| Entry |
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| Name |
complement factor I;
complement component C3b inactivator;
C3b inactivator;
C3b/C4b inactivator;
C3bINA;
complement C3b/C4b inactivator;
complement C4b inactivator;
conglutinogen-activating factor C;
complement C3b inactivator;
factor I;
complement C4bi
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage
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| Comment |
Cleavage of complement subcomponent C3b requires its binding to cofactor factor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. In peptidase family S1 (trypsin family)
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| History |
EC 3.4.21.45 created 1981
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Nagasawa S, Ichihara C, Stroud RM. |
|---|
| Title |
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator. |
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| Journal |
J Immunol 125:578-82 (1980) |
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| Reference |
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| Authors |
Crossley LG. |
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| Title |
C3b inactivator and beta 1H. |
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| Journal |
Methods Enzymol 80 Pt C:112-24 (1981) |
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| Reference |
|
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| Authors |
Muller-Eberhard HJ. |
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| Title |
Molecular organization and function of the complement system. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.45 |
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