KEGG   ENZYME: 3.4.21.12
Entry
EC 3.4.21.12                Enzyme                                 
Name
alpha-lytic endopeptidase;
myxobacter alpha-lytic proteinase;
alpha-lytic proteinase;
alpha-lytic protease;
Mycobacterium sorangium alpha-lytic proteinase;
Myxobacter 495 alpha-lytic proteinase;
Myxobacter alpha-lytic proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: Ala!, Val! in bacterial cell walls, elastin and other proteins
Comment
From the myxobacterium Lysobacter enzymogenes. In peptidase family S1 (trypsin family)
History
EC 3.4.21.12 created 1972
Orthology
K20136  alpha-lytic endopeptidase
Genes
LAB: LA76x_3467(alpha-LP)
LAQ: GLA29479_4711
LCP: LC55x_3409(alpha-LP)
LGU: LG3211_1771(alpha-LP)
LEZ: GLE_1730
LEM: LEN_3241
LYA: RDV84_14465 RDV84_23465 RDV84_23470
WEZ: IC757_15500
AWW: G8758_16675
NHY: JQS43_22700
Reference
1  [PMID:5482494]
  Authors
Olson MO, Nagabhushan N, Dzwiniel M, Smillie LB, Whitaker DR.
  Title
Priaary structure of alpha-lytic protease: a bacterial homologue of the pancreatic serine proteases.
  Journal
Nature 228:438-42 (1970)
DOI:10.1038/228438a0
Reference
2
  Authors
Polgar, L.
  Title
Structure and function of serine proteases.
  Journal
In: Neuberger, A. and Brocklehurst, K. (Eds.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, p. 159-200.
Reference
3  [PMID:3053694]
  Authors
Epstein DM, Wensink PC
  Title
The alpha-lytic protease gene of Lysobacter enzymogenes. The nucleotide sequence predicts a large prepro-peptide with homology to pro-peptides of other chymotrypsin-like enzymes.
  Journal
J Biol Chem 263:16586-90 (1988)
  Sequence
[ag:AAA25409]
Reference
4  [PMID:2611204]
  Authors
Bone R, Frank D, Kettner CA, Agard DA.
  Title
Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.
  Journal
Biochemistry 28:7600-9 (1989)
DOI:10.1021/bi00445a015
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.12
IUBMB Enzyme Nomenclature: 3.4.21.12
ExPASy - ENZYME nomenclature database: 3.4.21.12
BRENDA, the Enzyme Database: 3.4.21.12
CAS: 37288-76-9

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Gene (14)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (13)   
Protein sequence (214)   
   UniProt (127)   
   SWISS-PROT (3)   
   RefSeq(pep) (2)   
   PDBSTR (77)   
   PMD (5)   
DNA sequence (107)   
   RefSeq(nuc) (4)   
   GenBank (54)   
   EMBL (49)   
3D Structure (46)   
   PDB (46)   
Protein domain (7)   
   InterPro (7)   
All databases (388)   

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