KEGG   ENZYME: 3.4.21.119
Entry
EC 3.4.21.119               Enzyme                                 
Name
kallikrein 13;
KLK13;
kallikrein mK13;
mGK-13;
mK13;
mKLK13;
prorenin converting enzyme 1;
PRECE-1;
prorenin-converting enzyme;
PRECE;
proteinase P
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg! pair in the N-terminus, to yield mature renin
Comment
The enzyme is specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates [1]. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. This enzyme is also able to process pro-interleukin-1beta (pro-IL-1beta) in mouse submandibular gland to form IL-1beta [4]. Belongs in peptidase family S1A.
History
EC 3.4.21.119 created 2006
Orthology
K09462  glandular kallikrein 13
K09463  kallikrein 13
Genes
HSA26085(KLK13)
PTR748200(KLK13)
PPS103785249(KLK13)
GGO101150353
PON100438457(KLK13)
PPYG129020744(KLK13)
NLE100590429(KLK13)
HMH116478131(KLK13)
SSYN129459895(KLK13)
MCC106994830(KLK13)
MCF102147127(KLK13)
MTHB126943172
MNI105497126(KLK13)
CSAB103235116(KLK13)
CATY105595353(KLK13)
PANU101010957(KLK13)
TGE112612965(KLK13)
MLEU105528926(KLK13)
RRO104667255(KLK13)
RBB108515163
TFN117091664(KLK13)
PTEH111520159(KLK13)
CANG105514714(KLK13)
CJC100404986(KLK13)
SBQ101048919(KLK13)
CIMI108291972(KLK13)
ANAN105724339
CSYR103274747(KLK13)
MMUR105865555(KLK13)
LCAT123624202(KLK13)
PCOQ105809347(KLK13)
OGA105888336(KLK13)
MMU13647(Egfbp2) 626834(Klk13)
MCAL110297555(Klk13)
MPAH110334543(Klk13)
RNO292848(Klk13)
MCOC116100488(Klk13)
ANU117703334(Klk13)
ASYL127682571(Klk13)
MUN110553708(Klk13)
CGE100761429(Klk13)
MAUA101841402(Klk13)
PROB127213891(Klk13)
PLEU114683931(Klk13)
MORG121450399(Klk13)
MFOT126488187
AAMP119802875(Klk13)
NGI103743721(Klk13)
HGL101704794(Klk13)
CPOC100715865(Klk13)
CCAN109683888(Klk13)
DORD105994288(Klk13)
DSP122125635(Klk13)
DMER138812518(Klk13)
PLOP125338531(Klk13)
NCAR124967592
MMMA107151544
OPI101522907(KLK13)
TUP102490552(KLK13)
GVR103597725
CFA100856194(KLK13)
CLUD112645063(KLK13)
VVP112931504(KLK13)
VLG121485536(KLK13)
NPO129500597(KLK13)
AML100475439(KLK13)
UMR103657290(KLK13)
UAH113247319(KLK13)
UAR123778032(KLK13)
ELK111160751
LLV125089893
MPUF101686517(KLK13)
MNP132004925(KLK13)
MLK131817576(KLK13)
NVS122911766(KLK13)
ORO101378198(KLK13)
EJU114199580(KLK13)
ZCA113935388(KLK13)
MLX117998330(KLK13)
NSU110572994(KLK13)
LWW102745891
FCA102902318(KLK13)
PYU121018979(KLK13)
PCOO112850835(KLK13)
PBG122493792(KLK13)
PVIV125153822(KLK13)
LRUF124511920
LGF123578667(KLK13)
AJU106989681
PTG102966011(KLK13)
PPAD109252979(KLK13)
PUC125915707
PLEZ122208167(KLK13)
HHV120242195(KLK13)
BTA540297(KLK13)
BOM102280496
BIU109571793(KLK13)
BBUB102399235(KLK13)
BBIS104995704(KLK13)
CHX102180530(KLK13)
OAS101120106(KLK13)
BTAX128063390(KLK13)
CSUM138096362
ODA120872023
CCAD122420826(KLK13)
MREE136161614
OVR110135461
MBEZ129546480(KLK13)
SSC110261032(KLK13)
CFR102520551(KLK13)
CBAI105062685(KLK13)
CDK105100150(KLK13)
VPC102530731(KLK13)
BACU102997885(KLK13)
BMUS118885116(KLK13)
PCAD102983224(KLK13)
ECB100067063(KLK13)
EPZ103567745(KLK13)
EAI106847521(KLK13)
MYB102245547(KLK13)
MYD102763838(KLK13)
MLF102439648(KLK13)
MDT132216583(KLK13)
MYUM138999670(KLK13)
PKL118714910(KLK13)
EFUS103297594(KLK13)
MNA107531819(KLK13)
DRO112310174
AJM119052020(KLK13)
PDIC114511505(KLK13)
PHAS123830299
MMF118638346(KLK13)
PPAM129082821
HAI109391035(KLK13)
RFQ117035641(KLK13)
PALE102897491(KLK13)
PGIG120584016(KLK13)
PVP105311323
RAY107500471
MJV108409529(KLK13)
TOD119249650(KLK13)
SARA101550025(KLK13)
SFUM130043297
SETR126028037
ETF101641548
DNM105745980
MDO100028184(KLK13)
GAS123242913(KLK13)
SHR105749001(KLK13)
AFZ127557579
PCW110219944(KLK13)
PBRV138161843(KLK13)
OAA100082666(KLK13)
TACU119946078
PMOA120511634
ACOE138100884
TALA116962463 122153826 122153829
CLV102091959
PLET104617942
OHA104334555
CVF104287815
PRET103462834
PFOR103131593 103131598
PLAI106934988
PMEI106905726
AMAP126560367
CBRI134837539
AGIF122848296
VCAN122417355
CSET123318855
PPYR116179573
BMOR101744780
BMAN114250725
MSEX115453268
BANY112050571
MCIX123665327
PMAC106714794
PPOT106103148
PXU106128884
BPHI137925567
ZCE119837165
LSIN126969937
AAGE121729214
HAW110377627
ONU135082989
ATRA106135817
GMW113511242
LGLY125238005
CSTB134743616 134751022
CFUM141441498
RMD113557869
PAME138713446
 » show all
Reference
1  [PMID:2250008]
  Authors
Nakayama K, Kim WS, Nakagawa T, Nagahama M, Murakami K.
  Title
Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis.
  Journal
J Biol Chem 265:21027-31 (1990)
Reference
2  [PMID:2180937]
  Authors
Kim WS, Hatsuzawa K, Ishizuka Y, Hashiba K, Murakami K, Nakayama K.
  Title
A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization.
  Journal
J Biol Chem 265:5930-3 (1990)
Reference
3  [PMID:9507064]
  Authors
Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K.
  Title
Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22).
  Journal
Biochim Biophys Acta 1382:55-64 (1998)
DOI:10.1016/S0167-4838(97)00144-1
Reference
4  [PMID:16423834]
  Authors
Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K
  Title
Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice.
  Journal
J Biol Chem 281:7968-76 (2006)
DOI:10.1074/jbc.M507705200
  Sequence
[mmu:626834]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.119
IUBMB Enzyme Nomenclature: 3.4.21.119
ExPASy - ENZYME nomenclature database: 3.4.21.119
BRENDA, the Enzyme Database: 3.4.21.119
CAS: 342900-44-1

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