KEGG ENZYME: 3.4.19.9

ENZYME: 3.4.19.9

Entry

EC 3.4.19.9                 Enzyme

Name

folate gamma-glutamyl hydrolase;
GGH (gene name);
conjugase;
folate conjugase;
lysosomal gamma-glutamyl carboxypeptidase;
gamma-Glu-X carboxypeptidase;
pteroyl-poly-gamma-glutamate hydrolase;
carboxypeptidase G;
folic acid conjugase;
poly(gamma-glutamic acid) endohydrolase;
polyglutamate hydrolase;
poly(glutamic acid) hydrolase II;
pteroylpoly-gamma-glutamyl hydrolase;
gamma-glutamyl hydrolase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases

Sysname

tetrahydropteroyl-poly-gamma-glutamyl gamma-glutamyl hydrolase

Reaction(IUBMB)

tetrahydropteroyl-(gamma-glutamyl)n + (n-1) H2O = 5,6,7,8-tetrahydrofolate + (n-1) L-glutamate [RN:R04242]

Reaction(KEGG)

R04242

Substrate

tetrahydropteroyl-(gamma-glutamyl)n;
(n-1) H2O

Product

5,6,7,8-tetrahydrofolate [CPD:C00101];
(n-1) L-glutamate

Comment

The enzyme, which occurs only in animals and plants, can be either endo- and/or exopeptidase. It acts on tetrahydropteroyl polyglutamates and their modified forms, as well as the polyglutamates of the folate breakdown product N-(4-aminobenzoyl)-L-glutamate (pABA-Glu). The initial cleavage may release either monoglutamate or poly-gamma-glutamate of two or more residues, depending on the specific enzyme. For example, GGH1 from the plant Arabidopsis thaliana cleaves pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from the same organism yields mainly monoglutamates. The enzyme is lysosomal (and secreted) in animals and vacuolar in plants. In peptidase family C26.

History

EC 3.4.19.9 created 1972 as EC 3.4.12.10, transferred 1978 to EC 3.4.22.12, transferred 1992 to EC 3.4.19.9, modified 1997, modified 2018

Pathway

ec00790

Folate biosynthesis

Orthology

K01307

gamma-glutamyl hydrolase

Genes

HSA:

8836(GGH)

PTR:	464204(GGH)

PPS:	100969380(GGH)

GGO:	101150735(GGH)

PON:	100435664(GGH)

NLE:	100595851(GGH)

HMH:	116813249(GGH)

MCC:	700747(GGH)

MCF:	102126049(GGH)

MTHB:

126960608

MNI:	105482218(GGH)

CSAB:

103236874(GGH)

CATY:

105585198(GGH)

PANU:

101017510(GGH)

TGE:	112630600(GGH)

MLEU:

105541248(GGH)

RRO:	104660106(GGH)

RBB:	108543162(GGH)

TFN:	117079021(GGH)

PTEH:

111549272(GGH)

CANG:

105504476(GGH)

CJC:	100415059(GGH)

SBQ:	101047923(GGH)

CIMI:

108288428(GGH)

CSYR:

103271634(GGH)

MMUR:

105858423(GGH)

LCAT:

123644558(GGH)

PCOQ:

105813266(GGH)

OGA:	100964654(GGH)

MMU:	14590(Ggh)

MCAL:

110292984(Ggh)

MPAH:

110338856(Ggh)

RNO:	25455(Ggh)

MCOC:

116088030(Ggh)

ANU:	117698631(Ggh)

MUN:	110565305(Ggh)

CGE:	100751581(Ggh)

MAUA:

101825803(Ggh)

PROB:

127232366(Ggh)

PLEU:

114690070(Ggh)

MORG:

121458343(Ggh)

MFOT:

126503474

AAMP:

119826080(Ggh)

NGI:	103737737(Ggh)

HGL:	101724155(Ggh)

CPOC:

100719750(Ggh)

CCAN:

109698223(Ggh)

DORD:

105980440(Ggh)

DSP:	122095698(Ggh)

PLOP:

125360735(Ggh)

NCAR:

124995110

MMMA:

107142429(Ggh)

OCU:

100350070

OPI:	101527903(GGH)

TUP:	102485618(GGH)

GVR:	103606992(GGH)

CFA:	100856436(GGH)

CLUD:

112678516(GGH)

VVP:	112929757(GGH)

VLG:	121498767(GGH)

