KEGG   ENZYME: 3.4.21.19
Entry
EC 3.4.21.19                Enzyme                                 
Name
glutamyl endopeptidase;
V8 proteinase;
endoproteinase Glu-C;
staphylococcal serine proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: Glu!, Asp!
Comment
From Staphylococcus aureus strain V8. In appropriate buffer the specificity is restricted to Glu!. In peptidase family S1 (trypsin family)
History
EC 3.4.21.19 created 1978
Orthology
K01318  glutamyl endopeptidase
Genes
LCP: LC55x_2678
LGU: LG3211_2491
LEM: LEN_4462
LMB: C9I47_2143
VGA: BSQ33_15410
VSR: Vspart_01428(mpr)
MII: BTJ40_14815
TPUT: QJT81_19990
THIP: N838_17495
HAHH: O5O45_15740
MNR: ACZ75_25335
MASY: DPH57_00670
PLUE: EWM63_26175
MMEC: FIU01_08595
AOA: dqs_1446
CAQ: IM40_10800
NIY: FQ775_23160
BOT: CIT37_03835
PLEO: OHA_1_01719(mpr)
SIL: SPO2645
SDO: SD1155_03150 SD1155_04855
SAL: Sala_1680
SPHS: ETR14_24515
PALJ: LZC94_31765
BMX: BMS_2026
STI: Sthe_3367
AHEL: Q31a_27220
SING: V5E97_08630
PCAG: NCTC12856_01639(blaSE)
CPI: Cpin_3475
PEK: FFJ24_021825
PEV: KYH19_20545
SPIK: EXU85_07915
FIB: A6C57_18130
HSW: Hsw_2028
BSU: BSU02240(mpr)
BSR: I33_0263
BSL: A7A1_3257
BSH: BSU6051_02240(mpr)
BSY: I653_01090
BSUT: BSUB_00272(mpr)
BSUL: BSUA_00272(mpr)
BSUS: Q433_01385
BSO: BSNT_06531(mpr)
BSN: BSn5_12695
BSQ: B657_02240(mpr)
BSX: C663_0212(mpr)
BSP: U712_01140
BSS: BSUW23_01140(mpr)
BST: GYO_0423
BIT: BIS30_11660
BLI: BL01804(blaSE)
BLD: BLi00340(mpr)
BLH: BaLi_c03590(mpr)
BAY: RBAM_008630
BAQ: BACAU_0838(mpr)
BYA: BANAU_0781(mpr)
BQY: MUS_0875(mpr)
BAMP: B938_04160
BAML: BAM5036_0773(mpr)
BAMA: RBAU_0837(mpr)
BAMN: BASU_0813(mpr)
BAMB: BAPNAU_0794(mpr)
BAMT: AJ82_04810
BAMY: V529_08080(mpr)
BMP: NG74_00859(mpr)
BAO: BAMF_0814(mpr)
BAZ: BAMTA208_03925(mpr)
BQL: LL3_00873(mpr)
BXH: BAXH7_00819
BAMI: KSO_015500
BAMC: U471_08510
BAMF: U722_04305
BVM: B9C48_04275
BSON: S101395_03020(sspA) S101395_04703
BHT: DIC78_08900
BMOJ: HC660_02590(mpr)
BTEQ: G4P54_01340
BIQ: AN935_01145
BSTR: QI003_01340(mpr)
BCE: BC0789
BCA: BCE_0860
BCU: BCAH820_0866
BCG: BCG9842_B4509
BCEF: BcrFT9_00715
BTT: HD73_0905
BTHR: YBT1520_04470
BTHI: BTK_04505
BTI: BTG_17320
BTN: BTF1_01535
BTW: BF38_2029(mpr)
BTHY: AQ980_26370
BMYC: DJ92_5771
BBY: CY96_03095
BTRO: FJR70_26225
BMOB: MLA2C4_04240
BPAC: LMD38_22115
BPU: BPUM_1681
BPUM: BW16_09265
BPUS: UP12_08655
BGY: BGLY_0338(blaSE)
BALT: CFN77_09205
BAER: BAE_16290
BSAF: BSL056_09540
BCAB: EFK13_01500(mpr)
BRY: M0696_01345(mpr)
BJS: MY9_0225
BACW: QR42_08595
BACP: SB24_05600
BACB: OY17_06960
BACY: QF06_00080
BACL: BS34A_02780(mpr)
