KEGG   ENZYME: 3.4.21.105
Entry
EC 3.4.21.105               Enzyme                                 

Name
rhomboid protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains
Comment
These endopeptidases are multi-spanning membrane proteins. Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains. A catalytic dyad is involved in proteolysis rather than a catalytic triad, as was thought previously [14]. They are important for embryo development in Drosophila melanogaster. Rhomboid is a key regulator of EGF receptor signalling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway. Belongs in peptidase family S54. Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Rhomboids are widely conserved from bacteria to archaea to humans [9,13].
History
EC 3.4.21.105 created 2005
Orthology
K02857  rhomboid-related protein 1/2/3
K09650  rhomboid-like protein
K19225  rhomboid protease GluP
K23461  rhomboid
Genes
HSA: 162494(RHBDL3) 54933(RHBDL2) 55486(PARL) 9028(RHBDL1)
PTR: 453801(RHBDL1) 456773(RHBDL2) 460877(PARL) 747914(RHBDL3)
PPS: 100972422(RHBDL1) 100981191(PARL) 100991726(RHBDL2) 100995298(RHBDL3)
GGO: 101136818(PARL) 101140065(RHBDL2) 101145550(RHBDL3)
PON: 100173771(PARL) 100442110(RHBDL1) 100450187(RHBDL3) 100452148(RHBDL2)
NLE: 100591442(RHBDL1) 100595259(RHBDL3) 100601797(PARL) 100602665(RHBDL2)
MCC: 704652(PARL) 713926(RHBDL3) 715695(RHBDL2) 722357(RHBDL1)
MCF: 101926657(PARL) 102115426(RHBDL2) 102122957(RHBDL3) 102125336(RHBDL1)
CSAB: 103221155(PARL) 103225071(RHBDL2) 103225592(RHBDL1) 103242692(RHBDL3)
RRO: 104653641(RHBDL2) 104664642(PARL) 104669334(RHBDL3) 104681174(RHBDL1)
RBB: 108518006(RHBDL2) 108519442(RHBDL1) 108521059(PARL) 108541374(RHBDL3)
CJC: 100387112(RHBDL3) 100396196(RHBDL2) 100396223(RHBDL1) 100412777(MAP6D1)
SBQ: 101037572(PARL) 101038537(RHBDL1) 101045295(RHBDL2) 101048766(RHBDL3)
MMU: 214951(Rhbdl1) 230726(Rhbdl2) 246104(Rhbdl3) 381038(Parl)
MCAL: 110283853(Rhbdl1) 110293729(Rhbdl2) 110305988(Rhbdl3) 110311429(Parl)
MPAH: 110323732(Rhbdl2) 110329542(Parl) 110331834(Rhbdl3) 110338425(Rhbdl1)
RNO: 117025(Rhbdl1) 287556(Rhbdl3) 287979(Parl) 298512(Rhbdl2)
MUN: 110540057(Rhbdl2) 110545107(Rhbdl3) 110548718(Rhbdl1) 110549386(Parl)
CGE: 100751882(Parl) 100770158(Rhbdl2) 100771192(Rhbdl1) 100772788(Rhbdl3)
NGI: 103732644(Parl) 103746081(Rhbdl3) 103747709(Rhbdl2) 103752390(Rhbdl1)
HGL: 101700571(Rhbdl1) 101707842(Rhbdl2) 101719514(Parl) 101721490(Rhbdl3)
CCAN: 109679607(Rhbdl2) 109683330(Rhbdl3) 109694101(Parl) 109694512(Rhbdl1) 109701958
OCU: 100342968(RHBDL2) 100351338(PARL) 100353868(RHBDL3)
TUP: 102469095(RHBDL1) 102479636(RHBDL2) 102499708(PARL) 102499910(RHBDL3)
CFA: 482466(RHBDL2) 488100(PARL) 490092(RHBDL1) 491155(RHBDL3)
VVP: 112909109(RHBDL1) 112914650(RHBDL2) 112918011(RHBDL3) 112926248(PARL)
AML: 100474967(RHBDL1) 100475380(PARL) 100478612(RHBDL2) 100484664(RHBDL3)
UMR: 103666358(RHBDL2) 103667429(RHBDL3) 103668457(RHBDL1) 103676189(PARL)
UAH: 113245396(RHBDL1) 113254455(PARL) 113268258(RHBDL2) 113268990(RHBDL3)
ORO: 101369430(RHBDL2) 101374105(RHBDL3) 101379039(RHBDL1) 101382637(PARL)
FCA: 101091042(PARL) 101093071(RHBDL1) 101094436(RHBDL2) 101094637(RHBDL3)
