KEGG   ENZYME: 3.4.21.22
Entry
EC 3.4.21.22                Enzyme                                 
Name
coagulation factor IXa;
activated Christmas factor;
blood-coagulation factor IXa;
activated blood-coagulation factor IX;
autoprothrombin II;
blood platelet cofactor II;
activated blood coagulation factor XI
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Ile bond in factor X to form factor Xa
Comment
A chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family)
History
EC 3.4.21.22 created 1978
Orthology
K01321  coagulation factor IX (Christmas factor)
Genes
HSA2158(F9)
PTR465887(F9)
PPS100969131(F9)
GGO101128865(F9)
PON100446459(F9)
NLE100598601(F9)
MCC695578(F9)
MCF102146175(F9)
CSAB103232665(F9)
CATY105592697(F9)
PANU101018592(F9)
TGE112615930(F9)
RRO104682195(F9)
RBB108521383
TFN117078021(F9)
PTEH111536253(F9)
CJC100398468(F9)
SBQ101046698(F9)
CSYR103264135(F9)
MMUR105881058(F9)
OGA100947691(F9)
MMU14071(F9)
MCAL110286779(F9)
MPAH110314135(F9)
RNO24946(F9)
MCOC116092876(F9)
MUN110539834(F9)
CGE100757213(F9)
PLEU114681025(F9)
NGI103724689(F9)
HGL101724977(F9)
CPOC100135464(F9)
CCAN109675816(F9)
DORD105992875(F9)
DSP122097109(F9)
NCAR124972665
OCU100009113(F9)
OPI101527566(F9)
TUP102484971(F9)
CFA404015(F9)
VVP112927642(F9)
VLG121483470(F9)
AML100468418(F9)
UMR103672846(F9)
UAH113241876(F9)
UAR123797321(F9)
ELK111158974
LLV125092370
MPUF101678344(F9)
ORO101385212(F9)
EJU114224597(F9)
ZCA113930774(F9)
MLX118011743(F9)
FCA493973(F9)
PYU121024192
PBG122477004(F9)
PTG102971107(F9)
PPAD109250471(F9)
AJU106969973(F9)
HHV120222248(F9)
BTA280688(F9)
BOM102285916(F9)
BIU109555385(F9)
BBUB102416666(F9)
CHX102174637(F9)
OAS443316(F9)
ODA120881735(F9)
CCAD122435894(F9)
SSC397518(F9)
CFR102513153(F9)
CBAI105067060(F9)
CDK105086028(F9)
VPC102531998(F9)
BACU103020493(F9)
LVE103090469(F9)
OOR101271539(F9)
DLE111164550(F9)
PCAD102988201(F9)
PSIU116747622(F9)
ECB100054449(F9)
EPZ103567516(F9)
EAI106840103(F9)
MYB102257875(F9)
MYD102757434(F9)
MMYO118654725(F9)
MLF102429338(F9)
MNA107532746(F9)
PKL118722147(F9)
HAI109388665(F9)
DRO112300060(F9)
SHON118991400(F9)
AJM119035951 119035956(F9)
PDIC114505075(F9)
PHAS123819095(F9)
MMF118635992(F9)
RFQ117028021(F9)
PALE102881862(F9)
PGIG120612376(F9)
PVP105303800(F9)
RAY107503214(F9)
MJV108386638(F9)
TOD119246507(F9)
SARA101549359(F9)
LAV100663465(F9)
TMU101352726
DNM101418669(F9)
MDO100012394(F9)
GAS123253283(F9)
SHR100921381(F9)
PCW110197732(F9)
OAA100082935(F9)
GGA374258(F9)
PCOC116229652(F9)
MGP100551218(F9)
CJO107312750(F9)
NMEL110403425(F9)
APLA101804105
ACYG106037454(F9)
AFUL116494587(F9)
TGU100225886(F9)
LSR110482933(F9)
SCAN103816587(F9)
PMOA120508761(F9)
OTC121331811(F9)
PRUF121349130(F9)
GFR102038061(F9)
FAB101810173(F9)
PHI102114302(F9)
PMAJ107203652(F9)
CCAE111928537(F9)
CCW104691321(F9)
ETL114060716(F9)
ZAB102061407(F9)
FPG101924325(F9)
FCH102052819(F9)
CLV102088048(F9)
EGZ104130320(F9)
NNI104012866(F9)
ACUN113480064(F9)
TALA104362475(F9)
PADL103917338(F9)
ACHC115333694(F9)
AAM106484761(F9)
AROW112974089(F9)
NPD112944472(F9)
DNE112989701(F9)
ASN102384799(F9)
AMJ102565567(F9)
CPOO109310845(F9)
GGN109300611(F9)
PSS102463532(F9)
CMY102938403(F9)
CPIC101937636(F9)
TST117882789(F9)
CABI116820597(F9)
MRV120372101(F9)
ACS100563567(f9)
PVT110084962(F9) 110084966
SUND121936404 121936945
PBI103058462 112540883
PMUR107303228(F9) 114922195
TSR106538358(F9)
PGUT117679567 117679568
VKO123021890(F9) 123021893
PMUA114589339 114589340
ZVI118089875 118090360
GJA107116105(F9)
XLA100049721(f9.S) 108698922(f9.L)
XTR496659(f9)
NPR108793198(F9)
RTEM120913655(F9)
BBUF120977643(F9)
BGAR122919645(F9)
DRE100004411 359826(f9a) 678552(f9b)
SRX107718750 107720621 107725753 107744572 107752055 107752057
SANH107658031 107665423 107693933 107701106 107705017
SGH107548854 107551862 107555166 107601103
CCAR109052316 109097646 109101831
