KEGG ENZYME: 3.4.21.112

ENZYME: 3.4.21.112

Entry

EC 3.4.21.112               Enzyme

Name

site-1 protease;
mammalian subtilisin/kexin isozyme 1;
membrane-bound transcription factor site-1 protease;
proprotein convertase SKI-1;
proprotein convertase SKI-1/S1PPS1;
S1P endopeptidase;
S1P protease;
site-1 peptidase;
site-1 protease;
SKI-1;
SREBP proteinase;
SREBP S1 protease;
SREBP-1 proteinase;
SREBP-2 proteinase;
sterol regulatory element-binding protein proteinase;
sterol regulatory element-binding protein site 1 protease;
sterol-regulated luminal protease;
subtilase SKI-1;
subtilase SKI-1/S1P;
subtilisin/kexin-isozyme 1

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3

Comment

Cleaves sterol regulatory element-binding proteins (SREBPs) and thereby initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholesterol and unsaturated fatty acids into the bloodstream [1]. The enzyme also processes pro-brain-derived neurotrophic factor and undergoes autocatalytic activation in the endoplasmic reticulum through sequential cleavages [5]. The enzyme can also process the unfolded protein response stress factor ATF6 at an Arg-His-Lys-Lys! site [4,8], and the envelope glycoprotein of the highly infectious Lassa virus [5,8] and Crimean Congo hemorrhagic fever virus at Arg-Arg-Lys-Lys! [7,8]. Belongs in peptidase family S8A.

History

EC 3.4.21.112 created 2006

Orthology

K08653

membrane-bound transcription factor site-1 protease

Genes

HSA:	8720(MBTPS1)

PTR:	468050(MBTPS1)

PPS:	100979845(MBTPS1)

GGO:	101137346(MBTPS1)

PON:	100173978(MBTPS1)

PPYG:

129015051(MBTPS1)

NLE:	100590889(MBTPS1)

HMH:	116470760(MBTPS1)

SSYN:

129493488(MBTPS1)

MCC:	714706(MBTPS1)

MCF:	101865233(MBTPS1)

MTHB:

126945100

MNI:	105496763(MBTPS1)

CSAB:

103233385(MBTPS1)

CATY:

105597026(MBTPS1)

PANU:

101009647(MBTPS1)

TGE:	112613912(MBTPS1)

MLEU:

105532952(MBTPS1)

RRO:	104656040(MBTPS1)

RBB:	108521220(MBTPS1)

TFN:	117088126(MBTPS1)

PTEH:

111552520(MBTPS1)

CANG:

105511955(MBTPS1)

CJC:	100402317(MBTPS1)

SBQ:	101033437(MBTPS1)

CIMI:

108314636(MBTPS1)

ANAN:

105726616(MBTPS1)

CSYR:

103259977(MBTPS1)

MMUR:

105856630(MBTPS1)

LCAT:

123625023(MBTPS1)

ERUF:

138402176(MBTPS1)

PCOQ:

105813461(MBTPS1)

OGA:	100958393(MBTPS1)

MMU:	56453(Mbtps1)

MCAL:

110299776(Mbtps1)

MPAH:

110337284(Mbtps1)

RNO:	89842(Mbtps1)

MCOC:

116070271(Mbtps1)

ANU:	117722966(Mbtps1)

ASYL:

127671445(Mbtps1)

MUN:	110545139(Mbtps1)

CGE:	100689417(Mbtps1)

MAUA:

101834549(Mbtps1)

PROB:

127234618(Mbtps1)

PLEU:

114697468(Mbtps1)

PMAV:

102904166(Mbtps1)

MORG:

121447004(Mbtps1)

MFOT:

126502089 126515482

AAMP:

119801776(Mbtps1)

CNL:	130863291(Mbtps1)

NGI:	103729839(Mbtps1)

HGL:	101713902(Mbtps1)

CPOC:

100727902(Mbtps1)

CCAN:

109689505(Mbtps1)

DORD:

105983122(Mbtps1)

DSP:	122101093(Mbtps1)

DMER:

138822870 138823538

PLOP:

125358128(Mbtps1)

NCAR:

124966851

SVUL:

306647514(MBTPS1)

MMMA:

107150856(Mbtps1)

ITI:	101975909(Mbtps1)

SCIL:

308637925(MBTPS1)

MAVE:

308269011(MBTPS1)

OCU:

100344035

OPI:	101527892(MBTPS1)

OCZ:	121157874(MBTPS1)

TUP:	102475098(MBTPS1)

GVR:	103584301(MBTPS1)

CFA:	489684(MBTPS1)

CLUD:

112646741(MBTPS1)

VVP:	112924587(MBTPS1)

VLG:	121499788(MBTPS1)

NPO:	129497060(MBTPS1)

AML:	100475586(MBTPS1)

UMR:	103662102(MBTPS1)

UAH:	113252549(MBTPS1)

UAR:	123791361(MBTPS1)

ELK:

111153024

LLV:

125088808

MPUF:

101691039(MBTPS1)

