KEGG ENZYME: 3.4.21.36

ENZYME: 3.4.21.36

Entry

EC 3.4.21.36                Enzyme

Name

pancreatic elastase;
pancreatopeptidase E;
pancreatic elastase I;
elastase;
elaszym;
serine elastase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Hydrolysis of proteins, including elastin. Preferential cleavage: Ala!

Comment

Formed by activation of proelastase from mammalian pancreas by trypsin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11

History

EC 3.4.21.36 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)

Orthology

K01326

pancreatic elastase I

Genes

HSA:	1990(CELA1)

PTR:	740437(CELA1)

PPS:	100976646(CELA1)

GGO:	101143430(CELA1)

PON:	100450522(CELA1)

NLE:	100582065(CELA1)

HMH:	116461942(CELA1)

MCC:	695507(CELA1)

MCF:	102139348(CELA1)

MTHB:

126931069

MNI:	105474403(CELA1)

CSAB:

103238322(CELA1)

CATY:

105580335(CELA1)

PANU:

101017405(CELA1)

TGE:	112634318(CELA1)

MLEU:

105555511(CELA1)

RRO:	104670677(CELA1)

RBB:	108521573(CELA1)

TFN:	117090111(CELA1)

PTEH:

111541989(CELA1)

CANG:

105503631(CELA1)

CJC:	100390402(CELA1)

SBQ:	101036476(CELA1)

CIMI:

108316006(CELA1)

CSYR:

103259496(CELA1)

MMUR:

105871431(CELA1)

LCAT:

123640362(CELA1)

PCOQ:

105818446(CELA1)

OGA:	100952933(CELA1)

MMU:	109901(Cela1)

MCAL:

110310384(Cela1)

MPAH:

110334999(Cela1)

RNO:	24331(Cela1)

MCOC:

116082165(Cela1)

ANU:	117719376(Cela1)

MUN:	110562116(Cela1)

CGE:	100750829(Cela1)

MAUA:

101837660

PROB:

127226222(Cela1)

PLEU:

114696589(Cela1)

MORG:

121441508(Cela1)

MFOT:

126488771

AAMP:

119823569(Cela1)

NGI:	103739592(Cela1)

HGL:	101715061(Cela1)

CPOC:

100717214(Cela1)

CCAN:

109685226(Cela1)

DORD:

105987421(Cela1)

DSP:	122098353(Cela1)

NCAR:

124983609

OCU:

100348556

OPI:	101528047(CELA1)

TUP:	102501966(CELA1)

GVR:	103585233(CELA1)

CFA:	403515(CELA1)

CLUD:

112667257(CELA1)

VVP:	112921148(CELA1)

VLG:	121480381(CELA1)

AML:	100477910(CELA1)

UMR:	103675492(CELA1)

UAH:	113257608(CELA1)

UAR:	123794568(CELA1)

ELK:

111157854

LLV:

125106471

MPUF:

101681795(CELA1)

NVS:	122891998(CELA1)

ORO:	101378556(CELA1)

EJU:	114225754(CELA1)

ZCA:	113921656(CELA1)

MLX:	118009014(CELA1)

NSU:	110593557(CELA1)

LWW:	102739438(CELA1)

FCA:	494217(CELA1)

PYU:	121038565(CELA1)

PCOO:

112867476(CELA1)

PBG:	122473405(CELA1)

LRUF:

124501411

PTG:	102970463(CELA1)

PUC:

125919057

HHV:	120237869(CELA1)

BTA:	281139(CELA1)

BOM:	102265097(CELA1)

BIU:	109559087(CELA1)

BBUB:

102398695(CELA1)

BBIS:

105001528(CELA1)

CHX:	102187460(CELA1)

OAS:	101114258(CELA1)

ODA:	120858230(CELA1)

CCAD:

122427330(CELA1)

SSC:	396766(CELA1)

CFR:	102517832(CELA1)

CBAI:

105076244(CELA1)

CDK:	105107155(CELA1)

VPC:	102527457(CELA1)

BACU:

103016249(CELA1)

