KEGG ENZYME: 3.4.21.20

ENZYME: 3.4.21.20

Entry

EC 3.4.21.20                Enzyme

Name

cathepsin G;
chymotrypsin-like proteinase;
neutral proteinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Specificity similar to chymotrypsin C

Comment

From azurophil granules of polymorphonuclear leukocytes. In peptidase family S1 (trypsin family)

History

EC 3.4.21.20 created 1978

Orthology

K01319

cathepsin G

Genes

HSA:	1511(CTSG)

PTR:	467413(CTSG)

PPS:	100986490(CTSG)

GGO:	129526807(CTSG)

PON:	100436066(CTSG)

PPYG:

129012916(CTSG)

NLE:	100591056(CTSG)

HMH:	116484819(CTSG)

SSYN:

129489282(CTSG)

MCC:	716440(CTSG)

MCF:	102128983(CTSG)

MTHB:

126959476

MNI:	105477883(CTSG)

CSAB:

103228742(CTSG)

CATY:

105600217(CTSG)

TGE:	112628940(CTSG)

MLEU:

105532751(CTSG)

RRO:	104662664(CTSG)

RBB:	108529494(CTSG)

TFN:	117069889(CTSG)

PTEH:

111552914(CTSG)

CANG:

105503705(CTSG)

CJC:	100400068(CTSG)

SBQ:	101051891(CTSG)

CIMI:

108297942(CTSG)

ANAN:

105727941

CSYR:

103268298

MMUR:

105866609

LCAT:

123650612(CTSG)

PCOQ:

105812758(CTSG)

OGA:

100960859

MMU:	13035(Ctsg)

MCAL:

110309192

MPAH:

110325404

RNO:	290257(Ctsg)

MCOC:

116084819

ANU:

117705954

ASYL:

127690714 127691491

MUN:

110565885

CGE:

100767270

MAUA:

101822759

PROB:

127230065

PLEU:

114708764

MORG:

121434873

MFOT:

126492602

AAMP:

119799825

NGI:	103739491(Ctsg)

HGL:	101712232 101713070

CPOC:

100733338 100733619 101788102

CCAN:

109676125

DORD:

105992486

DSP:

122113370

PLOP:

125363504

NCAR:

124977216

MMMA:

107145301

ITI:

101959956

TUP:	102471354(CTSG)

GVR:	103591213(CTSG)

CFA:	106559147(CTSG)

CLUD:

112657572(CTSG)

VVP:

112926475

VLG:	121493561(CTSG)

NPO:	129499395(CTSG)

AML:

117797265

UMR:	103679302(CTSG)

UAH:

113246003

UAR:

123795667

ELK:

111162031

LLV:

125104802

MPUF:

101694605(CTSG)

MNP:

131998759

MLK:	131835329(CTSG)

NVS:

122893171

ORO:	101383583(CTSG)

EJU:

114217879

ZCA:

113910206

MLX:	118003492(CTSG)

NSU:

110585495

LWW:

102725822

FCA:	101098719(CTSG)

PYU:

121031584

PCOO:

112855266

PBG:

122468964

PVIV:

125168541

LRUF:

124508203

LGF:

123583478

AJU:

106987851

PTG:	102957657(CTSG)

PPAD:

109254958

PUC:

125909632

PLEZ:

122221283

HHV:

120246988

BTA:	505658 509956

BOM:	102286039 102286316

BIU:	109575203 109575305

BBUB:

102397903 102398425

BBIS:

104991012 104991013

CHX:	102174648 102175113

OAS:	101121298 101121553

BTAX:

128066749

CSUM:

138094988

ODA:

120875430

CCAD:

122454920 122454921 122454927 122455212

MREE:

136146963 136147267

OVR:	110152644 110152645

MBEZ:

129550078 129550133

SSC:

100154047

CFR:	102517784 116664194

CBAI:

105082494

CDK:	105102447 105106639 116153491

VPC:

102535149

BACU:

103009512(CTSG) 103010195

BMUS:

118890520 118890521

LVE:	103088005(CTSG) 103090225

OOR:

125963384

LALB:

132530682 132530695

GMF:	115852172 115852173

DLE:

111171097

PCAD:

102973677 102984870 112067657

PSIU:

116749160 116749990

PPHC:

136118413 136118414

NASI:

112392039 112415971

ECB:

100053921

EPZ:

103561062

EAI:

106848617

MYB:	102253470 102253776

MYD:	102773521 102773806

MMYO:

118663919

MLF:

102435780

MDT:

132241184

MYUM:

139008077

PKL:

118726109

EFUS:

103301542 103301543

MNA:	107544834 107544837 107545395

SHON:

118980879 118980880

AJM:	119037316 119037317 119037318 128625794

PDIC:

114492074 114492075

PHAS:

123820422

MMF:	118640469 118643159

PPAM:

129074070 129074071

HAI:	109393625 109393630

RFQ:

117024207

PALE:

102887729 102891138

PGIG:

120608593 120608594(CTSG)

PVP:	105309409 105309413

RAY:	107513514 107513515

MJV:

108392610

TOD:

119239508

SARA:

101552187(CTSG)

SFUM:

130041646

SETR:

126001710(CTSG)

LAV:

100654642

TMU:	101352768 101353729

ETF:

101647487

DNM:

105744603

GGA:	426049(CTSG)

PCOC:

116236147

MGP:

100541485

CJO:

107325409

TPAI:

128090371

LMUT:

125685051

NMEL:

110388892

APLA:

101802752

ACYG:

106049561

CATA:

118260048

AFUL:

116499218

TGU:

100225270

LSR:	110475735 110480577

SCAN:

103821693 103821694 103821935 103825764

PMOA:

120496702 120498085 120504508

OTC:	121341993 121347560

PRUF:

121351067 121361826

ATRC:

139601611 139601668 139601670 139602119

GFR:

102043497

FAB:	101806847 101807047 101807227 101814633 107604218

OMA:	130264165 130264166 130264494

PHI:	102102775 102112651

PMAJ:

107215203 107215418

CCAE:

111940154 111940383

CCW:	104696999 104697786

CBRC:

103622121 103624683

ACOE:

138099320 138099674

ETL:

114066403

ZAB:	102062382 102071916 102072267 102073681 113460182

ZLE:	135458563 135458565 135458567 135458571 135458845

ACHL:

103800861

SVG:

106857064

MMEA:

130580240 130586682

HRT:

120763451

SATI:

136371889 136372262 136372264 136372266

CCIC:

134054380

FPG:

101923544

FCH:

102052223

CCRI:

104157542

SHAB:

115618310

ACUN:

113489366(GZMM)

ACHC:

115349099

HALD:

104323364

HLE:

104829068

AGEN:

126041726

HHAR:

128148056

GCL:	127025655 127026710

CSTI:

104563314

LDI:

104344239

MNB:

103770335

DPUB:

104300279

PPUS:

135192110

AVIT:

104270211

BRHI:

104495491

EGZ:

104124380

NNI:	104016273 104018468

PCRI:

104033376

PCAO:

104048109

PADL:

103917384 103923464

AFOR:

103899345

FGA:

104073234

GSTE:

104261578

CBOY:

140643726

CLV:	102084529 102092430

CNIC:

135999183

MUI:

104542201

PGUU:

104465456

PLET:

104622743

EHS:

104508972

CMAC:

104473489

CUCA:

104064448

TEO:	104376191 104384648

BREG:

104633746

OHA:

104335035

ACAR:

104531565

CPEA:

104397501

CVF:	104294375(GZMM)

RTD:

128900724

CRID:

134524770 134526180

AAM:

106486400

AROW:

112973874

NPD:

112946802

TGT:	104580083(GZMM)

DNE:

112988091

SCAM:

104151008

ASN:	102371192 102372276 102374953 102386315(GZMM) 102386560 102388488 102388738 112548405

AMJ:	102561787 102562017 102567538(GZMM) 102570566(CTSG) 109283684

CPOO:

109320466

GGN:

109295051

PSS:	102450564 102450790 102454962 102455240 102455738 102458929 102460838 102462227 102463428 106732597 112547215

CMY:	102932252 102935119 102936749 102938128 102946952

CCAY:

125627292 125627337 125627338

DCC:	119842204 119848523

CPIC:

101931737 101932032 101943927 101945528 101946707 101946964 101947241 101947580 101952835 103306961

TST:	117868777 117869080 117869107

CABI:

116821549 116824255 116824333 116824401 116830792

MRV:	120380337 120380381 120380385 120380763 120391701 120391805 120391889 120391890

ACS:	100565934 103281292

ASAO:

132780322 132780323 132781475

PVT:	110079223 110079299

SUND:

121936732 121936805

PBI:	103062353 103067502

TSR:

106541429

PCAE:

139308364

APRI:

131188351 131188353

NSS:

113426433

PMUA:

114588244 114588535 114588667 114588668 114588669 114588671 114588673 114588674

PRAF:

128405535 128405536 128405542 128405858

ZVI:	118086035 118086037 118086038 118086039 118086043 118086368 118087220 118087286

HCG:	128343769 128346093 128346451 128346716

GJA:	107120589 107120597

STOW:

125433136 125433137 125433220 125433615

EMC:	129329667 129330240

XLA:	108696664 494802(gzmh.S)

XTR:	496758(gzmh)

NPR:

108791244

RTEM:

120909938

ACAT:

141103797

BBUF:

120989412

BGAR:

122930909

DTC:

141050873

PWL:

138268262

MUO:

115479509

GSH:

117349593

SANH:

107687736

SGH:

107554807

AMEX:

103040147(si:ch211-212d10.1)

NFU:

107375040

BPEC:

110174099

PPYR:

116178927

CCRN:

123299685

» show all

Reference

1 [PMID:7341917]

Authors

Barrett AJ.

Title

Cathepsin G.

Journal

Methods Enzymol 80 Pt C:561-5 (1981)
DOI:10.1016/s0076-6879(81)80044-4

Reference

2 [PMID:4016099]

Authors

Tanaka T, Minematsu Y, Reilly CF, Travis J, Powers JC.

Title

Human leukocyte cathepsin G. Subsite mapping with 4-nitroanilides, chemical modification, and effect of possible cofactors.

Journal

Biochemistry 24:2040-7 (1985)
DOI:10.1021/bi00329a036

Reference

3 [PMID:2569462]

Authors

Hohn PA, Popescu NC, Hanson RD, Salvesen G, Ley TJ.

Title

Genomic organization and chromosomal localization of the human cathepsin G gene.

Journal

J Biol Chem 264:13412-9 (1989)

Sequence

[hsa:1511]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.20

IUBMB Enzyme Nomenclature:

3.4.21.20

ExPASy - ENZYME nomenclature database:

3.4.21.20

BRENDA, the Enzyme Database:

3.4.21.20

CAS:	56645-49-9

All links

Gene (28)   
   MGENES (3)   
   RefGene (25)   
Protein sequence (29)   
   UniProt (7)   
   SWISS-PROT (3)   
   RefSeq(pep) (5)   
   PDBSTR (13)   
   PMD (1)   
DNA sequence (8)   
   RefSeq(nuc) (6)   
   GenBank (2)   
3D Structure (5)   
   PDB (5)   
Protein domain (6)   
   InterPro (6)   
All databases (76)   

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