KEGG   ENZYME: 3.4.21.1Help
Entry
EC 3.4.21.1                 Enzyme                                 

Name
chymotrypsin;
chymotrypsins A and B;
alpha-chymar ophth;
avazyme;
chymar;
chymotest;
enzeon;
quimar;
quimotrase;
alpha-chymar;
alpha-chymotrypsin A;
alpha-chymotrypsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Tyr!, Trp!, Phe!, Leu!
Comment
Chymotrypsin A is formed from cattle and pig chymotrypsinogen A, several iso-forms being produced according to the number of bonds hydrolysed in the precursor. Chymotrypsin B (formerly listed as EC 3.4.4.6), formed from chymotrypsinogen B, is homologous with chymotrypsin A. Enzymes with specificity similar to that of chymotrypsins A and B have been isolated from many species. In peptidase family S1 (trypsin family)
History
EC 3.4.21.1 created 1961 as EC 3.4.4.5 and EC 3.4.4.6, transferred 1972 to EC 3.4.21.1
Orthology
K01310  chymotrypsin
Genes
HSA: 1504(CTRB1) 440387(CTRB2)
PTR: 736467(CTRB2) 736783
PPS: 100979112(CTRB2) 100979449(CTRB1)
GGO: 101134917(CTRB2) 101141122(CTRB1)
PON: 100434840 100447221
MCC: 711100(CTRB2) 713851(CTRB1)
MCF: 102146658(CTRB2) 102147021(CTRB1)
CSAB: 103233307 103233308
RRO: 104677837 104677859
RBB: 108525819 108527423
CJC: 100391196(CTRB1) 100401959
MMU: 66473(Ctrb1)
RNO: 24291(Ctrb1)
CGE: 100769139
NGI: 103725666
HGL: 101710293 101719459(Ctrb1)
CCAN: 109684024(Ctrb2)
TUP: 102489237(CTRB1) 102489643
CFA: 479649 479650(CTRB2) 610373
BTA: 100848132 504241(CTRB1) 618826
SSC: 100621642(CTRB2) 100621820
CFR: 102521639 102521880(CTRB1) 102524246(CTRB2)
MYB: 102246722(CTRB1) 102256565
MYD: 102752429(CTRB1)
PALE: 102886813(CTRB1) 102897343
LAV: 100672744
MDO: 100023625
GGA: 431235(CTRB2)
MGP: 100544825
APLA: 101790190(CTRB1)
ACYG: 106033168
TGU: 100221838(CTRB1)
FPG: 101924388(CTRB1)
CLV: 102091024
EGZ: 104133960
CMY: 102937055(CTRB1) 102938194
CPIC: 101937265(CTRB1) 101951625
ACS: 100565667(ctrb2)
XLA: 108713630 108715072 379495(ctrl.L) 379607(ctrb1.L) 444360(ctrb2.L)
XTR: 100489516 101733231 394984(ctrb1) 496968(ctrb2) 548358(ctrl)
DRE: 322451(ctrb1) 562139
IPU: 108274430
LCO: 104938940
PRET: 103460505
CIN: 100181838
DME: Dmel_CG18179(CG18179) Dmel_CG6298(Jon74E)
SOC: 105193265
NVL: 108563252
MYI: 110459661
OBI: 106880032
LAK: 112042437
HMG: 100213885
MAJ: MAA_11795
 » show all
Taxonomy
Reference
1
  Authors
Wilcox, P.E.
  Title
Chymotrypsinogens - chymotrypsins.
  Journal
Methods Enzymol 19:64-108 (1970)
Reference
2
  Authors
Blow, D.M.
  Title
Structure and mechanism of chymotrypsin.
  Journal
Acc Chem Res 9:145-152 (1976)
Reference
3  [PMID:6768556]
  Authors
Bauer CA.
  Title
Active centers of alpha-chymotrypsin and of Streptomyces griseus proteases 1 and 3. S2-P2 enzyme-substrate interactions.
  Journal
Eur J Biochem 105:565-70 (1980)
DOI:10.1111/j.1432-1033.1980.tb04533.x
Reference
4
  Authors
Polgar, L.
  Title
Structure and function of serine proteases.
  Journal
In: Neuberger, A. and Brocklehurst, K. (Eds.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, p. 159-200.
Reference
5  [PMID:2917002]
  Authors
Tomita N, Izumoto Y, Horii A, Doi S, Yokouchi H, Ogawa M, Mori T, Matsubara K.
  Title
Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.
  Journal
Biochem Biophys Res Commun 158:569-75 (1989)
DOI:10.1016/S0006-291X(89)80087-7
  Sequence
[hsa:440387 1504]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.1
IUBMB Enzyme Nomenclature: 3.4.21.1
ExPASy - ENZYME nomenclature database: 3.4.21.1
BRENDA, the Enzyme Database: 3.4.21.1
CAS: 9004-07-3

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