KEGG   ENZYME: 3.4.21.1Help
Entry
EC 3.4.21.1                 Enzyme                                 

Name
chymotrypsin;
chymotrypsins A and B;
alpha-chymar ophth;
avazyme;
chymar;
chymotest;
enzeon;
quimar;
quimotrase;
alpha-chymar;
alpha-chymotrypsin A;
alpha-chymotrypsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Tyr!, Trp!, Phe!, Leu!
Comment
Chymotrypsin A is formed from cattle and pig chymotrypsinogen A, several iso-forms being produced according to the number of bonds hydrolysed in the precursor. Chymotrypsin B (formerly listed as EC 3.4.4.6), formed from chymotrypsinogen B, is homologous with chymotrypsin A. Enzymes with specificity similar to that of chymotrypsins A and B have been isolated from many species. In peptidase family S1 (trypsin family)
History
EC 3.4.21.1 created 1961 as EC 3.4.4.5 and EC 3.4.4.6, transferred 1972 to EC 3.4.21.1
Orthology
K01310  chymotrypsin
Genes
HSA: 1504(CTRB1) 440387(CTRB2)
PTR: 736467(CTRB2) 736783
PPS: 100979112(CTRB2) 100979449(CTRB1)
GGO: 101134917(CTRB2) 101141122(CTRB1)
PON: 100434840 100447221
MCC: 711100(CTRB2) 713851(CTRB1)
MCF: 102146658(CTRB2) 102147021(CTRB1)
CSAB: 103233307 103233308
RRO: 104677837 104677859
RBB: 108525819 108527423
CJC: 100391196(CTRB1) 100401959
SBQ: 101041600 101041923
MMU: 66473(Ctrb1)
RNO: 24291(Ctrb1)
CGE: 100769139
NGI: 103725666
HGL: 101710293 101719459(Ctrb1)
CCAN: 109684024(Ctrb2)
OCU: 100341936 100342191
TUP: 102489237(CTRB1) 102489643
CFA: 479649 479650(CTRB2) 610373
AML: 100478694 100479949
UMR: 103662066 103662113 103662114
ORO: 101364050(CTRB1) 101367705 101367998
FCA: 101091168 101096125 101096371
PTG: 102956672 102962235(CTRB1) 102962532
AJU: 106989660 106989661
BTA: 100848132 504241(CTRB1) 618826
BOM: 102265599(CTRB1) 102286947 102287233
BIU: 109571602 109572005 109572232
PHD: 102334841 102335205(CTRB1) 102335570
CHX: 102173875 102174148 102176156
OAS: 101116249 101117443
SSC: 100621642(CTRB2) 100621820
CFR: 102521639 102521880(CTRB1) 102524246(CTRB2)
CDK: 105104323 105105250 105106186
BACU: 103002465 103002741
LVE: 103078018(CTRB1) 103078294 103078577
OOR: 101283416 101285785 101286030
ECB: 100146723 102150576
EPZ: 103553045 103553048
EAI: 106833713 106836125
MYB: 102246722(CTRB1) 102256565
MYD: 102752429(CTRB1)
HAI: 109384817 109384818
RSS: 109433997 109459397
PALE: 102886813(CTRB1) 102897343
LAV: 100672744
TMU: 101346609 101352410
MDO: 100023625
SHR: 100915387 100926099 105749186 105749238
OAA: 100082597 100082620
GGA: 431235(CTRB2)
MGP: 100544825
CJO: 107319077 107319196
APLA: 101790190(CTRB1)
ACYG: 106033168
TGU: 100221838(CTRB1)
FAB: 101809681 101819337 107604530
PHI: 102099273 102099582(CTRB1) 102109513 102109699
PMAJ: 107209878 107209879
FPG: 101924388(CTRB1)
CLV: 102091024
EGZ: 104133960
ASN: 102376101 102376351 106722828
AMJ: 102565040(CTRB2) 102566903 109283535
CMY: 102937055(CTRB1) 102938194
CPIC: 101937265(CTRB1) 101951625
ACS: 100565667(ctrb2)
PBI: 103054169 103055448
GJA: 107107885 107107897
XLA: 108713630 108715072 379495(ctrl.L) 379607(ctrb1.L) 444360(ctrb2.L)
XTR: 100489516 101733231 394984(ctrb1) 496968(ctrb2) 548358(ctrl)
NPR: 108789591 108796300 108796301 108796302