BALM: BsLM_0229
BAEI: RE735_11000
BAFC: K3G25_18470
BAZS: BZ167_05365
BACH: BSZ43_01760
BACJ: CJO35_01765
BAWR: D9C22_01330
BGI: BGM20_16165
LFU: HR49_11295
LAGR: FJQ98_02325
GTM: GT3921_09415
GTN: GTNG_3484
GZA: IC807_15230
PTB: DER53_17085
ACAI: ISX45_04935
SAU: SA0901(sspA) SA1627(splF) SA1628(splD) SA1631(splA)
SAV: SAV1048(sspA) SAV1809(splF) SAV1810(splD) SAV1813(splA) SAV2596
SAW: SAHV_1041(sspA) SAHV_1794(splF) SAHV_1795(splD) SAHV_1798(splA) SAHV_2580
SAH: SaurJH1_1130 SaurJH1_1896 SaurJH1_1899 SaurJH1_2672
SAJ: SaurJH9_1107 SaurJH9_1861 SaurJH9_1864 SaurJH9_2618
SAM: MW0932(sspA) MW1752(splF) MW1755(splA)
SAS: SAS0984 SAS1733 SAS1736
SAR: SAR1022(sspA) SAR1902(splE) SAR1905
SAC: SACOL1057(sspA) SACOL1864 SACOL1865 SACOL1866 SACOL1869(splA)
SAX: USA300HOU_0996(sspA) USA300HOU_1801(splF) USA300HOU_1802(splE) USA300HOU_1803(splD) USA300HOU_1806(splA)
SAA: SAUSA300_0951(sspA) SAUSA300_1753(splF) SAUSA300_1754(splE) SAUSA300_1755(splD) SAUSA300_1758(splA)
SAO: SAOUHSC_00988 SAOUHSC_01935 SAOUHSC_01936 SAOUHSC_01938 SAOUHSC_01942
SAE: NWMN_0918(sspA) NWMN_1701(splF) NWMN_1702(splE) NWMN_1703(splD) NWMN_1706(splA)
SAD: SAAV_1817 SAAV_1818 SAAV_1821(splA) SAAV_2662
SUU: M013TW_0978 M013TW_2573
SUV: SAVC_04410 SAVC_08280 SAVC_08285 SAVC_08290 SAVC_08305
SUE: SAOV_0994c SAOV_1795(splF)
SUJ: SAA6159_00905(sspA) SAA6159_01739(splE) SAA6159_01740
SUK: SAA6008_01003
SUC: ECTR2_1642 ECTR2_1645 ECTR2_2450 ECTR2_904
SUT: SAT0131_01083 SAT0131_01929 SAT0131_01933
SUQ: HMPREF0772_11331 HMPREF0772_11332(splB) HMPREF0772_11333 HMPREF0772_11334 HMPREF0772_12186
SUZ: MS7_1006(sspA) MS7_1809 MS7_1810 MS7_1811 MS7_1814(splA) MS7_2228(etb)
SUD: ST398NM01_1046
SUX: SAEMRSA15_08800(sspA) SAEMRSA15_24990
SUW: SATW20_10450(sspA) SATW20_18060(splF) SATW20_18070(splE) SATW20_18080(splD) SATW20_18110(splA)
SUG: SAPIG1046
SUF: SARLGA251_09630(sspA) SARLGA251_16930(splE) SARLGA251_16940(splD) SARLGA251_16970(splA)
SAUA: SAAG_01714 SAAG_01715 SAAG_01716 SAAG_01717 SAAG_02706
SAUE: RSAU_000936 RSAU_001666(splF) RSAU_001667(splE) RSAU_001670(splA) RSAU_002437
SAUN: SAKOR_00969 SAKOR_01758 SAKOR_01761
SAUS: SA40_0919(sspA) SA40_2350
SAUU: SA957_0934(sspA) SA957_2434
SAUG: SA268_0936(sspA) SA268_2532
SAUZ: SAZ172_0989(sspA) SAZ172_1824(splF) SAZ172_1827(splA)
SAUT: SAI1T1_2007410(sspA) SAI1T1_2013270 SAI1T1_2013280 SAI1T1_2013310(splA)
SAUJ: SAI2T2_1007430(sspA) SAI2T2_1013290 SAI2T2_1013320(splA)
SAUK: SAI3T3_1007420(sspA) SAI3T3_1013270 SAI3T3_1013280 SAI3T3_1013310(splA)
SAUQ: SAI4T8_1007410(sspA) SAI4T8_1013280 SAI4T8_1013290 SAI4T8_1013320(splA)