MNP:	132005783(MBTPS1)

MLK:	131817365(MBTPS1)

NVS:	122911184(MBTPS1)

MMAQ:

308357858(MBTPS1)

ORO:	101375212(MBTPS1)

EJU:	114201363(MBTPS1)

ZCA:	113935723(MBTPS1)

MLX:	118023513(MBTPS1)

MANO:

123855214(MBTPS1)

NSU:	110594202(MBTPS1)

LWW:

102733209

FCA:	101081852(MBTPS1)

PYU:	121009861(MBTPS1)

PCOO:

112857556(MBTPS1)

PBG:	122494532(MBTPS1)

PVIV:

125153684(MBTPS1)

LRUF:

124511532

LGF:	123578349(MBTPS1)

AJU:

106985623

PTG:	102956847(MBTPS1)

PPAD:

109245612(MBTPS1)

PUC:

125916322

PLEZ:

122207878(MBTPS1)

HHV:	120227554(MBTPS1)

CCRU:

144223361(MBTPS1)

BTA:	511682(MBTPS1)

BOM:	102286126(MBTPS1)

BIU:	109572546(MBTPS1)

BJV:	133230023(MBTPS1)

BBUB:

102411648(MBTPS1)

BKE:	129632529(MBTPS1)

BBIS:

104996529(MBTPS1)

CHX:	102183994(MBTPS1)

OAS:	101101912(MBTPS1)

OCAN:

138419693(MBTPS1)

BTAX:

128062939(MBTPS1)

CSUM:

138095905(MBTPS1)

ODA:	120873199(MBTPS1)

CCAD:

122420771(MBTPS1)

MREE:

136160886(MBTPS1)

OVR:	110139041(MBTPS1)

MBEZ:

129547214(MBTPS1)

SSC:	100516674(MBTPS1)

CFR:	102516706(MBTPS1)

CBAI:

105079018(MBTPS1)

CDK:	105089450(MBTPS1)

VPC:	102542877(MBTPS1)

BACU:

103010202(MBTPS1)

BMUS:

118885035(MBTPS1)

LVE:	103091271(MBTPS1)

OOR:	101282350(MBTPS1)

LALB:

132509275(MBTPS1)

GMF:	115856746(MBTPS1)

DDP:	132416571(MBTPS1)

SCOO:

307179428(MBTPS1)

PCRS:

137215165(MBTPS1)

DLE:	111179450(MBTPS1)

PCAD:

102993106 114483867(MBTPS1)

PSIU:

116743954(MBTPS1)

PPHC:

136140581(MBTPS1)

NASI:

112393389(MBTPS1)

HAMP:

307066528(MBTPS1)

ECB:	100055849(MBTPS1)

EPZ:	103557970(MBTPS1)

EAI:	106831751(MBTPS1)

MYB:	102256869(MBTPS1)

MYD:	102773346(MBTPS1)

MMYO:

118674862(MBTPS1)

MLF:	102442331(MBTPS1)

MDT:	132217146(MBTPS1)

MYUM:

138997158(MBTPS1)

PKL:	118720705(MBTPS1)

EFUS:

103284416(MBTPS1)

POTS:

308235054(MBTPS1)

MNA:	107524966(MBTPS1)

DRO:	112300719(MBTPS1)

SHON:

118983023(MBTPS1)

AJM:	119047087(MBTPS1)

PDIC:

114515485(MBTPS1)

PHAS:

123805930(MBTPS1)

MMF:	118638458(MBTPS1)

PPAM:

129075151(MBTPS1)

HAI:	109378384(MBTPS1)

RFQ:	117034715(MBTPS1)

RHII:

308490453(MBTPS1)

PALE:

102897410(MBTPS1)

PGIG:

120622951(MBTPS1)

PVP:	105309280(MBTPS1)

RAY:	107521339(MBTPS1)

MJV:	108386509(MBTPS1)

TOD:	119249136(MBTPS1)

SARA:

101552768(MBTPS1)

SFUM:

130043512(MBTPS1)

SETR:

126027713(MBTPS1)

LAV:	100657282(MBTPS1)

TMU:

101348770

ETF:	101641729(MBTPS1)

DNM:	101433824(MBTPS1)

MDO:	100617183(MBTPS1)

GAS:	123236783(MBTPS1)

SHR:	100918690(MBTPS1)

AFZ:

127547853

PCW:	110210366(MBTPS1)

TVP:	118843007(MBTPS1)

PBRV:

138159371(MBTPS1)

MLAO:

141499018(MBTPS1)

OAA:	100092098(MBTPS1)

TACU:

119950029(MBTPS1)

GGA:	415704(MBTPS1)

PCOC:

116243594(MBTPS1)

MGP:	100541007(MBTPS1)

CJO:	107319051(MBTPS1)

TPAI:

128081721(MBTPS1)

LMUT:

125699213(MBTPS1)

NMEL:

110404327(MBTPS1)

APLA:

101798578(MBTPS1)

AACU:

137861908(MBTPS1)

OJA:	118172752(MBTPS1)

