KEGG ENZYME: 3.4.21.119

ENZYME: 3.4.21.119

Entry

EC 3.4.21.119               Enzyme

Name

kallikrein 13;
KLK13;
kallikrein mK13;
mGK-13;
mK13;
mKLK13;
prorenin converting enzyme 1;
PRECE-1;
prorenin-converting enzyme;
PRECE;
proteinase P

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg! pair in the N-terminus, to yield mature renin

Comment

The enzyme is specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates [1]. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. This enzyme is also able to process pro-interleukin-1beta (pro-IL-1beta) in mouse submandibular gland to form IL-1beta [4]. Belongs in peptidase family S1A.

History

EC 3.4.21.119 created 2006

Orthology

K09462

glandular kallikrein 13

K09463

kallikrein 13

Genes

HSA:	26085(KLK13)

PTR:	748200(KLK13)

PPS:	103785249(KLK13)

GGO:

101150353

PON:	100438457(KLK13)

PPYG:

129020744(KLK13)

NLE:	100590429(KLK13)

HMH:	116478131(KLK13)

SSYN:

129459895(KLK13)

MCC:	106994830(KLK13)

MCF:	102147127(KLK13)

MTHB:

126943172

MNI:	105497126(KLK13)

CSAB:

103235116(KLK13)

CATY:

105595353(KLK13)

PANU:

101010957(KLK13)

TGE:	112612965(KLK13)

MLEU:

105528926(KLK13)

RRO:	104667255(KLK13)

RBB:

108515163

TFN:	117091664(KLK13)

PTEH:

111520159(KLK13)

CANG:

105514714(KLK13)

CJC:	100404986(KLK13)

SBQ:	101048919(KLK13)

CIMI:

108291972(KLK13)

ANAN:

105724339

CSYR:

103274747(KLK13)

MMUR:

105865555(KLK13)

LCAT:

123624202(KLK13)

PCOQ:

105809347(KLK13)

OGA:	105888336(KLK13)

MMU:	13647(Egfbp2) 626834(Klk13)

MCAL:

110297555(Klk13)

MPAH:

110334543(Klk13)

RNO:	292848(Klk13)

MCOC:

116100488(Klk13)

ANU:	117703334(Klk13)

ASYL:

127682571(Klk13)

MUN:	110553708(Klk13)

CGE:	100761429(Klk13)

MAUA:

101841402(Klk13)

PROB:

127213891(Klk13)

PLEU:

114683931(Klk13)

MORG:

121450399(Klk13)

MFOT:

126488187

AAMP:

119802875(Klk13)

NGI:	103743721(Klk13)

HGL:	101704794(Klk13)

CPOC:

100715865(Klk13)

CCAN:

109683888(Klk13)

DORD:

105994288(Klk13)

DSP:	122125635(Klk13)

DMER:

138812518(Klk13)

PLOP:

125338531(Klk13)

NCAR:

124967592

MMMA:

107151544

OPI:	101522907(KLK13)

TUP:	102490552(KLK13)

GVR:

103597725

CFA:	100856194(KLK13)

CLUD:

112645063(KLK13)

VVP:	112931504(KLK13)

VLG:	121485536(KLK13)

NPO:	129500597(KLK13)

AML:	100475439(KLK13)

UMR:	103657290(KLK13)

UAH:	113247319(KLK13)

UAR:	123778032(KLK13)

ELK:

111160751

LLV:

125089893

MPUF:

101686517(KLK13)

MNP:	132004925(KLK13)

MLK:	131817576(KLK13)

NVS:	122911766(KLK13)

ORO:	101378198(KLK13)

EJU:	114199580(KLK13)

ZCA:	113935388(KLK13)

MLX:	117998330(KLK13)

NSU:	110572994(KLK13)

LWW:

102745891

FCA:	102902318(KLK13)

PYU:	121018979(KLK13)

PCOO:

112850835(KLK13)

PBG:	122493792(KLK13)

PVIV:

125153822(KLK13)

LRUF:

124511920

LGF:	123578667(KLK13)

AJU:

106989681

PTG:	102966011(KLK13)

PPAD:

109252979(KLK13)

PUC:

125915707

PLEZ:

122208167(KLK13)

HHV:	120242195(KLK13)

BTA:	540297(KLK13)

BOM:

102280496

BIU:	109571793(KLK13)