SAUV: SAI7S6_1007420(sspA) SAI7S6_1013290(splF) SAI7S6_1013300 SAI7S6_1013330(splA)
SAUW: SAI5S5_1007380(sspA) SAI5S5_1013240 SAI5S5_1013270(splA)
SAUX: SAI6T6_1007390(sspA) SAI6T6_1013250(splF) SAI6T6_1013260 SAI6T6_1013290(splA)
SAUY: SAI8T7_1007420(sspA) SAI8T7_1013280 SAI8T7_1013310(splA)
SAUF: X998_1048 X998_1827 X998_1828 X998_1829 X998_1832
SAB: SAB0915c(sspA) SAB1669c(splF) SAB1670c(splE)
SUY: SA2981_1003(sspA) SA2981_1764(splF) SA2981_1765(splD) SA2981_1768(splA) SA2981_2534
SAUB: C248_1073(sspA)
SAUM: BN843_18150 BN843_18160 BN843_18170 BN843_18200 BN843_9550
SAUC: CA347_965(sspA)
SAUR: SABB_01014(sspA) SABB_01932(splF) SABB_01933(splE) SABB_01934(splD) SABB_01937(splA)
SAUI: AZ30_05005 AZ30_09165 AZ30_09170 AZ30_09175 AZ30_09190
SAUD: CH52_00640 CH52_06025 CH52_10065 CH52_10080 CH52_10085
SAMS: NI36_05015 NI36_13010
SUH: SAMSHR1132_08970
SER: SERP1397(sspA)
SEP: SE_0172 SE_1543
SEPP: SEB_01530
SEPS: DP17_458(gseA)
SHA: SH0170
SHH: ShL2_00097(splF)
SSP: SSP0282
SCA: SCA_2075
SSD: SPSINT_0295 SPSINT_0299
SDT: SPSE_2159
SWA: A284_01095 A284_11160
SPAS: STP1_1178 STP1_1520
SXY: BE24_10545
SXL: SXYLSMQ121_0310 SXYLSMQ121_2360
SXO: SXYL_00314(sspA)
SHU: SHYC_05203(exhA)
SCAP: AYP1020_2166(splF)
SSCH: LH95_00675 LH95_00680 LH95_00690 LH95_09160
SSCZ: RN70_00890 RN70_00905 RN70_00960
SEQO: SE1039_22640
SSIF: AL483_11995
SCV: A4G25_09840
SPET: CEP67_06905 CEP67_09050
SLZ: B5P37_02425
SCOH: BZ166_06060
SURY: MUA21_11200
SNL: BJD96_01860
SKL: C7J89_03375
SFQ: C7J90_06070
SHOM: EGX58_04880
SMUS: C7J88_06110 C7J88_06940
SCAR: DWB96_01145
SARL: SAP2_04080(gseA)
SPIC: SAMEA4384060_0473(splF)
SSH: NCTC13712_00994(sspA) NCTC13712_02148
SSIM: SAMEA4384339_0216(splF)
SDB: CNQ82_03205
SLLO: ISP08_02125
SRAI: LN051_06680 LN051_08050
SPSD: JMB28_02070
STAS: HYI43_00650
SEDA: MNY58_01630
SCAQ: QMO72_01720
SROT: ML435_04760(sspA)
STAP: AOB58_2138
SHSI: QQM35_02095
SGAI: K3U27_07850
SSUC: ACSSAF_01630
SSCU: CEP64_05140
SFF: FOB90_05625 FOB90_07015 FOB90_07080 FOB90_07085
SSTE: SAMEA4384403_0924(sspA_1) SAMEA4384403_1136(sspA_2)
MLEN: H3V22_03180
MVT: I6J10_05620
MCAK: MCCS_05630(sspA)
MBOE: HT586_11190
LMOC: LMOSLCC5850_0633
LWE: lwe1890
LIV: LIV_1848
LII: JL52_09750
LIW: AX25_09915
PHC: BBI08_11470
NTR: B0W44_11605
LFB: C1X05_03425 C1X05_03865
TVU: AB849_001955
LPAA: BHS01_03030
SNT: SPT_0436
SND: MYY_0470
SPNN: T308_01940
SNP: SPAP_0417
SPNE: SPN034156_14420(cbpG)
STD: SPPN_02270 SPPN_10050
SMEN: SAMEA4412692_1942(sspA_1) SAMEA4412692_1955(sspA_2)
SZG: J5M87_03015
WCE: WS08_0604(gseA)
