EC                 Enzyme                                 

pyroglutamyl-peptidase II;
pyroglutamyl aminopeptidase II;
thyrotropin-releasing factor pyroglutamate aminopeptidase;
pyroglutamate aminopeptidase II;
pyroglutamyl peptidase II;
thyroliberin-hydrolyzing pyroglutamate aminopeptidase;
thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase;
thyrotropin-releasing hormone-degrading peptidase;
TRH aminopeptidase
Acting on peptide bonds (peptidases);
Omega peptidases
Release of the N-terminal pyroglutamyl group from pGlu!His-Xaa tripeptides and pGlu!His-Xaa-Gly tetrapeptides
Highly specific for thyrotropin releasing hormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family M1 (membrane alanyl aminopeptidase family)
EC created 1992
K01306  pyroglutamyl-peptidase II
HSA: 29953(TRHDE)
PTR: 467071(TRHDE)
PPS: 100977009(TRHDE)
GGO: 101146939(TRHDE)
PON: 100460431(TRHDE)
NLE: 100588911(TRHDE)
MCC: 717653(TRHDE)
MCF: 102125346(TRHDE)
CSAB: 103238733(TRHDE)
RRO: 104654596(TRHDE)
RBB: 108528755(TRHDE)
CJC: 100415258(TRHDE)
SBQ: 101052029(TRHDE)
MMU: 237553(Trhde)
MCAL: 110303955(Trhde)
MPAH: 110326499(Trhde)
RNO: 366894(Trhde)
CGE: 100762211(Trhde)
NGI: 103735329(Trhde)
HGL: 101714026(Trhde)
CCAN: 109699927(Trhde)
OCU: 100352490(TRHDE)
TUP: 102488055(TRHDE)
CFA: 481166(TRHDE)
VVP: 112922179(TRHDE)
AML: 100471917(TRHDE)
UMR: 103656979(TRHDE)
UAH: 113256259(TRHDE)
ORO: 101370339(TRHDE)
ELK: 111142230
FCA: 101085556(TRHDE)
PTG: 102949202(TRHDE)
PPAD: 109270521(TRHDE)
AJU: 106967413(TRHDE)
BTA: 100336818(TRHDE)
BOM: 102279861(TRHDE)
BIU: 109558307
BBUB: 102391297(TRHDE)
CHX: 102175003(TRHDE)
OAS: 100310794(TRHDE)
SSC: 100620702(TRHDE)
CFR: 102512405(TRHDE)
CDK: 105095993(TRHDE)
BACU: 103006364(TRHDE)
LVE: 103087695(TRHDE)
OOR: 101271464(TRHDE)
DLE: 111173731(TRHDE)
PCAD: 102992907(TRHDE)
ECB: 100057250(TRHDE)
EPZ: 103560318(TRHDE)
EAI: 106822089(TRHDE)
MYB: 102257792(TRHDE)
MYD: 102759450(TRHDE)
MNA: 107526667(TRHDE)
HAI: 109387696(TRHDE)
DRO: 112319112(TRHDE)
PALE: 102892053(TRHDE)
RAY: 107512623(TRHDE)
MJV: 108391359(TRHDE)
LAV: 100670199(TRHDE)
TMU: 101357589
MDO: 100016797(TRHDE)
SHR: 105750663(TRHDE)
PCW: 110195938(TRHDE)
OAA: 100079276(TRHDE)
GGA: 427868(TRHDE)
MGP: 100550266(TRHDE)
CJO: 107310276(TRHDE)
NMEL: 110392825(TRHDE)
APLA: 101793030(TRHDE)
ACYG: 106046722(TRHDE)
TGU: 100230387(TRHDE)
LSR: 110469833(TRHDE)
SCAN: 103813667(TRHDE)
GFR: 102039975(TRHDE)
FAB: 101811314(TRHDE)
PHI: 102104144(TRHDE)
PMAJ: 107204601(TRHDE)
CCAE: 111932896(TRHDE)
CCW: 104698393(TRHDE)
ETL: 114059991(TRHDE)
FPG: 101921757(TRHDE)
FCH: 102050378(TRHDE)
CLV: 102089579(TRHDE)
EGZ: 104132924(TRHDE)
NNI: 104010989(TRHDE)
ACUN: 113489363(TRHDE)
PADL: 103919943(TRHDE)
AAM: 106488685(TRHDE)
ASN: 102377345(TRHDE)
AMJ: 102572757(TRHDE)
PSS: 102455963(TRHDE)
CMY: 102929819(TRHDE)
CPIC: 101933457(TRHDE)
ACS: 100551808(trhde)
PVT: 110085004(TRHDE)
PBI: 103057029(TRHDE)
PMUR: 107283818(TRHDE)
TSR: 106554017(TRHDE)
PMUA: 114604978(TRHDE)
GJA: 107115337(TRHDE)
XLA: 108705027(trhde.L) 108713143(trhde.S)
XTR: 100489066(trhde)
NPR: 108788310(TRHDE)
DRE: 100006808(trhde.1) 562409(trhde.2)
IPU: 108279435(trhde) 108279602
PHYP: 113531778(trhde)
AMEX: 103029429(trhde)
EEE: 113569187(trhde)
TRU: 101065693(trhde)
LCO: 104931506(trhde)
MZE: 101477232(trhde)
ONL: 100692659(trhde)
OLA: 101170139(trhde)
XMA: 102225911(trhde)
XCO: 114160787(trhde)
PRET: 103459315(trhde)
CVG: 107090612(trhde)
NFU: 107386826(trhde)
KMR: 108250579(trhde)
ALIM: 106526106(trhde)
AOCE: 111564467
CSEM: 103382523(trhde)
LCF: 108895871(trhde)
SDU: 111224541(trhde)
SLAL: 111665930(trhde)
HCQ: 109532578
BPEC: 110161508(trhde)
MALB: 109952969(trhde)
ELS: 105023119(trhde)
SFM: 108936360(trhde) 108942250
PKI: 111851702(trhde) 111858635
LCM: 102356972(TRHDE)
CMK: 103185331(trhde)
RTP: 109927660(trhde)
SPU: 588093
SKO: 100372228
HST: 105188811
OBO: 105285042
CLEC: 106669711
 » show all
1  [PMID:115687]
Bauer K, Nowak P.
Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond.
Eur J Biochem 99:239-46 (1979)
2  [PMID:2862039]
O'Connor B, O'Cuinn G.
Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain.
Eur J Biochem 150:47-52 (1985)
3  [PMID:20504468]
Wilk S, Wilk EK
Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme.
Neurochem Int 15:81-9 (1989)
Other DBs
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IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 60063-88-9

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