CAUA113054325 113058792 113074406 113081131 113109828 113113961
PPRM120470818 120474441(f9a) 120476467(f9b)
IPU108268424(f9a) 108276806(f9b) 108277713
PHYP113529026 113538408(f9) 113544655
SMEO124386197(f9a) 124393102(f9b) 124394151
TFD113635590(f9a) 113637905 113650395(f9b)
AMEX103022627(f9) 103033862 103041525
EEE113574745 113576276(f9) 113583063
TRU101064607 101068927(f9) 445943(f9)
TNGGSTEN00012000G001 GSTEN00021128G001 GSTEN00031251G001
LCO104923492(f9) 104933045 104934181
NCC104958005(f9) 104966981
CGOB115014925(f9) 115017358 115018674
ELY117259475 117260738(f9a) 117263254(f9b)
PLEP121944792 121947762(f9a) 121952108(f9b)
SLUC116037008(f9b) 116052318(f9a) 116058414
ECRA117952317(f9a) 117955774(f9b)
PFLV114553065 114563384(f9) 114566228
GAT120816259 120817387(f9a) 120821765(f9b)
PPUG119210652(f9a) 119215010(f9b) 119219178
MSAM119883019 119888354(f9a) 119896138(f9b)
CUD121516494(f9a) 121518348 121518745(f9b)
MZE101464969 101466133 101487720
ONL100694381 100704957 100710669
OAU116319684 116322509(f9a) 116335354
OLA111948660
OML112142967(f9b) 112149281
XMA102218647 102223546 102232890
XCO114139367 114153445 114161730
XHE116707484 116714655 116728004
PRET103471616(f9) 103475255(proc) 103475699
PFOR103138877 103140167(f9) 103152964(proc)
PLAI106940167 106941078 106945726(f9) 106951497(proc)
PMEI106914303(proc) 106916355(f9) 106917156 106926451
GAF122832819 122837096(f9a) 122845323
CVG107084182 107089261 107103483
CTUL119786309(f9a) 119791588 119795204
GMU124860629(f9a) 124876095(f9b) 124884100
NFU107386752(f9)
KMR108238908(f9b) 108250981
ALIM106524024(f9) 106534439
NWH119411452 119419953(f9b)
AOCE111567418 111579637 111583320
CSEM103378120 103390768(f9) 103395530
POV109635678(f9) 109643586
SSEN122760751 122773154 122778257(f9a) 122779212(f9b)
HHIP117768879(f9a) 117772464 117774356(f9b)
LCF108872530 108893791 108902924
SDU111216838 111217075 111232459(f9)
SLAL111646698 111666341 111672128
XGL120785141(f9a) 120791817 120802120(f9b)
HCQ109510358 109511925(f9)
BPEC110155882 110158837(f9) 110174768
MALB109955339 109959991
SASA100380442(fa9) 106602969(f9) 106611733 106612366
OTW112216678 112228949(f9b) 112256184(f9a) 112265006
OMY110490052 110504952(f9a) 110507316 110534144(f9b)
OGO123993164 123994829 124006117(f9b) 124011005
ONE115106768 115129409 115135497(f9) 115137179
SALP111949682 111951166 111960637 111967439
SNH120018467 120028772 120057325(f9b) 120062323
ELS105029672 105029823 109614554
SFM108922151 108922945 108929003
PKI111835018 111837223 111859692
AANG118210210 118224271(f9a) 118236647
LOC102691633 102698954(f9)
PSPA121317879(f9b) 121322738
ARUT117412272 117430184
LCM102357491(F9)
CMK103178220(f9) 103179434
RTP109929282
BFO118406418
BBEL109483133
SCLV120345815
MDE105262172
AARA120904390
MPHA105831068
PFUC122520349
SLIU111356960 111357163
HHAL106689756
FOC113210820
FCD110842688
PJA122244892
PCHN125044487
HAME121859461
DSV119457932
RSAN119379359 119396908
RMP119174990
VDE111248144
VJA111261258
SDM118188966 118193394
MMER123529175 123530131
NVE5510641
ATEN116287514 116301277
TADTRIADDRAFT_26286
 » show all
Reference
1  [PMID:1012029]
  Authors
Fujikawa K, Davie EW.
  Title
Bovine factor IX (Christmas factor).
  Journal
Methods Enzymol 45:74-83 (1976)
DOI:10.1016/S0076-6879(76)45011-5
Reference
2  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
DOI:10.1002/9780470122938.ch6
Reference
3  [PMID:6412750]
  Authors
Link RP, Castellino FJ.
  Title
Kinetic comparison of bovine blood coagulation factors IXa alpha and IXa beta toward bovine factor X.
  Journal
Biochemistry 22:4033-41 (1983)
DOI:10.1021/bi00286a007
Reference
4  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.22
IUBMB Enzyme Nomenclature: 3.4.21.22
ExPASy - ENZYME nomenclature database: 3.4.21.22
BRENDA, the Enzyme Database: 3.4.21.22
CAS: 37316-87-3

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