DRE: 322451(ctrb1) 562139
SRX: 107740462 107740487 107740502 107755026 107755043 107755119 107755120
SANH: 107657100 107696673 107696674 107696676
SGH: 107548936 107548953 107548954 107563459 107563461 107563495 107578455
CCAR: 109051619 109051621 109051655 109061241
IPU: 108274430
AMEX: 103027485 103028134 103028442 103033388 103033709
TRU: 101074356 101074582 101077681 101077910
TNG: GSTEN00002885G001 GSTEN00019361G001 GSTEN00019362G001 GSTEN00019363G001
LCO: 104938940
MZE: 101469324 101483816 105941050
OLA: 101170410 105356289
XMA: 102231986 111608451
PRET: 103460505
NFU: 107381521 107381578
CSEM: 103378636 103378813 103378814 103378818 103378820
LCF: 108894207 108894209
HCQ: 109508622 109508859 109529759 109529808
BPEC: 110161934 110161954 110161965
SASA: 100196064(ctrb) 106576578 106588135 106591457 106592898 106609703
ELS: 105020421 105025470 105025471
SFM: 108926238 108926269 108926271
LCM: 102353013 102363505
CMK: 103176139 103176140 103176141 103176142 103176187 103176191
BFO: BRAFLDRAFT_105242 BRAFLDRAFT_117038 BRAFLDRAFT_117045 BRAFLDRAFT_119700 BRAFLDRAFT_119701 BRAFLDRAFT_132269 BRAFLDRAFT_215636 BRAFLDRAFT_240723 BRAFLDRAFT_261914 BRAFLDRAFT_56781 BRAFLDRAFT_56782 BRAFLDRAFT_63514 BRAFLDRAFT_63516 BRAFLDRAFT_70627 BRAFLDRAFT_71413 BRAFLDRAFT_71416
CIN: 100181838
SKO: 100375731 100377421
DME: Dmel_CG18179(CG18179) Dmel_CG6298(Jon74E)
SOC: 105193265
NVL: 108563252
FCD: 110847506 110850452
DPX: DAPPUDRAFT_105418 DAPPUDRAFT_127351 DAPPUDRAFT_244722 DAPPUDRAFT_301538 DAPPUDRAFT_335851 DAPPUDRAFT_340740
ISC: IscW_ISCW014005
LGI: LOTGIDRAFT_226539
MYI: 110459661
OBI: 106880032
LAK: 112042437
NVE: NEMVE_v1g140545
EPA: 110236060 110236291 110236638 110236968 110237783 110242679 110244488 110245130 110251471 110253045 110253082 110253113
HMG: 100213885
MAJ: MAA_11795
FCY: FRACYDRAFT_244069
PIF: PITG_02707 PITG_21623
PSOJ: PHYSODRAFT_310065
 » show all
Taxonomy
Reference
1
  Authors
Wilcox, P.E.
  Title
Chymotrypsinogens - chymotrypsins.
  Journal
Methods Enzymol 19:64-108 (1970)
Reference
2
  Authors
Blow, D.M.
  Title
Structure and mechanism of chymotrypsin.
  Journal
Acc Chem Res 9:145-152 (1976)
Reference
3  [PMID:6768556]
  Authors
Bauer CA.
  Title
Active centers of alpha-chymotrypsin and of Streptomyces griseus proteases 1 and 3. S2-P2 enzyme-substrate interactions.
  Journal
Eur J Biochem 105:565-70 (1980)
DOI:10.1111/j.1432-1033.1980.tb04533.x
Reference
4
  Authors
Polgar, L.
  Title
Structure and function of serine proteases.
  Journal
In: Neuberger, A. and Brocklehurst, K. (Eds.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, p. 159-200.
Reference
5  [PMID:2917002]
  Authors
Tomita N, Izumoto Y, Horii A, Doi S, Yokouchi H, Ogawa M, Mori T, Matsubara K.
  Title
Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.
  Journal
Biochem Biophys Res Commun 158:569-75 (1989)
DOI:10.1016/S0006-291X(89)80087-7
  Sequence
[hsa:440387 1504]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.1
IUBMB Enzyme Nomenclature: 3.4.21.1
ExPASy - ENZYME nomenclature database: 3.4.21.1
BRENDA, the Enzyme Database: 3.4.21.1
CAS: 9004-07-3

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