PTG: 102953926(RHBDL1) 102966303(RHBDL2) 102969628(RHBDL3) 102969917(PARL)
PPAD: 109251907(RHBDL3) 109255463(RHBDL2) 109259636(RHBDL1) 109275208(PARL)
AJU: 106967349(PARL) 106973271(RHBDL2) 106977336(RHBDL1) 106985245(RHBDL3)
BTA: 100336895(RHBDL1) 514191(PARL) 514943(RHBDL2) 535623(RHBDL3)
BOM: 102267300(RHBDL3) 102279965(RHBDL1) 102282409(RHBDL2) 102282701(PARL)
BIU: 109556912(RHBDL2) 109557532(PARL) 109573185(RHBDL3) 109578340(RHBDL1)
BBUB: 102395527(RHBDL3) 102396156(PARL) 102400102(RHBDL2) 102414294(RHBDL1)
CHX: 102170845(RHBDL2) 102173434(RHBDL1) 102186804(PARL) 102187708(RHBDL3)
OAS: 101102026(PARL) 101110639(RHBDL1) 101115635(RHBDL3) 101117975(RHBDL2)
SSC: 100514296(RHBDL2) 100522032(RHBDL3) 100739380(PARL) 102164926(RHBDL1)
CFR: 102508789(RHBDL1) 102513177(RHBDL3) 102515444(PARL) 102522404(RHBDL2)
CDK: 105085895(PARL) 105088219(RHBDL3) 105090970(RHBDL2) 105098438(RHBDL1)
BACU: 102997324(RHBDL1) 103010626(RHBDL3) 103012865(PARL) 103013581 103015879(RHBDL2)
LVE: 103080294(RHBDL1) 103080823(PARL) 103090747(RHBDL2) 103091370(RHBDL3)
OOR: 101286435(RHBDL3) 101289466(RHBDL2) 101290127(RHBDL1) 101290324(PARL)
DLE: 111173440(PARL) 111175615(RHBDL2) 111185115(RHBDL1) 111185874(RHBDL3)
PCAD: 102977712(RHBDL3) 102980656(RHBDL1) 102983242(RHBDL2) 102994917(PARL)
ECB: 100058851(PARL) 100066958(RHBDL1) 100068889(RHBDL2) 100071775(RHBDL3)
EPZ: 103542974(RHBDL1) 103551231(RHBDL2) 103551829(RHBDL3) 103554759(PARL)
EAI: 106830573(RHBDL2) 106834531(PARL) 106836175(RHBDL1) 106844618(RHBDL3)
MYB: 102241382(RHBDL3) 102246769(PARL) 102248737(RHBDL2) 102254499(RHBDL1)
MYD: 102757308(RHBDL2) 102765700(RHBDL1) 102774042(PARL) 102774862(RHBDL3)
MNA: 107533047(RHBDL3) 107541111(PARL) 107541655(RHBDL2) 107543217(RHBDL1)
HAI: 109371269(PARL) 109385165(RHBDL3) 109385880(RHBDL1) 109390954(RHBDL2)
DRO: 112298401(RHBDL1) 112299587(RHBDL2) 112307870(PARL) 112308820(RHBDL3)
PALE: 102885710(RHBDL3) 102894455(PARL) 102895339(RHBDL1) 102897150(RHBDL2)
RAY: 107506113(RHBDL1) 107507017(PARL) 107514637(RHBDL3) 107517056(RHBDL2)
MJV: 108386099(RHBDL1) 108394703(RHBDL3) 108400155(RHBDL2) 108406789(PARL)
LAV: 100653587(RHBDL1) 100657744(RHBDL2) 100660204(PARL) 100665813(RHBDL3)
MDO: 100016926(RHBDL1) 100018675(RHBDL3) 100027636(PARL) 100031939(RHBDL2)
SHR: 100921266(RHBDL3) 100926501(PARL) 100930684(RHBDL1) 100932354(RHBDL2)
PCW: 110192170(RHBDL3) 110206325(RHBDL2) 110221259(PARL) 110221824(RHBDL1)
OAA: 100078408(PARL) 100082184(RHBDL2) 100087354(RHBDL1) 100089671(RHBDL3)
GGA: 417411(RHBDL3) 424767(PARL) 429205(RHBDL1)
MGP: 100544045(RHBDL3) 100544454(PARL) 100546725(RHBDL1)
CJO: 107317817(PARL) 107320910(RHBDL1) 107322155(RHBDL3)
NMEL: 110398243(PARL) 110405760(RHBDL1) 110407272(RHBDL3)
APLA: 101792169(RHBDL3) 101803884(PARL) 106020203(RHBDL1)
ACYG: 106034754(RHBDL3) 106039200(PARL)
TGU: 100190158(PARL) 100221056(RHBDL3) 115497260(RHBDL1)
LSR: 110470236(RHBDL1) 110474332(RHBDL3) 110484842(PARL)
SCAN: 103815537(PARL) 103819788(RHBDL3)
GFR: 102042149(RHBDL3) 102042645(PARL)
FAB: 101812184(RHBDL1) 101814172(PARL) 101816853(RHBDL3)
PHI: 102100139(RHBDL3) 102100599(RHBDL1) 102108104(PARL)
PMAJ: 107208963(PARL) 107210962(RHBDL1) 107212561(RHBDL3)