BCLA:

308448408(MBTPS1)

ACYG:

106043118(MBTPS1)

ABRC:

308176334(MBTPS1)

CATA:

118246377(MBTPS1)

AFUL:

116493912(MBTPS1)

TGU:	100232413(MBTPS1)

LSR:	110473012(MBTPS1)

VMC:	128812948(MBTPS1)

VCHA:

128793686(MBTPS1)

AIB:	137481221(MBTPS1)

SCAN:

103816646(MBTPS1)

PMOA:

120507953(MBTPS1)

OTC:	121333755(MBTPS1)

PRUF:

121348984(MBTPS1)

ATRC:

139596303(MBTPS1)

MATE:

118691157(MBTPS1)

MAEN:

136561430(MBTPS1)

GFR:	102042134(MBTPS1)

FAB:	101810063(MBTPS1)

OMA:	130258048(MBTPS1)

PHI:	102103379(MBTPS1)

PMAJ:

107209834(MBTPS1)

CCAE:

111934551(MBTPS1)

CCW:	104687491(MBTPS1)

CBRC:

103620175(MBTPS1)

ACOE:

138117167(MBTPS1)

ETL:	114067233(MBTPS1)

ZAB:	102060456(MBTPS1)

ZLE:	135452566(MBTPS1)

ACHL:

103797658(MBTPS1)

SVG:	106855849(MBTPS1)

MMEA:

130572710(MBTPS1)

HRT:	120758026(MBTPS1)

SATI:

136366612(MBTPS1)

CFAI:

136295752(MBTPS1)

CCIC:

134048467(MBTPS1)

NNT:	104406274(MBTPS1)

SHAB:

115619656(MBTPS1)

POCC:

134158848(MBTPS1)

FPG:	101922174(MBTPS1)

FCH:	102053830(MBTPS1)

FRS:	119158024(MBTPS1)

CCRI:

104157272(MBTPS1)

ACUN:

113484305(MBTPS1)

ANOC:

141963574(MBTPS1)

SURA:

141948550(MBTPS1)

TALA:

104355899(MBTPS1)

ACHC:

115345397(MBTPS1)

HALD:

104310832(MBTPS1)

HLE:	104842312(MBTPS1)

AGEN:

126040283

HHAR:

128146641(MBTPS1)

BBUT:

142036765(MBTPS1)

GCL:

127020932

CSTI:

104549532(MBTPS1)

LDI:	104344330(MBTPS1)

MNB:	103771286(MBTPS1)

DPUB:

104299006(MBTPS1)

PPUS:

135184562(MBTPS1)

IIN:	128973218(MBTPS1)

AVIT:

104271458(MBTPS1)

BRHI:

104488155(MBTPS1)

EGZ:	104130222(MBTPS1)

NNI:	104016367(MBTPS1)

PCRI:

104024730(MBTPS1)

PCAO:

104039812

PARX:

142061106(MBTPS1)

PADL:

103914198(MBTPS1)

AFOR:

103896834(MBTPS1)

FGA:	104073097(MBTPS1)

CBOR:

142087161(MBTPS1)

GSTE:

104251136(MBTPS1)

CBOY:

140657029(MBTPS1)

MAME:

142413878(MBTPS1)

CLV:	102088320(MBTPS1)

CNIC:

135991939(MBTPS1)

NMAY:

308045093(MBTPS1)

MUI:

104534043

PGUU:

104463282(MBTPS1)

PLET:

104618633(MBTPS1)

EHS:	104503567(MBTPS1)

CMAC:

104477676(MBTPS1)

CUCA:

104055931(MBTPS1)

PCUR:

138726687(MBTPS1)

TEO:	104378119(MBTPS1)

BREG:

104641688(MBTPS1)

GAME:

129212178(MBTPS1)

OHA:	104334773(MBTPS1)

ACAR:

104521656(MBTPS1)

CEUR:

306724419(MBTPS1)

CPEA:

104394793(MBTPS1)

CVF:	104290422(MBTPS1)

RTD:	128908274(MBTPS1)

CRID:

134515364(MBTPS1)

LMIC:

141741949(MBTPS1)

NARQ:

141471601(MBTPS1)

AAM:	106483180(MBTPS1)

AROW:

112976690(MBTPS1)

NPD:	112950548(MBTPS1)

TGT:	104564340(MBTPS1)

DNE:	112984306(MBTPS1)

SCAM:

104146294(MBTPS1)

ASN:	102387504(MBTPS1)

AMJ:	102575073(MBTPS1)

CPOO:

109310483(MBTPS1)

GGN:	109289636(MBTPS1)

PSS:	102450666(MBTPS1)

CIZ:	142020489(MBTPS1)

CMY:	102940720(MBTPS1)

CCAY:

125620568(MBTPS1)

LKP:	140896183(MBTPS1)

NDS:	141996498(MBTPS1)

DCC:	119841264(MBTPS1)

CPIC:

101944235(MBTPS1)

TST:	117886536(MBTPS1)

EOB:	135888645(MBTPS1)

