KEGG   ENZYME: 3.4.21.10
Entry
EC 3.4.21.10                Enzyme                                 
Name
acrosin;
acrosomal proteinase;
acrozonase;
alpha-acrosin;
beta-acrosin;
upsilon-acrosin;
acrosomal protease;
acrosin amidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: Arg!, Lys!
Comment
Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family)
History
EC 3.4.21.10 created 1972
Orthology
K01317  acrosin
Genes
HSA49(ACR)
PTR458950(ACR)
PPS100979160(ACR)
GGO101144239(ACR)
PON100448292(ACR)
NLE100586140(ACR)
MCC716579(ACR)
MCF102115325(ACR)
MTHB126964017
CSAB103223579 103223651(ACR)
PANU101010633 116270711
TGE112633283(ACR)
RRO104655563(ACR)
RBB108545017(ACR)
TFN117096242(ACR)
PTEH111549166(ACR)
CJC100406660(ACR)
SBQ101047167(ACR)
CSYR103271503(ACR)
MMUR105884990(ACR)
LCAT123640348(ACR)
OGA100963151(ACR)
MMU11434(Acr)
MCAL110310440(Acr)
MPAH110334980(Acr)
RNO24163(Acr)
MCOC116078085(Acr)
MUN110566471(Acr)
CGE100754856(Acr)
MAUA101839533(Acr)
PLEU114693039(Acr)
MORG121461410(Acr)
AAMP119823273(Acr)
NGI103735496(Acr)
HGL101712354(Acr)
CPOC100717414(Acr)
CCAN109693070(Acr)
DORD105992722(Acr)
NCAR124982996
OCU100009184(ACR)
OPI101522965(ACR)
TUP102477933(ACR)
GVR103591321(ACR)
CFA606765(ACR)
CLUD112665305(ACR)
VVP112935879(ACR)
VLG121492162(ACR)
AML100482745(ACR)
UMR103674103(ACR)
UAH113241583(ACR)
UAR123803812(ACR)
ELK111157685
MPUF101682369(ACR)
ORO101363888 101379789(ACR)
EJU114203158 114203159 114203316 114218308(ACR)
ZCA113909159 113909160 113922803 113933199 113933897 118355967
MLX117997712(ACR)
NSU110578315(ACR)
LWW102727815(ACR)
FCA101083949(ACR)
PYU121040095(ACR)
PBG122473012(ACR)
LRUF124502535
PTG102954045(ACR)
PPAD109265792(ACR)
AJU106987633(ACR)
HHV120233554(ACR)
BTA280711(ACR)
BOM102270129(ACR)
BBUB102391015(ACR)
BBIS104980012(ACR)
CHX102191416(ACR)
OAS443195(ACR)
ODA120857786(ACR)
CCAD122423039(ACR)
SSC397098(ACR)
CFR102504353(ACR)
CBAI105070825(ACR)
CDK105106149(ACR)
VPC102543078(ACR)
BACU103017313(ACR)
LVE103072664(ACR)
OOR101282422(ACR)
DLE111186384(ACR)
PCAD102982720(ACR)
PSIU116760485(ACR)
ECB100057028(ACR)
EPZ103543987(ACR)
EAI106846026(ACR)
MYB102256900(ACR)
MYD102774021(ACR)
MMYO118657372(ACR)
MLF102426257(ACR)
MNA107536030(ACR)
PKL118714759(ACR)
HAI109396613(ACR)
DRO112321661(ACR)
SHON118989694(ACR) 119003110
AJM119060332(ACR)
PDIC114496816 114513967(ACR)
PHAS123816028(ACR) 123831647
MMF118641119(ACR)
RFQ117028267(ACR)
PALE102886339(ACR)
PGIG120602806(ACR)
PVP105308288(ACR)
RAY107500248(ACR)
MJV108407873(ACR)
TOD119248216(ACR)
SARA101548761(ACR)
LAV100674496(ACR)
TMU101350147
ETF101649792(ACR)
DNM101443016(ACR)
MDO103093639
GAS123250441(ACR)
SHR100916052 100932714(ACR)
PCW110201632 110202102 110205953 110213369
GGA426864(ACR) 769176(ACRL)
PCOC116238651 116238654
MGP100539639 692129(ACR)
CJO107306626 107318185 107319775(ACR)
NMEL110392172(ACR) 110392173
APLA101793578 101795648
ACYG106029620
AFUL116485356 116502165
TGU100221796 100222616 100224801 100226600 100229676 100230182 100230310 105759945 115492572 115492576 115492597 115494525 116806618 116808091
LSR110471229 110473210 110479258 110479484 110480942 110482998 110483008 110483013 110483020 116184413
SCAN103819459 103821213 103821538 103821544 103821545 103821704 103822492 103826285 115484943 115484944 115484945 115485249 115485250
PMOA120496586 120498862 120498864 120498865 120498866 120500129 120502776 120509454 120512090
OTC121334138 121334139 121334140 121334141 121334143 121334176 121334177 121334178 121334180 121337836 121338543 121339675 121339796 121347555 121347803 121347903
PRUF121351071 121355021 121355048 121355049 121355079 121356475 121356480 121358543 121358661 121358663 121358665 121358666 121362311 121363619 121365244
GFR102032254 102032420 102034420 102034591 102034751 102034910 102036222 102039449 102040074 102040400 102042777
FAB101805845 101806079 101806420 101807419 101810525(ACR) 101810913 101813807 101815502 101821184 101821498 101822159