CCAE: 111922522(PARL) 111922564(RHBDL1) 111937404(RHBDL3)
CCW: 104693060(PARL) 104694250(RHBDL3) 120410786(RHBDL1)
ETL: 114056844(RHBDL3) 114062344(PARL) 114071876(RHBDL1)
FPG: 101910681(PARL) 101916424(RHBDL3) 106112721(RHBDL1)
FCH: 102050957(RHBDL1) 102055499(RHBDL3) 102059074(PARL)
CLV: 102085794(RHBDL3) 102087133(PARL) 102094909(RHBDL1)
EGZ: 104123756(RHBDL3) 104135493(PARL)
NNI: 104014373(RHBDL3) 104023524(RHBDL1) 104023681(PARL)
ACUN: 113483473(PARL) 113485812(RHBDL1) 113486703(RHBDL3)
PADL: 103916732(RHBDL3) 103926305(PARL)
AAM: 106484745(PARL) 106493114(RHBDL3)
ASN: 102368004(RHBDL3) 102375886(RHBDL2) 102376993 102377147(RHBDL1)
AMJ: 102569235(PARL) 102572703(RHBDL1) 102572803(RHBDL3) 102573319(RHBDL2)
PSS: 102448376(RHBDL2) 102448490(PARL) 102454812(RHBDL1) 102462839(RHBDL3)
CMY: 102932324(RHBDL2) 102942181(PARL) 102943255(RHBDL1) 102945614(RHBDL3)
CPIC: 101932732(PARL) 101932755(RHBDL2) 101949096(RHBDL1) 101951639(RHBDL3)
ACS: 100552010(rhbdl3) 100553171(parl) 100556273(rhbdl2) 100556287 103281783(rhbdl1)
PVT: 110073840(RHBDL3) 110082751(RHBDL2) 110084041(PARL) 110089424(RHBDL1)
PBI: 103050233(RHBDL1) 103052191(PARL) 103053550 103063065(RHBDL2)
PMUR: 107283705(RHBDL2) 107287723(PARL) 107290385(RHBDL1) 107296932(RHBDL3)
TSR: 106537860(PARL) 106547827(RHBDL1) 106549767(RHBDL2) 106552939(RHBDL3)
PMUA: 114584616(RHBDL1) 114587434(RHBDL3) 114597623(PARL) 114601766(RHBDL2)
GJA: 107108690(RHBDL2) 107117310(RHBDL1) 107121725(RHBDL3) 107124094(PARL)
XLA: 108701217 108701693 108704657(rhbdl2.S) 108708122 444640(rhbdl1.S) 495156(rhbdl2.L)
XTR: 100036610(parl) 101732375(rhbdl3) 116407510(rhbdl1) 549275(rhbdl2)
NPR: 108790110(RHBDL2) 108799529(RHBDL1) 108804886(PARL)
DRE: 100887821(rhbdl1) 541485(parla) 550128(rhbdl3) 792002(rhbdl2) 792889(parl)
IPU: 108262806(rhbdl1) 108272931(rhbdl3) 108277433(parl) 108280367
PHYP: 113523653(rhbdl3) 113525278 113534065(rhbdl1) 113544557(parl)
AMEX: 103025472(parl) 103026852(rhbdl1) 103027172 103036677(rhbdl2) 103039963(rhbdl3)
EEE: 113578833(rhbdl3) 113578966(rhbdl2) 113586571(rhbdl1) 113588545(parl)
TRU: 101066388 101069435(rhbdl2) 101070725(rhbdl1) 101076161(parl) 101079532(rhbdl3)
LCO: 104919692(rhbdl1) 104924720(rhbdl2) 104929841(rhbdl3) 104933382 104936814
NCC: 104941896(rhbdl2) 104946346(rhbdl1) 104947982(rhbdl3) 104951470(parl)
MZE: 101467219(rhbdl1) 101469142 101471225 101484197(rhbdl3) 101485896(rhbdl2)
ONL: 100693793(rhbdl3) 100693843(rhbdl1) 100694830 100704802(parl) 100704808(rhbdl2)
OLA: 101155323(parl) 101157837(rhbdl3) 101162960(rhbdl1) 101173974 101175267(rhbdl2)
XMA: 102220748(rhbdl1) 102221859 102232512(rhbdl2) 102234504(rhbdl3) 102237666
XCO: 114136242(rhbdl1) 114141755(rhbdl2) 114144557(rhbdl3) 114146124 114161739
PRET: 103468056(rhbdl3) 103475301(parl) 103477786(rhbdl2) 103479407 103481079(rhbdl1)
CVG: 107083768 107084726(rhbdl2) 107085024(rhbdl1) 107086868(parl) 107103031(rhbdl3)
NFU: 107379334(rhbdl2) 107379887(parl) 107382321(rhbdl3) 107384009 107388048(rhbdl1)
KMR: 108229223 108237141(rhbdl1) 108240311(rhbdl2) 108245304(rhbdl3) 108245528(parla)
ALIM: 106515261(rhbdl3) 106517376(rhbdl1) 106523050(rhbdl2) 106535003 106536115
CSEM: 103378338(parl) 103381702(rhbdl1) 103383613(rhbdl3) 103387918(rhbdl2)