CABI:

116827893(MBTPS1)

MRV:	120384545(MBTPS1)

EMQ:	137155521(MBTPS1)

ACS:	100556053(mbtps1)

ASAO:

132783138(MBTPS1)

PVT:	110085711(MBTPS1)

SUND:

121914613(MBTPS1)

PBI:

103049734

PMUR:

107293778(MBTPS1)

CTIG:

120312701(MBTPS1)

TSR:	106552500(MBTPS1)

PGUT:

117670395(MBTPS1)

PCAE:

139323407(MBTPS1)

APRI:

131184045(MBTPS1)

PTEX:

113445359(MBTPS1)

NSS:	113414959(MBTPS1)

VKO:	123025384(MBTPS1)

PMUA:

114601908(MBTPS1)

PRAF:

128419127(MBTPS1)

ZVI:	118086542(MBTPS1)

HCG:	128334373(MBTPS1)

GJA:	107106027(MBTPS1)

STOW:

125443589(MBTPS1)

EMC:	129343954(MBTPS1)

XLA:	447205(mbtps1.L)

XTR:	780252(mbtps1)

NPR:	108796565(MBTPS1)

RTEM:

120917646(MBTPS1)

ACAT:

141112530(MBTPS1)

PADS:

140338610(MBTPS1)

BBUF:

120980428(MBTPS1)

BGAR:

122920423(MBTPS1)

DTC:	141089714(MBTPS1)

HSQ:	130276698(MBTPS1)

PCOB:

134969655(MBTPS1)

PWL:	138266972(MBTPS1)

MUO:	115470543(MBTPS1)

GSH:	117359367(MBTPS1)

DRE:	326710(mbtps1)

DAES:

130245443(mbtps1)

SRX:	107726427 107733569(mbtps1)

SANH:

107672278 107694940

SGH:	107583850 107596929

CCAR:

109068651 109108692

CAUA:

113070216 113118429

CGIB:

127934276 127977671

PTET:

122363099(mbtps1)

LROH:

127180924(mbtps1)

GRF:	141345470(mbtps1)

OMC:	131524777(mbtps1)

PPRM:

120487676

RKG:	130088164(mbtps1)

SCEP:

307160688(mbtps1)

MAMB:

125254133(mbtps1)

CIDE:

127499954

CERY:

137023385(mbtps1)

MASI:

127417054 127455952

TROS:

130563122(mbtps1)

TDW:	130435351(mbtps1)

MANU:

129418755(mbtps1)

PDAB:

135773544(mbtps1)

IPU:

108264661

IFU:	128606764(mbtps1)

PHYP:

113534287(mbtps1)

SMEO:

124395792(mbtps1)

TFD:	113652572(mbtps1)

TVC:	132851196(mbtps1)

CGAR:

128527884(mbtps1)

NGRA:

132888032(mbtps1)

TRN:	134322779(mbtps1)

AMEX:

103032608(mbtps1)

CMAO:

118817811(mbtps1)

EEE:	113573595(mbtps1)

CHAR:

105904521(mbtps1)

SPIL:

134093909(mbtps1)

ASAD:

121723232(mbtps1)

TRU:	101067515(mbtps1)

TFS:	130536390(mbtps1)

TNG:	GSTEN00008265G001

NCC:	104942697(mbtps1)

TBEN:

117491635(mbtps1)

CGOB:

115009869(mbtps1)

PGEO:

117448079(mbtps1)

GACU:

117539663(mbtps1)

EMAC:

134859390(mbtps1)

ELY:	117262355(mbtps1)

EFO:	125887636(mbtps1)

PLEP:

121950344(mbtps1)

SLUC:

116057500(mbtps1)

SVIT:

144522583(mbtps1)

ECRA:

117948885(mbtps1)

ESP:	116694408(mbtps1)

PFLV:

114560398(mbtps1)

PFLT:

120563937(mbtps1)

GAT:	120809525(mbtps1) 120812201

PPUG:

119196315(mbtps1)

AFB:	129108006(mbtps1)

CLUM:

117732413(mbtps1)

PSWI:

130194858(mbtps1)

CANA:

137804452(mbtps1)

TBU:	306741526(mbtps1)

CVE:	137888549(mbtps1)

AMIR:

142938883(mbtps1)

MSAM:

119893369(mbtps1)

SCHU:

122874309(mbtps1)

EARM:

139286487(mbtps1)

CUD:	121515303(mbtps1)

SPUL:

138612535(mbtps1)

LMIX:

132973073(mbtps1)

HTC:	141796869(mbtps1)

ALAT:

119024812(mbtps1)

ASTR:

137594430(mbtps1)

PKLU:

139201758(mbtps1)

LCO:	104928249(mbtps1)

AMMM:

307250307(mbtps1)

MZE:	101483615(mbtps1)

ONL:	100692051(mbtps1)

OAU:	116315809(mbtps1)

OLA:	101164978(mbtps1)

OML:	112152162(mbtps1)

CSAI:

133444489(mbtps1)

XMA:	102226028(mbtps1)

