KEGG   ENZYME: 3.4.21.27
Entry
EC 3.4.21.27                Enzyme                                 

Name
coagulation factor XIa;
blood-coagulation factor XIa;
activated blood-coagulation factor XI;
activated plasma thromboplastin antecedent
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Ala and Arg!Val bonds in factor IX to form factor IXa
Comment
In peptidase family S1 (trypsin family), and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa
History
EC 3.4.21.27 created 1978
Orthology
K01323  coagulation factor XI
Genes
HSA: 2160(F11)
PTR: 461643(F11)
PPS: 100986597(F11)
GGO: 101144810(F11)
PON: 100443368(F11)
NLE: 100594390(F11)
MCC: 702117(F11)
MCF: 102143421(F11)
CSAB: 103236638(F11)
RRO: 104673818(F11)
RBB: 108522438(F11)
CJC: 100409213(F11)
SBQ: 101048656(F11)
MMU: 109821(F11)
MCAL: 110300267(F11)
MPAH: 110337055(F11)
RNO: 290757(F11)
MUN: 110558005
CGE: 100768163(F11)
NGI: 103750494(F11)
HGL: 101717554(F11)
CCAN: 109684333(F11)
OCU: 100009596(F11)
TUP: 102486112(F11)
CFA: 475623(F11)
VVP: 112934788(F11)
AML: 100468102(F11)
UMR: 103681005(F11)
UAH: 113262289
ORO: 101379606(F11)
ELK: 111144552
FCA: 101094340
PTG: 102971589(F11)
PPAD: 109250989(F11)
AJU: 106982228
BTA: 407998(F11)
BOM: 102269276(F11)
BIU: 109553537(F11)
BBUB: 102397200(F11)
CHX: 102184496(F11)
OAS: 101116630(F11)
SSC: 110257404(F11)
CFR: 102512586(F11)
CDK: 105102382(F11)
BACU: 103000341(F11)
LVE: 103081629(F11)
OOR: 101278094
DLE: 111173428
ECB: 100056603(F11)
EPZ: 103543237(F11)
EAI: 106840364(F11)
MYB: 102250308(F11)
MYD: 102765408(F11)
MNA: 107534053(F11)
PALE: 102886513
MJV: 108396404(F11)
LAV: 100660487
MDO: 100013939(F11)
SHR: 100914754(F11)
PCW: 110195650
OAA: 100089965
IPU: 108257189
PHYP: 113536074
LCO: 104920427
XMA: 111609537
KMR: 108238782
POV: 109631873
BPEC: 110167400
CIN: 100184334
VEM: 105559925
TCA: 664603
ATD: 109595979
TNL: 113496261
CSCU: 111637837
 » show all
Reference
1
  Authors
Kurachi, K. and Davie, E.W.
  Title
Human factor XI (plasma thromboplastin antecedent).
  Journal
Methods Enzymol 80:211-220 (1981)
Reference
2  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009
Reference
3  [PMID:3636155]
  Authors
Fujikawa K, Chung DW, Hendrickson LE, Davie EW.
  Title
Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein.
  Journal
Biochemistry 25:2417-24 (1986)
DOI:10.1021/bi00357a018
  Sequence
[hsa:2160]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.27
IUBMB Enzyme Nomenclature: 3.4.21.27
ExPASy - ENZYME nomenclature database: 3.4.21.27
BRENDA, the Enzyme Database: 3.4.21.27
CAS: 37203-61-5

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