KEGG   ENZYME: 3.4.21.106
Entry
EC 3.4.21.106               Enzyme                                 
Name
hepsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
Comment
This type-II membrane-associated serine peptidase has been implicated in cell growth and development [1,3]. The enzyme has been shown to activate blood coagulation factor VII by cleavage of the Arg152!Ile153 peptide bound in BHK cells, thus indicating a possible role in the initiation of blood coagulation [2]. There is no cleavage after aromatic or aliphatic residues [1]. The occupancy of the S2 site is an absolute requirement for catalysis and a basic residue at that site is preferred to an aliphatic residue. The nature of the residue at S3 also affects hydrolysis, with Gln being much more favourable than Ala [1]. Belongs in peptidase family S1A.
History
EC 3.4.21.106 created 2006
Orthology
K08665  hepsin
Genes
HSA3249(HPN)
PTR455944(HPN)
PPS100987098(HPN)
GGO101135897(HPN)
PON100173788(HPN)
NLE100591395(HPN)
MCC707242(HPN)
MCF102120705(HPN)
MTHB126941908
CSAB103234489(HPN)
CATY105578154(HPN)
PANU101024426(HPN)
TGE112612344(HPN)
RRO104667121(HPN)
RBB108512302(HPN)
TFN117092331(HPN)
PTEH113219585
CJC100401729(HPN)
SBQ101040717(HPN)
CSYR103271110(HPN)
MMUR105876945(HPN)
LCAT123624496(HPN)
OGA100944961(HPN)
MMU15451(Hpn)
MCAL110297696(Hpn)
MPAH110330287(Hpn)
RNO29135(Hpn)
MCOC116101186(Hpn)
MUN110551185(Hpn)
CGE100757163(Hpn)
MAUA101832050(Hpn)
PLEU114698928(Hpn)
MORG121449413(Hpn)
MFOT126486649
AAMP119820441(Hpn)
NGI103729906(Hpn)
HGL101708013(Hpn)
CPOC100719031(Hpn)
CCAN109694561(Hpn)
DORD105993093(Hpn)
DSP122097496(Hpn)
NCAR124966370
OCU100345382(HPN)
OPI101535144(HPN)
TUP102472167(HPN)
CFA484583(HPN)
CLUD112643575(HPN)
VVP112928515(HPN)
VLG121484104(HPN)
AML100473121(HPN)
UMR103682491(HPN)
UAH113244804(HPN)
UAR123791724(HPN)
ELK111161519
LLV125088420
MPUF101674851(HPN)
ORO101374485(HPN)
EJU114224384(HPN)
ZCA113935608(HPN)
MLX118022823(HPN)
NSU110590118(HPN)
FCA101099007(HPN)
PYU121011591(HPN)
PBG122495012(HPN)
LRUF124511761
PTG102961568(HPN)
PPAD109251456(HPN)
AJU106974756(HPN)
HHV120226193(HPN)
BTA508148(HPN)
BOM102265892(HPN)
BIU109572366(HPN)
BBUB102415384(HPN)
CHX102188889(HPN)
OAS101117692(HPN)
ODA120872538(HPN)
CCAD122421422(HPN)
SSC100624088(HPN)
CFR102522484(HPN)
CBAI105065097(HPN)
CDK105088028(HPN)
VPC102536793(HPN)
BACU103014212(HPN)
LVE103089245(HPN)
OOR101279617(HPN)
DLE111181162(HPN)
PCAD102995164
PSIU116744599(HPN)
ECB100058873(HPN)
EPZ103547718(HPN)
EAI106829219(HPN)
MYB102254751(HPN)
MYD102771439(HPN)
MMYO118674541(HPN)
MLF102435620(HPN)
MNA107543422(HPN)
PKL118720817(HPN)
HAI109372038(HPN)
DRO112320092(HPN)
SHON118982509(HPN)
AJM119037343(HPN)
PDIC114511573(HPN)
PHAS123823824(HPN)
MMF118638623(HPN)
RFQ117034958(HPN)
PALE102898712(HPN)
PGIG120592437(HPN)
PVP105306622(HPN)
RAY107504252(HPN)
MJV108398953(HPN)
TOD119250196(HPN)
SARA101546934(HPN)
LAV100673906(HPN)
TMU101353096
DNM101419719(HPN)
MDO100015125(HPN)
GAS123240062(HPN)
SHR100924033(HPN)
PCW110201622(HPN)
OAA107547747(HPN)
ASN102385148(HPN)
AMJ102570449(HPN)
PSS102443380(HPN)
CMY102934816(HPN)
CPIC101951444(HPN)
TST117869689(HPN)
CABI116829844(HPN)
MRV120390042(HPN)
ACS100553659(hpn)
PVT110070730(HPN)
SUND121915445(HPN)
PBI103059263(HPN)
PMUR107287563(HPN)