XCO:	114150984(mbtps1)

XHE:	116734660(mbtps1)

PRET:

103466358(mbtps1)

PFOR:

103144371(mbtps1)

PLAI:

106961953(mbtps1)

PMEI:

106904213(mbtps1)

GAF:	122834955(mbtps1)

PPRL:

129363690(mbtps1)

CVG:	107082488(mbtps1)

CTUL:

119796810(mbtps1)

GMU:	124857647(mbtps1)

NFU:	107388539(mbtps1)

KMR:	108246903(mbtps1)

ALIM:

106535339(mbtps1)

NWH:	119416153(mbtps1)

LTU:	140307698(mbtps1)

MCEP:

125015001(mbtps1)

AOCE:

111587755(mbtps1)

EJA:	138212427(mbtps1)

BFRE:

138636586(mbtps1)

LCF:

108901908

CSEM:

103379480(mbtps1)

POV:	109640734(mbtps1)

SSEN:

122776263(mbtps1)

SSOE:

131470271(mbtps1)

HHIP:

117762984(mbtps1)

HSP:	118109916(mbtps1)

PPLT:

128444867(mbtps1)

SMAU:

118315118(mbtps1)

SDU:	111225253(mbtps1)

SLAL:

111655735(mbtps1)

XGL:	120793456(mbtps1)

HCQ:	109530407(mbtps1)

SSCV:

125971225(mbtps1)

SBIA:

133501724(mbtps1)

PEE:	133403024(mbtps1)

PTAO:

133477659(mbtps1)

BPEC:

110169296(mbtps1)

ENY:	140348550(mbtps1)

MALB:

109962518(mbtps1)

BSPL:

114857486(mbtps1)

SJO:	128359191(mbtps1)

SSCO:

133982333(mbtps1)

TTY:	137182544(mbtps1)

GMH:	115550526(mbtps1)

SASA:

106560820 106573750

STRU:

115151963(mbtps1)

OTW:	112252364(mbtps1)

OMY:	110520509(mbtps1)

OGO:	124000665(mbtps1)

ONE:

115109390

OKI:

109889336

OKE:	118401258(mbtps1)

OMM:	135524417(mbtps1)

OCLA:

139400266

SALP:

111952396

SNH:

120053920

SFON:

129867086

CCLU:

121531878 121576639

ELS:	105018457(mbtps1)

OEP:	134020993(mbtps1)

SFM:	108918985(mbtps1)

PKI:	111851928(mbtps1)

AANG:

118228452(mbtps1)

AROT:

135255796(mbtps1)

CCOG:

133130743(mbtps1)

LOC:	102686177(mbtps1)

PSPA:

121296512 121325594

ARUT:

117424734 117425854(mbtps1)

PSEX:

120535317(mbtps1)

LCM:	102363551(MBTPS1)

CMK:	103185935(mbtps1)

RTP:	109914523(mbtps1)

CPLA:

122558523(mbtps1)

CPUN:

140453222(mbtps1)

HOC:	132823999(mbtps1)

SCAU:

119971423(mbtps1)

STOZ:

140430771(mbtps1)

CMAM:

144681925(mbtps1)

LERI:

129705153(mbtps1)

HAKA:

140740536(mbtps1)

PMRN:

116944177(MBTPS1)

LRJ:	133350884(MBTPS1)

BFO:

118417031

BBEL:

109483234

CIN:

100177229

SCLV:

120331694

CLEP:

143461839

SPU:

100890867

LPIC:

129253867

LVG:

121407384

AJJ:

139961952

APLC:

110984753

ARUN:

117289244

AAMU:

139934951

AFIL:

140135859

AJC:

117111220

SKO:

100375372

PFLL:

139147781

DME:	Dmel_CG7169(S1P)

DER:

6543922

DSE:

6616478

DSI:	Dsimw501_GD12102(Dsim_GD12102)

DYA:	Dyak_GE22309 Dyak_GE22979

DSR:

110189899

DPO:

117185167

DPE:

6603411

DMN:

108153004

DWI:

6642962

DGR:

6558333

DMO:	Dmoj_GI11330

DNV:

108650338

DVI:	6622828(S1P)

CCAT:

101463489

BOD:	106617994(S1P)

BDR:

105233020

RZE:

108362021

AOQ:

129241826

ALUD:

128860475

MDE:

105261606

LCQ:

111688423

LSQ:

119603186

CVJ:	135955868(S1P)

GFS:

119637916

ECOE:

129943245

CLON:

129614958

HIS:

119647602

AGA:

1280482

ACOZ:

120958494

AARA:

120900548

AMER:

121600398

ASTE:

118517626

AMAP:

126567782

AFUN:

125768637

AMOU:

128310006

AMRS:

128707245

ANIL:

128720921

AALI:

118466874

ADAR:

125953391

ACOS:

131260470

AAG:

5578190

AALB:

109431986 115254126

ASUA:

134220204

CQU:	CpipJ_CPIJ005032

CPII:

120419930

CBRI:

134827136

CNS:

116345525

BCOO:

119071878

LLL:

129795458

PPAP:

129803337

CFEL:

113385761 113385762

BMOR:

101735340

BMAN:

114246930

MSEX:

115448534

DPL:	KGM_206129

BANY:

112052662

MJU:

123880640

NIQ:

126780286

VCD:	124543048(S1P)

MCIX:

123668350

PMAC:

106719754

PPOT:

106102926

PXU:

106113860

BPHI:

137921343(S1P)

PRAP:

110999936

PBX:

123718638

PNAP:

125062443

ZCE:

119835664

CCRC:

123705461

LSIN:

126978930

AAGE:

121738720

HAW:

110373879

HZE:

124645265

TNL:

113494015

SLIU:

111360697

OFU:

114354306

ONU:

135086944

ATRA:

106133987

GMW:

113518054

ECLR:

140743563(S1P)

PXY:	105387100(S1P)

PGW:

126379849

LGLY:

125240479

CSTB:

134754468

CFUM:

141434360(S1P)

TCA:

100142346

TMOL:

138122825(S1P)

DPA:	109542269 125503162

ESIM:

136411311(S1P)

EFOR:

136339283(S1P)

SOY:

115889981

RFG:	143203593(S1P)

AGRG:

126739295

ATD:

109601130

CSET:

123310785

HAXR:

123677917

AGB:

108915945

LDC:

111516225

DVV:

114327673

NVL:

108566486

DCOR:

135793568(S1P)

APLN:

108733662

PPYR:

116173441

OTU:	111416919(S1)

CCRN:

123296694

AME:

412293

ACER:

107997634

ALAB:

122715239

ADR:

102674817

AFLR:

100870673

BIM:

100743550

BBIF:

117205413

BVK:

117237205

BVAN:

117161934

BHUN:

126872131

BTER:

100643281

BAFF:

126922084

BFER:

139992413(S1p)

BPYO:

122567421

BPAS:

132912571

FVI:

122537551

CCAL:

108631999

OBB:

114880807

OLG:

117602840

MGEN:

117217555

APUR:

144469289(S1p)

NMEA:

116431697

CGIG:

122399011

SOC:

105204443

MPHA:

105840999

AEC:

105153826

ACEP:

105624409

ACOC:

108694260

MZT:	108730492(S1P)

CCOA:

108782197

TCZ:

108767990

TSEP:

108746874

PBAR:

105423249

VEM:

105568700

COBS:

139113627(S1p)

TLN:	139820068(S1p)

TAME:

143903098(S1p)

HST:

105190108

DQU:

106752164

CFO:

105258722

FEX:

115245342

PMEC:

138940477(S1p)

LHU:	105673703(S1P)

PGC:

109856230

OBO:	105276501(S1P)

PCF:

106789824

PFUC:

122513614

VPS:

122637055

VCRB:

124431210

VVE:

124956988

NVI:

100123523

CSOL:

105367321

TPRE:

106660560

LHT:

122499880

LBD:

127285168

MDL:

103570637

CGLO:

123266774

CTYP:

141538319(S1p)

FAS:

105273665

DAM:

107037897

AGIF:

122861192

CINS:

118073797

VCAN:

122412262

CCIN:

107262953

DSM:

124414381

NPT:	124219782(S1P)

NFB:

124183689

NLO:

107217200

NVG:

124309312

AROA:

105692671

API:

100167456

DNX:

107165716

AGS:

114120220

RMD:

113551141

ACOO:

126832892

DVT:

126903977

BTAB:

109040752

DCI:

103515602

CLEC:

106666878

HHAL:

106681599(S1P)

NLU:

111045421

LDA:	142321677(S1P)

HVI:

124354764

MQU:

128996662

PHU:	Phum_PHUM379790

FOC:

113201833

TPAL:

117642856

ZNE:

110835787

CSEC:

111870796

PAME:

138699494(S1P)

SGRE:

126272877

BROR:

134532536

IEL:	124165217(S1P)

HAMR:

139698259(S1P)

DPX:	DAPPUDRAFT_310948

DMK:

116917810

DPZ:

124328705

AFRA:

136033572

EAF:

111712528

LSM:	121114766(S1P)

TCF:

131877297

PVM:	113811507(S1P)

PJA:

122248436

PCHN:

125028017

PMOO:

119573042

HAME:

121868536

PCLA:

123762899(S1P)

CQD:	128695148(S1P)

PTRU:

123517774

SPRM:

135101394

ESN:	127003415 127009202

MNZ:

135195521

MRJ:	136830401(S1P)

PORN:

139763485(S1P)

OOT:	143032293(S1P)

HAZT:

108679444

PPOI:

119107421 119107424

DSV:

119436080

DALB:

135900053(S1P)

RSAN:

119372697

RMP:	119177057(S1P)

VDE:

111250847

VJA:

111266565

GOE:

100903493

TUT:

107371259

DPTE:

113789221

DFR:	124492018(S1P)

CSCU:

111614042

CVS:	136971691(S1P)

PTEP:

107449241(S1)

ABRU:

129984198

UDV:	129223829 129224171

SDM:

118203366

LPOL:

106469138

BMY:	BM_BM7860(Bm7860)

LOA:	LOAG_07390

HRO:	HELRODRAFT_194246

LGI:	LOTGIDRAFT_123675

PVUL:

126815056

PCAN:

112576875

LSAX:

138959419

BARL:

143286104

BGT:

106070330

GAE:

121389388

HRF:

124138924

HRJ:

124262033

HASI:

137258040

HCRA:

139454158

CRG:

105329246

CANU:

128189449

CVN:

111136449

OED:

125667309

MYI:

110453394

PMAX:

117337362

AIRR:

138315813

YBA:

132554905

MCAF:

127702398

MMER:

123548566

RPHI:

132717740

DPOL:

127844565

MAEA:

128243141

OBI:

106870664

OSN:

115210751

LJP:

135465404

LAK:	106159410 106164261

SMM:	Smp_154140

SHX:	MS3_00009089(MBTPS1)

OVI:	T265_10520 T265_15172

LLON:

135496394

NVE:

116614670

EPA:

110232444

ATEN:

116307890

ADF:	107334656 107356457

AMIL:

114962121

MCAZ:

138018880

MFOO:

137986840

PDAM:

113685328

SPIS:

111326854

DGT:

114516410

XEN:

124436466

HMG:	100215239(LOC100215239)

HSY:

130614626

RES:

135691290

TAD:	TRIADDRAFT_19704

AQU:

100638666

CCLM:

134178285

OSA:

4340224

DOSA:

Os06g0163500

OBR:

102708067

OGL:

127776359

BDI:

100822086

ATS:

109739065

TDC:	119328603 119341286

TAES:

123154733 123159906 123169567

TUA:

125521694

HVG:

123407312

LPER:

127318096

LRD:

124685092

SBI:

8070876

ZMA:

103638020

MFLO:

136519571

SITA:

101786320

SVS:

117852683

PVIR:

120669830 120702713

PHAI:

112889226

PAUA:

133930808

TANG:

140777559

PDA:

103710901

EGU:

105040812

MUS:

135614419

ZOF:	121970175 121975264

DCT:

110095889

PEQ:

110020972

AOF:

109823710

ATH:	AT5G19660(S1P)

ALY:

9310026

CRB:

17883247

CSAT:

104706301 104738055 104770338

EUS:	EUTSA_v10012541mg

BRP:

103856389

BNA:	106386752 106434371

BOE:

106335448

RSZ:	108847656 130501498

THJ:

104804980

CPAP:

110818536

CIT:

102618142

CIC:	CICLE_v10007326mg

PVY:

116143797

MINC:

123194828

TCC:

18588592

GRA:	105768164 105792892

GHI:	107907212 107932897 107939494 107958761

GAB:	108456724 108467638

HSYR:

120123243 120149767 120159316

DZI:	111284694 111299108

EGR:

104438271

RARG:

115749137

GMX:	100797547 100819188

GSJ:	114368873 114418556

PVU:

137838080

VRA:	106773295 106773552

VAR:

108345744

VUN:

114180240

VUM:

124839248

CCAJ:

109800131

APRC:

113867273

MTR:

11426104

TPRA:

123884222

CAM:

101499133

PSAT:

127116672

VVO:	131636684 131637334

LJA:

130738969

ADU:

107478620

AIP:

107630293

AHF:	112738107 112790245

LANG:

109331606

PCIN:

129290869

QSA:	O6P43_004028 O6P43_007922

FVE:

101310645

AANS:

126785628

RCN:

112187428

PPER:

18771256

PMUM:

103340965

PAVI:

110770930

PDUL:

117634669

MDM:	103406901 103424935

MSYL:

126594356 126605305

PXB:

103962970

PCOX:

137732952

ZJU:

107431787

MNT:

21386072

CSAV:

115705849

HLP:

133797038

CSV:

101222509

CMO:

103501563

BHJ:

120071246

MCHA:

111014445

CMAX:

111485106

CMOS:

111461434

CPEP:

111780254

RCU:

8268362

MEAN:

126668937

JCU:

105637725

HBR:

110671793

MESC:

110603909

POP:

7458767

PEU:

105138931

PALZ:

118051665

PNZ:

133674411

JRE:

108979365

CILL:

122305000

CAVE:

132165671 132165803

AGLU:

133857170

QSU:

112005890

QLO:

115975594

CSAA:

142616390

TWL:

119997084

VVI:

100264570

VRI:

117925571

SLY:

101247955

SOT:

102580686

SSTN:

125870626

SDUL:

129876568

SVER:

125833419

CANN:

107843032 107843362

LBB:	132606906 132630106

NTA:	107774733 107799117 107828026

NSY:

104219033

NTO:	104087576 104112171

NAU:	109218473 109233344

INI:	109162005 109185809

ITR:	116016576 116017686

SIND:

105173516

OEU:

111411249

EGT:

105966442

SSPL:

121779821 121782145

SMIL:

131003031 131014087

SHIS:

125213987

APAN:

127251760

HPUM:

140885085

PHUA:

140976414

PEBU:

140805833

PTAB:

142549434

CARB:

113693704 113697030

HAN:

110886911

BHW:	143548953 143569339

ECAD:

122596690

LSV:	111908708(LOC111908708) 111918552(LOC111918552)

CCAV:

112504615 112505915

DCR:

108196558

AGRV:

141724635

CSIN:

114288823

RVL:

131320157

AEW:	130779532 130785234

DLT:

127795017

CFLO:

132277203

BVG:	104902212(LOC104902212)

SOE:

110775696

CQI:	110691020 110707781

ATRI:

130824598

SLAF:

141605926

MOF:

131158850

NNU:	104592191 104595191

MING:

122077037

TSS:

122653979

PSOM:

113348309 113349054

MSIN:

131256775

ACAK:

137945591 137950480

NCOL:

116254050

ATR:

18426576

CJF:

131074801

SMO:	SELMODRAFT_50575 SELMODRAFT_85837

PPP:

112280075

VCN:	VOLCADRAFT_85780

MNG:	MNEG_10128

CSL:	COCSUDRAFT_11172

CVR:	CHLNCDRAFT_33771

APRO:

F751_4604

OLU:	OSTLU_40456

OTA:	OT_ostta16g02710

BPG:	Bathy16g02470

MIS:	MICPUN_64337

MPP:	MICPUCDRAFT_22445

GSL:	Gasu_14550

CCP:	CHC_T00004250001

MBR:	MONBRDRAFT_27758

SRE:	PTSG_07047

DDI:	DDB_G0282397(mbtps1)

DPP:	DICPUDRAFT_42435

DFA:	DFA_02038(mbtps1) DFA_02083

ACAN:

ACA1_264710

TET:	TTHERM_01337350

AAF:	AURANDRAFT_67978

PIF:	PITG_06885

PSOJ:

PHYSODRAFT_536264

SPAR:

SPRG_09285 SPRG_15469

NGR:	NAEGRDRAFT_64673

EHX:	EMIHUDRAFT_106641

» show all

Reference

1 [PMID:10428864]

Authors

Espenshade PJ, Cheng D, Goldstein JL, Brown MS.

Title

Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins.

Journal

J Biol Chem 274:22795-804 (1999)
DOI:10.1074/jbc.274.32.22795

Reference

2 [PMID:10428865]

Authors

Cheng D, Espenshade PJ, Slaughter CA, Jaen JC, Brown MS, Goldstein JL.

Title

Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins.

Journal

J Biol Chem 274:22805-12 (1999)
DOI:10.1074/jbc.274.32.22805

Reference

3 [PMID:10644685]

Authors

Toure BB, Munzer JS, Basak A, Benjannet S, Rochemont J, Lazure C, Chretien M, Seidah NG

Title

Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.

Journal

J Biol Chem 275:2349-58 (2000)
DOI:10.1074/jbc.275.4.2349

Sequence

[hsa:8720]

Reference

4 [PMID:11163209]

Authors

Ye J, Rawson RB, Komuro R, Chen X, Dave UP, Prywes R, Brown MS, Goldstein JL.

Title

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.

Journal

Mol Cell 6:1355-64 (2000)
DOI:10.1016/S1097-2765(00)00133-7

Reference

5 [PMID:11606739]

Authors

Lenz O, ter Meulen J, Klenk HD, Seidah NG, Garten W

Title

The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P.

Journal

Proc Natl Acad Sci U S A 98:12701-5 (2001)
DOI:10.1073/pnas.221447598

Reference

6 [PMID:11943176]

Authors

Basak A, Chretien M, Seidah NG.

Title

A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus.

Journal

FEBS Lett 514:333-9 (2002)
DOI:10.1016/S0014-5793(02)02394-3

Reference

7 [PMID:12885882]

Authors

Vincent MJ, Sanchez AJ, Erickson BR, Basak A, Chretien M, Seidah NG, Nichol ST.

Title

Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.

Journal

J Virol 77:8640-9 (2003)
DOI:10.1128/JVI.77.16.8640-8649.2003

Reference

Authors

Seidah NG, Chretien M.

Title

Proprotein convertase SKI-1/S1P.

Journal

In: Barrett AJ, Rawlings ND, Woessner JF (eds). Handbook of Proteolytic Enzymes. 2nd ed. Vol. 2. London: Elsevier; 2004. p. 1845-1847.

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.112

IUBMB Enzyme Nomenclature:

3.4.21.112

ExPASy - ENZYME nomenclature database:

3.4.21.112

BRENDA, the Enzyme Database:

3.4.21.112

CAS:	167140-48-9

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Protein sequence (1441)   
   UniProt (1424)   
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   RefSeq(pep) (11)   
   PDBSTR (1)   
   PMD (1)   
DNA sequence (54)   
   RefSeq(nuc) (13)   
   GenBank (35)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   InterPro (4)   
All databases (4154)   

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