KEGG   ENZYME: 3.4.21.108
Entry
EC 3.4.21.108               Enzyme                                 

Name
HtrA2 peptidase;
high temperature requirement protein A2;
HtrA2;
Omi stress-regulated endoprotease;
serine proteinase OMI;
HtrA2 protease;
OMI/HtrA2 protease;
HtrA2/Omi;
Omi/HtrA2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues
Comment
This enzyme is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment [4]. It can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP) [3]. Belongs in peptidase family S1C.
History
EC 3.4.21.108 created 2006
Orthology
K08669  HtrA serine peptidase 2
Genes
HSA: 27429(HTRA2)
PTR: 459339(HTRA2)
PPS: 100985283(HTRA2)
GGO: 101153780(HTRA2)
PON: 100461940(HTRA2)
NLE: 100591213(HTRA2)
MCC: 709938(HTRA2)
MCF: 102126403(HTRA2)
CSAB: 103220019(HTRA2)
CATY: 105596870(HTRA2)
PANU: 100999628(HTRA2)
RRO: 104674825(HTRA2)
RBB: 108531686(HTRA2)
TFN: 117062068(HTRA2)
PTEH: 111523451(HTRA2)
CJC: 100385512(HTRA2)
SBQ: 101046884(HTRA2)
MMUR: 105884574(HTRA2)
MMU: 64704(Htra2)
MCAL: 110295867(Htra2)
MPAH: 110317283(Htra2)
RNO: 297376(Htra2)
MCOC: 116099123(Htra2)
CGE: 100760629(Htra2)
PLEU: 114694427(Htra2)
NGI: 103726986(Htra2)
HGL: 101725239(Htra2)
CCAN: 109692441(Htra2)
OCU: 100338967(HTRA2)
TUP: 102501824(HTRA2)
CFA: 475782(HTRA2)
VVP: 112916707(HTRA2)
VLG: 121490681(HTRA2)
AML: 100471770(HTRA2)
UMR: 103671421(HTRA2)
UAH: 113243611(HTRA2)
ORO: 101375505 101382419(HTRA2)
ELK: 111148182
MPUF: 101681959(HTRA2)
EJU: 114218893(HTRA2)
MLX: 118007942(HTRA2)
FCA: 768259(HTRA2)
PYU: 121019218(HTRA2)
PBG: 122497060(HTRA2)
PTG: 102968855(HTRA2)
PPAD: 109263345(HTRA2)
AJU: 106988577(HTRA2)
HHV: 120237033(HTRA2)
BTA: 523039(HTRA2)
BOM: 102273081
BIU: 109565903(HTRA2)
BBUB: 102389817(HTRA2)
CHX: 102181963(HTRA2)
OAS: 101120228(HTRA2)
ODA: 120851251(HTRA2)
CCAD: 122441473(HTRA2)
SSC: 100512831(HTRA2)
CFR: 102522927(HTRA2)
CBAI: 105078073(HTRA2)
CDK: 105105950(HTRA2)
BACU: 103003966(HTRA2)
LVE: 103086746(HTRA2)
OOR: 101276862(HTRA2)
DLE: 111169079(HTRA2)
PCAD: 102995172(HTRA2)
ECB: 100053688(HTRA2)
EPZ: 103557683(HTRA2)
EAI: 106823864(HTRA2)
MYB: 102242360(HTRA2)
MYD: 102772576(HTRA2)
MMYO: 118668824(HTRA2)
MNA: 107529250(HTRA2)
HAI: 109371208(HTRA2)
DRO: 112303094(HTRA2)
SHON: 119000105(HTRA2)
AJM: 119038363(HTRA2)
MMF: 118630461(HTRA2)
PALE: 102890616(HTRA2)
PGIG: 120594570(HTRA2)
RAY: 107502930(HTRA2)
MJV: 108402276(HTRA2)
TOD: 119259102(HTRA2)
LAV: 100659066(HTRA2)
TMU: 101344176
MDO: 100025882(HTRA2)
SHR: 100923981(HTRA2)
PCW: 110221089(HTRA2)
OAA: 114811155(HTRA2)
GGA: 395990(HTRA2)
PCOC: 116225954(HTRA2)
MGP: 100538527(HTRA2)
CJO: 107306835(HTRA2)
NMEL: 110390926(HTRA2)
ACYG: 106043211(HTRA2)
TGU: 115494796(HTRA2)
LSR: 110468691(HTRA2)
SCAN: 103823115(HTRA2)
PMOA: 120509181(HTRA2)
GFR: 102042326(HTRA2)
FAB: 101806812(HTRA2)
PHI: 102107154(HTRA2)
PMAJ: 107203523(HTRA2)
CCAE: 111929153(HTRA2)
CCW: 104690945(HTRA2)
ETL: 114068870(HTRA2)
FPG: 101914636(HTRA2)
FCH: 102050387(HTRA2)
CLV: 102085893(HTRA2)
EGZ: 104130002(HTRA2)
