| Entry |
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| Name |
pancreatic elastase;
pancreatopeptidase E;
pancreatic elastase I;
elastase;
elaszym;
serine elastase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala!
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| Comment |
Formed by activation of proelastase from mammalian pancreas by trypsin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11
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| History |
EC 3.4.21.36 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)
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| Orthology |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Shotton, D.M. |
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| Title |
Elastase. |
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| Journal |
Methods Enzymol 19:113-140 (1970) |
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| Reference |
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| Authors |
Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC. |
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| Title |
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates. |
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| Journal |
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| Reference |
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| Authors |
Kawashima I, Tani T, Shimoda K, Takiguchi Y. |
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| Title |
Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. |
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| Journal |
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| Reference |
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| Authors |
Bieth JG, Dirrig S, Jung ML, Boudier C, Papamichael E, Sakarellos C, Dimicoli JL. |
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| Title |
Investigation of the active center of rat pancreatic elastase. |
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| Journal |
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| Reference |
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| Authors |
Bode W, Meyer E Jr, Powers JC. |
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| Title |
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.36 |
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