRN02_006535
SPAPH3Z74_07395
SPAIFPZ24_09495
SARIH5J25_11160
SINBSIDU_05225
SPHTK426_13890
SHYDCJD35_00670
SCLOSCLO_1005130
SUFLFIL70_08875
SBARH5V43_06540
SAMISAMIE_1013420
SFLASPHFLASMR4Y_00889
SPHYCHN51_15650
PARJJ4G78_01735
PHAOHF685_02730
SANDH3309_01815
ALBAEB_P3359
ADOA6F68_02423
ELQGa0102493_11315
ERKCD351_05510
PORLBG023_112757
PHZCHX26_14920
BBWBDW_02365
BCOPJD108_04770
MAUBMAUB_58670
LUOHHL09_05425
GAHGAH_00714
HSLOE_3561F
HDLHALDL1_14125
HHBHhub_3025
HAGSJT689_08665
HABOJRZ79_07070
HNOLT974_12565
HLULT972_02350
HANRLJ422_07320
HJEHacjB3_14840
SALRFQU85_07095
HALXM0R89_03215
HAXZM0R88_03435
SAIMK0C01_01570
NPHNP_0062A(jamm1)
NMONmlp_1363
NHOHWV23_07480
NSALHWV07_10225
HALIBV210_06260
HWAHQ_3151A(jamm1)
HWCHqrw_3693(jamm1)
HVOHVO_2505(jamm1)
HMEHFX_2518
HGIABY42_12540
HALEG3A49_15945
HLSKU306_00710
HBOHbor_09090
HAQDU484_05260
HAJDU500_05700
HAERDU502_03420
HRAEI982_02210
HLMDV707_15975
HALMFCF25_03910
HLAHlac_1268
HALPDOS48_06100
HALBEKH57_01570
HEZZEO776_17235
HALQHrr1229_015415
HSSJ7656_04050
HSAIHPS36_11600 HPS36_15125
HAZZKI388_12725
SRUBC2R22_14385
HALNB4589_016100
HALGHUG10_09880
HALUHUG12_06250 HUG12_18900
HMPK6T50_07050
HREK6T36_06835
HRMK6T25_08980
HACBHbl1158_13395
HDFAArcSl_1379
HAHHalar_1918
HTUHtur_3493
HDABB347_15770
HSALJMJ58_10900
HLOJ0X27_05820
HAKZJ0X25_05175
NMGNmag_1532(jamm1)
HXAHalxa_3457
NATNJ7G_2623
NPENatpe_0454
NVRFEJ81_02550
NPLFGF80_08285
NAYHYG81_08425
HALYHYG82_11375
HJTDVR14_11570
NGENatgr_2171
NOUNatoc_2392
HLRHALLA_18180
HLCCHINAEXTREME10025
NAJB1756_09040
NAGAArcMg_0382
NANAArc1_0390
NBGDV706_04980
NASGCU68_08030
SAWLNGM29_01555
PFMPyrfu_0246
 » show all
Reference
1  [PMID:22970855]
  Authors
Hepowit NL, Uthandi S, Miranda HV, Toniutti M, Prunetti L, Olivarez O, De Vera IM, Fanucci GE, Chen S, Maupin-Furlow JA
  Title
Archaeal JAB1/MPN/MOV34 metalloenzyme (HvJAMM1) cleaves ubiquitin-like small archaeal modifier proteins (SAMPs) from protein-conjugates.
  Journal
Mol Microbiol 86:971-87 (2012)
DOI:10.1111/mmi.12038
  Sequence
[hvo:HVO_2505]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.19.15
IUBMB Enzyme Nomenclature: 3.4.19.15
ExPASy - ENZYME nomenclature database: 3.4.19.15
BRENDA, the Enzyme Database: 3.4.19.15

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