CTIG120300145(HPN)
TSR106556162
PGUT117669327(HPN)
VKO123019417(HPN)
PMUA114603542(HPN)
ZVI118087370(HPN)
GJA107119876(HPN)
STOW125434214(HPN)
XLA108697289(hpn.S) 108705714
XTR100145343(hpn)
NPR108798671(HPN)
RTEM120916218(HPN)
BBUF120993612(HPN)
BGAR122929102(HPN)
DRE569259(hpn)
SRX107726693 107728492
SANH107665644 107666884(hpn)
SGH107592179
CCAR109072368
CAUA113059255 113115742
PPRM120488365 120488377
MAMB125243809(hpn)
IPU108256296(hpn)
PHYP113532956(hpn)
SMEO124375558(hpn)
TFD113649815(hpn)
AMEX103024311
EEE113571958
TRU101061536 101065267 101065721 105419034 105419796 115250346 115250347 115250348 115250351 115250352 115250354
TNGGSTEN00035339G001
LCO104928115(hpn)
NCC104962735(hpn)
CGOB115020873(hpn)
ELY117266518(hpn)
EFO125893309(hpn)
PLEP121946050(hpn)
SLUC116035244(hpn)
ECRA117946121(hpn)
ESP116690948(hpn)
PFLV114557880(hpn)
GAT120810983(hpn)
PPUG119197556(hpn)
MSAM119897955(hpn)
CUD121514033(hpn)
ALAT119006513(hpn)
MZE101473962(hpn)
ONL100700000(hpn)
OAU116314979(hpn)
OLA101171277(hpn)
OML112143879(hpn)
XMA102234257(hpn)
XCO114141601(hpn)
XHE116717949(hpn)
PRET103478304(hpn)
PFOR103139639(hpn)
PLAI106936844(hpn)
PMEI106907984(hpn)
GAF122831525(hpn)
CVG107103338(hpn)
CTUL119786448(hpn)
GMU124866406(hpn)
NFU107378964(hpn)
KMR108232207(hpn)
ALIM106526042(hpn)
NWH119409584(hpn)
AOCE111572959(hpn)
MCEP125016055(hpn)
CSEM103388772(hpn)
POV109631942(hpn)
SSEN122775258(hpn)
HHIP117777537(hpn)
HSP118114279(hpn)
LCF108888185
SDU111227890(hpn)
SLAL111658126(hpn)
XGL120784437(hpn)
HCQ109529638(hpn)
BPEC110171625
MALB109958531(hpn)
BSPL114843287(hpn)
SASA106577761 106605629
STRU115177452 115182642
OTW112227142 112245872
OMY110519917 110538566
OGO123997990 124005695
ONE115102104 115140887
SALP111958996 111964607
SNH120030840 120048547
CCLU121543056 121556065
ELS105019132(hpn)
SFM108919201(hpn)
PKI111838295(hpn)
AANG118224888(hpn)
LOC102686706(hpn)
PSPA121298869 121304226
ARUT117433772 117972151
LCM102358874(HPN)
BFO118412369 118420750
SCLV120342018
AAG5572013
CQUCpipJ_CPIJ007867
NMEA116424042
NVI107980550
BANY112047005
PPOT106101227
TNL113504189
DCI103516171
CLEC112127464
PJA122264538
PPOI119092146
HROHELRODRAFT_170189
LGILOTGIDRAFT_84942
HRF124116241 124116242
OSN115221693
NVE5520281
ATEN116308916
SPIS111345236
MNGMNEG_2561
EHXEMIHUDRAFT_193990
 » show all
Reference
1  [PMID:9003440]
  Authors
Zhukov A, Hellman U, Ingelman-Sundberg M.
  Title
Purification and characterization of hepsin from rat liver microsomes.
  Journal
Biochim Biophys Acta 1337:85-95 (1997)
DOI:10.1016/S0167-4838(96)00152-5
Reference
2  [PMID:7814421]
  Authors
Kazama Y, Hamamoto T, Foster DC, Kisiel W.
  Title
Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation.
  Journal
J Biol Chem 270:66-72 (1995)
DOI:10.1074/jbc.270.1.66
Reference
3  [PMID:8346233]
  Authors
Torres-Rosado A, O'Shea KS, Tsuji A, Chou SH, Kurachi K.
  Title
Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth.
  Journal
Proc Natl Acad Sci U S A 90:7181-5 (1993)
DOI:10.1073/pnas.90.15.7181
  Sequence
[hsa:3249]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.106
IUBMB Enzyme Nomenclature: 3.4.21.106
ExPASy - ENZYME nomenclature database: 3.4.21.106
BRENDA, the Enzyme Database: 3.4.21.106
CAS: 112398-23-9

DBGET integrated database retrieval system