SDU: 111216992(parl) 111220066(rhbdl1) 111229103 111235767(rhbdl2) 111237699(rhbdl3)
SLAL: 111650954(rhbdl3) 111654467 111658732(rhbdl1) 111661634(rhbdl2) 111663398(parl)
HCQ: 109510735(parl) 109511186(rhbdl3) 109515419(rhbdl2) 109516844 109530205(rhbdl1)
BPEC: 110158822 110159797(rhbdl1) 110172660(rhbdl3) 110174331(rhbdl2) 110174766
MALB: 109954687(rhbdl2) 109958472(rhbdl3) 109963616(rhbdl1) 109973268(parl)
ELS: 105006886 105007687 105019293(rhbdl2) 105021283(rhbdl1) 105029033(rhbdl3)
SFM: 108919105(rhbdl2) 108923855(rhbdl1) 108926825 108940046(rhbdl3) 114909499
PKI: 111833595(rhbdl3) 111836666(parl) 111841902(rhbdl1) 111844501(rhbdl2)
LCM: 102345090(PARL) 102357284(RHBDL1) 102357617(RHBDL3) 102365369(RHBDL2)
CMK: 103186052(rhbdl1) 103186427(parl) 103191477
RTP: 109917991(parl) 109918338 109929763(rhbdl2)
DME: Dmel_CG1004(rho) Dmel_CG1214(ru) Dmel_CG1697(rho-4) Dmel_CG33166(stet) Dmel_CG8972(rho-7)
DSI: Dsimw501_GD13615(Dsim_GD13615) Dsimw501_GD13619(Dsim_GD13619) Dsimw501_GD17034(Dsim_GD17034) Dsimw501_GD25869(Dsim_GD25869) Dsimw501_GD26881(Dsim_GD26881)
TCA: 657740(stet) 661151 661276 663099(rho-4)
CEL: CELE_C48B4.2(rom-2) CELE_F26F4.3(rom-1) CELE_Y54E10A.14(rom-5)
CBR: CBG10042(Cbr-rom-2) CBG14977(Cbr-rom-5) CBG18183(Cbr-rom-1)
NVE: 5503215
EPA: 110246136
ADF: 107333131
AMIL: 114971339
PDAM: 113686261
SPIS: 111328489
DGT: 114529568
HMG: 100197728
AQU: 105315300
QSU: 112014492
SCE: YGR101W(PCP1)
ERC: Ecym_4420
KMX: KLMA_50443(PCP1)
NCS: NCAS_0E01050(NCAS0E01050)
NDI: NDAI_0G01180(NDAI0G01180)
TPF: TPHA_0D03000(TPHA0D03000)
TBL: TBLA_0E00580(TBLA0E00580)
TDL: TDEL_0F03280(TDEL0F03280)
KAF: KAFR_0K01640(KAFR0K01640)
CAL: CAALFM_C302030WA(CaO19.1643)
SLB: AWJ20_4032(PCP1)
NCR: NCU03080
NTE: NEUTE1DRAFT91388(NEUTE1DRAFT_91388)
MGR: MGG_04531
MAW: MAC_03768
MAJ: MAA_04245
CMT: CCM_05958
ANI: AN1372.2
ANG: ANI_1_82074(An08g00670)
ABE: ARB_08031
TVE: TRV_04346
CNB: CNBG0510
TASA: A1Q1_06597
ABP: AGABI1DRAFT70511(AGABI1DRAFT_70511)
ABV: AGABI2DRAFT193382(AGABI2DRAFT_193382)
MGL: MGL_1969
DFA: DFA_08225
SPAR: SPRG_20100
ECP: ECP_0679
ECOS: EC958_0774
ECY: ECSE_0727
EBR: ECB_00624
EBL: ECD_00624
EBE: B21_00614(ybl24)
EBD: ECBD_2995
ECC: c0741
ESE: ECSF_0594
ELC: i14_0710
ELD: i02_0710
ELF: LF82_073
ECOI: ECOPMV1_00666(aarA)
ECOJ: P423_03205
EFE: EFER_2447
SSN: SSON_0610
SBO: SBO_0519
PLU: plu3362
PAY: PAU_01287
PSI: S70_16165
PSX: DR96_2293(aarA)
PRG: RB151_012040(aarA)
PHEI: NCTC12003_02851(aarA)
PRJ: NCTC6933_01215(aarA)
MMK: MU9_1476
PAR: Psyc_1655
PALI: A3K91_2108
PSYA: AOT82_1163
ACC: BDGL_000268(aarA)
AGU: AS4_32700
MCT: MCR_1270
MCS: DR90_649
MCAT: MC25239_01233(gluP)
MCUN: NCTC10297_01824(aarA)
SBL: Sbal_3385
CJA: CJA_0273
HCH: HCH_03410
CHAE: CH06BL_16970(aarA)
RSO: RSp1525
RSE: F504_4997
RSY: RSUY_36480(gluP)
RME: Rmet_3861
BVE: AK36_2277
BAM: Bamb_1514
BGU: KS03_807
BGO: BM43_1280
BUK: MYA_1448
ODI: ODI_R2291
MFA: Mfla_1842
MEH: M301_1965
OTR: OTERR_06130(gluP)
DAR: Daro_2385
CJU: C8J_0940
CJI: CJSA_0946
CJM: CJM1_0976
CJS: CJS3_1052
CJEJ: N564_00969
CJEU: N565_01015
CJEN: N755_01008
CJEI: N135_01038
CJER: H730_05895
CJY: QZ67_01075(aarA)
CJQ: UC78_0959
CJR: CJE1083
CFZ: CSG_11070
CCQ: N149_0936
