KEGG   ENZYME: 3.4.21.19
Entry
EC 3.4.21.19                Enzyme                                 
Name
glutamyl endopeptidase;
V8 proteinase;
endoproteinase Glu-C;
staphylococcal serine proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: Glu!, Asp!
Comment
From Staphylococcus aureus strain V8. In appropriate buffer the specificity is restricted to Glu!. In peptidase family S1 (trypsin family)
History
EC 3.4.21.19 created 1978
Orthology
K01318  glutamyl endopeptidase
Genes
LCPLC55x_2678
LGULG3211_2491
LEMLEN_4462
LMBC9I47_2143
VGABSQ33_15410
VSRVspart_01428(mpr)
MIIBTJ40_14815
THIPN838_17495
MCYSMCB1EB_0941
PBHAAW51_4215
MNRACZ75_25335
MASYDPH57_00670
AOAdqs_1446
CAQIM40_10800
NIYFQ775_23160
BOTCIT37_03835 CIT37_03845
RPCRPC_3414
PLEOOHA_1_01719(mpr)
SILSPO2645
LMDMETH_17285
SDOSD1155_03150 SD1155_04855
SALSala_1680
SSANNX02_00655
SPHSETR14_24515
NCBC0V82_24965
BMXBMS_2026
BSTOC0V70_07160
BSRI33_0263
BSLA7A1_3257
BSHBSU6051_02240(mpr)
BSYI653_01090
BSUTBSUB_00272(mpr)
BSULBSUA_00272(mpr)
BSUSQ433_01385
BSOBSNT_06531(mpr)
BSNBSn5_12695
BSQB657_02240(mpr)
BSXC663_0212(mpr)
BSPU712_01140
BSSBSUW23_01140(mpr)
BSTGYO_0423
BLIBL01804(blaSE)
BLDBLi00340(mpr)
BLHBaLi_c03590(mpr)
BAYRBAM_008630
BAQBACAU_0838(mpr)
BYABANAU_0781(mpr)
BAMPB938_04160
BQYMUS_0875(mpr)
BAMLBAM5036_0773(mpr)
BAMARBAU_0837(mpr)
BAMNBASU_0813(mpr)
BAMBBAPNAU_0794(mpr)
BAMTAJ82_04810
BAMYV529_08080(mpr)
BMPNG74_00859(mpr)
BAOBAMF_0814(mpr)
BAZBAMTA208_03925(mpr)
BQLLL3_00873(mpr)
BXHBAXH7_00819
BAMIKSO_015500
BAMCU471_08510
BAMFU722_04305
BVMB9C48_04275
BSONS101395_03020(sspA) S101395_04703
BHTDIC78_08900
BMOJHC660_02590(mpr)
BTEQG4P54_01340
BIQAN935_01145
BCEBC0789
BCABCE_0860
BCUBCAH820_0866
BCGBCG9842_B4509
BCEFBcrFT9_00715
BTTHD73_0905
BTHRYBT1520_04470
BTHIBTK_04505
BTIBTG_17320
BTNBTF1_01535
BTWBF38_2029(mpr)
BTHYAQ980_26370
BMYCDJ92_5771
BBYCY96_03095
BTROFJR70_26225
BMOBMLA2C4_04240
BPACLMD38_22115
BPUBPUM_1681
BPUMBW16_09265
BPUSUP12_08655
BJSMY9_0225
BACWQR42_08595
BACPSB24_05600
BACBOY17_06960
BACYQF06_00080
BACLBS34A_02780(mpr)
BALMBsLM_0229
BGYBGLY_0338(blaSE)
BALTCFN77_09205
BSAFBSL056_09540
BITBIS30_11660
BGIBGM20_16165
GTMGT3921_09415
GTNGTNG_3484
GZAIC807_15230 IC807_15240
PTBDER53_17085
ACAIISX45_04935
LFUHR49_11295
LYSLBYS11_18575
LAGRFJQ98_02325
SAUSA0901(sspA) SA1627(splF)
SAVSAV1048(sspA) SAV1809(splF) SAV1810(splD) SAV1813(splA) SAV2596
