KEGG   ENZYME: 3.4.21.34
Entry
EC 3.4.21.34                Enzyme                                 

Name
plasma kallikrein;
serum kallikrein;
kininogenin;
kallikrein I;
kallikrein II;
kininogenase;
kallikrein;
callicrein;
glumorin;
padreatin;
padutin;
kallidinogenase;
bradykininogenase;
panceatic kallikrein;
onokrein P;
dilminal D;
depot-Padutin;
urokallikrein;
urinary kallikrein
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of some Arg! and Lys! bonds, including Lys!Arg and Arg!Ser in (human) kininogen to release bradykinin
Comment
Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates.
History
EC 3.4.21.34 created 1965 as EC 3.4.4.21, transferred 1972 to EC 3.4.21.8, part transferred 1981 to EC 3.4.21.34
Orthology
K01324  plasma kallikrein
Genes
HSA: 3818(KLKB1)
PTR: 471375(KLKB1)
PPS: 100985593(KLKB1)
GGO: 101142617(KLKB1)
PON: 100172926(KLKB1)
NLE: 100594044 115835879
MCC: 696639(KLKB1)
MCF: 102142369(KLKB1)
CSAB: 103236637(KLKB1)
RRO: 104673817(KLKB1)
RBB: 108522428(KLKB1)
CJC: 100409572(KLKB1)
SBQ: 101048983(KLKB1)
MMU: 16621(Klkb1)
MCAL: 110299702(Klkb1)
MPAH: 110336817(Klkb1)
RNO: 25048(Klkb1)
MUN: 110558008(Klkb1)
CGE: 100767873(Klkb1)
NGI: 103750509(Klkb1)
HGL: 101719264(Klkb1)
CCAN: 109684302(Klkb1)
OCU: 100356267(KLKB1)
TUP: 102485674(KLKB1)
CFA: 475624(KLKB1)
VVP: 112934777(KLKB1)
AML: 100468355(KLKB1)
UMR: 103680968(KLKB1)
UAH: 113262285(KLKB1)
ORO: 101379313(KLKB1)
ELK: 111144530
FCA: 101094092(KLKB1)
PTG: 102971874(KLKB1)
PPAD: 109250991(KLKB1)
AJU: 106982221(KLKB1)
BTA: 533547(KLKB1)
BOM: 102270694(KLKB1)
BIU: 109553560(KLKB1)
BBUB: 102396882(KLKB1)
CHX: 102184030(KLKB1)
OAS: 101116376(KLKB1)
SSC: 397144(KLKB1)
CFR: 102512343(KLKB1)
CDK: 105102384(KLKB1)
PCAD: 112063073
ECB: 100056650(KLKB1)
EAI: 106840366(KLKB1)
MYB: 102247445(KLKB1)
MYD: 102764838(KLKB1)
MNA: 107534033(KLKB1)
HAI: 109395838(KLKB1)
DRO: 112306752(KLKB1)
PALE: 102883484(KLKB1)
RAY: 107510433(KLKB1)
MJV: 108396405(KLKB1)
LAV: 100660779
TMU: 101358166
MDO: 100013981(KLKB1)
SHR: 100917450(KLKB1)
OAA: 100086786
GGA: 422723(F11)
MGP: 100549617
CJO: 107313680
NMEL: 110397297
APLA: 101805242
ACYG: 106035178
TGU: 100228027
LSR: 110474988
SCAN: 103826205
GFR: 102045543(F11)
FAB: 101814154(KLKB1)
PHI: 102108065(F11)
PMAJ: 107203558
CCAE: 111927976
CCW: 104690592(KLKB1)
ETL: 114067778
FPG: 101918416(F11)
FCH: 102054661
CLV: 102094577
EGZ: 104129485
NNI: 104021299
ACUN: 113479233
PADL: 103922514
AAM: 106484024
ASN: 102385242(KLKB1)
AMJ: 102566272(KLKB1)
PSS: 102455335
CPIC: 101952530(KLKB1)
ACS: 100557428(klkb1)
PVT: 110077890(KLKB1)
PBI: 103051995(KLKB1)
PMUR: 107302682
TSR: 106542021(KLKB1)
PMUA: 114604642(KLKB1)
GJA: 107121980(KLKB1)
XLA: 446603(klkb1.L)
XTR: 100486524(klkb1)
NPR: 108784940
IPU: 108257413
PHYP: 113536237
MZE: 101476310
OLA: 101167304
CVG: 107092604
NFU: 107374492
AOCE: 111572227
SDU: 111223201
SLAL: 111673270
HCQ: 109519192
ELS: 105027740
SFM: 108938912
PKI: 111854240
LCM: 102361209(KLKB1)
RTP: 109919186
SKO: 100375116
MDE: 101900180
LCQ: 111686343
VEM: 105568413
LHU: 105671298
NVI: 100114471(SP16) 103318165
MDL: 103575539
TCA: 662662(P58)
ATD: 109602881
PRAP: 110993713
DNX: 107173926
RMD: 113548576
ZNE: 110835922
MYI: 110443096
LAK: 106151350
NVE: 5502645
ADF: 107353459
AMIL: 114955798
SPIS: 111344747
HMG: 105847477
 » show all
Reference
1  [PMID:6918767]
  Authors
Heimark RL, Davie EW.
  Title
Bovine and human plasma prekallikrein.
  Journal
Methods Enzymol 80 Pt C:157-72 (1981)
DOI:10.1016/s0076-6879(81)80016-x
Reference
2  [PMID:6976185]
  Authors
McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC.
  Title
Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates.
  Journal
Biochemistry 20:7196-206 (1981)
DOI:10.1021/bi00528a022
Reference
3  [PMID:3237096]
  Authors
Silverberg M, Kaplan AP.
  Title
Prekallikrein.
  Journal
Methods Enzymol 163:85-95 (1988)
DOI:10.1016/0076-6879(88)63010-2
Reference
4  [PMID:2598771]
  Authors
Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chretien M.
  Title
The cDNA structure of rat plasma kallikrein.
  Journal
DNA 8:563-74 (1989)
DOI:10.1089/dna.1989.8.563
  Sequence
[rno:25048]
Reference
5  [PMID:2534361]
  Authors
Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S.
  Title
Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein.
  Journal
Chem Pharm Bull (Tokyo) 37:3108-11 (1989)
DOI:10.1248/cpb.37.3108
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.34
IUBMB Enzyme Nomenclature: 3.4.21.34
ExPASy - ENZYME nomenclature database: 3.4.21.34
BRENDA, the Enzyme Database: 3.4.21.34
CAS: 410538-33-9

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