KEGG   ENZYME: 3.4.21.22Help
Entry
EC 3.4.21.22                Enzyme                                 

Name
coagulation factor IXa;
activated Christmas factor;
blood-coagulation factor IXa;
activated blood-coagulation factor IX;
autoprothrombin II;
blood platelet cofactor II;
activated blood coagulation factor XI
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Ile bond in factor X to form factor Xa
Comment
A chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family)
History
EC 3.4.21.22 created 1978
Orthology
K01321  coagulation factor IX (Christmas factor)
Genes
HSA: 2158(F9)
PTR: 465887(F9)
PPS: 100969131(F9)
GGO: 101128865(F9)
PON: 100446459(F9)
NLE: 100598601(F9)
MCC: 695578(F9)
MCF: 102146175(F9)
CSAB: 103232665(F9)
RRO: 104682195(F9)
CJC: 100398468(F9)
SBQ: 101046698(F9)
MMU: 14071(F9)
RNO: 24946(F9)
CGE: 100757213(F9)
NGI: 103724689(F9)
HGL: 101724977(F9)
CCAN: 109675816(F9)
OCU: 100009113(F9)
TUP: 102484971(F9)
CFA: 404015(F9)
AML: 100468418(F9)
UMR: 103672846(F9)
ORO: 101385212(F9)
FCA: 493973(F9)
PTG: 102971107(F9)
AJU: 106969973(F9)
BTA: 280688(F9)
BOM: 102285916(F9)
BIU: 109555385(F9)
PHD: 102315574(F9)
CHX: 102174637(F9)
OAS: 443316(F9)
SSC: 397518(F9)
CFR: 102513153(F9)
CDK: 105086028(F9)
BACU: 103020493(F9)
LVE: 103090469(F9)
OOR: 101271539(F9)
ECB: 100054449(F9)
EPZ: 103567516(F9)
EAI: 106840103(F9)
MYB: 102257875(F9)
MYD: 102757434(F9)
HAI: 109388665(F9)
RSS: 109457519(F9)
PALE: 102881862(F9)
LAV: 100663465(F9)
TMU: 101352726
MDO: 100012394(F9)
SHR: 100921381(F9)
OAA: 100082935(F9)
GGA: 374258(F9)
MGP: 100551218(F9)
CJO: 107312750(F9)
APLA: 101799046 101804105(F9)
ACYG: 106037454(F9)
TGU: 100225886(F9)
GFR: 102038061(F9)
FAB: 101810173(F9)
PHI: 102114302(F9)
PMAJ: 107203652(F9)
CCW: 104691321(F9)
FPG: 101924325(F9)
FCH: 102052819(F9)
CLV: 102088048(F9)
EGZ: 104130320(F9)
AAM: 106484761(F9)
ASN: 102384799(F9)
AMJ: 102565567(F9)
PSS: 102463532(F9)
CMY: 102938403(F9)
CPIC: 101937636(F9)
ACS: 100563567(f9)
PBI: 103058462(F9)
GJA: 107116105(F9)
XLA: 100049721(f9.S) 108698922(f9.L)
XTR: 496659(f9)
NPR: 108793198(F9)
DRE: 678552(f9b)
AMEX: 103022627(f9) 103033862
TRU: 101068927(f9) 445943(f9)
OLA: 111948660
PRET: 103471616(f9) 103475255(proc) 103475699
NFU: 107386752(f9)
CSEM: 103390768(f9) 103395530
HCQ: 109511925(f9)
BPEC: 110155882 110158837(f9)
LCM: 102357491(F9)
 » show all
Taxonomy
Reference
1  [PMID:1012029]
  Authors
Fujikawa K, Davie EW.
  Title
Bovine factor IX (Christmas factor).
  Journal
Methods Enzymol 45:74-83 (1976)
DOI:10.1016/S0076-6879(76)45011-5
Reference
2  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
Reference
3  [PMID:6412750]
  Authors
Link RP, Castellino FJ.
  Title
Kinetic comparison of bovine blood coagulation factors IXa alpha and IXa beta toward bovine factor X.
  Journal
Biochemistry 22:4033-41 (1983)
Reference
4  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.22
IUBMB Enzyme Nomenclature: 3.4.21.22
ExPASy - ENZYME nomenclature database: 3.4.21.22
BRENDA, the Enzyme Database: 3.4.21.22
CAS: 37316-87-3

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