BBUB:

102399235(KLK13)

BBIS:

104995704(KLK13)

CHX:	102180530(KLK13)

OAS:	101120106(KLK13)

BTAX:

128063390(KLK13)

CSUM:

138096362

ODA:

120872023

CCAD:

122420826(KLK13)

MREE:

136161614

OVR:

110135461

MBEZ:

129546480(KLK13)

SSC:	110261032(KLK13)

CFR:	102520551(KLK13)

CBAI:

105062685(KLK13)

CDK:	105100150(KLK13)

VPC:	102530731(KLK13)

BACU:

102997885(KLK13)

BMUS:

118885116(KLK13)

PCAD:

102983224(KLK13)

ECB:	100067063(KLK13)

EPZ:	103567745(KLK13)

EAI:	106847521(KLK13)

MYB:	102245547(KLK13)

MYD:	102763838(KLK13)

MLF:	102439648(KLK13)

MDT:	132216583(KLK13)

MYUM:

138999670(KLK13)

PKL:	118714910(KLK13)

EFUS:

103297594(KLK13)

MNA:	107531819(KLK13)

DRO:

112310174

AJM:	119052020(KLK13)

PDIC:

114511505(KLK13)

PHAS:

123830299

MMF:	118638346(KLK13)

PPAM:

129082821

HAI:	109391035(KLK13)

RFQ:	117035641(KLK13)

PALE:

102897491(KLK13)

PGIG:

120584016(KLK13)

PVP:

105311323

RAY:

107500471

MJV:	108409529(KLK13)

TOD:	119249650(KLK13)

SARA:

101550025(KLK13)

SFUM:

130043297

SETR:

126028037

ETF:

101641548

DNM:

105745980

MDO:	100028184(KLK13)

GAS:	123242913(KLK13)

SHR:	105749001(KLK13)

AFZ:

127557579

PCW:	110219944(KLK13)

PBRV:

138161843(KLK13)

OAA:	100082666(KLK13)

TACU:

119946078

PMOA:

120511634

ACOE:

138100884

TALA:

116962463 122153826 122153829

CLV:

102091959

PLET:

104617942

OHA:

104334555

CVF:

104287815

PRET:

103462834

PFOR:

103131593 103131598

PLAI:

106934988

PMEI:

106905726

AMAP:

126560367

CBRI:

134837539

AGIF:

122848296

VCAN:

122417355

CSET:

123318855

PPYR:

116179573

BMOR:

101744780

BMAN:

114250725

MSEX:

115453268

BANY:

112050571

MCIX:

123665327

PMAC:

106714794

PPOT:

106103148

PXU:

106128884

BPHI:

137925567

ZCE:

119837165

LSIN:

126969937

AAGE:

121729214

HAW:

110377627

ONU:

135082989

ATRA:

106135817

GMW:

113511242

LGLY:

125238005

CSTB:

134743616 134751022

CFUM:

141441498

RMD:

113557869

PAME:

138713446

» show all

Reference

1 [PMID:2250008]

Authors

Nakayama K, Kim WS, Nakagawa T, Nagahama M, Murakami K.

Title

Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis.

Journal

J Biol Chem 265:21027-31 (1990)

Reference

2 [PMID:2180937]

Authors

Kim WS, Hatsuzawa K, Ishizuka Y, Hashiba K, Murakami K, Nakayama K.

Title

A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization.

Journal

J Biol Chem 265:5930-3 (1990)

Reference

3 [PMID:9507064]

Authors

Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K.

Title

Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22).

Journal

Biochim Biophys Acta 1382:55-64 (1998)
DOI:10.1016/S0167-4838(97)00144-1

Reference

4 [PMID:16423834]

Authors

Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K

Title

Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice.

Journal

J Biol Chem 281:7968-76 (2006)
DOI:10.1074/jbc.M507705200

Sequence

[mmu:626834]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.119

IUBMB Enzyme Nomenclature:

3.4.21.119

ExPASy - ENZYME nomenclature database:

3.4.21.119

BRENDA, the Enzyme Database:

3.4.21.119

CAS:	342900-44-1

All links

Gene (52)   
   MGENES (4)   
   RefGene (48)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   RefSeq(nuc) (1)   
   GenBank (1)   
Protein domain (5)   
   InterPro (5)   
All databases (63)   

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