CCF: YSQ_04025
CCY: YSS_05410
CCOI: YSU_04060
CCOF: VC76_04850(aarA)
CCOO: ATE51_01622(aarA)
CURE: CUREO_0626
CHYO: CHH_0948
CSPF: CSF_1127
CCUN: CCUN_0947
CLX: CLAN_0854
CAVI: CAV_0536
CAMY: CSUIS_0905
CGEO: CGEO_0983
CBLA: CBLAS_0983
CCOR: CCORG_0863
ABU: Abu_0593
ABT: ABED_0548
ATP: ATR_0670
ACIB: ACBT_1707
ACRE: ACRYA_0594
APOC: APORC_0508
AELL: AELL_0748
AAQI: AAQM_1836
ASUI: ASUIS_0692
ACLO: ACLO_0728
ALK: ALEK_0838
AMYT: AMYT_0689
AMAR: AMRN_0728
ACAA: ACAN_0748
AMOL: AMOL_0653
APAI: APAC_0617
HBV: ABIV_0626
HEBR: AEBR_0766
PACO: AACT_0852
ARC: ABLL_0724
SUN: SUN_2072
GME: Gmet_2385
GLO: Glov_2353
GEO: Geob_3558
PPD: Ppro_2186
DDE: Dde_2421
DDS: Ddes_1385
DMA: DMR_19850
DGG: DGI_1923
DFL: DFE_1956
DAS: Daes_2673
DPI: BN4_11403
DBA: Dbac_2879
DRT: Dret_1329
DAL: Dalk_2456
ADE: Adeh_2794
MXA: MXAN_4630
SAT: SYN_01026
SFU: Sfum_0904
AVI: Avi_2805
BBT: BBta_5280
BARH: WN72_31350
RVA: Rvan_1570
MSC: BN69_0387
MMED: Mame_04699
DSH: Dshi_3383
PGD: Gal_00753
CID: P73_3836
BBAT: Bdt_2373
BBW: BDW_10380
BBAC: EP01_08355
BEX: A11Q_2448
BSU: BSU24870(glpG)
BSR: I33_2569
BSL: A7A1_3554
BSH: BSU6051_24870(glpG)
BSUT: BSUB_02664(glpG)
BSUL: BSUA_02664(glpG)
BSUS: Q433_13610
BSO: BSNT_08929(yqgP)
BSQ: B657_24870(glpG)
BSX: C663_2371
BSS: BSUW23_02400(ydcA) BSUW23_12330(glpG)
BST: GYO_0682(ydcA) GYO_2752
BLI: BL02214(ydcA) BL03719(gluP)
BLD: BLi00549(ydcA) BLi02664(yggP)
BLH: BaLi_c05710(ydcA) BaLi_c27450(gluP)
BAQ: BACAU_0434(ydcA)
BYA: BANAU_0425(ydcI1)
BAMP: B938_02240
BAML: BAM5036_0449(ydcA)
BAMA: RBAU_0469(ydcA)
BAMN: BASU_0455(ydcA)
BAMB: BAPNAU_0438(ydcA)
BAMT: AJ82_02725
BAMY: V529_04570(ydcA)
BMP: NG74_00477(gluP)
BAO: BAMF_0438(ydcA)
BAZ: BAMTA208_02230(ydcA)
BQL: LL3_00461
BXH: BAXH7_00463(ydcA)
BQY: MUS_0465(gluP)
BAMI: KSO_017225
BAMC: U471_04700
BAMF: U722_02500
BAR: GBAA_0249
BAT: BAS0235
BAI: BAA_0275
BANT: A16_02660
BANR: A16R_02670
BANS: BAPAT_0236
BANV: DJ46_4654
BCX: BCA_0285
BCF: bcf_01390
BTL: BALH_0234
BTW: BF38_1496
BMYC: DJ92_2843
BJS: MY9_2511
BACP: SB24_07305
BACB: OY17_05105
BACO: OXB_0477
BACY: QF06_10630
BACL: BS34A_27280(glpG)
BALM: BsLM_2445
BBEV: BBEV_1267(gluP) BBEV_2816
BFD: NCTC4823_01852(gluP) NCTC4823_03603(ydcA)
BMQ: BMQ_0223 BMQ_4503(glpG)
BMD: BMD_0217 BMD_4489(glpG)
BMH: BMWSH_0732(yqgP) BMWSH_5009(ydcA)
BKW: BkAM31D_01290(gluP_1) BkAM31D_05720(gluP_2)
GEA: GARCT_00258(gluP_1) GARCT_02427(gluP_2)
AFL: Aflv_0891
AXL: AXY_03410
LSP: Bsph_4306
VPN: A21D_02033(gluP_1) A21D_03231(gluP_2)
PSYO: PB01_17910
BLEN: NCTC4824_00737(ydcA) NCTC4824_01708(gluP)
SAU: SA1379
SAV: SAV1549
SAW: SAHV_1536
SAM: MW1501
SAS: SAS1487
SAR: SAR1626
SAC: SACOL1606
SAE: NWMN_1452
SAD: SAAV_1541
SUE: SAOV_1549
SUJ: SAA6159_01484(gluP)
SUK: SAA6008_01518(gluP)
SUZ: MS7_1566
SUG: SAPIG1614
SAUA: SAAG_01463
SAUS: SA40_1420
SAUU: SA957_1503
SAUG: SA268_1507
SAUF: X998_1574
SAB: SAB1421c
SAUB: C248_1592
SAUC: CA347_1545
SAUR: SABB_00470
SAUI: AZ30_07895
SAUD: CH52_11325
SAMS: NI36_08355
SER: SERP1114
SEP: SE1235
SEPP: SEB_01255
SEPS: DP17_193
SHA: SH1367
SHH: ShL2_01250(gluP)
SSP: SSP1207
SCA: SCA_1171
SDT: SPSE_1248
SDP: NCTC12225_01464(gluP)
SPAS: STP1_0126
SHU: SHYC_06835(gluP)
SCAP: AYP1020_0847(gluP)
