KEGG   ENZYME: 3.4.21.36Help
Entry
EC 3.4.21.36                Enzyme                                 

Name
pancreatic elastase;
pancreatopeptidase E;
pancreatic elastase I;
elastase;
elaszym;
serine elastase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala!
Comment
Formed by activation of proelastase from mammalian pancreas by trypsin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11
History
EC 3.4.21.36 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)
Orthology
K01326  pancreatic elastase I
Genes
HSA: 1990(CELA1)
PTR: 740437(CELA1)
PPS: 100976646(CELA1)
GGO: 101143430(CELA1)
PON: 100450522(CELA1)
NLE: 100582065(CELA1)
MCC: 695507(CELA1)
MCF: 102139348(CELA1)
CSAB: 103238322(CELA1)
RRO: 104670677(CELA1)
RBB: 108521573(CELA1)
CJC: 100390402(CELA1)
SBQ: 101036476(CELA1)
MMU: 109901(Cela1)
MCAL: 110310384(Cela1)
MPAH: 110334999(Cela1)
RNO: 24331(Cela1)
MUN: 110562116(Cela1)
CGE: 100750829(Cela1)
NGI: 103739592(Cela1)
HGL: 101715061(Cela1)
CCAN: 109685226(Cela1)
OCU: 100348556(CELA1)
TUP: 102501966(CELA1)
CFA: 403515(CELA1)
VVP: 112921148(CELA1)
AML: 100477910(CELA1)
UMR: 103675492(CELA1)
UAH: 113257608(CELA1)
ORO: 101378556(CELA1)
FCA: 494217(CELA1)
PTG: 102970463(CELA1)
AJU: 106969209(CELA1)
BTA: 281139(CELA1)
BOM: 102265097(CELA1)
BIU: 109559087(CELA1)
BBUB: 102398695(CELA1)
CHX: 102187460(CELA1)
OAS: 101114258(CELA1)
SSC: 396766(CELA1)
CFR: 102517832(CELA1)
CDK: 105107155(CELA1)
BACU: 103016249(CELA1)
LVE: 103073295(CELA1)
OOR: 101276770(CELA1)
DLE: 111173681(CELA1)
PCAD: 102974342(CELA1)
ECB: 100052672(CELA1)
EPZ: 103545629(CELA1)
EAI: 106835230(CELA1)
MYB: 102247948(CELA1)
MYD: 102768502(CELA1)
MNA: 107528159(CELA1)
HAI: 109371421(CELA1)
DRO: 112318498(CELA1)
PALE: 102894029(CELA1)
RAY: 107509814(CELA1)
MJV: 108401690(CELA1)
LAV: 100676855(CELA1)
TMU: 101357926
SHR: 100934635(CELA1)
PCW: 110194049(CELA1)
GGA: 425200(CELA1)
MGP: 100543650(CELA1)
CJO: 107325771(CELA1)
NMEL: 110389208(CELA1)
APLA: 101796072(CELA1)
ACYG: 106048709(CELA1)
TGU: 100221837
LSR: 110477839(CELA1) 110481815
SCAN: 103825509(CELA1)
FAB: 101814575(CELA1)
PHI: 102106901 102107083(CELA1) 102110430
PMAJ: 107199081(CELA1) 107215653
CCAE: 111940565
CCW: 104683700 104686505
FPG: 101916345(CELA1) 101922556
FCH: 102047421(CELA1)
NNI: 104019207(CELA1)
ACUN: 113491005(CELA1)
PADL: 103926268(CELA1)
AAM: 106484943(CELA1) 106490266
ASN: 102373062
AMJ: 102576128
PSS: 102448958 102454481(CELA1) 102463241
CPIC: 101952427(CELA1)
ACS: 100567701(cela1)
PVT: 110074414(CELA1)
PBI: 103057004(CELA1)
GJA: 107107390 107122101(CELA1)
XLA: 108707551 108718720 379467(cela1.L) 398300(cela1) 444358 447166 734670
XTR: 100135144(Elas) 100170431(cela1) 101730694 496972 496993(cela1) 595061(ela1)
NPR: 108799131 108799132 108799135 108799136
DRE: 445032(cela1.3) 445282(cela1.6)
SRX: 107721235 107727187
SANH: 107694262(cela1) 107698556
SGH: 107566436 107570146
CCAR: 109064316 109064772(cela1) 109095828
IPU: 108255297(tmprss12)
PHYP: 113537786
AMEX: 103039974 103040289 103040969
EEE: 113580603(cela1) 113590533
TRU: 101061139 101078582 115246798
TNG: GSTEN00033842G001 GSTEN00033843G001
LCO: 104922033 104922034 104922035
NCC: 104958759 104964279
MZE: 101480566 101480856 112434834
ONL: 100695248 100711148
OLA: 101155843 101156080 101156319
XMA: 102222248 102227665 111605784 111605785
XCO: 114136090 114136175
PRET: 103464657(cela1) 103464856
CVG: 107096176 107102979 107103436 107103448
NFU: 107385386 107385387
KMR: 108231507 108231669 108231670
ALIM: 106517591 106517653
AOCE: 111576043 111576044 111576047
CSEM: 103386708 103386709 103386721
POV: 109635616 109635618
LCF: 108902128 108902129
SDU: 111233576 111233577 111233578
SLAL: 111655087 111655090 111655102
HCQ: 109521386 109521676
BPEC: 110173733 110173734 110173767 110173768 110173769 110173770
MALB: 109964907 109965486
SASA: 106566159 106566160 106566163
OTW: 112221936 112221943
SALP: 112072806
ELS: 105008138 105028855 105028857 105028858 105028859 105028860 105028861 105028862 105028863 105028864 105028867 106024132 114828646 114828906 114828908 114832647
SFM: 108928375 108931181 114909327 114909328 114909329 114909331 114909338 114909339 114909340 114909341 114909342 114909343 114909344 114909358 114909359 114909363 114909364 114909761 114909764 114909765 114909766 114909768 114909769 114909770 114909771
PKI: 111835297
LCM: 102347906 102349204 102353251(CELA1)
CMK: 103189977(cela1)
RTP: 109925812
BFO: BRAFLDRAFT_282807
PCAN: 112563167 112563174 112563175
 » show all
Taxonomy
Reference
1
  Authors
Shotton, D.M.
  Title
Elastase.
  Journal
Methods Enzymol 19:113-140 (1970)
Reference
2  [PMID:6380580]
  Authors
Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.
  Title
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
  Journal
Biochemistry 23:2995-3002 (1984)
Reference
3  [PMID:3646943]
  Authors
Kawashima I, Tani T, Shimoda K, Takiguchi Y.
  Title
Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.
  Journal
DNA 6:163-72 (1987)
DOI:10.1089/dna.1987.6.163
Reference
4  [PMID:2909256]
  Authors
Bieth JG, Dirrig S, Jung ML, Boudier C, Papamichael E, Sakarellos C, Dimicoli JL.
  Title
Investigation of the active center of rat pancreatic elastase.
  Journal
Biochim Biophys Acta 994:64-74 (1989)
DOI:10.1016/0167-4838(89)90063-0
Reference
5  [PMID:2655701]
  Authors
Bode W, Meyer E Jr, Powers JC.
  Title
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
  Journal
Biochemistry 28:1951-63 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.36
IUBMB Enzyme Nomenclature: 3.4.21.36
ExPASy - ENZYME nomenclature database: 3.4.21.36
BRENDA, the Enzyme Database: 3.4.21.36
CAS: 9004-06-2

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