KEGG   ENZYME: 3.4.21.45
Entry
EC 3.4.21.45                Enzyme                                 
Name
complement factor I;
complement component C3b inactivator;
C3b inactivator;
C3b/C4b inactivator;
C3bINA;
complement C3b/C4b inactivator;
complement C4b inactivator;
conglutinogen-activating factor C;
complement C3b inactivator;
factor I;
complement C4bi
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage
Comment
Cleavage of complement subcomponent C3b requires its binding to cofactor factor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. In peptidase family S1 (trypsin family)
History
EC 3.4.21.45 created 1981
Orthology
K01333  complement factor I
Genes
HSA3426(CFI)
PTR471271(CFI)
PPS100972456(CFI)
GGO101152970(CFI)
PON100189676(CFI)
NLE100590769(CFI)
MCC720962(CFI)
MCF101866929(CFI)
CSAB103236106(CFI)
CATY105571432(CFI)
PANU101023963(CFI)
TGE112624633(CFI)
RRO104682415(CFI)
RBB108541018(CFI)
TFN117085781(CFI)
PTEH111547889(CFI)
CJC100391781(CFI) 100394341
SBQ101045793(CFI)
CSYR103267946(CFI)
MMUR105872309(CFI)
LCAT123627750(CFI)
OGA100959368(CFI)
MMU12630(Cfi)
MCAL110291924(Cfi)
MPAH110320634(Cfi)
RNO79126(Cfi)
MCOC116094321(Cfi)
MUN110553204(Cfi)
CGE100767614(Cfi)
MAUA101829287(Cfi)
PLEU114682718(Cfi)
MORG121447064(Cfi)
AAMP119801008(Cfi)
NGI103742424(Cfi)
HGL101705881(Cfi)
CPOC100713918(Cfi)
CCAN109678683(Cfi)
DORD105991150(Cfi)
DSP122127129(Cfi)
NCAR124994476
OCU100338923(CFI)
OPI101528177(CFI)
TUP102481776(CFI)
CFA478515(CFI)
CLUD112671641(CFI)
VVP112934203(CFI)
VLG121493423(CFI)
AML100475600(CFI)
UMR103661739(CFI)
UAH113255559(CFI)
UAR123793364(CFI)
ELK111155213
LLV125093278
MPUF101692598(CFI)
ORO101376260(CFI)
EJU114222678(CFI)
ZCA113924300(CFI)
MLX118027090(CFI)
FCA101086649(CFI)
PYU121031034(CFI)
PBG122477475(CFI)
PTG102962910(CFI)
PPAD109248078(CFI)
AJU106983652(CFI)
HHV120236148(CFI)
BTA513197(CFI)
BOM102287323(CFI)
BIU109560254(CFI)
BBUB102416082(CFI)
CHX102183858(CFI)
OAS101119307(CFI)
ODA120861725(CFI)
CCAD122422182(CFI)
SSC100516921(CFI)
CFR102523268(CFI)
CBAI105067955(CFI)
CDK105089900(CFI)
VPC102543905(CFI)
BACU103002616(CFI)
LVE103075383(CFI)
OOR101289802(CFI)
DLE111171502(CFI)
PCAD102980811(CFI)
PSIU116754803(CFI)
ECB100072852(CFI)
EPZ103567319(CFI)
EAI106829798(CFI)
MYB102252498(CFI)
MYD102756039(CFI)
MMYO118673008(CFI)
MLF102426219(CFI)
MNA107534378(CFI)
PKL118702788(CFI)
HAI109379435(CFI)
DRO112296270(CFI)
SHON118977076(CFI)
AJM119057361(CFI)
PDIC114491965(CFI)
PHAS123806835(CFI)
MMF118630969(CFI)
RFQ117022207(CFI)
PALE102890675(CFI)
PGIG120591239(CFI)
PVP105292996(CFI)
RAY107508824(CFI)
MJV108397532(CFI)
TOD119243629(CFI)
SARA101540747(CFI)
LAV100669003(CFI)
TMU101355196
DNM101446071(CFI)
MDO100010034(CFI)
GAS123251043(CFI)
SHR100930026(CFI)
PCW110218594(CFI)
OAA100074735(CFI)
GGA428773(CFI)
PCOC116231271(CFI)
MGP100543148(CFI)
CJO107313597(CFI)
NMEL110398616(CFI)
APLA101794428(CFI)
ACYG106038641(CFI)
AFUL116488545(CFI)
TGU100220637(CFI)
LSR110467995(CFI)
SCAN103825999(CFI)
PMOA120502832(CFI)
OTC121348420(CFI)
PRUF121360344(CFI)
GFR102034612(CFI)
FAB101809393(CFI)
PHI102111430(CFI)
PMAJ107203568(CFI)
CCAE111927779(CFI)
CCW104697127(CFI)