SSCH: LH95_06040
SSCZ: RN70_06220
SAGQ: EP23_03580
SARL: SAP2_13000
SPIC: SAMEA4384060_1398(gluP)
SSH: NCTC13712_01546(gluP)
SSIM: SAMEA4384339_1440(gluP)
SSTE: SAMEA4384403_1222(gluP)
MCL: MCCL_1192
MCAK: MCCS_14770(gluP)
LMO: lmo1337
LMOE: BN418_1576
LMOB: BN419_1570
LMOD: LMON_1400
LMOW: AX10_00760
LMOM: IJ09_03325
LMP: MUO_06905
LMOX: AX24_04140
LMQ: LMM7_1422
LMS: LMLG_1920
LMOK: CQ02_06875
LIN: lin1374
LWE: lwe1352
LSG: lse_1253
LIV: LIV_1288
LGZ: NCTC10812_01277(gluP)
ESI: Exig_2811
EAN: Eab7_2621
PPY: PPE_01711
PPM: PPSC2_09000(ydcA)
PPO: PPM_1713(ydcA)
PPOL: X809_09255
PPOY: RE92_03300
PSAB: PSAB_09765
PRI: PRIO_2558
ASOC: CB4_01514(gluP)
COHN: KCTCHS21_35470(ydcA)
AAC: Aaci_2212
AAD: TC41_2338
SIV: SSIL_0414
JEO: JMA_08230
KUR: ASO14_302
KZO: NCTC404_01174(gluP)
LLK: LLKF_0163(ybhB)
LLT: CVCAS_0148(ybhB)
LLS: lilo_0134(ybhB)
LLJ: LG36_0148(ybhB)
LLC: LACR_0176
LLR: llh_1075
LLW: kw2_0163
LGR: LCGT_0084
LGV: LCGL_0084
SPYA: A20_0238(ybhB)
SPS: SPs0165
SPF: SpyM50171
SPYH: L897_01110
SPW: SPCG_2059
SJJ: SPJ_2114
SPX: SPG_2031
SNT: SPT_2103
SND: MYY_2012
SPNN: T308_10010
SPV: SPH_2282
SPP: SPP_2149
SNP: SPAP_2139
SAG: SAG0404
SAN: gbs0439
SAK: SAK_0477
SGC: A964_0410
SAGM: BSA_4840
SAGI: MSA_4760
SAGR: SAIL_4870
SAGP: V193_00925
SAGC: DN94_00925
SAGE: EN72_02385
SAGG: EN73_02315
SAGN: W903_0499
SMUA: SMUFR_0270
STN: STND_1773
STW: Y1U_C1721
STHE: T303_00110
SSI: SSU1829
SUP: YYK_08820
SSUY: YB51_9385
SSUT: TL13_1847(glpG)
SSUI: T15_2110
SGO: SGO_0161
SEZ: Sez_0215
SEQ: SZO_17520
SEQU: Q426_08195
SUB: SUB1693
SDS: SDEG_1982
SDA: GGS_1806
SDC: SDSE_2073
SGT: SGGB_2078
SMB: smi_0146
SOR: SOR_0131
STK: STP_1712
STB: SGPB_1887
SCF: Spaf_1956
SMN: SMA_2055
SIF: Sinf_1836
SIE: SCIM_1512
SIB: SIR_1682
SIU: SII_1673
SANG: SAIN_0182
SANC: SANR_0211
SANS: DK43_09205
SCG: SCI_1744
SCON: SCRE_1700
SCOS: SCR2_1700
SIK: K710_1991
SLU: KE3_1897
STRN: SNAG_0197(gluP)
STRG: SRT_17850
SVB: NCTC12167_01773(gluP)
LJO: LJ_1618
LJH: LJP_1358c
LAC: LBA1506
LAD: LA14_1500
LAF: SD55_1480
LDB: Ldb1479
LBU: LBUL_1374
LDL: LBU_1267
LGA: LGAS_1384
LHE: lhv_1567
LHL: LBHH_0606
LHV: lhe_1453
LHH: LBH_1309
LHD: HUO_04240
LAM: LA2_08440
LKE: WANG_0278
LAE: LBAT_0572
LPW: LpgJCM5343_13820(glpG)
LCA: LSEI_1661
LCS: LCBD_0335
LPAP: LBPC_1583
LCB: LCABL_18770(yqgP)
LRH: LGG_01705
LRG: LRHM_1641
LPL: lp_1571
LPJ: JDM1_1316
LPZ: Lp16_1192
LRE: Lreu_1208
LRF: LAR_1141
LRT: LRI_0762
LFE: LAF_1281
LFF: LBFF_1394
LSN: LSA_06440
LBH: Lbuc_1167
LHIL: G8J22_01585(gluP)
LBR: LVIS_0998
LSL: LSL_0550
LSI: HN6_00497
LSJ: LSJ_0595
LRM: LRC_12370
PPE: PEPE_0730
PPEN: T256_03870
PCE: PECL_1103
LSA: LCA_1331
OOE: OEOE_0919
LME: LEUM_0674
LMM: MI1_03060
LMK: LMES_0600
LCI: LCK_01146
LKI: LKI_08900
LGS: LEGAS_0752(glpP)
WCE: WS08_0997
WCT: WS74_1063
WSO: WSWS_01312(gluP)
EFA: EF2790
EFL: EF62_2942
EFS: EFS1_2253
EFQ: DR75_1481
ENE: ENT_19560
EFM: M7W_1166
EHR: EHR_10090
ECAS: ECBG_01850
EMU: EMQU_1729
EDU: LIU_09940
MPS: MPTP_0601
THL: TEH_19890
CRN: CAR_c13220(glpG)
CML: BN424_2049(gluP)
CARC: NY10_687
JDA: BW727_100604(gluP)
CAC: CA_C0954
CAE: SMB_G0971(gluP)
CAY: CEA_G0966
CPE: CPE1452
CPF: CPF_1705
CPR: CPR_1438
CTC: CTC_00530
CBO: CBO0398
CBY: CLM_0468