SAWSAHV_1041(sspA) SAHV_1794(splF) SAHV_1795(splD) SAHV_1798(splA) SAHV_2580
SAHSaurJH1_1130 SaurJH1_1896 SaurJH1_1899 SaurJH1_2672
SAJSaurJH9_1107 SaurJH9_1861 SaurJH9_1864 SaurJH9_2618
SAMMW0932(sspA) MW1752(splF) MW1755(splA)
SASSAS0984 SAS1733 SAS1736
SARSAR1022(sspA) SAR1902(splE) SAR1905
SACSACOL1057(sspA) SACOL1864 SACOL1865 SACOL1866 SACOL1869(splA)
SAXUSA300HOU_0996(sspA) USA300HOU_1801(splF) USA300HOU_1802(splE) USA300HOU_1803(splD) USA300HOU_1806(splA)
SAASAUSA300_0951(sspA) SAUSA300_1753(splF) SAUSA300_1754(splE) SAUSA300_1755(splD) SAUSA300_1758(splA)
SAOSAOUHSC_00988 SAOUHSC_01935 SAOUHSC_01936 SAOUHSC_01938 SAOUHSC_01942
SAENWMN_0918(sspA) NWMN_1701(splF) NWMN_1702(splE) NWMN_1703(splD) NWMN_1706(splA)
SADSAAV_1817 SAAV_1818 SAAV_1821(splA) SAAV_2662
SUUM013TW_0978 M013TW_2573
SUVSAVC_04410 SAVC_08280 SAVC_08285 SAVC_08290 SAVC_08305
SUESAOV_0994c SAOV_1795(splF)
SUJSAA6159_00905 SAA6159_01739(splE) SAA6159_01740(splE_1)
SUKSAA6008_01003
SUCECTR2_1642 ECTR2_1645 ECTR2_2450 ECTR2_904
SUTSAT0131_01083 SAT0131_01929 SAT0131_01933
SUQHMPREF0772_11331 HMPREF0772_11332(splB) HMPREF0772_11333 HMPREF0772_11334 HMPREF0772_12186
SUZMS7_1006(sspA) MS7_1809 MS7_1810 MS7_1811 MS7_1814(splA) MS7_2228(etb)
SUDST398NM01_1046
SUXSAEMRSA15_08800(sspA) SAEMRSA15_24990
SUWSATW20_10450(sspA) SATW20_18060(splF) SATW20_18070(splE) SATW20_18080(splD) SATW20_18110(splA)
SUGSAPIG1046
SUFSARLGA251_09630(sspA) SARLGA251_16930(splE) SARLGA251_16940(splD) SARLGA251_16970(splA)
SAUASAAG_01714 SAAG_01715 SAAG_01716 SAAG_01717 SAAG_02706
SAUERSAU_000936 RSAU_001666(splF) RSAU_001667(splE) RSAU_001670(splA) RSAU_002437
SAUNSAKOR_00969 SAKOR_01758 SAKOR_01761
SAUSSA40_0919(sspA) SA40_2350
SAUUSA957_0934(sspA) SA957_2434
SAUGSA268_0936(sspA) SA268_2532
SAUZSAZ172_0989(sspA) SAZ172_1824(splF) SAZ172_1827(splA)
SAUTSAI1T1_2007410(sspA) SAI1T1_2013270 SAI1T1_2013280 SAI1T1_2013310(splA) SAI1T1_2019320
SAUJSAI2T2_1007430(sspA) SAI2T2_1013290 SAI2T2_1013320(splA) SAI2T2_1019330
SAUKSAI3T3_1007420(sspA) SAI3T3_1013270 SAI3T3_1013280 SAI3T3_1013310(splA) SAI3T3_1019320
SAUQSAI4T8_1007410(sspA) SAI4T8_1013280 SAI4T8_1013290 SAI4T8_1013320(splA) SAI4T8_1019330
SAUVSAI7S6_1007420(sspA) SAI7S6_1013290(splF) SAI7S6_1013300 SAI7S6_1013330(splA) SAI7S6_1019320
SAUWSAI5S5_1007380(sspA) SAI5S5_1013240 SAI5S5_1013270(splA) SAI5S5_1019260