NPO:	129505393(GGH)

AML:	100482891(GGH)

UMR:	103677471(GGH)

UAH:	113268062(GGH)

UAR:	123786702(GGH)

ELK:

111155475

LLV:

125098098

MPUF:

101684113(GGH)

MNP:	132014045(GGH)

MLK:	131826781(GGH)

NVS:	122904566(GGH)

ORO:	101373905(GGH)

EJU:	114213492(GGH)

ZCA:	113909455(GGH)

MLX:	118014862(GGH)

NSU:	110578663(GGH)

LWW:	102730641(GGH)

FCA:	101100943(GGH)

PYU:	121038202(GGH)

PCOO:

112859756(GGH)

PBG:	122495452(GGH)

LRUF:

124507681

PTG:	102970330(GGH)

PPAD:

109250251(GGH)

PUC:

125924657

AJU:

106988829

HHV:	120246941(GGH)

BTA:	525303(GGH)

BOM:	102276825(GGH)

BIU:	109568566(GGH)

BBUB:

102416206(GGH)

BBIS:

104991813(GGH)

CHX:	102190334(GGH)

OAS:	101118706(GGH)

BTAX:

128059501(GGH)

ODA:	120878613(GGH)

CCAD:

122451112(GGH)

MBEZ:

129559876(GGH)

SSC:	100154232(GGH)

CFR:	102507789(GGH)

CBAI:

105081466(GGH)

CDK:	105094475(GGH)

VPC:	102540963(GGH)

BACU:

103016741(GGH)

LVE:	103090393(GGH)

OOR:	101273875(GGH)

DLE:	111185619(GGH)

PCAD:

102976253(GGH)

PSIU:

116742760(GGH)

NASI:

112398135(GGH)

ECB:	100052567(GGH)

EPZ:	103553263(GGH)

EAI:	106834311(GGH)

MYB:	102240048(GGH)

MYD:	102768461(GGH)

MMYO:

118670881(GGH)

MLF:	102425869(GGH)

PKL:	118718304(GGH)

EFUS:

103287607(GGH)

MNA:	107526439(GGH)

DRO:	112315497(GGH)

SHON:

118995507(GGH)

AJM:	119040494(GGH)

PDIC:

114514678(GGH)

PHAS:

123833368(GGH)

MMF:	118631705(GGH)

PPAM:

129084011(GGH)

HAI:	109375951(GGH)

RFQ:	117034021(GGH)

PALE:

102886790(GGH)

PGIG:

120607206(GGH)

PVP:	105295062(GGH)

RAY:	107521315(GGH)

MJV:	108385737(GGH)

TOD:	119241085(GGH)

SARA:

101544129(GGH) 105943532

LAV:	100671079(GGH)

TMU:

101347582

ETF:	101657878(GGH)

DNM:	101445199(GGH)

MDO:	100029624(GGH)

GAS:	123253406(GGH)

SHR:	100922531(GGH)

AFZ:

127543825

PCW:	110219063(GGH)

OAA:	100082379(GGH)

GGA:	421144(GGH)

PCOC:

116242169(GGH)

MGP:	100540892(GGH)

CJO:	107310260(GGH)

TPAI:

128091393(GGH)

LMUT:

125690446(GGH)

NMEL:

110394036(GGH)

APLA:

101790897(GGH)

ACYG:

106039060(GGH)

CATA:

118251210(GGH)

AFUL:

116485718(GGH)

TGU:	100220150(GGH)

LSR:	110484740(GGH)

SCAN:

103816283(GGH)

PMOA:

120499222(GGH)

OTC:	121340354(GGH)

PRUF:

121356883(GGH)

GFR:	102038404(GGH)

FAB:	101814012(GGH)

OMA:	130249136(GGH)

PHI:	102105349(GGH)

PMAJ:

107200637(GGH)

CCAE:

111924794(GGH)

CCW:	104692925(GGH)

CBRC:

103624869(GGH)

ETL:	114062627(GGH)

ZAB:	102074695(GGH)

ACHL:

103804553(GGH)

SVG:	106851244(GGH)

MMEA:

130579940(GGH)

HRT:	120754572(GGH)

FPG:	101919182(GGH)

FCH:	102055448(GGH)

CLV:	102087830(GGH)

EGZ:	104122047(GGH)

NNI:	104010542(GGH)

PCRI:

104025000(GGH)

PLET:

104622960(GGH)

