KEGG   ENZYME: 3.4.21.37
Entry
EC 3.4.21.37                Enzyme                                 
Name
leukocyte elastase;
lysosomal elastase;
neutrophil elastase;
polymorphonuclear leukocyte elastase;
elastase;
elaszym;
serine elastase;
granulocyte elastase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins, including elastin. Preferential cleavage Val! > Ala!
Comment
Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11
History
EC 3.4.21.37 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)
Orthology
K01327  leukocyte elastase
Genes
HSA1991(ELANE)
PPS100969272(ELANE)
PON100452808(ELANE)
PPYG129026101(ELANE)
NLE100595921(ELANE)
HMH116482905(ELANE)
MCC106992354(ELANE)
MCF102135637(ELANE)
MTHB126942977
MNI105486435(ELANE)
CSAB103233572(ELANE)
CATY105591688(ELANE)
TGE112612320(ELANE)
MLEU105532878(ELANE)
RRO104671432(ELANE)
RBB108537896(ELANE)
TFN117074366(ELANE)
PTEH111534745(ELANE)
CANG105527607(ELANE)
CJC100389262(ELANE)
SBQ101030517(ELANE)
CIMI108293190(ELANE)
ANAN105706144
MMUR105860756(ELANE)
LCAT123632351(ELANE)
PCOQ105811217(ELANE)
OGA100965078(ELANE)
MMU50701(Elane)
MCAL110304016(Elane)
MPAH110326943(Elane)
RNO299606(Elane)
MCOC116076175
ANU117696369
MUN110551370(Elane)
CGE100752732(Elane)
MAUA106022252(Elane)
PROB127216810
PLEU114684136(Elane)
MORG121459202(Elane)
MFOT126489243
AAMP119815440
NGI103737354
HGL101705441 101715199(Elane)
CPOC100724414
CCAN109693670
DSP122122820
PLOP125348533
MMMA107157229
OCU127490148
OPI101525948
TUP102488298(ELANE)
GVR103607669(ELANE)
CFA442980(ELANE)
CLUD112666918
VVP112935508
VLG121496213
NPO129521404
AML105234312
UMR103681765
UAR123794053
LLV125087398
MPUF101684702
MNP132009634
MLK131825709
NVS122910277
ORO101375336
EJU114226239
ZCA113916132
MLX118005404
NSU110594100
LWW102729363
FCA100301482(ELANE)
PYU121021310(ELANE)
PBG122486349
PVIV125159748
LRUF124527663
PTG102951727(ELANE)
PPAD109257711
PUC125928787
AJU113597259
HHV120242411
BTA100126050(ELANE)
BOM102274925(ELANE)
BBUB102411920(ELANE)
BBIS104991906(ELANE)
CHX102173292(ELANE)
OAS101110841(ELANE)
BTAX128051781(ELANE)
ODA120864495(ELANE)
MBEZ129558743(ELANE)
SSC100522182(ELANE)
CFR102507529
CBAI105078346
CDK105106576(ELANE)
VPC102529857(ELANE)
BACU103003856(ELANE)
BMUS118892699(ELANE)
LVE103074519(ELANE)
OOR101272927(ELANE)
DLE111170497(ELANE)
PCAD102995281(ELANE)
PSIU116750552(ELANE)
NASI112396312
ECB111774155(ELANE)
EPZ103544822(ELANE)
EAI106834239(ELANE)
MYB106723590(ELANE)
MYD102756029(ELANE)
MMYO118658984(ELANE)
MLF102437746(ELANE)
PKL118711780(ELANE)
EFUS103294436(ELANE)
MNA107538546(ELANE)
DRO112312421(ELANE)
SHON118984390(ELANE)
AJM119044598
PDIC114503126
MMF118616311(ELANE)
PPAM129080092(ELANE)
HAI109390590(ELANE)
RFQ117038398(ELANE)
PALE102888696(ELANE)
PGIG120583673(ELANE)
RAY107500956
MJV108395534
TOD119240359
SETR126030031(ELANE) 126030032
LAV100672001(ELANE)
TMU101350466
ETF101653944
DNM101412103
MDO100030465(ELANE)
GAS123232212
AFZ127545084
PCW110196241(ELANE)
OAA791113
XTR448597(prtn3)
AGIF122856252
 » show all
Reference
1  [PMID:7043201]
  Authors
Barrett AJ.
  Title
Leukocyte elastase.
  Journal
Methods Enzymol 80 Pt C:581-8 (1981)
DOI:10.1016/s0076-6879(81)80046-8
Reference
2  [PMID:6380580]
  Authors
Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.
  Title
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
  Journal
Biochemistry 23:2995-3002 (1984)
DOI:10.1021/bi00308a023
Reference
3  [PMID:3646070]
  Authors
Stein RL, Strimpler AM, Hori H, Powers JC.
  Title
Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.
  Journal
Biochemistry 26:1301-5 (1987)
DOI:10.1021/bi00379a015
Reference
4  [PMID:2655701]
  Authors
Bode W, Meyer E Jr, Powers JC.
  Title
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
  Journal
Biochemistry 28:1951-63 (1989)
DOI:10.1021/bi00431a001
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.37
IUBMB Enzyme Nomenclature: 3.4.21.37
ExPASy - ENZYME nomenclature database: 3.4.21.37
BRENDA, the Enzyme Database: 3.4.21.37
CAS: 9004-06-2

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