SAUXSAI6T6_1007390(sspA) SAI6T6_1013250(splF) SAI6T6_1013260 SAI6T6_1013290(splA) SAI6T6_1019270
SAUYSAI8T7_1007420(sspA) SAI8T7_1013280 SAI8T7_1013310(splA) SAI8T7_1019300
SAUFX998_1048 X998_1827 X998_1828 X998_1829 X998_1832
SABSAB0915c(sspA) SAB1669c(splF) SAB1670c(splE)
SUYSA2981_1003(sspA) SA2981_1764(splF) SA2981_1765(splD) SA2981_1768(splA) SA2981_2534
SAUBC248_1073(sspA)
SAUMBN843_18150 BN843_18160 BN843_18170 BN843_18200 BN843_9550
SAUCCA347_965(sspA)
SAURSABB_01014(sspA) SABB_01932(splF) SABB_01933(splE) SABB_01934(splD) SABB_01937(splA)
SAUIAZ30_05005 AZ30_09165 AZ30_09170 AZ30_09175 AZ30_09190
SAUDCH52_00640 CH52_06025 CH52_10065 CH52_10080 CH52_10085
SAMSNI36_05015 NI36_13010
SUHSAMSHR1132_08970
SERSERP1397(sspA)
SEPSE_0172 SE_1543
SEPPSEB_01530
SEPSDP17_458(gseA)
SHASH0128 SH0170
SHHShL2_00056(splE) ShL2_00097(splF)
SSPSSP0282
SCASCA_2075
SSDSPSINT_0295 SPSINT_0299 SPSINT_0676
SDTSPSE_1846 SPSE_2159
SDPNCTC12225_00990(splB_1) NCTC12225_01668(splB_2)
SWAA284_01095 A284_11160
SPASSTP1_1178 STP1_1520
SXYBE24_10545
SXLSXYLSMQ121_0310 SXYLSMQ121_1010 SXYLSMQ121_2360
SXOSXYL_00314(sspA)
SHUSHYC_05203(exhA)
SCAPAYP1020_2166(splF)
SSCHLH95_00675 LH95_00680 LH95_00690 LH95_02140 LH95_09160 LH95_11445
SSCZRN70_00890 RN70_00905 RN70_00960 RN70_02425 RN70_12150
SEQOSE1039_22640
SSIFAL483_11995
SCVA4G25_09840
SPETCEP67_06905 CEP67_09050
SLZB5P37_02425
SCOHBZ166_06060
SNLBJD96_01860
SKLC7J89_03375
SFQC7J90_06070
SHOMEGX58_04880
SMUSC7J88_00925 C7J88_06110 C7J88_06940
SCARDWB96_01145
SARLSAP2_04080(gseA)
SPICSAMEA4384060_0473(splF)
SSHNCTC13712_00994(sspA) NCTC13712_02148
SSIMSAMEA4384339_0216(splF)
SDBCNQ82_03205
SLLOISP08_02125
SSCUCEP64_05140 CEP64_11115
SFFFOB90_05625 FOB90_07015 FOB90_07080 FOB90_07085 FOB90_11730
SSTESAMEA4384403_0924(sspA_1) SAMEA4384403_1136(sspA_2)
MLENH3V22_03180 H3V22_04155 H3V22_10635
MVTI6J10_05620 I6J10_12330
MCAKMCCS_05630(sspA)
MBOEHT586_11190
LMNLM5578_0710
LMYLM5923_0665
LMOCLMOSLCC5850_0633
LMODLMON_0640
LMOQLM6179_0946
LMRLMR479A_0652
LMOMIJ09_07155
LMFLMOf2365_1900
LMCLm4b_01887
LMOGBN389_18960(blaSE)
LMPMUO_09600
LMOLLMOL312_1881
LMOJLM220_20150
LMOZLM1816_11552
LMOXAX24_07120
LMSLMLG_0604
LMJLMOG_02111
LMWLMOSLCC2755_0646
LMZLMOSLCC2482_0689
LMOOLMOSLCC2378_1894
LMOTLMOSLCC2540_0645
LMOALMOATCC19117_1889
LMOKCQ02_09705
LMVY193_06205
LWElwe1890
LIVLIV_1848
LIIJL52_09750
LIWAX25_09915
LIAJL58_09960
LIOJL53_10430
PHCBBI08_11470