EHS:	104507585(GGH)

PCAO:

104043581(GGH)

ACUN:

113476136(GGH)

TALA:

104366116(GGH)

PADL:

103923701(GGH)

AFOR:

103904135(GGH)

ACHC:

115340518(GGH)

HALD:

104322862(GGH)

HLE:	104841356(GGH)

AGEN:

126048700

GCL:

127013561

CCRI:

104168491(GGH)

CSTI:

104556310(GGH)

CMAC:

104486147(GGH)

MUI:	104545592(GGH)

BREG:

104634075(GGH)

FGA:	104083153(GGH)

GSTE:

104250575(GGH)

LDI:	104346954(GGH)

MNB:	103779473(GGH)

OHA:	104332333(GGH)

NNT:	104408930(GGH)

SHAB:

115608637(GGH)

DPUB:

104303510(GGH)

PGUU:

104461288(GGH)

ACAR:

104518736(GGH)

CPEA:

104386907(GGH)

AVIT:

104271515(GGH)

CVF:	104290665(GGH)

RTD:	128905838(GGH)

CUCA:

104061357(GGH)

TEO:	104370467(GGH)

BRHI:

104498174(GGH)

AAM:	106494371(GGH)

AROW:

112960446(GGH)

NPD:	112944771(GGH)

TGT:	104574289(GGH)

DNE:	112986697(GGH)

SCAM:

104143203(GGH)

ASN:	102387582(GGH)

AMJ:	102558989(GGH)

CPOO:

109315539(GGH)

GGN:	109304918(GGH)

PSS:	102460960(GGH)

CMY:	102935783(GGH)

CCAY:

125631060 125632498

DCC:	119850627 119850728(GGH)

CPIC:

101933582 101939707(GGH)

TST:	117871823(GGH) 117873525

CABI:

116835020(GGH) 116835024

MRV:	120396693(GGH) 120398947

ACS:	100563793(ggh)

ASAO:

132774875(GGH)

PVT:	110088990(GGH)

SUND:

121929266(GGH)

PBI:	103066894(GGH)

PMUR:

107302720(GGH)

CTIG:

120304754(GGH)

TSR:	106543965(GGH)

PGUT:

117672835(GGH)

APRI:

131194464(GGH)

PTEX:

113440010(GGH)

NSS:	113429700(GGH)

VKO:	123020532(GGH)

PMUA:

114600570(GGH)

PRAF:

128417414(GGH)

ZVI:	118090197(GGH)

HCG:	128324245(GGH)

GJA:	107110867(GGH)

STOW:

125439289(GGH)

EMC:	129333487(GGH)

XLA:	444589(ggh.L) 496099(ggh.2.L)

XTR:	100490929 594986(ggh)

NPR:	108796604(GGH) 108800416

RTEM:

120933180 120941032(GGH)

BBUF:

120986275 121001484(GGH)

BGAR:

122927317 122938575(GGH)

MUO:	115469379 115469730 115477823(GGH)

GSH:	117353640(GGH) 117363100

DRE:	406624(ggh) 553228 563836

SRX:	107712179 107718463 107721078 107730126 107731608 107747801

SANH:

107678461 107698074 107698580 107698674 107702651

SGH:	107549371 107559845(ggh) 107563161

CCAR:

109062240 109065404 109113352

CAUA:

113039422 113040374 113051621 113071001 113080560 113100972 113106321 113106741

CGIB:

127942866 127961202 127963771 127988165 128017701 128018295

PTET:

122327434 122348540(ggh) 122350418

LROH:

127153286 127167842(ggh) 127169251

OMC:	131529799 131543534(ggh) 131545908

PPRM:

120480168(ggh) 120481097 120486849

RKG:	130073732 130073754 130079888 130082122 130106264(ggh)

MAMB:

125263366 125265880 125265881 125280440

CIDE:

127516561 127517836 127519816

MASI:

127415483 127427803 127439213

TROS:

130549011 130552680(ggh) 130568280

TDW:	130430074 130433686(ggh) 130440223

MANU:

129413986 129452904(ggh) 129453125 129453126 129453128 129453718

IPU:	108265017 108267579(ggh) 108281015

IFU:	128607408 128609898(ggh) 128625153

PHYP:

113537998 113539783(ggh) 113546028

SMEO:

124387339(ggh) 124400153 124401930

TFD:	113639101 113646029 113657562(ggh)

