KEGG   ENZYME: 3.4.19.15
Entry
EC 3.4.19.15                Enzyme                                 

Name
desampylase;
SAMP-protein conjugate cleaving protease;
HvJAMM1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
Sysname
N6-[small archaeal modifier protein]-[protein]-L-lysine hydrolase
Reaction(IUBMB)
an N6-[small archaeal modifier protein]-[protein]-L-lysine + H2O = a [protein]-L-lysine + a small archaeal modifier protein
Substrate
N6-[small archaeal modifier protein]-[protein]-L-lysine;
H2O [CPD:C00001]
Product
[protein]-L-lysine [CPD:C02188];
small archaeal modifier protein
Comment
The enzyme, characterized from the archaeon Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolysing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein. The enzyme contains Zn2+. cf. EC 3.4.19.12, ubiquitinyl hydrolase 1. In peptidase family M67.
History
EC 3.4.19.15 created 2015 as EC 3.4.24.88, transferred 2016 to EC 3.4.19.15
Orthology
K20110  desampylase
Genes
NOV: TQ38_006285
NOT: C7W88_02335
NTD: EGO55_12795
NOR: FA702_05950
NGF: FRF71_08915
NOG: GKE62_12120
SPHD: HY78_27620
SPAN: AWL63_17655
SKR: BRX40_11505
SPLM: BXU08_01815
SINB: SIDU_05225
SPHT: K426_13890
ALB: AEB_P3359
BBW: BDW_02365
GAH: GAH_00714
HSL: OE_3561F
HHB: Hhub_3025
NPH: NP_0062A(jamm1)
NMO: Nmlp_1363
HWA: HQ_3151A(jamm1)
HWC: Hqrw_3693(jamm1)
HVO: HVO_2505(jamm1)
HME: HFX_2518
HLA: Hlac_1268
HTU: Htur_3493
NMG: Nmag_1532(jamm1)
NAT: NJ7G_2623
 » show all
Reference
1  [PMID:22970855]
  Authors
Hepowit NL, Uthandi S, Miranda HV, Toniutti M, Prunetti L, Olivarez O, De Vera IM, Fanucci GE, Chen S, Maupin-Furlow JA
  Title
Archaeal JAB1/MPN/MOV34 metalloenzyme (HvJAMM1) cleaves ubiquitin-like small archaeal modifier proteins (SAMPs) from protein-conjugates.
  Journal
Mol Microbiol 86:971-87 (2012)
DOI:10.1111/mmi.12038
  Sequence
[hvo:HVO_2505]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.19.15
IUBMB Enzyme Nomenclature: 3.4.19.15
ExPASy - ENZYME nomenclature database: 3.4.19.15
BRENDA, the Enzyme Database: 3.4.19.15

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