CBL: CLK_3588
CBK: CLL_A0777
CBB: CLD_0351
CBI: CLJ_B0456
CBN: CbC4_0744
CBT: CLH_0743
CBF: CLI_0473
CBM: CBF_0444
CBE: Cbei_4326
CBZ: Cbs_4326
CBEI: LF65_04849
CKL: CKL_2722
CKR: CKR_2416
CSR: Cspa_c40870(gluP1) Cspa_c46070(gluP2)
CPAS: Clopa_3971
CSB: CLSA_c39990(gluP)
CBV: U729_109
CSQ: CSCA_3699
CTYK: CTK_C06420
CCOH: SAMEA4530647_0421(gluP)
AOE: Clos_1948
CTH: Cthe_1048
HSC: HVS_13290(gluP)
CCE: Ccel_1860
CSD: Clst_0677
BFI: CIY_28860
RIX: RO1_32130
RIM: ROI_34840
COO: CCU_19090
CCT: CC1_12330
ROB: CK5_02110
BPRO: PMF13cell1_01123(gluP)
CSCI: HDCHBGLK_01021(gluP)
BPRL: CL2_01890
HSD: SD1D_0053
CPRO: CPRO_29880(gluP)
EHL: EHLA_3226
RTO: RTO_02300
STH: STH1868
DSY: DSY1625
DHD: Dhaf_2772
SGY: Sgly_1786
SAY: TPY_3057
BPRS: CK3_08240
APR: Apre_0056
ERH: ERH_1104
LPIL: LIP_1494
ABRA: BN85311620
APAL: BN85411490
SMIR: SMM_0701
SMIA: P344_04210
SPRN: S100390_v1c07060(gluP)
SPIT: STU14_v1c07060(gluP)
MBJ: KQ51_00751(gluP)
CGB: cg0049
CGU: WA5_0034
CGT: cgR_0049
CGM: cgp_0049
CGJ: AR0_00210
CDIP: ERS451417_00032(ybhB_1)
CJK: jk0034
CPL: Cp3995_0019(ybhB)
COD: Cp106_0019(ybhB)
CPSE: CPTA_00544
CPSU: CPTB_00988
CPSF: CPTC_00653
CRD: CRES_0037
CUN: Cul210932_0021(ybhB)
CUS: CulFRC11_0021(ybhB)
CUQ: Cul210931_0021(ybhB)
CUZ: Cul05146_0022(ybhB)
CUJ: CUL131002_0022(ybhB)
CVA: CVAR_0057
CTER: A606_00280
CPHO: CPHO_00125
CAQU: CAQU_00120
CAMG: CAMM_00710
CGK: CGERO_00130(gluP)
CPRE: Csp1_00720(gluP)
CSUR: N24_0026
SLD: T261_3693
TWH: TWT_009
TWS: TW009
BTP: D805_1619
RXY: Rxyl_1145
ELE: Elen_1449
GPA: GPA_30260
PRM: EW15_1208
CYT: cce_3733
RCA: Rcas_1097
CAU: Caur_0757
CAG: Cagg_2850
HAU: Haur_3513
ATM: ANT_30170
TRA: Trad_0561
RBA: RB2364
PIR: VN12_02440(glpG_1)
RUL: UC8_34980
TTF: THTE_2742
PLM: Plim_3276
PEH: Spb1_39970(glpG_2)
PLS: VT03_31550(gluP_2)
PLH: VT85_02370(gluP_2) VT85_19075(gluP_5) VT85_19585(gluP_6)
GPN: Pan110_33920(gluP)
MRI: Mal4_17710(gluP_1)
SDYN: Mal52_18250(glpG_2)
GES: VT84_37865(gluP_2)
FTJ: FTUN_4049
ULI: ETAA1_26340(gluP_1)
PBOR: BSF38_02455(gluP_3) BSF38_04440(gluP_5)
AGV: OJF2_06510(gluP_1) OJF2_52820(gluP_4)
LIE: LIF_A0775(glpG)
LIC: LIC_12696
LIS: LIL_12785
ACA: ACP_3298
ABAS: ACPOL_5253
SUS: Acid_0319
ABAC: LuPra_01410(gluP_1) LuPra_01866
FSC: FSU_2686
BTH: BT_1807
BTHO: Btheta7330_01204(aarA_2)
BXY: BXY_14590
BOA: Bovatus_01862(aarA_1)
PCAG: NCTC12856_00459(gluP)
SGN: SGRA_2511
MGOT: MgSA37_01611(gluP)
FAE: FAES_4812(glpG)
HSW: Hsw_1020
CHER: DK880_00823(gluP)
MARM: YQ22_04295
KOS: KORDIASMS9_01941(aarA)
CTAI: NCTC12078_01514(gluP_1)
TMW: THMA_0599
TMQ: THMB_0599
TMX: THMC_0599
TPT: Tpet_0334
TRQ: TRQ2_0352
TNA: CTN_0080
TNP: Tnap_0366
TLE: Tlet_0852
TME: Tmel_0543
TAF: THA_1375
THER: Y592_06255
FNO: Fnod_0980
PMO: Pmob_0209
MARN: LN42_06835
DTN: DTL3_0262
KOL: Kole_1586
PHO: PH1497(PH1497)
PYN: PNA2_0084
PYS: Py04_1384
TON: TON_1044
TGA: TGAM_1405
THE: GQS_10345
THA: TAM4_1542
THM: CL1_1648
TNU: BD01_1033
TEU: TEU_11055
STO: STK_01770
MSE: Msed_2170
MCN: Mcup_0119
AHO: Ahos_0968
TTN: TTX_0357(glpG)
TUZ: TUZN_0835
NDV: NDEV_0919
KCR: Kcr_0205
BARB: AOA66_0232
 » show all
Reference
1  [PMID:15684070]
  Authors
Urban S, Wolfe MS
  Title
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity.