LVE:	103073295(CELA1)

OOR:	101276770(CELA1)

DLE:	111173681(CELA1)

PCAD:

102974342(CELA1)

PSIU:

116760273(CELA1)

NASI:

112394060(CELA1)

ECB:	100052672(CELA1)

EPZ:	103545629(CELA1)

EAI:	106835230(CELA1)

MYB:	102247948(CELA1)

MYD:	102768502(CELA1)

MMYO:

118651592(CELA1)

MLF:	102425049(CELA1)

MNA:	107528159(CELA1)

PKL:	118729955(CELA1)

HAI:	109371421(CELA1)

DRO:	112318498(CELA1)

SHON:

118976499(CELA1)

AJM:	119043253(CELA1)

PDIC:

114513590(CELA1)

PHAS:

123812399(CELA1)

MMF:	118624215(CELA1)

RFQ:	117028478(CELA1)

PALE:

102894029(CELA1)

PGIG:

120602185(CELA1)

PVP:	105307020(CELA1)

RAY:	107509814(CELA1)

MJV:	108401690(CELA1)

TOD:	119247933(CELA1)

SARA:

101540175(CELA1)

LAV:	100676855(CELA1)

TMU:

101357926

ETF:	101641967(CELA1)

DNM:	101414606(CELA1)

GAS:	123249383(CELA1)

SHR:	100934635(CELA1)

AFZ:

127537940

PCW:	110194049(CELA1)

GGA:	425200(CELA1)

PCOC:

116235256(CELA1)

MGP:	100543650(CELA1)

CJO:	107325771(CELA1)

NMEL:

110389208(CELA1)

APLA:

101796072(CELA1)

ACYG:

106048709(CELA1)

AFUL:

116499837(CELA1)

TGU:	100221837 115491516

LSR:	110477839(CELA1) 110481815

SCAN:

103825509(CELA1)

PMOA:

120500616

OTC:	121343207(CELA1)

PRUF:

121355270(CELA1)

FAB:	101814575(CELA1)

PHI:	102106901 102107083 102110430

PMAJ:

107199081(CELA1) 107215653

CCAE:

111940565

CCW:

104686505

CBRC:

103611939(CELA1) 103623983

ACHL:

103799780

SVG:	106862694(CELA1)

FPG:	101916345(CELA1) 101922556

FCH:	102047421(CELA1) 102049653

NNI:	104019207(CELA1) 104021776

PLET:

104623491

PCRI:

104029719

PCAO:

104039511

ACUN:

113491005(CELA1)

TALA:

104362533 116962754(CELA1)

PADL:

103926268(CELA1)

AFOR:

103896182 103906277(CELA1)

ACHC:

115339281 115350932(CELA1)

HALD:

104315431(CELA1) 104325027

HLE:	104829083 104832387(CELA1)

AGEN:

126037957 126046754

GCL:	127012704 127028370

CCRI:

104165414(CELA1) 104167619

CSTI:

104555973

EHS:	104505048 104507676(CELA1)

CMAC:

104481329

MUI:	104544685 104548512(CELA1)

GSTE:

104254078 104254860

LDI:

104351171

MNB:	103776141(CELA1) 103777738 103777739

OHA:	104336180(CELA1)

NNT:	104413213(CELA1)

SHAB:

115618604(CELA1)

DPUB:

104302131 104302322

ACAR:

104524145(CELA1) 104532936

CPEA:

104396063(CELA1)

AVIT:

104272591(CELA1)

CVF:	104284142(CELA1) 104291266

CUCA:

104059898(CELA1)

BRHI:

104491351

AAM:	106484943(CELA1) 106490266

AROW:

112972125(CELA1) 112978271

NPD:	112952274(CELA1)

TGT:	104574908(CELA1)

DNE:	112981555 112991461(CELA1)

SCAM:

104148805

ASN:

102373062

AMJ:

102576128

CPOO:

109321009

GGN:

109291075

PSS:	102448958 102454481(CELA1) 102463241

CMY:	119564313 119564316

CPIC:

101952427(CELA1)