SURESporoP32a_10335
NTRB0W44_11605
LFBC1X05_03425 C1X05_03865
TVUAB849_001955
LPAABHS01_03030
SNTSPT_0436
SNDMYY_0470
SPNNT308_01940
SNPSPAP_0417
SPNESPN034156_14420(cbpG)
STDSPPN_02270 SPPN_10050
SMENSAMEA4412692_1942(sspA_1) SAMEA4412692_1955(sspA_2)
WCEWS08_0604(gseA)
WCTWS74_0605(gseA)
WCIWS105_0602(gseA)
EFIOG1RF_12235
VCPH9L18_04195
ABAECL176_10075
CTCCTC_00612
CTETBN906_00638
ASFSFBM_0615
ASMMOUSESFB_0575(splA)
ASOSFBmNL_00653 SFBmNL_00655
ASBRATSFB_0509(splA)
ALLOKWG61_11520
MCHEBB28_20115
MIZBAB75_22315
MSTEMSTE_04077(mpr)
MSAOMYCSP_18135
MSALDSM43276_03714(mpr)
CGYCGLY_16755
CMVCMUST_14380
CMATHBA49_06840 HBA49_07150
TPRTpau_4335
SLCSL103_14910
SRNA4G23_04576
SNRSNOUR_35850
SSIAA7J05_33500
STROSTRMOE7_04915
SGZC0216_19455
SRKFGW37_11160
SPADDVK44_20420
SRIMCP984_29820
ARRARUE_c15360(blaSE)
ARNCGK93_08370
ARIUM93_01150 UM93_10910
AAUAAur_1625
PNVJMY29_07715
SERJSGUI_0506
PPCHMPREF9154_0632
ARUBJ5A65_08780
MPHMLP_03900
AERAERYTH_16480
FREFranean1_5547
NMLNamu_1110
SACGFDZ84_26640
APRECNX65_22495
AMIAmir_4522
SSYIEKG83_28985
KPHYAOZ06_49980
AHMTL08_01180
ACTIUA75_01145
ACADUA74_01145
AHGAHOG_01110(blaSE1) AHOG_01120(blaSE2)
VMAVAB18032_07970
MCRAID554_06735
VERHUT12_06225
NAVJQS30_06110
AEQAEQU_0663
LSCKIK02_01705
CYJCyan7822_3498
MICMic7113_0815
MPROBJP34_24590
SCSSta7437_2755
STANSTA3757_12900
HAUHaur_1651 Haur_5027
STISthe_3367
AHELQ31a_27220
PCAGNCTC12856_01639(blaSE)
CPICpin_3475
PEKFFJ24_021825
SPIKEXU85_07915
RSIRunsl_1309
RUNDR864_15375
FIBA6C57_18130
HSWHsw_2028
MOXDAMO_1971
MHIMhar_0640
 » show all
Reference
1  [PMID:1012010]
  Authors
Drapeau GR.
  Title
Protease from Staphyloccus aureus.
  Journal
Methods Enzymol 45:469-75 (1976)
DOI:10.1016/S0076-6879(76)45041-3
Reference
2  [PMID:96922]
  Authors
Drapeau GR.
  Title
The primary structure of staphylococcal protease.
  Journal
Can J Biochem 56:534-44 (1978)
DOI:10.1139/o78-082
Reference
3  [PMID:3306605]
  Authors
Carmona C, Gray GL
  Title
Nucleotide sequence of the serine protease gene of Staphylococcus aureus, strain V8.
  Journal
Nucleic Acids Res 15:6757 (1987)
DOI:10.1093/nar/15.16.6757
  Sequence
[sau:SA0901]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.19
IUBMB Enzyme Nomenclature: 3.4.21.19
ExPASy - ENZYME nomenclature database: 3.4.21.19
BRENDA, the Enzyme Database: 3.4.21.19
CAS: 137010-42-5

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