NNI: 104013943(HTRA2)
ACUN: 113490506(HTRA2)
PADL: 103922175(HTRA2)
AAM: 106487415(HTRA2)
AROW: 112978200(HTRA2)
NPD: 112954033(HTRA2)
DNE: 112995277(HTRA2)
ASN: 102378167(HTRA2)
AMJ: 102573820(HTRA2)
CPOO: 109324453(HTRA2)
GGN: 109291026
PSS: 102456624(HTRA2)
CMY: 102937290(HTRA2)
CPIC: 101936375(HTRA2)
TST: 117878397(HTRA2)
CABI: 116830477(HTRA2)
ACS: 100565079(htra2)
PVT: 110079828(HTRA2)
PBI: 103059726(HTRA2)
PMUR: 107292494(HTRA2)
TSR: 106538932(HTRA2)
PGUT: 117670678(HTRA2)
PMUA: 114603783(HTRA2)
ZVI: 118095517(HTRA2)
GJA: 107110467(HTRA2)
XLA: 108706463(htra2.S)
XTR: 100492982(htra2)
NPR: 108804097
DRE: 100137109(zgc:174193) 110438948 110438965 560917 797799 799791(si:dkey-33c12.10)
SGH: 107582530
CAUA: 113057043
IPU: 108263241
PHYP: 113539574(htra2)
AMEX: 103043568
EEE: 113585783(htra2)
TRU: 101079124(htra2)
LCO: 104921575
NCC: 104960364
CGOB: 115027100(htra2)
ELY: 117266700
PLEP: 121953346
SLUC: 116035658
ECRA: 117936052
PFLV: 114546640(htra2)
GAT: 120832623
MSAM: 119903298
CUD: 121526039
MZE: 101482753
ONL: 100693638
OAU: 116334688
OLA: 101174474
OML: 112157885
XMA: 102226566(htra2)
XCO: 114134420(htra2)
PRET: 103458895(htra2)
CVG: 107087576
CTUL: 119784285
NFU: 107392303
KMR: 108235278
ALIM: 106521377
AOCE: 111578923(htra2)
CSEM: 103376892
POV: 109628063
LCF: 108892481
SDU: 111225343
SLAL: 111651107(htra2)
XGL: 120795653
HCQ: 109522905(htra2)
BPEC: 110155255(htra2)
MALB: 109955094
SASA: 106589831
OTW: 112224672
OMY: 110499413
SALP: 111968136
SNH: 120029524
ELS: 105015851
SFM: 108918851
PKI: 111845796
LOC: 102688355(htra2)
LCM: 102356234(HTRA2)
BFO: 118413391
BBEL: 109471472
SCLV: 120344804
APLC: 110973949
SKO: 102807217
DME: Dmel_CG8464(HtrA2)
DER: 6552632
DSE: 6606394
DSI: Dsimw501_GD20417(Dsim_GD20417)
DAN: 6500264
DSR: 110176513
DPE: 6588623
DMN: 108157255
DWI: 6647029
DGR: 6568330
DAZ: 108620802
DNV: 108660102
DHE: 111601551
DVI: 6630732
CCAT: 101457197
MDE: 101893592
LCQ: 111675035
ACOZ: 120959623
AARA: 120905933
AAG: 5567933
AME: 551969
ACER: 107997943
BIM: 100747622
BBIF: 117208046
BTER: 100651265
CCAL: 108623857
OBB: 114872063
MGEN: 117219609
NMEA: 116432289
CGIG: 122405263
SOC: 105199767
MPHA: 105830742
AEC: 105152625
ACEP: 105624355
PBAR: 105432441
VEM: 105564315
HST: 105188006
DQU: 106750279
CFO: 105256231
FEX: 115243091
LHU: 105672452
PGC: 109861450
OBO: 105274742
PCF: 106791733
NVI: 100122950
CSOL: 105368312
MDL: 103578876
CCIN: 107272031
DPA: 109538837
BMOR: 100533207(htra2)
BMAN: 114248093
MSEX: 115453358
BANY: 112051830
PMAC: 106713982
PPOT: 106110637
PXU: 106116412
PRAP: 110994139
ZCE: 119837952
HAW: 110379176
PXY: 105386447
BTAB: 109042751
DCI: 103513681
CLEC: 106670287
HHAL: 106679589
NLU: 111049046
ZNE: 110835296
CSEC: 111861347
FCD: 110858213
PVM: 113804151
HAME: 121859542
HAZT: 108668712
EAF: 111717466
DSV: 119437453
RSAN: 119392517
RMP: 119160800
DPTE: 113798514
CSCU: 111623622
PTEP: 107446348
SDM: 118186308
PCAN: 112565039
GAE: 121384327
CRG: 105347711
OBI: 106876978
LAK: 106151169