WCT: WS74_0605(gseA)
WCI: WS105_0602(gseA)
FRU: M3M36_06680
EFI: OG1RF_12235
CTC: CTC_00612
CTET: BN906_00638
ASF: SFBM_0615
ASM: MOUSESFB_0575(splA)
ASO: SFBmNL_00655
ASB: RATSFB_0509(splA)
FTK: PXT33_012295
ALLO: KWG61_11520
TFC: T23_16890(gseA)
MCHE: BB28_20115
MIZ: BAB75_22315
MSTE: MSTE_04077(mpr)
MSAO: MYCSP_18135
MSAL: DSM43276_03714(mpr)
CGY: CGLY_16755
CMV: CMUST_14380
CMAT: HBA49_06840
TPR: Tpau_4335
SLC: SL103_14910
SRN: A4G23_04576
SNR: SNOUR_35850
SSIA: A7J05_33500
STRO: STRMOE7_04915
SGZ: C0216_19455
SRK: FGW37_11160
SPAD: DVK44_20420
SRIM: CP984_29820
SDUR: M4V62_05095
LYH: FrondiHNR_02935 FrondiHNR_10455
ARR: ARUE_c15360(blaSE)
ARN: CGK93_08370
ARI: UM93_01150 UM93_10910
AAU: AAur_1625
PNV: JMY29_07715
PAGO: IRJ34_08135
PAYN: HMI60_11905
SERJ: SGUI_0506
PPC: HMPREF9154_0632
ARUB: J5A65_08780
MPH: MLP_03900
FRE: Franean1_5547
NML: Namu_1110
SACG: FDZ84_26640
APRE: CNX65_22495
AMI: Amir_4522
SSYI: EKG83_28985
KPHY: AOZ06_49980
AHM: TL08_01180
ACTI: UA75_01145
ACAD: UA74_01145
AHG: AHOG_01110(blaSE1) AHOG_01120(blaSE2)
ACAU: ACOJVX_00725
VMA: VAB18032_07970
MCRA: ID554_06735
VER: HUT12_06225
VET: ACQVFL_05065
NAV: JQS30_06110
LSC: KIK02_01705
CYJ: Cyan7822_3498
MIC: Mic7113_0815
MPRO: BJP34_24590
HAU: Haur_1651 Haur_5027
MOX: DAMO_1971
MEER: NKF70_11040
MHI: Mhar_0640
 » show all
Reference
1  [PMID:1012010]
  Authors
Drapeau GR.
  Title
Protease from Staphyloccus aureus.
  Journal
Methods Enzymol 45:469-75 (1976)
DOI:10.1016/S0076-6879(76)45041-3
Reference
2  [PMID:96922]
  Authors
Drapeau GR.
  Title
The primary structure of staphylococcal protease.
  Journal
Can J Biochem 56:534-44 (1978)
DOI:10.1139/o78-082
Reference
3  [PMID:3306605]
  Authors
Carmona C, Gray GL
  Title
Nucleotide sequence of the serine protease gene of Staphylococcus aureus, strain V8.
  Journal
Nucleic Acids Res 15:6757 (1987)
DOI:10.1093/nar/15.16.6757
  Sequence
[sau:SA0901]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.19
IUBMB Enzyme Nomenclature: 3.4.21.19
ExPASy - ENZYME nomenclature database: 3.4.21.19
BRENDA, the Enzyme Database: 3.4.21.19
CAS: 137010-42-5

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Gene (739)   
   MGENES (739)   
Protein sequence (950)   
   UniProt (116)   
   SWISS-PROT (12)   
   RefSeq(pep) (802)   
   PDBSTR (20)   
DNA sequence (21147)   
   RefSeq(nuc) (16686)   
   GenBank (2252)   
   EMBL (2209)   
3D Structure (13)   
   PDB (13)   
Protein domain (1)   
   InterPro (1)   
All databases (22850)   

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