KEGG   ENZYME: 3.4.21.120
Entry
EC 3.4.21.120               Enzyme                                 
Name
oviductin;
oviductal protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage at Gly-Ser-Arg373! of glycoprotein gp43 in Xenopus laevis coelemic egg envelope to yield gp41
Comment
The egg envelope of the South African clawed frog (Xenopus laevis) is modified during transit of the egg through the pars rectus oviduct, changing the egg envelope from an unfertilizable form to a fertilizable form. This process involves the conversion of glycoprotein gp43 to gp41 (ZPC) by the pars recta protease oviductin. It is thought that the enzymically active protease molecule comprises the N-terminal protease domain coupled to two C-terminal CUB domains, which are related to the mammalian spermadhesin molecules implicated in mediating sperm-envelope interactions [2]. The enzyme is also found in the Japanese toad (Bufo japonicus) [3]. Belongs in peptidase family S1.
History
EC 3.4.21.120 created 2007
Orthology
K20111  oviductin
Genes
FCA101094990(PRSS45)
DNM101419309(OVCH2)
MDO100027745(OVCH2)
GAS123252509(OVCH2)
SHR100916932(OVCH2)
PCW110214514 110221029(OVCH2)
OAA100076426(OVCH2)
GGA769290(OVCH2)
PCOC116243035(OVCH2)
MGP100541355(OVCH2)
CJO107314584(OVCH2)
NMEL110400771(OVCH2)
APLA101798316(OVCH2)
ACYG106040936(OVCH2)
AFUL116492998(OVCH2)
TGU101233893(OVCH2)
SCAN103822216(OVCH2)
PMOA120509839(OVCH2)
OTC121345925(OVCH2)
PRUF121363438(OVCH2)
FAB101811575(OVCH2)
CBRC103624757(OVCH2)
ETL114056538(OVCH2)
ZAB102073198(OVCH2)
ACHL103798044
FPG101910452(OVCH2)
FCH102053250(OVCH2)
CLV102088414(OVCH2)
EGZ104123416(OVCH2)
NNI104009438(OVCH2)
PLET104620159(OVCH2)
PCRI104024839
ACUN113481338(OVCH2)
TALA104368000(OVCH2)
PADL103925731(OVCH2)
AFOR103906788(OVCH2)
ACHC115352013(OVCH2)
HALD104318905(OVCH2)
CCRI104167480(OVCH2)
CSTI104562637(OVCH2)
EHS104516288(OVCH2)
CMAC104481627
MUI104547726(OVCH1)
FGA104080710(OVCH2)
GSTE104258893(OVCH2)
LDI104343863
MNB103776831
OHA104331810(OVCH2)
NNT104400011(OVCH2)
DPUB104296691(OVCH2)
PGUU104465530(OVCH2)
ACAR104526740(OVCH2)
AVIT104272833(OVCH2)
CVF104293202(OVCH2)
AAM106497080(OVCH2)
AROW112968269(OVCH1) 112976466(OVCH2)
NPD112948859(OVCH2)
TGT104565345(OVCH2)
DNE112985657(OVCH2)
SCAM104147459(OVCH2)
ASN102383299(OVCH2)
CPOO109321538(OVCH2)
GGN109299063(OVCH2)
PSS102457326(OVCH2)
CMY102933552(OVCH2)
CPIC101937537(OVCH2)
TST117877146(OVCH2)
CABI116829411(OVCH2)
MRV120403930(OVCH2)
ACS100566043(ovch2)
PVT110080913(OVCH2)
SUND121919050(OVCH2)
PBI103050766(OVCH2)
PMUR107291095 107300098
CTIG120306700(OVCH2)
PGUT117666159(OVCH2)
VKO123021390(OVCH2)
PMUA114597670(OVCH2)
ZVI118086666(OVCH2)
GJA107111731(OVCH2)
STOW125426843(OVCH2)
XLA398108(ovch2.S)
XTR100496902(ovch2)
NPR108789647
BBUF120980257
BGAR122920569
DRE101884131
SRX107745938
SANH107686667
SGH107573059(ovch1)
CCAR109109152
CAUA113043111
PPRM120460425
MAMB125247009
IPU108269171
AMEX103035632
EEE113582490
LCO104933350
MSAM119893236
CUD121514824
ONL102078047
OAU116319115
XCO114134724
PRET103466254
POV109644191
LCF108902303
BPEC110169478
MALB109962594
SASA106561585(ovch2)
OGO124040188
ONE115115356
SALP111961034
ELS105018253
PKI111858128
AANG118215559
LOC102682878(ovch2)
PSPA121294874
ARUT117432097
LCM102365172(OVCH2)
CMK103175111
BFO118412348
BBEL109466424
CIN100184879
APLC110980135
SKO100378374 100378523 102807143 102807270 102807871
CPII120422399
CCAL108628700
NVI100678261
FCD110863444
PVM113800311 113813378
PJA122251632
HAME121871538
LSM121127949
DSV119433928
RSAN119404594
RMP119180620
TUT107370120
CSCU111620851 111632901
PTEP107446495
BGT106055103
CRG105335512 105342011
PMAX117332187 117332337 117333570
LAK106156710 106178747
NVE5519957
EPA110254161
ATEN116302919
AMIL114976087
 » show all
Reference
1  [PMID:1581303]
  Authors
Hardy DM, Hedrick JL.
  Title
Oviductin. Purification and properties of the oviductal protease that processes the molecular weight 43,000 glycoprotein of the Xenopus laevis egg envelope.
  Journal
Biochemistry 31:4466-72 (1992)
DOI:10.1021/bi00133a012
Reference
2  [PMID:10084976]
  Authors
Lindsay LL, Wieduwilt MJ, Hedrick JL
  Title
Oviductin, the Xenopus laevis oviductal protease that processes egg envelope glycoprotein gp43, increases sperm binding to envelopes, and is translated as part of an unusual mosaic protein composed of two protease and several CUB domains.
  Journal
Biol Reprod 60:989-95 (1999)
DOI:10.1095/biolreprod60.4.989
  Sequence
[xla:398108]
Reference
3  [PMID:11846486]
  Authors
Hiyoshi M, Takamune K, Mita K, Kubo H, Sugimoto Y, Katagiri C
  Title
Oviductin, the oviductal protease that mediates gamete interaction by affecting the vitelline coat in Bufo japonicus: its molecular cloning and analyses of expression and posttranslational activation.
  Journal
Dev Biol 243:176-84 (2002)
DOI:10.1006/dbio.2001.0558
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.120
IUBMB Enzyme Nomenclature: 3.4.21.120
ExPASy - ENZYME nomenclature database: 3.4.21.120
BRENDA, the Enzyme Database: 3.4.21.120

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