EGL: EGR_02598
NVE: 116617828
EPA: 110232501
ADF: 107348404
AMIL: 114963716
PDAM: 113671173
SPIS: 111326210
DGT: 114516112
HMG: 101239153
ATH: AT5G27660(DEG14)
CRB: 17883659
BRP: 103874520
BOE: 106306356
THJ: 104802800
CIT: 102608405
PVY: 116111841
GRA: 105792510
GHI: 107894209
GAB: 108468039
DZI: 111293631
GSJ: 114398353
VRA: 106775158
VAR: 108342259
CAM: 101500419
LJA: Lj1g3v4921060.1(Lj1g3v4921060.1) Lj1g3v4921060.2(Lj1g3v4921060.2) Lj1g3v4921060.3(Lj1g3v4921060.3)
ADU: 107492133
AIP: 107645908
LANG: 109329681
PPER: 18772880
PMUM: 103344586
PAVI: 110759195
PXB: 103965318
CSV: 101212324
CMO: 103494739
BHJ: 120080204
MCHA: 111018849
CMAX: 111465556
CMOS: 111444435
CPEP: 111798791
RCU: 8287072
JCU: 105647513
HBR: 110659756
MESC: 110620825
POP: 7473270
PEU: 105125071
PALZ: 118060835
JRE: 109012743
VVI: 100264796
VRI: 117930880
CANN: 107863029
NSY: 104247943
NTO: 104112327
NAU: 109242764
INI: 109181984
ITR: 116006573
SIND: 105172372
OEU: 111386814
HAN: 110890458
LSV: 111884540
CCAV: 112505655
DCR: 108224612
BVG: 104890298
SOE: 110794681
CQI: 110736872
NNU: 104609043
MING: 122082010
OSA: 4350193
DOSA: Os11t0246600-00(Os11g0246600)
OBR: 102706235
BDI: 100822885
ATS: 109732288
SBI: 8057143
ZMA: 100277723(cl62390_1)
SITA: 101768487
PHAI: 112872446
PDA: 103715494
EGU: 105051535
DCT: 110101476
PEQ: 110033765
AOF: 109827286
ATR: 18448569
PPP: 112283886
APRO: F751_2338
SPAR: SPRG_10340
IDO: I598_0941(htrA_1)
 » show all
Reference
1  [PMID:12835328]
  Authors
Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES.
  Title
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
  Journal
J Biol Chem 278:31469-72 (2003)
DOI:10.1074/jbc.C300240200
Reference
2  [PMID:10873535]
  Authors
Savopoulos JW, Carter PS, Turconi S, Pettman GR, Karran EH, Gray CW, Ward RV, Jenkins O, Creasy CL.
  Title
Expression, purification, and functional analysis of the human serine protease HtrA2.
  Journal
Protein Expr Purif 19:227-34 (2000)
DOI:10.1006/prep.2000.1240
  Sequence
[hsa:27429]
Reference
3  [PMID:14512424]
  Authors
Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J.
  Title
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
  Journal
J Biol Chem 278:49417-27 (2003)
DOI:10.1074/jbc.M308659200
  Sequence
[hsa:27429]
Reference
4  [PMID:10971580]
  Authors
Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL
  Title
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.
  Journal
Eur J Biochem 267:5699-710 (2000)
DOI:10.1046/j.1432-1327.2000.01589.x
  Sequence
[hsa:27429] [mmu:64704]
Reference
5  [PMID:11967569]
  Authors
Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y.
  Title
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
  Journal
Nat Struct Biol 9:436-41 (2002)
DOI:10.1038/nsb795
  Sequence
[hsa:27429]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.108
IUBMB Enzyme Nomenclature: 3.4.21.108
ExPASy - ENZYME nomenclature database: 3.4.21.108
BRENDA, the Enzyme Database: 3.4.21.108

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