high temperature requirement protein A2;
Omi stress-regulated endoprotease;
serine proteinase OMI;
Acting on peptide bonds (peptidases);
Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues
This enzyme is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment . It can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP) . Belongs in peptidase family S1C.