Acting on peptide bonds (peptidases);
Cleavage of C-terminal glycinamide from polypeptides
Inactivates vasopressin and oxytocin by splitting off glycinamide. Also cleaves ester substrates of trypsin and chymotrypsin. Although glycinamide is by far the preferred leaving group, other aminoacylamides may also be released, e.g. phenylalaninamide. The toad skin enzyme is inhibited by diisopropyl fluorophosphate.
EC 22.214.171.124 created 1978 as EC 126.96.36.199, transferred 1981 to EC 188.8.131.52
Fruhaufova, L., Suska-Brezezinska, E., Barth, T. and Rychlik, I.
Rat liver enzyme inactivating oxytocin and its deamino-carba analogues.