PHI102099449 102100182 102100356 102100726 102100912 102101252 102103033 102104135 102104469 102106778 102109508 102109747 102110299 102110481 102112356 106628778
PMAJ107198756 107199113 107201238 107201239 107203286 107204160 107204248 107215191 107215761 107215800
CCAE111923201 111926213 111926214 111926220 111926221 111926222 111926224 111928838 111940106 111940691 111941730 111942340 111944320 111945825
CCW104685158 104685740 104689773 104697239 104697783 120411926
CBRC103612817 103612821 103612825 103614592 103616380 103617098 103622407 103624576
ETL114056934 114056935 114057344 114060836(ACR) 114069705 114070062 114070831 114072025 114072026
ZAB102063828 102064750 102066368 102070519 102071220 102071394 102071579 102072285 102073834 113460530
ACHL103801502 103801658 103801918 103803315 103805198 103808654
FPG101920858
FCH102053562 102058125
CLV102087611 102095569(ACR) 106145737
EGZ104122507
NNI104019823
PLET104627099
PCRI104031627 104035799
PCAO104050265
ACUN113479662 113487369 113487370 113489756 113490271 113490487 113490852 113490873 113490890 113490949
TALA116959616 116959617 116964185 122153390 122153391 122153392 122153397 122153398 122153399 122153400 122153401 122153403 122153404 122153405 122153406 122153421 122153464 122154133 122154134 122154135 122154136
PADL103924103(ACR)
AFOR103893174 103895289(ACR)
ACHC115341357 115341358 115342214(ACR)
HALD104322403(ACR)
HLE104833452(ACR)
AGEN126044256 126044257
CMAC104475581 104478175 104482174
MUI104545267
FGA104077990
LDI104348808 104349430
NNT104406223 104408143
DPUB104300448 104300680 104306213
PGUU104460770
ACAR104523418 104527929
CPEA104388655 104389105 104389332 104391094(ACR)
CUCA104061494 104064630
AAM106496144
AROW112968660 112968683
NPD112953970 112953971
DNE112989979 112989984
SCAM104145754
ASN102370826 102371080 102384412
AMJ102561178 102574978 106737926
GGN109292091(ACR)
PSS102455380 102455626 106731832
CMY102938344(ACR)
CPIC101943992
TST117873481 117873487
CABI116838331 116838335
MRV120393791 120396067
ACS100558380 107983695
PVT110070564 110070565 110070568 110070571 110084405 110084406 110084408(ACR) 110084420
SUND121930811 121930815 121932298 121932299(ACR) 121932300
PBI103055962 103067049 107326529 112542530 112542531
PMUR107297332 114923114 114923390 114923503
CTIG120303703 120320074
TSR106547407
PGUT117672950 117672959 117672961 117672962 117676845
VKO123023716(ACR)
PMUA114604849 114604850 114604851 114604852 114604853 114604859 114606012
ZVI118091564 118091572 118091573 118091575
GJA107118562(ACR) 107120174
STOW125434607 125434608
XLA108695414 108695553(acr.2.L) 108707440 108707950 108713848 108714853 108719368 108719374 734611(XB5892359.L)
XTR100487305 100487784 100490933 100497024 100497408 100497443 101731233 101732810 101733125 101733280 108645680 108645681(acr.2) 108647852 116408674 116408790 116411577 116411715 116412122 733551
NPR108802724
RTEM120916063 120920625 120930362
BBUF120986103 120986112 120986123
BGAR122925776 122925777
PSPA121299590 121318214
ARUT117419697 117426277 117965962
LCM102354559
CMK103180626 103182529 103190823
OTU111423136
PMAC106721108
NLU111057367
PTEP107455313
HRF124145417
EHXEMIHUDRAFT_124077
 » show all
Reference
1  [PMID:7043204]
  Authors
Muller-Esterl W, Fritz H.
  Title
Sperm Acrosin.
  Journal
Methods Enzymol 80 Pt C:621-32 (1981)
DOI:10.1016/s0076-6879(81)80049-3
Reference
2  [PMID:2500154]
  Authors
Skoog MT, Mehdi S, Wiseman JS, Bey P.
  Title
The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates.
  Journal
Biochim Biophys Acta 996:89-94 (1989)
DOI:10.1016/0167-4838(89)90099-X
Reference
3  [PMID:2114285]
  Authors
Keime S, Adham IM, Engel W.
  Title
Nucleotide sequence and exon-intron organization of the human proacrosin gene.
  Journal
Eur J Biochem 190:195-200 (1990)
DOI:10.1111/j.1432-1033.1990.tb15564.x
  Sequence
[hsa:49]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.10
IUBMB Enzyme Nomenclature: 3.4.21.10
ExPASy - ENZYME nomenclature database: 3.4.21.10
BRENDA, the Enzyme Database: 3.4.21.10
CAS: 9068-57-9

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