KEGG   ENZYME: 3.4.21.36
Entry
EC 3.4.21.36                Enzyme                                 

Name
pancreatic elastase;
pancreatopeptidase E;
pancreatic elastase I;
elastase;
elaszym;
serine elastase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala!
Comment
Formed by activation of proelastase from mammalian pancreas by trypsin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11
History
EC 3.4.21.36 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)
Orthology
K01326  pancreatic elastase I
Genes
HSA: 1990(CELA1)
PTR: 740437(CELA1)
PPS: 100976646(CELA1)
GGO: 101143430(CELA1)
PON: 100450522(CELA1)
NLE: 100582065(CELA1)
MCC: 695507(CELA1)
MCF: 102139348(CELA1)
CSAB: 103238322(CELA1)
RRO: 104670677(CELA1)
RBB: 108521573(CELA1)
CJC: 100390402(CELA1)
SBQ: 101036476(CELA1)
MMU: 109901(Cela1)
MCAL: 110310384(Cela1)
MPAH: 110334999(Cela1)
RNO: 24331(Cela1)
MUN: 110562116(Cela1)
CGE: 100750829(Cela1)
NGI: 103739592(Cela1)
HGL: 101715061(Cela1)
CCAN: 109685226(Cela1)
OCU: 100348556(CELA1)
TUP: 102501966(CELA1)
CFA: 403515(CELA1)
VVP: 112921148(CELA1)
AML: 100477910(CELA1)
UMR: 103675492(CELA1)
UAH: 113257608(CELA1)
ORO: 101378556(CELA1)
ELK: 111157854
FCA: 494217(CELA1)
PTG: 102970463(CELA1)
BTA: 281139(CELA1)
BOM: 102265097(CELA1)
BIU: 109559087(CELA1)
BBUB: 102398695(CELA1)
CHX: 102187460(CELA1)
OAS: 101114258(CELA1)
SSC: 396766(CELA1)
CFR: 102517832(CELA1)
CDK: 105107155(CELA1)
BACU: 103016249(CELA1)
LVE: 103073295(CELA1)
OOR: 101276770(CELA1)
DLE: 111173681(CELA1)
PCAD: 102974342(CELA1)
ECB: 100052672(CELA1)
EPZ: 103545629(CELA1)
EAI: 106835230(CELA1)
MYB: 102247948(CELA1)
MYD: 102768502(CELA1)
MNA: 107528159(CELA1)
HAI: 109371421(CELA1)
DRO: 112318498(CELA1)
PALE: 102894029(CELA1)
RAY: 107509814(CELA1)
MJV: 108401690(CELA1)
LAV: 100676855(CELA1)
TMU: 101357926
SHR: 100934635(CELA1)
PCW: 110194049(CELA1)
GGA: 425200(CELA1)
MGP: 100543650(CELA1)
CJO: 107325771(CELA1)
NMEL: 110389208(CELA1)
APLA: 101796072(CELA1)
ACYG: 106048709(CELA1)
LSR: 110477839(CELA1) 110481815
SCAN: 103825509(CELA1)
FAB: 101814575(CELA1)
PMAJ: 107199081(CELA1) 107215653
CCAE: 111940565
CCW: 104686505
FPG: 101916345(CELA1) 101922556
FCH: 102047421(CELA1)
NNI: 104019207(CELA1) 104021776
ACUN: 113491005(CELA1)
PADL: 103926268(CELA1)
AAM: 106484943(CELA1) 106490266
ASN: 102373062
AMJ: 102576128
CPIC: 101952427(CELA1)
ACS: 100567701(cela1)
PVT: 110074414(CELA1)
PBI: 103057004(CELA1)
GJA: 107107390 107122101(CELA1)
XTR: 100135144(cela1.6) 100170431(cela1.1) 496972(cela1.5) 496993(cela1.2) 595061(cela1.4)
DRE: 100334908 100535584(cela1.2) 445032(cela1.3) 445282(cela1.6) 574008(cela1.4)
SANH: 107694262(cela1) 107698556
IPU: 108255297(tmprss12)
PHYP: 113537786
EEE: 113580603(cela1) 113590533
PRET: 103464657(cela1) 103464856
SALP: 112072806
PKI: 111835297
CMK: 103189977(cela1)
RTP: 109925812
BFO: 118428236
SKO: 100375882
TCA: 100141575 100141641(h103) 659885(P123)
BMOR: 692380
PRAP: 110995718
HAW: 110379155
TUT: 107361579
MYI: 110460740
EPA: 110238475
AMIL: 114965735
 » show all
Reference
1
  Authors
Shotton, D.M.
  Title
Elastase.
  Journal
Methods Enzymol 19:113-140 (1970)
Reference
2  [PMID:6380580]
  Authors
Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.
  Title
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
  Journal
Biochemistry 23:2995-3002 (1984)
DOI:10.1021/bi00308a023
Reference
3  [PMID:3646943]
  Authors
Kawashima I, Tani T, Shimoda K, Takiguchi Y.
  Title
Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.
  Journal
DNA 6:163-72 (1987)
DOI:10.1089/dna.1987.6.163
Reference
4  [PMID:2909256]
  Authors
Bieth JG, Dirrig S, Jung ML, Boudier C, Papamichael E, Sakarellos C, Dimicoli JL.
  Title
Investigation of the active center of rat pancreatic elastase.
  Journal
Biochim Biophys Acta 994:64-74 (1989)
DOI:10.1016/0167-4838(89)90063-0
Reference
5  [PMID:2655701]
  Authors
Bode W, Meyer E Jr, Powers JC.
  Title
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
  Journal
Biochemistry 28:1951-63 (1989)
DOI:10.1021/bi00431a001
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.36
IUBMB Enzyme Nomenclature: 3.4.21.36
ExPASy - ENZYME nomenclature database: 3.4.21.36
BRENDA, the Enzyme Database: 3.4.21.36
CAS: 9004-06-2

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