TVC:	132838067 132848478(ggh) 132853923

AMEX:

103026830 103043942 103044433 111194246

CMAO:

118799564 118812861 118825691(ggh)

EEE:	113579324 113583714 113590246

CHAR:

105894779 105894780 105894887 105897885

TRU:	101066803(ggh) 101071237

TFS:	130513766(ggh) 130525553

TNG:	GSTEN00025459G001 GSTEN00030938G001

LCO:	104920826 104928764 104929067 104937010

NCC:	104950284 104961852

TBEN:

117473248 117496101 117496109 117496946 117497892

CGOB:

115008906 115012961 115025318 115025756

PGEO:

117440752 117446089 117453165 117465701(ggh) 117465804

GACU:

117539769 117539777 117558677

EMAC:

134873948 134883350 134883866(ggh) 134883919

ELY:	117252006 117256558 117264276

EFO:	125882066 125890173 125902821

PLEP:

121944931 121955898 121960604(ggh)

SLUC:

116034560 116040061(ggh) 116054359

ECRA:

117937576(ggh) 117944025 117944298

ESP:	116671953 116688492 116689222

PFLV:

114549269 114554356 114555211

GAT:	120830861 120834571

PPUG:

119198866(ggh) 119198868 119224715 119230070

AFB:	129101020 129106066 129110909

CLUM:

117730429 117736610 117749884 117749887

PSWI:

130197256 130206409 130206410(ggh) 130207742

MSAM:

119886844 119892181 119912675(ggh)

SCHU:

122866592(ggh) 122876919 122887854

CUD:	121507204 121510147 121527080(ggh)

ALAT:

119008444(ggh) 119019044 119021831

MZE:	101473896 101480685 101486490

ONL:	100692082 100704938

OAU:	116310507 116313210 116324455(ggh)

OLA:	101155553 101161409 101175559

OML:	112145648 112148585 112151516(ggh)

CSAI:

133423221(ggh) 133449232 133449233 133450628

XMA:	102226146 102227572 102233721

XCO:	114136300 114136863 114155218

XHE:	116711215 116711744 116730477

PRET:

103456931 103464304 103470103

PFOR:

103140516 103141766 103143243

PLAI:

106935993 106944947 106957108

PMEI:

106903532 106924708 106932146

GAF:	122823937(ggh) 122827478 122834265

PPRL:

129354631 129365735 129378889(ggh)

CVG:	107081843(ggh) 107086287 107099038

CTUL:

119787327(ggh) 119787503 119798569

GMU:	124856936 124858035(ggh) 124878161

NFU:	107383077 107384984 107394140

KMR:	108233685 108234706(ggh) 108243634

ALIM:

106513681 106515525 106522369

NWH:	119412899 119413036 119426899(ggh)

AOCE:

111563821 111564690 111565277 111566848

MCEP:

124995771(ggh) 125007310 125012910

CSEM:

103377435 103386516 103397649

POV:	109637155 109639637 109644647 109644648

SSEN:

122761983 122767834 122768547 122768554 122769492 122779010 122780799 122780800 122780804

HHIP:

117754203(ggh) 117761174 117761760 117761761 117761762 117768541

HSP:	118098591(ggh) 118104634 118104949 118115064

SMAU:

118291009(ggh) 118309828 118313794

LCF:	108873658 108882243 108885089(ggh)

SDU:	111230814 111231562 111237818

SLAL:

111645170 111645769(ggh) 111649717 111668504

XGL:	120783009 120789609(ggh) 120805714

HCQ:	109510306 109519086 109526524

SSCV:

125986317 125993736

SBIA:

133492654(ggh) 133499504 133507406

PEE:	133396415(ggh) 133399929

PTAO:

133470019(ggh) 133475203

BPEC:

110156566 110158323 110158334 110167053 110171015

MALB:

109956504 109960883 109972403

BSPL:

114853036(ggh) 114856110 114862015

SJO:	128356230 128365106 128382038(ggh)

SASA:

106566184 106579566(GGH) 106580573(GGH) 106583721 106590426

STRU:

115150037 115150609 115195536 115200432 115207288

OTW:	112221987 112233580 112234052 112262616

OMY:	110489713(ggh) 110494812 110535297 110536323

OGO:	123990335 124003921 124035266 124039595

ONE:	115104551 115130168 115140607 115143531

OKI:	109896140 109899294 109899897 109909641 109909857 109909859

OKE:	118358527 118370504 118389606

SALP:

111953407 111957406 111973442 112074482

SNH:	120027805 120037226 120051003 120062797

CCLU:

121569211(ggh) 121574722 121577934 121583158

ELS:	105006271 105014093(rnf122) 105019553

SFM:	108929602(ggh) 108931250 108940349

PKI:	111834805 111837171 111857520

AANG:

118210571 118225428(ggh) 118237315

LOC:	102684400 102693303(ggh) 102696303

PSPA:

121298090 121302983 121314299

ARUT:

117397909 117435332(ggh) 117964043 117966135

PSEX:

120530253(ggh) 120538951 120541518

LCM:

102357327

CMK:

103180721

RTP:	109919274 109938117

CPLA:

122543091 122549453 122549454 122561264

HOC:	132810496 132810512 132826503 132837015

LERI:

129696261 129696262 129704186 129704188 129713166

PMRN:

116940654 116940755 116941273 116947235

LRJ:	133343243 133343485 133345582

BFO:	118428959 118428980

BBEL:

109484058

SPU:	115923532 582718

LPIC:

129269219

APLC:

110980374

AJC:	117108648 117108649 117108650

SKO:	100376948 100377250 100378724 102807920

DME:	Dmel_CG32155(l(3)72Dp)

DER:	6544839 6544840

DSE:

6605895

DSI:	Dsimw501_GD14608(Dsim_GD14608)

DYA:	Dyak_GE19534 Dyak_GE19535 Dyak_GE23118 Dyak_GE23119

DSR:	110190582 110190653 110190654

DPO:	4812137 4812393

DPE:	113566355 6599706

DMN:	108151283 108151286

DWI:	6638672 6638673 6642180

DGR:

6557649

DMO:	Dmoj_GI12643 Dmoj_GI12644

DAZ:	108612709 108614335

DNV:	108650079 108650081

DHE:	111600468 111600478

DVI:

6623638

CCAT:

101459395

BOD:

106616995

BDR:

105224814

RZE:	108373705 108373707

AOQ:

129240869

TDA:

119664185

MDE:	101892443 101892617

SCAC:

106081973

LCQ:	111680034 111680036

LSQ:

119611975

GFS:

119645121

ECOE:

129947578

CLON:

129607510

HIS:	119648672 119649360

AGA:

1277260

ACOZ:

120950002

AARA:

120896072

AMER:

121593565

ASTE:

118513097

AFUN:

125769290

AMOU:

128301176

AALI:

118465905

AAG:

5573776

AALB:

109402593 109416472

CQU:	CpipJ_CPIJ006930

CPII:

120424879

CNS:	116345762 116349973

BCOO:

119080985

BIM:

100742651

BBIF:

117214380

BVK:

117231476

BVAN:

117166538

BTER:

100651812

BAFF:

126917525

BPYO:

122572940

BPAS:

132906783

OBB:

114873242

OLG:

117605258

MGEN:

117227279

NMEA:

116423959

CGIG:

122403188

SOC:

105196643

MPHA:

105833742

AEC:

105148388

ACEP:

105627444

PBAR:

105430931

VEM:

105565622

PGC:

109851946

PCF:

106793498

TPRE:

106650503

LHT:	122506235 122508374 122508397

LBD:	127285613 127285614

MDL:

103569120

CGLO:

123268800

FAS:	105267568 105270830

DAM:

107045077

CINS:

118063914

NFB:

124176675

NLO:

107217796

TCA:

659635

DPA:

109537699

SOY:	115874295 115890232

AGRG:

126739310

ATD:

109605216

CSET:

123322174

AGB:	108912203 108912234

LDC:

111514295

NVL:	108567519 108567547

PPYR:

116173930

OTU:	111414754 111423587

BMOR:

101736547

BMAN:

114249578

MSEX:

115450911

DPL:	KGM_204888A

BANY:

112044054 112044916 112055583

MJU:

123867958

NIQ:

126774557

VCD:

124536057

MCIX:

123659602

PMAC:

106708714

PPOT:

106104540

PXU:

106121066

PRAP:

110999791 110999805

PBX:	123709854 123710256

PNAP:

125049121 125049240

ZCE:	119828177 119840852

CCRC:

123694560 123694561

LSIN:

126968925 126970166 126970170

HAW:	110370080 135117520

HZE:

124635046

TNL:

113496419

SLIU:

111358766

OFU:	114359872 114359874 114359892

PXY:

105393491

PGW:

126372342

CFEL:

113388194 113388195

CCRN:

123291364

API:	100161199 100167343 100571243

DNX:	107162989 107163018 107163019

AGS:	114124325 114124338 114124339

RMD:	113555681 114253640 114253641

ACOO:

126833724 126834006

DVT:

126907349

BTAB:

109030105 109040644 109040645 109043775

DCI:	103506392 103508601 103510655

CLEC:

106662649 106674278

HHAL:

106688034 106688705 106690332

NLU:	111053256 111053436 111058597

HVI:	124357059 124366166 124366169 124366170

MQU:	128986402 128986474 129002923 129003077

PHU:	Phum_PHUM191920

FOC:	113202079 113203470

TPAL:

117650044 117651407

ZNE:	110829400 110829401 110829402

CSEC:

111863412 111863454 111863481

SGRE:

126355183 126355271

IEL:

124159059

FCD:

110848151

DPX:	DAPPUDRAFT_302567 DAPPUDRAFT_305752 DAPPUDRAFT_307408 DAPPUDRAFT_315503

DMK:

116934583

DPZ:	124315408 124326485

PVM:	113807057 113828928 113829328

PJA:	122251136 122254923 122266422

PCHN:

125025917 125025961 125043893 125043961

PMOO:

119577125 119586071

HAME:

121855122 121861553

PCLA:

123754008

CQD:	128699024 128700516

PTRU:

123518530

ESN:

126987834

HAZT:

108675247

EAF:	111711448 111714885 111715381

LSM:

121127517

TCF:	131876842 131876843

PPOI:

119094373 119095513 119101555 119101557

RMP:	119179291 119179292

VDE:

111251856

VJA:

111268378

TUT:	107361416 107368043

DPTE:

113790317

DFR:

124495161

CSCU:

111634942

PTEP:

107448459

ABRU:

129988588 129988876

UDV:	129226133 129226394

SDM:

118184332

LPOL:

106465362

PMEO:

129581026 129589846 129589855

LGI:	LOTGIDRAFT_229608

PVUL:

126811839 130010340

PCAN:

112561388

BGT:	106066004 106078575 106078642

GAE:	121378218 121378219

HRF:	124150840 124150884 124150885 124150887

HRJ:	124262107 124262108 124262114 124262122

CRG:

105317584

CVN:

111128057

CANU:

128177824

OED:

125651772

MYI:	110442066 110464678

PMAX:

117315515 117333501

MCAF:

127709080

MMER:

123564971

RPHI:

132716969 132756072

DPOL:

127866722

LAK:

106166411

NVE:	116614404 116620875 5499460 5504677 5505604 5516937 5520163 5520215

EPA:	110238085 110239918 110239960 110240017 110244007 110251763

ATEN:

116288702 116291157 116302182 116308884

ADF:	107351159 107351173 107353245 107353247

AMIL:

114946883 114947371 114947372

PDAM:

113677037 113680336 113683869

SPIS:

111320493 111325560 111325581 111329701 111337063 111347046

DGT:	114518074 114524118 114524495 114537983

XEN:	124439822 124439823 124439824 124446505 124446517 124447382 124447465

HMG:	100198228 100203476 100207447 100209771 100209963 100215242

HSY:	130614116 130614317 130614373 130625609 130625920 130644188 130644622 130645265 130646186 130656966

TAD:	TRIADDRAFT_34071

AQU:	100636296 100636727 105316060

ATH:	AT1G78660(GGH1) AT1G78670(GGH3) AT1G78680(GGH2)

ALY:	9298735 9298737 9298738 9323814 9323815 9323816

CRB:	17895161 17895321 17895703

CSAT:

104703200 104703201 104714134 104714135 104752295 104752296

EUS:	EUTSA_v10018738mg EUTSA_v10018776mg

BRP:	103832344 103832347 103853141

BNA:	106354680 106354681 106381435 106390062 106397984

BOE:	106300899 106324790

RSZ:	108823691 108827022 108828095 108843491

THJ:

104813997

CPAP:

110812565

CIT:	102628535 102629472 102629856

CIC:	CICLE_v10020608mg CICLE_v10020872mg CICLE_v10021719mg CICLE_v10024365mg

PVY:	116115190 116135797 116137046

MINC:

123209358

TCC:

18594335

GRA:	105777093 105777125

GHI:	107917114 107918036 107934690

GAB:

108480536

HSYR:

120160765

DZI:

111276559

EGR:	104448560 104448563 104448570 104451569 108954044

GMX:	100796947 547881(GH)

GSJ:	114376495 114376919

PVU:	PHAVU_005G080600g PHAVU_005G080700g

VRA:	106778129 106778134 106778138

VAR:	108333002 108333003

VUN:	114183153 114183810

VUM:	124829827 124830475

CCAJ:

109811931 109811946

APRC:

113853566

MTR:	11415421 11415422 11416437

TPRA:

123895025 123895026

CAM:	101490861 101491176

PSAT:

127086165

VVO:	131647994 131653409 131653410 131653657

LJA:	Lj0g3v0178769.1(Lj0g3v0178769.1) Lj0g3v0338049.1(Lj0g3v0338049.1)

ADU:

107459833

AIP:

107613260

AHF:	112703586 112771592

LANG:

109334584 109348097

PCIN:

129314964 129316055

QSA:	O6P43_001067 O6P43_029220

FVE:

101290933

RCN:	112168382 112168386 112168389

PPER:

18779010

PMUM:

103325967

PAVI:

110757564

PDUL:

117624639

MDM:	103408080 103418191 103448789

MSYL:

126589975 126614617

PXB:	103926865 103934880

ZJU:

107403905

MNT:

21386200

CSAV:

115698128

CSV:	101203165 101206873 101219276

CMO:

103501819

BHJ:	120086372 120086854

MCHA:

111008276 111008284

CMAX:

111480987

CMOS:

111446777

CPEP:

111789236

RCU:

8288177

HBR:

110650012

MESC:

110602166 110610408

POP:	112326977 18095447 18103357 7484350

PEU:	105109679 105139350

PALZ:

118027469 118038288

JRE:

109011928

CILL:

122281519 122281520 122282488

CAVE:

132174432 132175090

QSU:

112014043

QLO:

115955772

TWL:

119985976

VVI:

100262251

VRI:	117908414 117909674

SLY:	100191133(GGH1) 100191134(GGH3) 100191135(GGH2)

SPEN:

107024264 107024510 107031819

SOT:	102581354 102584938 102585261

SSTN:

125850831 125850832 125865588

SDUL:

129876185 129892198

CANN:

107845624 107878577

LBB:	132619119 132629167

NTA:	107760660 107783395 107799082 107805981 107828474(GGH2)

NSY:	104220526 104249293

NTO:	104100144 104120726

NAU:	109206503 109206504 109229853

INI:	109188447(DR15) 109188449

ITR:

116005822

SIND:

105176926

OEU:

111370840

EGT:	105966772 105970294 105970361 105970363 105970364

SSPL:

121783415 121784903

SMIL:

131012086 131012088

SHIS:

125214248 125214249

APAN:

127254462

HAN:

110912906

ECAD:

122592401 122599177

LSV:	111898963 111913893

CCAV:

112500606 112506641

DCR:

108220262

CSIN:

114263512

RVL:

131331493

AEW:

130751405

BVG:

104891329

SOE:	110786247 110795307

CQI:	110690162 110734036 110737819

ATRI:

130817708

MOF:

131151142

NNU:	104586570 104591286

MING:

122058769

TSS:

122652236

PSOM:

113302144 113328845 113342758 113352792 113356356

OSA:

4339329

DOSA:

Os05t0517500-01(Os05g0517500)

OBR:

102700528

OGL:

127774622

BDI:

100828890

ATS:

109747252

TDC:	119287156 119349013

TAES:

123063295 123140200 123182645

TUA:

125524873

LPER:

127327003

LRD:	124648015 124707301

SBI:	8067519 8082979

ZMA:

100274493

SITA:

101782252

SVS:

117850729

PVIR:

120644125 120664914 120688409 120698113

PHAI:

112886673

PDA:

103708964

EGU:

105047475

MUS:

103989604

ZOF:	122040454 122044975

DCT:

110094990

PEQ:

110025254

AOF:

109848496

MSIN:

131240948

NCOL:

116260413

ATR:

18426350

SMO:	SELMODRAFT_109437 SELMODRAFT_177157 SELMODRAFT_423816

PPP:	112277717 112287009 112293995 112294850

CRE:	CHLRE_06g275050v5 CHLRE_07g315050v5

VCN:	VOLCADRAFT_102798 VOLCADRAFT_106317

MNG:	MNEG_1386 MNEG_14015 MNEG_1646

CSL:	COCSUDRAFT_31205 COCSUDRAFT_54091 COCSUDRAFT_64380

CVR:	CHLNCDRAFT_133025 CHLNCDRAFT_52559

APRO:

F751_0355 F751_6351

MIS:	MICPUN_76094

MBR:	MONBRDRAFT_29193

SRE:	PTSG_00836 PTSG_07318

DDI:	DDB_G0286535(gghA) DDB_G0289365(gghB)

DPP:	DICPUDRAFT_31892 DICPUDRAFT_51633 DICPUDRAFT_73725

DFA:	DFA_01284 DFA_11781(gghA)

ACAN:

ACA1_266910 ACA1_267110 ACA1_305550

TET:	TTHERM_000129409 TTHERM_00030360 TTHERM_000564438 TTHERM_00130000 TTHERM_00321670 TTHERM_00449200 TTHERM_00564450 TTHERM_00819530 TTHERM_01027470 TTHERM_01156850

PTM:	GSPATT00002255001 GSPATT00005223001 GSPATT00009190001 GSPATT00035342001 GSPATT00036518001 GSPATT00037241001 GSPATT00038899001

SMIN:

v1.2.013270.t1(symbB.v1.2.013270.t1) v1.2.013687.t1(symbB.v1.2.013687.t1) v1.2.023128.t1(symbB.v1.2.023128.t1) v1.2.024246.t1(symbB.v1.2.024246.t1)

PTI:	PHATR_13333

PIF:	PITG_07349

PSOJ:

PHYSODRAFT_359609

SPAR:

SPRG_03486 SPRG_08278 SPRG_16945 SPRG_17396

EHX:	EMIHUDRAFT_68526 EMIHUDRAFT_78425

GTT:	GUITHDRAFT_72685

NGR:	NAEGRDRAFT_2938 NAEGRDRAFT_56320 NAEGRDRAFT_60907

» show all

Reference

Authors

McGuire, J.J. and Coward, J.K.

Title

Pteroylpolyglutamates: biosynthesis, degradation and function.

Journal

In: Blakley, R.L. and Benkovic, S.J. (Eds.), Folates and Pterins, John Wiley and Sons, New York, 1984, p. 135-191.

Reference

2 [PMID:8343522]

Authors

Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J.

Title

The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells.

Journal

Biochim Biophys Acta 1164:227-35 (1993)
DOI:10.1016/0167-4838(93)90253-N

Sequence

[rno:25455]

Reference

3 [PMID:7565632]

Authors

Yao R, Rhee MS, Galivan J.

Title

Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells.

Journal

Mol Pharmacol 48:505-11 (1995)

Reference

4 [PMID:8816764]

Authors

Yao R, Schneider E, Ryan TJ, Galivan J.

Title

Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro.

Journal

Proc Natl Acad Sci U S A 93:10134-8 (1996)
DOI:10.1073/pnas.93.19.10134

Sequence

[hsa:8836]

Reference

5 [PMID:8621474]

Authors

Yao R, Nimec Z, Ryan TJ, Galivan J

Title

Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase.

Journal

J Biol Chem 271:8525-8 (1996)
DOI:10.1074/jbc.271.15.8525

Sequence

[rno:25455]

Reference

6 [PMID:15961386]

Authors

Orsomando G, de la Garza RD, Green BJ, Peng M, Rea PA, Ryan TJ, Gregory JF 3rd, Hanson AD

Title

Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles.

Journal

J Biol Chem 280:28877-84 (2005)
DOI:10.1074/jbc.M504306200

Reference

7 [PMID:18757550]

Authors

Akhtar TA, McQuinn RP, Naponelli V, Gregory JF 3rd, Giovannoni JJ, Hanson AD

Title

Tomato gamma-glutamylhydrolases: expression, characterization, and evidence for heterodimer formation.

Journal

Plant Physiol 148:775-85 (2008)
DOI:10.1104/pp.108.124479

Other DBs

ExplorEnz - The Enzyme Database:

3.4.19.9

IUBMB Enzyme Nomenclature:

3.4.19.9

ExPASy - ENZYME nomenclature database:

3.4.19.9

BRENDA, the Enzyme Database:

3.4.19.9

CAS:

9074-87-7

DBGET integrated database retrieval system