TST:	117873949 117888768(CELA1)

CABI:

116828524(CELA1)

MRV:	120390814(CELA1) 120398331

ACS:	100567701(cela1)

PVT:	110074414(CELA1)

SUND:

121922753(CELA1)

PBI:	103057004(CELA1)

PGUT:

117663091(CELA1)

VKO:	123029820(CELA1)

HCG:	128345844(CELA1)

GJA:	107107390 107122101(CELA1)

XLA:	108707551(cela1.3.L) 108718720 379467(cela1.1.L) 398300(cela1.2.L) 444358(cela1.4.L) 447166(cela1.1.S) 734670(cela1.5.L)

XTR:	100135144(cela1.6) 100170431(cela1.1) 496972(cela1.5) 496993(cela1.2) 595061(cela1.4)

NPR:	108799131 108799132 108799135 108799136

RTEM:

120929415 120929416 120929417 120929418

BBUF:

120993948 120993949 120993950 120993951 120993952 120993953 120996160 120996161 120996162

BGAR:

122931373 122931374 122931375 122931376 122931377 122931378 122931379 122931439 122931440 122932370 122932499

DRE:	100334908 100535584(cela1.2) 445032(cela1.3) 445282(cela1.6) 574008(cela1.4)

SRX:	107721235 107727187

SANH:

107694262(cela1) 107698556

SGH:	107566436 107570146

CCAR:

109064316 109064772(cela1) 109095828

CAUA:

113039478 113040710 113040754 113076267 113083500 113092165

CGIB:

127942880 127988174 127988514

PPRM:

120474270 120474286(cela1.6)

MAMB:

125263462 125263464 125263465 125263467 125263469

CIDE:

127519846 127519847

MASI:

127438482 127439030

IPU:

108255297

PHYP:

113537786

SMEO:

124402006

TFD:	113639119(cela1.6)

AMEX:

103039974 103040289 103040969

EEE:	113580603(cela1) 113590533

TRU:	101061139 101078582 115246798

TNG:	GSTEN00033842G001 GSTEN00033843G001

LCO:	104922033 104922034 104922035

NCC:	104958759 104964279

CGOB:

115007747 115008133

ELY:	117256300 117257532 117257533

EFO:	125887960 125887970 125889526

PLEP:

121949361 121950040 121956806

SLUC:

116051564 116051565

ECRA:

117943472 117943473

ESP:	116687750 116687751

PFLV:

114554111 114554298

GAT:	120835835 120835837

PPUG:

119229690 119229691

MSAM:

119886402 119886403 119886405

CUD:	121507047 121507175 121527331 121527664 121528438

ALAT:

119008969 119021248 119021932 119021933

MZE:	101480566 101480856 112434834

ONL:	100695248 100711148

OAU:	116326855 116326856

OLA:	101155843 101156080 101156319

OML:	112145106 112145107 112145108

XMA:	102222248 102227665 111605784 111605785

XCO:	114136090 114136175

XHE:

116709845

PRET:

103464657(cela1) 103464856

PFOR:

103150137 103155732

PLAI:

106952143 106957078

PMEI:

106923337 106926983

GAF:	122833708 122834557

CVG:	107096176 107102979 107103436 107103448

CTUL:

119788659 119793546 119797900 119797982

GMU:	124856859 124856987 124857003

NFU:	107385386 107385387

KMR:	108231507 108231669 108231670

ALIM:

106517591 106517653

NWH:	119411858 119412794

AOCE:

111576043 111576044 111576047

MCEP:

125006425 125006426 125006427 125006428

CSEM:

103386708 103386709 103386721

POV:	109635616 109635618

SSEN:

122765813 122767731 122767747

HHIP:

117761344

HSP:	118104644 118104742 118104854

LCF:	108902128 108902129

SDU:	111233576 111233577 111233578

SLAL:

111655087 111655090 111655102

XGL:	120783161 120807229 120807565

HCQ:	109521386 109521676

SSCV:

125977407 125977409

BPEC:

110173733 110173734 110173767 110173768 110173769 110173770

MALB:

109964907 109965486

BSPL:

114852896 114855614 114856315 114856326

SASA:

106566159 106566160

STRU:

115151166 115207303 115207304

OTW:	112221936 112221943

OMY:	110494786 110495200

OGO:

124004103

ONE:	115121299 115121300

SALP:

112072806

SNH:	120023990 120058115 120058127

CCLU:

121575742 121575773 121575774 121575775

ELS:	105008138 105028855 105028857 105028858 105028859 105028860 105028861 105028862 105028863 105028864 105028867 106024132 114828646 114828906 114828908 114832647

SFM:	108928375 108931181 114909327 114909328 114909329 114909331 114909338 114909339 114909340 114909341 114909342 114909343 114909344 114909358 114909359 114909363 114909364 114909761 114909764 114909765 114909766 114909768 114909769 114909770 114909771

PKI:

111835297

AANG:

118226326

LOC:	102682440 102682647 102685766 102686168 102686373 102694205(cela1) 102694966 102695168 102695359

PSPA:

121313742 121325216

ARUT:

117394884 117400728 117421297

PSEX:

120524874 120530015 120530016

LCM:	102347906 102349204 102353251(CELA1)

CMK:

103189977

RTP:

109925812

CPLA:

122543357

BFO:

118428236

BBEL:

109463813

SKO:

100375882

AARA:

120901253

AMER:

121591892

ASTE:

118504872

CQU:	CpipJ_CPIJ014524 CpipJ_CPIJ016103

BCOO:

119071949

TPRE:

106649941 106654999

DAM:

107035816

AGIF:

122848403

TCA:	100141575 100141641(h103)

SOY:

115880183

ATD:	109606652 109608947

AGB:

108904599

APLN:

108736032 108743702

OTU:

111426720

MSEX:

115441484

SGRE:

126336433 126336815

DPX:	DAPPUDRAFT_306115

DMK:

116931355

HAZT:

108667907

VDE:

111251367

VJA:

111272603

TUT:

107361579

DFR:

124489771

PCAN:

112563167 112563174 112563175

BGT:	106051298 106054788 106054789 106066913 106066935 106067232 106067241 106074660 106076928 106076930 106077861 106079069

HRF:	124116237 124119804 124125091 124143995 124146749

HRJ:	124253772 124264923 124271215 124287653

CRG:	105328721 105347894 105348528

MYI:

110460740

PMAX:

117328829 117333202

MMER:

123558383

DPOL:

127853801 127853835 127866712

OSN:

115224571

EPA:

110238475

ATEN:

116307996

ADF:	107331798 107339738

AMIL:

114965735

TAD:	TRIADDRAFT_63088

» show all

Reference

Authors

Shotton, D.M.

Title

Elastase.

Journal

Methods Enzymol 19:113-140 (1970)

Reference

2 [PMID:6380580]

Authors

Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.

Title

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.

Journal

Biochemistry 23:2995-3002 (1984)
DOI:10.1021/bi00308a023

Reference

3 [PMID:3646943]

Authors

Kawashima I, Tani T, Shimoda K, Takiguchi Y.

Title

Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.

Journal

DNA 6:163-72 (1987)
DOI:10.1089/dna.1987.6.163

Reference

4 [PMID:2909256]

Authors

Bieth JG, Dirrig S, Jung ML, Boudier C, Papamichael E, Sakarellos C, Dimicoli JL.

Title

Investigation of the active center of rat pancreatic elastase.

Journal

Biochim Biophys Acta 994:64-74 (1989)
DOI:10.1016/0167-4838(89)90063-0

Reference

5 [PMID:2655701]

Authors

Bode W, Meyer E Jr, Powers JC.

Title

Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.

Journal

Biochemistry 28:1951-63 (1989)
DOI:10.1021/bi00431a001

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.36

IUBMB Enzyme Nomenclature:

3.4.21.36

ExPASy - ENZYME nomenclature database:

3.4.21.36

BRENDA, the Enzyme Database:

3.4.21.36

CAS:

9004-06-2

DBGET integrated database retrieval system