  Journal
Proc Natl Acad Sci U S A 102:1883-8 (2005)
DOI:10.1073/pnas.0408306102
  Sequence
[bsu:BSU24870]
Reference
2  [PMID:15753289]
  Authors
Brossier F, Jewett TJ, Sibley LD, Urban S.
  Title
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma.
  Journal
Proc Natl Acad Sci U S A 102:4146-51 (2005)
DOI:10.1073/pnas.0407918102
  Sequence
Reference
3  [PMID:15096522]
  Authors
Herlan M, Bornhovd C, Hell K, Neupert W, Reichert AS.
  Title
Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor.
  Journal
J Cell Biol 165:167-73 (2004)
DOI:10.1083/jcb.200403022
Reference
4  [PMID:15047175]
  Authors
Pascall JC, Brown KD
  Title
Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2.
  Journal
Biochem Biophys Res Commun 317:244-52 (2004)
DOI:10.1016/j.bbrc.2004.03.039
  Sequence
[hsa:54933]
Reference
5  [PMID:14732705]
  Authors
Sik A, Passer BJ, Koonin EV, Pellegrini L
  Title
Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide.
  Journal
J Biol Chem 279:15323-9 (2004)
DOI:10.1074/jbc.M313756200
  Sequence
[hsa:55486]
Reference
6  [PMID:12820957]
  Authors
Urban S, Freeman M.
  Title
Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.
  Journal
Mol Cell 11:1425-34 (2003)
DOI:10.1016/S1097-2765(03)00181-3
Reference
7  [PMID:12707284]
  Authors
Herlan M, Vogel F, Bornhovd C, Neupert W, Reichert AS.
  Title
Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA.
  Journal
J Biol Chem 278:27781-8 (2003)
DOI:10.1074/jbc.M211311200
  Sequence
[sce:YGR101W]
Reference
8  [PMID:12774122]
  Authors
McQuibban GA, Saurya S, Freeman M.
  Title
Mitochondrial membrane remodelling regulated by a conserved rhomboid protease.
  Journal
Nature 423:537-41 (2003)
DOI:10.1038/nature01633
  Sequence
[sce:YGR101W]
Reference
9  [PMID:12620104]
  Authors
Koonin EV, Makarova KS, Rogozin IB, Davidovic L, Letellier MC, Pellegrini L.
  Title
The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers.
  Journal
Genome Biol 4:R19 (2003)
DOI:10.1186/gb-2003-4-3-r19
Reference
10 [PMID:12200155]
  Authors
Urban S, Freeman M.
  Title
Intramembrane proteolysis controls diverse signalling pathways throughout evolution.
  Journal
Curr Opin Genet Dev 12:512-8 (2002)
DOI:10.1016/S0959-437X(02)00334-9
Reference
11 [PMID:12225666]
  Authors
Urban S, Schlieper D, Freeman M.
  Title
Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids.
  Journal
Curr Biol 12:1507-12 (2002)
DOI:10.1016/S0960-9822(02)01092-8
Reference
12 [PMID:12169630]
  Authors
Urban S, Lee JR, Freeman M.
  Title
A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands.
  Journal
EMBO J 21:4277-86 (2002)
DOI:10.1093/emboj/cdf434
Reference
13 [PMID:11672525]
  Authors
Urban S, Lee JR, Freeman M
  Title
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases.
  Journal
Cell 107:173-82 (2001)
DOI:10.1016/S0092-8674(01)00525-6
  Sequence
Reference
14 [PMID:15616571]
  Authors
Lemberg MK, Menendez J, Misik A, Garcia M, Koth CM, Freeman M.
  Title
Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.
  Journal
EMBO J 24:464-72 (2005)
DOI:10.1038/sj.emboj.7600537
  Sequence
[bsu:BSU24870]
Reference
15 [PMID:17051161]
  Authors
Wang Y, Zhang Y, Ha Y.
  Title
Crystal structure of a rhomboid family intramembrane protease.
  Journal
Nature 444:179-80 (2006)
DOI:10.1038/nature05255
  Sequence
[eco:b3424]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.105
IUBMB Enzyme Nomenclature: 3.4.21.105
ExPASy - ENZYME nomenclature database: 3.4.21.105
BRENDA, the Enzyme Database: 3.4.21.105
CAS: 713145-02-9

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