CBRC103617333(CFI)
ETL114062194(CFI)
ZAB102066067(CFI)
FPG101911338(CFI)
FCH102045934(CFI)
CLV102092444(CFI)
EGZ104135533(CFI)
NNI104021159(CFI)
PLET104614576(CFI)
PCRI104025751(CFI)
ACUN113479850(CFI)
TALA104356053(CFI)
PADL103926063(CFI)
ACHC115341707(CFI)
HALD104316698(CFI)
CCRI104159922(CFI)
CSTI104553759(CFI)
EHS104516943(CFI)
FGA104070959(CFI)
GSTE104251848(CFI)
LDI104352306(CFI)
MNB103781088(CFI)
AAM106492118(CFI)
AROW112972467(CFI)
NPD112957257(CFI)
DNE112984124(CFI)
ASN102384439(CFI)
AMJ102572976(CFI)
CPOO109309390(CFI)
GGN109301071(CFI)
PSS102454452(CFI)
CMY102932412(CFI)
CPIC101933482(CFI)
TST117877917(CFI)
CABI116827254(CFI)
MRV120406189(CFI)
ACS100555342(cfi) 100563609
PVT110087284(CFI)
SUND121930675(CFI)
PBI103056264 103056500
PMUR107298569(CFI)
TSR106539604 106539605
PGUT117679940(CFI)
VKO123023110 123023111
PMUA114603966(CFI)
ZVI118083430 118083431
GJA107118175 107123133(CFI)
STOW125440189(CFI)
XLA379108(cfi.S) 399318(cfi.L)
XTR613100(cfi)
NPR108798100(CFI)
RTEM120917703(CFI)
BBUF120989917(CFI)
BGAR122943806(CFI)
DRE557557(cfi)
SRX107737955 107737970
SANH107702173(cfi)
SGH107568969 107568971
CCAR109057532 109061380
CAUA113041663 113065792 113065803
PPRM120463305(cfi)
MAMB125260724
IPU100306949(cfi)
PHYP113530961(cfi)
SMEO124399229(cfi)
TFD113653080 125140095
AMEX103047746
EEE113568303(cfi)
TRU101075279(cfi)
TNGGSTEN00003996G001
LCO104938260(cfi)
ELY117246410 117246411
EFO125883860 125884142
PLEP121962086 121962091
SLUC116034106(cfi)
PFLV114546173(cfi)
GAT120821950(cfi)
PPUG119222913(cfi)
MSAM119913094(cfi)
CUD121505031(cfi)
MZE101470311(cfi)
ONL100696560(cfi)
OAU116335889(cfi)
OLA101171529(cfi)
OML112155793(cfi)
XMA102223757(cfi)
XCO114157609
XHE116718699(cfi)
PRET103480967
PFOR103149071(cfi)
PLAI106949960(cfi)
PMEI106932608(cfi)
GAF122820807(cfi)
CVG107097440(cfi)
CTUL119797147(cfi)
GMU124881303(cfi)
NFU107396474(cfi)
KMR108249806(cfi)
ALIM106532882(cfi)
NWH119410228(cfi)
AOCE111562753(cfi)
MCEP125009009(cfi)
CSEM103389508(cfi)
POV109634739(cfi)
SSEN122761302 122766591
HHIP117751928 117752171
HSP118102985 124851379 124851380
LCF108892255 108892267
SDU111237515 111237520
SLAL111661054 111661063
XGL120797247(cfi) 120797253
HCQ109508328(cfi)
BPEC110163439
MALB109972927(cfi)
BSPL114850378 114851249
SASA106592446(cfi)
OTW121847369(cfi)
OMY100653483(cfi)
OGO124007698(cfi)
CCLU121554603 121554604
ELS105009079 114828738
SFM108936640(cfi)
PKI111852119(cfi)
AANG118232239(cfi)
LOC102695911(cfi)
PSPA121323181(cfi)
ARUT117420862(cfi)
LCM102357588(CFI)
CMK103189378(cfi)
RTP109921992(cfi)
BANY112045704
 » show all
Reference
1  [PMID:7391570]
  Authors
Nagasawa S, Ichihara C, Stroud RM.
  Title
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator.
  Journal
J Immunol 125:578-82 (1980)
Reference
2  [PMID:6210825]
  Authors
Crossley LG.
  Title
C3b inactivator and beta 1H.
  Journal
Methods Enzymol 80 Pt C:112-24 (1981)
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.45
IUBMB Enzyme Nomenclature: 3.4.21.45
ExPASy - ENZYME nomenclature database: 3.4.21.45
BRENDA, the Enzyme Database: 3.4.21.45
CAS: 80295-66-5

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